Information on EC 1.14.13.134 - beta-amyrin 11-oxidase

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The expected taxonomic range for this enzyme is: Glycyrrhiza uralensis

EC NUMBER
COMMENTARY hide
1.14.13.134
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RECOMMENDED NAME
GeneOntology No.
beta-amyrin 11-oxidase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
11alpha-hydroxy-beta-amyrin + O2 + NADPH + H+ = 11-oxo-beta-amyrin + 2 H2O + NADP+
show the reaction diagram
(1b)
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beta-amyrin + 2 O2 + 2 NADPH + 2 H+ = 11-oxo-beta-amyrin + 3 H2O + 2 NADP+
show the reaction diagram
overall reaction
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beta-amyrin + O2 + NADPH + H+ = 11alpha-hydroxy-beta-amyrin + H2O + NADP+
show the reaction diagram
(1a)
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
glycyrrhetinate biosynthesis
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NIL
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SYSTEMATIC NAME
IUBMB Comments
beta-amyrin,NADPH:oxygen oxidoreductase (hydroxylating)
Requires cytochrome P-450. Part of the glycyrrhizin biosynthesis pathway. The enzyme is also able to oxidize 30-hydroxy-beta-amyrin to 11alpha,30-dihydroxy-beta-amyrin but this is not thought to be part of glycyrrhizin biosynthesis.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
11-oxo-beta-amyrin + O2 + NADPH + H+
30-hydroxy-11-oxo-beta-amyrin + H2O + NADP+
show the reaction diagram
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single oxidation reaction catalyzed by CYP72A154
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-
?
30-hydroxy-11-oxo-beta-amyrin + O2 + NADPH + H+
glycyrrhetaldehyde + H2O + NADP+
show the reaction diagram
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single oxidation reaction catalyzed by CYP72A154
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-
?
30-hydroxy-beta-amyrin + O2 + NADPH + H+
11-deoxoglycyrrhetinic acid + H2O + NADP+
show the reaction diagram
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?
beta-amyrin + O2 + NADPH + H+
11-oxo-beta-amyrin + H2O + NADP+
show the reaction diagram
beta-amyrin + O2 + NADPH + H+
30-hydroxy-beta-amyrin + H2O + NADP+
show the reaction diagram
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single oxidation reaction catalyzed by CYP72A154
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-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
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not detected in leaves and stems
Manually annotated by BRENDA team
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli DH10Bac cells and in Saccharomyces cerevisiae strain BJ2168
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expressed in Spodoptera frugiperda 9 (Sf9) insect cells
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