Information on EC 1.14.11.12 - gibberellin-44 dioxygenase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.14.11.12
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RECOMMENDED NAME
GeneOntology No.
gibberellin-44 dioxygenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
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-
Diterpenoid biosynthesis
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gibberellin biosynthesis III (early C-13 hydroxylation)
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
(gibberellin-44),2-oxoglutarate:oxygen oxidoreductase
Requires Fe2+.
CAS REGISTRY NUMBER
COMMENTARY hide
112198-85-3
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
different mutants: mutations in genes involved in the ethylene signal transduction pathway and a mutation at the start of exon 2
UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
gibberellin 44 + 2-oxoglutarate + O2
gibberellin 19 + succinate + CO2
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
gibberellin 44 + 2-oxoglutarate + O2
gibberellin 19 + succinate + CO2
show the reaction diagram
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Fe2+
-
required
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
about 4.7fold enhanced expression in Arabidopsis thaliana mutant aba2 with a mutation at the the start of exon 2
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
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assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
381000
-
gel filtration, HPLC
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE