Information on EC 1.13.12.1 - arginine 2-monooxygenase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.13.12.1
-
RECOMMENDED NAME
GeneOntology No.
arginine 2-monooxygenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-arginine + O2 = 4-guanidinobutanamide + CO2 + H2O
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
oxidative decarboxylation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
L-arginine degradation X (arginine monooxygenase pathway)
-
-
arginine metabolism
-
-
Arginine and proline metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
L-arginine:oxygen 2-oxidoreductase (decarboxylating)
A flavoprotein. Also acts on canavanine and homoarginine.
CAS REGISTRY NUMBER
COMMENTARY hide
9027-36-5
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Brevibacterium lipolyticum
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
canavanine + O2
3-guanidoxypropionamide + CO2 + H2O
show the reaction diagram
homoarginine + O2
5-guanidinovaleramide + CO2 + H2O
show the reaction diagram
L-arginine + O2
4-guanidinobutanamide + CO2 + H2O
show the reaction diagram
L-arginine + O2
?
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-arginine + O2
?
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
flavin
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Chloroacetophenone
-
-
diethyldicarbonate
-
modifies one histidyl residue per flavin
homoarginine
-
competitive to L-arginine
iodoacetate
-
-
oxygen
-
inactivation
p-chloromercuribenzoate
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
81
canavanine
-
-
100
homoarginine
-
-
2.3
L-arginine
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0004
Brevibacterium lipolyticum
-
-
additional information
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
9
-
L-arginine
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
dithionite and thioglycolate protect against inactivation by O2
-
L-arginine protects against inactivation by O2
-
partially purified enzyme is rather unstable
-
storage in N2-atmosphere protects against inactivation by O2
-
OXIDATION STABILITY
ORGANISM
UNIPROT
LITERATURE
inactivated by O2
-
439353
partially purified enzyme extremely unstable in presence of O2
-
390102
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE