Information on EC 1.13.11.78 - 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.13.11.78
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RECOMMENDED NAME
GeneOntology No.
2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2-amino-1-hydroxyethyl)phosphonate + O2 = glycine + phosphate
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
2-aminoethylphosphonate degradation III
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Phosphonate and phosphinate metabolism
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SYSTEMATIC NAME
IUBMB Comments
2-amino-1-hydroxyethylphosphonate:oxygen 1-oxidoreductase (glycine-forming)
Requires Fe2+. The enzyme, characterized from a marine bacterium, is involved in a 2-aminoethylphosphonate degradation pathway.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+/-)-(2-amino-1-hydroxyethyl)phosphonate + O2
?
show the reaction diagram
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50% conversion
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?
(2-amino-1-hydroxyethyl)phosphonate + O2
glycine + phosphate
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(2-amino-1-hydroxyethyl)phosphonate + O2
glycine + phosphate
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
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partial activation compared to Fe2+
Co2+
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partial activation compared to Fe2+
Cu2+
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partial activation compared to Fe2+
Fe2+
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dependent on, contains 1.2 mol of iron per mole of enzyme
Fe3+
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partial activation compared to Fe2+
Iron
the enzyme contains 1.2 Fe per monomer, contains a dinuclear iron cluster. The mixed-valent FeII/FeIII state is the catalytically active cofactor form
Mn2+
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partial activation compared to Fe2+
Ni2+
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partial activation compared to Fe2+
Zn2+
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partial activation compared to Fe2+
additional information
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not influenced by Mg2+
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Ni2+-affinity chromatography
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells