Information on EC 1.13.11.69 - carlactone synthase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.13.11.69
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RECOMMENDED NAME
GeneOntology No.
carlactone synthase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
9-cis-10'-apo-beta-carotenal + 2 O2 = carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
5-deoxystrigol biosynthesis
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Carotenoid biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
9-cis-10'-apo-beta-carotenal:O2 oxidoreductase (14,15-cleaving, carlactone-forming)
Requires Fe2+. The enzyme participates in a pathway leading to biosynthesis of strigolactones, plant hormones involved in promotion of symbiotic associations known as arbuscular mycorrhiza. Also catalyses EC 1.13.11.70, all-trans-10'-apo-beta-carotenal 13,14-cleaving dioxygenase, but 10-fold slower.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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transgenic SlCCD8 knockout lines display an increased shoot branching, reduced plant height, increased number of nodes and excessive adventitious root development. Transgenic lines show a reproductive phenotypes such as smaller flowers, fruits, as well as fewer and smaller seeds per fruit. Infestation by Phelipanche ramosa is reduced by 90% in lines with a relatively mild reduction in strigolactone biosynthesis and secretion while arbuscular mycorrhizal symbiosis, apical dominance and fruit yield are only mildly affected
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
9-cis-10'-apo-beta-carotenal + 2 O2
carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal
show the reaction diagram
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?
all-trans-10'-apo-beta-carotenal + O2
13-apo-beta-carotenone + (2E,4E,6E)-4-methylocta-2,4,6-trienedial
show the reaction diagram
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?
additional information
?
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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no evidence for feedback regulation
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
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expression of gene is widely distributed, but at low level
Manually annotated by BRENDA team
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme is upregulated in the root eleongation zone following 24 h auxin treatment, and hypocotyl, and this is not required for the inhibition of shoot branching
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expression is induced by auxin
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gene is repressed by low phosphate stress
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no evidence is found for auxin-induced upregulation of enzyme expression in nodal tissue
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information