Information on EC 1.13.11.59 - torulene dioxygenase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.13.11.59
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RECOMMENDED NAME
GeneOntology No.
torulene dioxygenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
torulene + O2 = 4'-apo-beta,psi-caroten-4'-al + 3-methylbut-2-enal
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Carotenoid biosynthesis
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Metabolic pathways
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neurosporaxanthin biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
torulene:oxygen oxidoreductase
It is assumed that 3-methylbut-2-enal is formed. The enzyme cannot cleave the saturated 3',4'-bond of gamma-carotene which implies that a 3',4'-double bond is neccessary for this reaction.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3,4-didehydrolycopene + O2
apo-4'-lycopenal + 3-methylbut-2-enal
show the reaction diagram
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Cao2 accepts both cyclic and acyclic carotenals
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?
beta-apo-10'-carotenal + O2
retinal + 3-methylbut-2-enal
show the reaction diagram
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i.e. beta-apo-15'-carotenal
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?
beta-apo-8'-carotenal + O2
beta-apo-14'-carotenal + 3-methylbut-2-enal
show the reaction diagram
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?
beta-apo-8'-lycopenal + O2
crocetindial + ?
show the reaction diagram
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main product. Substrate contains both a non-oxygenated tail and an aldehyde end group, reaction leads mainly to the dialdehyde
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?
torulene + O2
beta-apo-4'-carotenal + 3-methylbut-2-enal
show the reaction diagram
additional information
?
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression as GST fusion protein
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expression in Escherichia coli
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
Cao-2 exhibits the same transcriptional pattern as Al-2, which encodes the phytoene synthase/beta-cyclase. The mRNA levels for both genes are very low in vegetative mycelia grown in the dark, and increase markedly upon illumination. Illumination does not lead to any detectable increase of the Cao-2 and Al-2 mRNA amounts in wc-1 or wc-2 mutants, confirming that Cao-2 photoinduction is mediated by the WC-1/WC-2 photoreceptor system
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mRNA accumulates following light exposure to reach a maximum approximately 1 h after illumination onset
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G71D
mutant strain accumulates torulene and is not able to produce neurosporaxanthin
additional information