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Disease on EC 1.13.11.52 - indoleamine 2,3-dioxygenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Habitual
Role of Indoleamine 2,3-Dioxygenase and Tryptophan 2,3-Dioxygenase in Patients with Recurrent Miscarriage.
Abortion, Spontaneous
Coding region polymorphisms in the indoleamine 2,3-dioxygenase (INDO) gene and recurrent spontaneous abortion.
Indoleamine 2,3-dioxygenase levels at the normal and recurrent spontaneous abortion fetal-maternal interface.
Acquired Immunodeficiency Syndrome
HIV-1 Tat Protein Induces the Production of IDO in Human Monocyte Derived-Dendritic Cells through a Direct Mechanism: Effect on T Cells Proliferation.
Intracerebroventricular administration of HIV-1 Tat induces brain cytokine and indoleamine 2,3-dioxygenase expression: A possible mechanism for AIDS comorbid depression.
Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling.
Tryptophan depletion in context of the inflammatory and general nutritional status of a low-income South African HIV-infected population.
Acute Coronary Syndrome
Indoleamine 2,3-Dioxygenase (IDO) Enzyme Links Innate Immunity and Altered T-Cell Differentiation in Non-ST Segment Elevation Acute Coronary Syndrome.
Acute Kidney Injury
Indoleamine-2,3-Dioxygenase Activates Wnt/?-Catenin Inducing Kidney Fibrosis after Acute Kidney Injury.
Adenocarcinoma
Expression of indoleamine 2,3-dioxygenase in metastatic pancreatic ductal adenocarcinoma recruits regulatory T cells to avoid immune detection.
Expression of PD-L1, indoleamine 2,3-dioxygenase and the immune microenvironment in gastric adenocarcinoma.
Increased synthesis of indoleamine-2,3-dioxygenase protein is positively associated with impaired survival in patients with serous-type, but not with other types of, ovarian cancer.
Indoleamine 2,3-Dioxygenase (IDO) Expression Is an Independent Prognostic Marker in Esophageal Adenocarcinoma.
Influence of Indoleamine-2,3-Dioxygenase and Its Metabolite Kynurenine on ?? T Cell Cytotoxicity against Ductal Pancreatic Adenocarcinoma Cells.
Adenocarcinoma of Lung
Association between peripheral blood markers and immune-related factors on tumor cells in patients with resected primary lung adenocarcinoma.
Expression of PD-L1, PD-L2, and IDO1 on tumor cells and density of CD8-positive tumor-infiltrating lymphocytes in early-stage lung adenocarcinoma according to histological subtype.
Adrenocortical Carcinoma
Indoleamine 2,3-Dioxygenase-1 Expression in Adrenocortical Carcinoma.
Alopecia
Fibroblast cell-based therapy prevents induction of alopecia areata in an experimental model.
Alopecia Areata
Psoriasis is characterized by deficient negative immune regulation compared to transient delayed-type hypersensitivity reactions.
Alzheimer Disease
Circulating Antibodies to IDO/THO Pathway Metabolites in Alzheimer's Disease.
Indoleamine 2,3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus.
Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease.
Proinflammatory cytokine interferon-gamma increases induction of indoleamine 2,3-dioxygenase in monocytic cells primed with amyloid beta peptide 1-42: implications for the pathogenesis of Alzheimer's disease.
Swimming exercise prevents behavioural disturbances induced by an intracerebroventricular injection of amyloid-?1-42 peptide through modulation of cytokine/NF-kappaB pathway and indoleamine-2,3-dioxygenase in mouse brain.
Synthesis and biological evaluation of novel tryptoline derivatives as indoleamine 2,3-dioxygenase (IDO) inhibitors.
The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease.
Anemia
Proceedings: Rat liver tryptophan pyrrolase activity in iron deficiency anaemia.
Anemia, Aplastic
[An experimental study on the regulation of bone marrow-derived mesenchymal stem cells through indoleamine 2,3-dioxygenase signaling pathway by thymosin ?1 for improving the immunosuppression mediated by T cell].
Anemia, Hemolytic, Autoimmune
Indoleamine 2,3 dioxygenase contributes to transferable tolerance in rat red blood cell inducible model of experimental autoimmune haemolytic anaemia.
Anemia, Iron-Deficiency
Proceedings: Rat liver tryptophan pyrrolase activity in iron deficiency anaemia.
Anhedonia
Indoleamine 2,3-dioxygenase mediates anhedonia and anxiety-like behaviors caused by peripheral lipopolysaccharide immune challenge.
Major depression model induced by repeated and intermittent lipopolysaccharide administration: Long-lasting behavioral, neuroimmune and neuroprogressive alterations.
Mapping inflammation onto mood: Inflammatory mediators of anhedonia.
Arrhythmias, Cardiac
Circadian arrhythmia dysregulates emotional behaviors in aged Siberian hamsters.
Arteriosclerosis
Autologous mesenchymal stem cells prevent transplant arteriosclerosis by enhancing local expression of interleukin-10, interferon-?, and indoleamine 2,3-dioxygenase.
Arthritis
Addition of an indoleamine-2,3,-dioxygenase inhibitor to B cell depletion therapy blocks autoreactive B cell activation and recurrence of arthritis.
Amelioration of Rat Collagen-induced Arthritis through CD4+ T Cells Apoptosis and Synovial Interleukin-17 Reduction by Indoleamine 2,3-dioxygenase Gene Therapy.
Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway.
IDO and Kynurenine Metabolites in Peripheral and CNS Disorders.
Indoleamine 2,3-dioxygenase as a modifier of pathogenic inflammation in cancer and other inflammation-associated diseases.
Therapeutic antibody targeting of indoleamine-2,3-dioxygenase (IDO2) inhibits autoimmune arthritis.
Arthritis, Experimental
A distinct tolerogenic subset of splenic IDO(+)CD11b(+) dendritic cells from orally tolerized mice is responsible for induction of systemic immune tolerance and suppression of collagen-induced arthritis.
Amelioration of Rat Collagen-induced Arthritis through CD4+ T Cells Apoptosis and Synovial Interleukin-17 Reduction by Indoleamine 2,3-dioxygenase Gene Therapy.
Human embryonic stem cell-derived mesenchymal stromal cells ameliorate collagen-induced arthritis by inducing host-derived indoleamine 2,3 dioxygenase.
Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer's patches in an orally tolerized, collagen-induced arthritis mouse model.
Arthritis, Infectious
Indoleamine 2,3-dioxygenase activity as a potential biomarker of immune suppression during visceral leishmaniasis.
Arthritis, Psoriatic
Tryptophan catabolism in synovial fluid of various arthropathies and its relationship with inflammatory cytokines.
Arthritis, Rheumatoid
Distribution of myeloid dendritic cells and plasmacytoid dendritic cells in the synovial tissues of rheumatoid arthritis.
Treg cell function in rheumatoid arthritis is compromised by ctla-4 promoter methylation resulting in a failure to activate the indoleamine 2,3-dioxygenase pathway.
Tryptophan catabolism in synovial fluid of various arthropathies and its relationship with inflammatory cytokines.
Aspergillosis
Thymosin alpha1: an endogenous regulator of inflammation, immunity, and tolerance.
Asthma
Decreased expression of indolamine 2,3-dioxygenase in childhood allergic asthma and its inverse correlation with fractional concentration of exhaled nitric oxide.
Inhibition of experimental asthma by indoleamine 2,3-dioxygenase.
Manipulation of indoleamine 2,3-dioxygenase (IDO) for clinical transplantation: promises and challenges.
Myeloid differentiation primary response protein 88 blockade upregulates indoleamine 2,3-dioxygenase expression in rheumatoid synovial fibroblasts.
Relationships of indoleamine 2,3-dioxygenase activity and cofactors with asthma and nasal polyps.
Th17/Treg imbalance is associated with reduced indoleamine 2,3 dioxygenase activity in childhood allergic asthma.
Astrocytoma
Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types.
Inhibition of indoleamine 2,3-dioxygenase activity in IFN-gamma stimulated astroglioma cells decreases intracellular NAD levels.
Metabolism of L-tryptophan to kynurenate and quinolinate in the central nervous system: effects of 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
Role of indoleamine-2,3-dioxygenase in alpha/beta and gamma interferon-mediated antiviral effects against herpes simplex virus infections.
Atherosclerosis
Activation of indoleamine 2,3-dioxygenase-induced tryptophan degradation in advanced atherosclerotic plaques: Tampere vascular study.
Atherosclerosis Linked to Aberrant Amino Acid Metabolism and Immunosuppressive Amino Acid Catabolizing Enzymes.
Elevated indoleamine-2,3-dioxygenase enzyme activity in a novel mouse model of HIV-associated atherosclerosis.
Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health.
Indoleamine 2,3-dioxygenase enzyme activity correlates with risk factors for atherosclerosis: the Cardiovascular Risk in Young Finns Study.
Indoleamine 2,3-Dioxygenase Fine-Tunes Immune Homeostasis in Atherosclerosis and Colitis through Repression of Interleukin-10 Production.
Indoleamine 2,3-dioxygenase-1 is protective in atherosclerosis and its metabolites provide new opportunities for drug development.
Inhibition of indoleamine 2,3-dioxygenase (IDO) promotes vascular inflammation and increases atherosclerosis in Apoe-/- mice.
Moderating effect of indoleamine 2,3-dioxygenase (IDO) activation in the association between depressive symptoms and carotid atherosclerosis: Evidence from the Young Finns study.
Redox Pioneer: Professor Roland Stocker.
Autoimmune Diseases
Aryl hydrocarbon receptor and kynurenine: recent advances in autoimmune disease research.
Gene therapy with adenovirus-delivered indoleamine 2,3-dioxygenase improves renal function and morphology following allogeneic kidney transplantation in rat.
Limited Effect of Indolamine 2,3-Dioxygenase Expression and Enzymatic Activity on Lupus-Like Disease in B6.Nba2 Mice.
Manipulation of indoleamine 2,3-dioxygenase (IDO) for clinical transplantation: promises and challenges.
Myeloid differentiation primary response protein 88 blockade upregulates indoleamine 2,3-dioxygenase expression in rheumatoid synovial fibroblasts.
Potential role of indoleamine 2,3-dioxygenase in primary biliary cirrhosis.
Role of indoleamine 2,3-dioxygenase in testicular immune-privilege.
Autoimmune Pancreatitis
Autoimmune Pancreatitis Type 2: Diagnostic Utility of PD-L1 Immunohistochemistry.
Bacteremia
Expression of inflammation-associated genes in circulating leukocytes and activity of indoleamine-2,3-dioxygenase in dairy cattle with acute puerperal metritis and bacteremia.
Bacterial Infections
Immunological paradigms and the pathogenesis of ovine chlamydial abortion.
Inhibition of indoleamine 2,3-dioxygenase suppresses NK cell activity and accelerates tumor growth.
Boutonneuse Fever
Intralesional expression of mRNA of interferon- gamma , tumor necrosis factor- alpha , interleukin-10, nitric oxide synthase, indoleamine-2,3-dioxygenase, and RANTES is a major immune effector in Mediterranean spotted fever rickettsiosis.
Brain Abscess
Potential role of human brain microvascular endothelial cells in the pathogenesis of brain abscess: inhibition of Staphylococcus aureus by activation of indoleamine 2,3-dioxygenase.
Brain Injuries
Kynurenine pathway enzymes in brain: responses to ischemic brain injury versus systemic immune activation.
Neuroprotective effects of human umbilical cord-derived mesenchymal stem cells on periventricular leukomalacia-like brain injury in neonatal rats.
Overexpression of kynurenic acid and 3-hydroxyanthranilic acid after rat traumatic brain injury.
Brain Ischemia
Inhibition of indoleamine 2,3-dioxygenase suppresses NK cell activity and accelerates tumor growth.
Kynurenine pathway enzymes in brain: responses to ischemic brain injury versus systemic immune activation.
Species heterogeneity between gerbils and rats: quinolinate production by microglia and astrocytes and accumulations in response to ischemic brain injury and systemic immune activation.
Brain Neoplasms
A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory proteins.
IDO expression in brain tumors increases the recruitment of regulatory T cells and negatively impacts survival.
Imaging Correlates of Differential Expression of Indoleamine 2,3-Dioxygenase in Human Brain Tumors.
The Kynurenine/Tryptophan Ratio and Glioblastoma Patients Treated with Hsppc-96 Vaccine.
Breast Neoplasms
Analysis of indoleamine 2-3 dioxygenase (IDO1) expression in breast cancer tissue by immunohistochemistry.
Association between Cyclooxygenase-2 and Indoleamine 2,3-Dioxygenase Expression in Breast Cancer Patients from Pakistan.
Breast cancer: Occluded role of mitochondria N-acetylserotonin/melatonin ratio in co-ordinating pathophysiology.
Cancer/stroma interplay via cyclooxygenase-2 and indoleamine 2,3-dioxygenase promotes breast cancer progression.
Chemoresistance was correlated with elevated expression and activity of indoleamine 2,3-dioxygenase in breast cancer.
Codelivered Chemotherapeutic Doxorubicin via a Dual-Functional Immunostimulatory Polymeric Prodrug for Breast Cancer Immunochemotherapy.
Dual-Blockade Immune Checkpoint for Breast Cancer Treatment Based on a Tumor-Penetrating Peptide Assembling Nanoparticle.
Effect of the association of 1-methyl-DL-tryptophan with paclitaxel on the expression of indoleamine 2,3-dioxygenase in cultured cancer cells from patients with breast cancer.
Expression of Programmed cell death protein 1 (PD-1) and Indoleamine 2,3-dioxygenase (IDO) in the tumor microenvironment and in tumor-draining lymph nodes of breast cancer.
Forkhead box P3 and indoleamine 2,3-dioxygenase co-expression in Pakistani triple negative breast cancer patients.
Heme oxygenase-1 inhibits rat and human breast cancer cell proliferation: mutual cross inhibition with indoleamine 2,3-dioxygenase.
High expression of indoleamine 2,3-dioxygenase in the tumour is associated with medullary features and favourable outcome in basal-like breast carcinoma.
High Indoleamine 2,3-Dioxygenase Is Correlated With Microvessel Density and Worse Prognosis in Breast Cancer.
IDO Inhibition Facilitates Antitumor Immunity of V?9V?2 T Cells in Triple-Negative Breast Cancer.
Immunological and nonimmunological effects of indoleamine 2,3-dioxygenase on breast tumor growth and spontaneous metastasis formation.
Indoleamine 2,3-dioxygenase activity and L-tryptophan transport in human breast cancer cells.
Indoleamine 2,3-dioxygenase expression and overall survival in patients diagnosed with breast cancer in Pakistan.
Indoleamine-2,3-dioxygenase and Interleukin-6 associated with tumor response to neoadjuvant chemotherapy in breast cancer.
Inhibition of Indoleamine 2,3-Dioxygenase Enhances the Therapeutic Efficacy of Immunogenic Chemotherapeutics in Breast Cancer.
Prognostic value of tumor infiltrating lymphocyte subsets in breast cancer depends on hormone receptor status.
Review of 10 years of research on breast cancer patients: Focus on indoleamine 2,3-dioxygenase.
Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells.
Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer.
The footprint of kynurenine pathway in every cancer: a new target for chemotherapy.
Tryptophan catabolism increases in breast cancer patients compared to healthy controls without affecting the cancer outcome or response to chemotherapy.
Type III TGF-? receptor downregulation generates an immunotolerant tumor microenvironment.
[Indoleamine 2,3-dioxygenase activity during chemotherapy in patients with breast cancer]
[Indoleamine 2,3-dioxygenase activity during chemotherapy or hormone therapy in patients with breast cancer].
[Indoleamine 2,3-Dioxygenase Activity during Fulvestrant Therapy for Aromatase Inhibitor-Resistant Metastatic Breast Cancer].
[Indoleamine 2,3-dioxygenase expression in breast cancer patients during chemotherapy]
[Study of indoleamine 2,3-dioxygenase expression in patients with breast cancer]
Carcinogenesis
Cancer prevention and therapy through the modulation of the tumor microenvironment.
Cell intrinsic & extrinsic factors in cervical carcinogenesis.
Early Carcinogenesis Involves the Establishment of Immune Privilege via Intrinsic and Extrinsic Regulation of Indoleamine 2,3-dioxygenase-1: Translational Implications in Cancer Immunotherapy.
FOXP3+ regulatory T cells and tumoral indoleamine 2,3-dioxygenase expression predicts the carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas.
Inhibitory effects of a selective prostaglandin E2 receptor antagonist RQ-15986 on inflammation-related colon tumorigenesis in APC-mutant rats.
Kynurenine emerges from the shadows - Current knowledge on its fate and function.
Recent advances in small molecule based cancer immunotherapy.
The deletion of tryptophan peroxidase activity during dye carcinogenesis.
The Role of Indoleamine 2,3-Dioxygenase in Diethylnitrosamine-Induced Liver Carcinogenesis.
Towards a genetic definition of cancer-associated inflammation: role of the IDO pathway.
Carcinoma
Analysis of transcription factors regulating induction of indoleamine 2,3-dioxygenase by IFN-gamma.
CXCR3 ligands promote expression of functional indoleamine 2,3-dioxygenase (IDO) in basal cell carcinoma keratinocytes.
Differential Expression and Clinicopathological Significance of HER2, Indoleamine 2,3-Dioxygenase and PD-L1 in Urothelial Carcinoma of the Bladder.
Exosome-derived miR-142-5p remodels lymphatic vessels and induces IDO to promote immune privilege in the tumour microenvironment.
Exosomes-carrying Epstein-Barr virus-encoded small RNA-1 induces indoleamine 2, 3-dioxygenase expression in tumor-infiltrating macrophages of oral squamous-cell carcinomas and suppresses T-cell activity by activating RIG-I/IL-6/TNF-? pathway.
Expression and prognostic impact of indoleamine 2,3-dioxygenase in oral squamous cell carcinomas.
Expression of Indoleamine 2,3-Dioxygenase Gene Is a Feature of Poorly Differentiated Non-muscle-invasive Urothelial Cell Bladder Carcinomas.
Expression of indoleamine 2,3-dioxygenase in carcinoma of human endometrium and uterine cervix.
Expression of indoleamine 2,3-dioxygenase in tumor endothelial cells correlates with long-term survival of patients with renal cell carcinoma.
Expression of indoleamine 2,3-dioxygenase predicts shorter survival in patients with vulvar squamous cell carcinoma (vSCC) not influencing on the recruitment of FOXP3-expressing regulatory T cells in cancer nests.
Expression of New York esophageal squamous cell carcinoma 1 and its association with Foxp3 and indoleamine-2,3-dioxygenase in microenvironment of nonsmall cell lung cancer.
High IDO1 Expression Is Associated with Poor Outcome in Patients with Anal Cancer Treated with Definitive Chemoradiotherapy.
Indoleamine 2,3-dioxygenase promotes peritoneal metastasis of ovarian cancer by inducing an immunosuppressive environment.
Indoleamine-pyrrole 2,3-dioxygenase might be a prognostic biomarker for patients with renal cell carcinoma.
Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma.
Interferon gamma-induced apoptosis of head and neck squamous cell carcinoma is connected to indoleamine-2,3-dioxygenase via mitochondrial and ER stress-associated pathways.
Involvement of indoleamine 2,3-dioxygenase in impairing tumor-infiltrating CD8 T-cell functions in esophageal squamous cell carcinoma.
Localization of indoleamine 2,3-dioxygenase in human esophageal squamous cell carcinomas.
Myeloid CD11c+ S100+ dendritic cells express indoleamine 2,3-dioxygenase at the inflammatory border to invasive lower lip squamous cell carcinoma.
Prognostic value of tumour-infiltrating CD8+?lymphocytes in rectal cancer after neoadjuvant chemoradiation: is indoleamine-2,3-dioxygenase (IDO1) a friend or foe?
Role of the immunosuppressive enzyme indoleamine 2,3-dioxygenase in the progression of ovarian carcinoma.
SAHA down-regulates the expression of indoleamine 2,3-dioxygenase via inhibition of the JAK/STAT1 signaling pathway in gallbladder carcinoma cells.
Targeting the IDO-BCL2A1-Cytochrome c Pathway Promotes Apoptosis in Oral Squamous Cell Carcinoma.
The expression and prognostic relevance of indoleamine 2,3-dioxygenase in tongue squamous cell carcinoma.
The immunoregulatory mechanisms of carcinoma for its survival and development.
The immunotherapeutic role of indoleamine 2,3-dioxygenase in head and neck squamous cell carcinoma: A systematic review.
The paradoxical patterns of expression of indoleamine 2,3-dioxygenase in colon cancer.
Tumoral indoleamine 2,3-dioxygenase expression predicts poor outcome in laryngeal squamous cell carcinoma.
[Inhibitory Effect of Feiji Recipe on IDO Induced Immune Escape on the Murine Model of Lewis Lung Carcinoma].
[Study of indoleamine 2,3-dioxygenase expression in patients of esophageal squamous cell carcinoma]
Carcinoma, Basal Cell
CXCR3 ligands promote expression of functional indoleamine 2,3-dioxygenase (IDO) in basal cell carcinoma keratinocytes.
Carcinoma, Ehrlich Tumor
Dual effects of indoleamine 2,3-dioxygenase inhibitors on the therapeutic effects of cyclophosphamide and cycloplatam on Ehrlich ascites tumor in mice.
Carcinoma, Hepatocellular
Effect of potent antiglucocorticoids on dexamethasone induced enzymes in cultured hepatoma and rat liver cells.
Effects of exogenous histones upon the induction of tryptophan pyrrolase and tyrosine transaminase in liver and Morris hepatomas.
Expression and prognosis role of indoleamine 2,3-dioxygenase in hepatocellular carcinoma.
Glucocorticoid receptors in Morris hepatomas and host liver and the correlation of biological activity with receptor levels.
Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation.
Immunoactivative role of indoleamine 2,3-dioxygenase in human hepatocellular carcinoma.
Indoleamine 2,3-dioxygenase provides adaptive resistance to immune checkpoint inhibitors in hepatocellular carcinoma.
Indoleamine 2,3-dioxygenase: As a potential prognostic marker and immunotherapeutic target for hepatocellular carcinoma.
Metabolic adaptations in rat hepatomas. II. Tryptophan pyrrolase and tyrosine alpha-ketoglutarate transaminase.
METABOLIC ADAPTATIONS IN RAT HEPATOMAS. VI. SUBSTRATE-HORMONE RELATIONSHIPS IN TRYPTOPHAN PYRROLASE INDUCTION.
Pretranslational control of tryptophan oxygenase levels in Morris hepatoma and host liver.
Regulation of gene expression in rat hepatocytes and hepatoma cells by insulin: quantitation of messenger ribonucleic acid's coding for tyrosine aminotransferase, tryptophan oxygenase, and phosphoenolpyruvate carboxykinase.
Tryptophan oxygenase in the liver and Albert hepatoma in mice.
TRYPTOPHAN PYRROLASE ACTIVITY IN TRANSPLANTED "MINIMAL-DEVIATION" HEPATOMAS.
[On tryptophan pyrrolase activity in minimal hepatomas of C3HA mice under the effects of cortisone]
[Substrate and hormonal induction of tryptophan pyrrolase detected in hepatoma 22a cells during transplantation to C3HA mice immunized with syngeneic liver antigens]
[Tryptophan pyrrolase activity in the liver and in some transplantable C3HA mouse hepatomas]
Carcinoma, Lewis Lung
[Inhibitory Effect of Feiji Recipe on IDO Induced Immune Escape on the Murine Model of Lewis Lung Carcinoma].
Carcinoma, Non-Small-Cell Lung
Expression of New York esophageal squamous cell carcinoma 1 and its association with Foxp3 and indoleamine-2,3-dioxygenase in microenvironment of nonsmall cell lung cancer.
High indoleamine-2,3-dioxygenase 1 (IDO) activity is linked to primary resistance to immunotherapy in non-small cell lung cancer (NSCLC).
IDO Immune Status after Chemoradiation May Predict Survival in Lung Cancer Patients.
Indoleamine 2,3-dioxygenase activity and clinical outcome following induction chemotherapy and concurrent chemoradiation in Stage III non-small cell lung cancer.
Indoleamine-2,3-Dioxygenase in Non-Small Cell Lung Cancer: A Targetable Mechanism of Immune Resistance Frequently Coexpressed With PD-L1.
Induction of indoleamine 2,3-dioxygenase (IDO) enzymatic activity contributes to interferon-gamma induced apoptosis and death receptor 5 expression in human non-small cell lung cancer cells.
Long-lasting disease stabilization in the absence of toxicity in metastatic lung cancer patients vaccinated with an epitope derived from indoleamine 2,3 dioxygenase.
NK cell-based therapeutics for lung cancer.
Revisiting IDO and its value as a predictive marker for anti-PD-1 resistance.
Carcinoma, Ovarian Epithelial
Atractylenolide I modulates ovarian cancer cell-mediated immunosuppression by blocking MD-2/TLR4 complex-mediated MyD88/NF-?B signaling in vitro.
Carcinoma, Renal Cell
Expression of indoleamine 2,3-dioxygenase in tumor endothelial cells correlates with long-term survival of patients with renal cell carcinoma.
Indoleamine-pyrrole 2,3-dioxygenase might be a prognostic biomarker for patients with renal cell carcinoma.
Carcinoma, Squamous Cell
Exosome-derived miR-142-5p remodels lymphatic vessels and induces IDO to promote immune privilege in the tumour microenvironment.
Expression of indoleamine 2,3-dioxygenase predicts shorter survival in patients with vulvar squamous cell carcinoma (vSCC) not influencing on the recruitment of FOXP3-expressing regulatory T cells in cancer nests.
High IDO1 Expression Is Associated with Poor Outcome in Patients with Anal Cancer Treated with Definitive Chemoradiotherapy.
Interferon gamma-induced apoptosis of head and neck squamous cell carcinoma is connected to indoleamine-2,3-dioxygenase via mitochondrial and ER stress-associated pathways.
Localization of indoleamine 2,3-dioxygenase in human esophageal squamous cell carcinomas.
Myeloid CD11c+ S100+ dendritic cells express indoleamine 2,3-dioxygenase at the inflammatory border to invasive lower lip squamous cell carcinoma.
The expression and prognostic relevance of indoleamine 2,3-dioxygenase in tongue squamous cell carcinoma.
The immunotherapeutic role of indoleamine 2,3-dioxygenase in head and neck squamous cell carcinoma: A systematic review.
[Study of indoleamine 2,3-dioxygenase expression in patients of esophageal squamous cell carcinoma]
Cardiovascular Diseases
The contribution of gut bacterial metabolites in the human immune signaling pathway of non-communicable diseases.
The immunometabolic role of indoleamine 2,3-dioxygenase in atherosclerotic cardiovascular disease: immune homeostatic mechanisms in the artery wall.
Carotid Artery Diseases
Moderating effect of indoleamine 2,3-dioxygenase (IDO) activation in the association between depressive symptoms and carotid atherosclerosis: Evidence from the Young Finns study.
Cataract
Elevated Expression of indoleamine 2,3-dioxygenase (IDO) and accumulation of kynurenic acid in the pathogenesis of STZ-induced diabetic cataract in Wistar rats.
Indoleamine 2,3-dioxygenase overexpression causes kynurenine-modification of proteins, fiber cell apoptosis and cataract formation in the mouse lens.
Kynurenine inhibits fibroblast growth factor 2-mediated expression of crystallins and MIP26 in lens epithelial cells.
Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens. Relevance for senile nuclear cataract.
Synthesis and biological evaluation of novel tryptoline derivatives as indoleamine 2,3-dioxygenase (IDO) inhibitors.
Central Nervous System Infections
Role of human brain microvascular endothelial cells during central nervous system infection. Significance of indoleamine 2,3-dioxygenase in antimicrobial defence and immunoregulation.
Central Nervous System Neoplasms
Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).
Cerebral Infarction
Matrix metalloproteinase inhibitors attenuate neuroinflammation following focal cerebral ischemia in mice.
Chlamydia Infections
Cytokine-mediated indoleamine 2,3-dioxygenase induction in response to Chlamydia infection in human macrophage cultures.
Cholera
Indoleamine 2,3-dioxygenase Expression and Functional Activity in Dendritic Cells Exposed to Cholera Toxin.
Chronic Periodontitis
Indoleamine 2,3-dioxygenase expression and regulation in chronic periodontitis.
Coinfection
Herpes simplex virus co-infection-induced Chlamydia trachomatis persistence is not mediated by any known persistence inducer or anti-chlamydial pathway.
Colitis
Deficiency of indoleamine 2,3-dioxygenase enhances commensal-induced antibody responses and protects against Citrobacter rodentium-induced colitis.
Indoleamine 2,3-Dioxygenase Fine-Tunes Immune Homeostasis in Atherosclerosis and Colitis through Repression of Interleukin-10 Production.
Induction of Indoleamine 2,3-dioxygenase by Pre-treatment with Poly(I:C) May Enhance the Efficacy of MSC Treatment in DSS-induced Colitis.
Inhibition of indoleamine 2,3-dioxygenase augments trinitrobenzene sulfonic acid colitis in mice.
Interleukin-17 induces an atypical M2-like macrophage subpopulation that regulates intestinal inflammation.
Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice.
Preconditioning with interleukin-1 beta and interferon-gamma enhances the efficacy of human umbilical cord blood-derived mesenchymal stem cells-based therapy via enhancing prostaglandin E2 secretion and indoleamine 2,3-dioxygenase activity in dextran sulfate sodium-induced colitis.
The therapeutic efficacy of mesenchymal stromal cells on experimental colitis was improved by the IFN-? and poly(I:C) priming through promoting the expression of indoleamine 2,3-dioxygenase.
Xeno-Free Condition Enhances Therapeutic Functions of Human Wharton's Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis by Upregulated Indoleamine 2,3-Dioxygenase Activity.
Colitis, Ulcerative
Indoleamine 2,3-dioxygenase expression in human inflammatory bowel disease.
Proteomic analysis of cytokine induced proteins in human intestinal epithelial cells: implications for inflammatory bowel diseases.
Colonic Neoplasms
Celastrol Suppresses Tryptophan Catabolism in Human Colon Cancer Cells as Revealed by Metabolic Profiling and Targeted Metabolite Analysis.
Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma.
The paradoxical patterns of expression of indoleamine 2,3-dioxygenase in colon cancer.
Colorectal Neoplasms
(-)-Epigallocatechin gallate inhibits the expression of indoleamine 2,3-dioxygenase in human colorectal cancer cells.
Changes in the levels of thioredoxin and indoleamine-2,3-dioxygenase activity in plasma of patients with colorectal cancer treated with chemotherapy.
Clinical Significance of Program Death Ligand-1 and Indoleamine-2,3-Dioxygenase Expression in Colorectal Carcinoma.
Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer.
Indoleamine-2,3-dioxygenase 1/cyclooxygenase 2 expression prediction for adverse prognosis in colorectal cancer.
Interferon-Induced IDO1 Mediates Radiation Resistance and Is a Therapeutic Target in Colorectal Cancer.
Low-dose X-ray radiotherapy-radiodynamic therapy via nanoscale metal-organic frameworks enhances checkpoint blockade immunotherapy.
Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells.
Relationship between indoleamine 2,3-dioxygenase activity and lymphatic invasion propensity of colorectal carcinoma.
Targeting Immune-Related Molecules in Cancer Therapy: A Comprehensive In Vitro Analysis on Patient-Derived Tumor Models.
Communicable Diseases
Persistent infectious diseases say - IDO. Role of indoleamine-2,3-dioxygenase in disease pathogenesis and implications for therapy.
Remarkable role of indoleamine 2,3-dioxygenase and tryptophan metabolites in infectious diseases: potential role in macrophage-mediated inflammatory diseases.
Coronary Artery Disease
Dysregulation of Tryptophan Catabolism in Metabolic Syndrome.
Immunomodulatory effects in vitro of vitamin K antagonist acenocoumarol.
Indoleamine 2,3 dioxygenase (IDO) level as a marker for significant coronary artery disease.
Indoleamine 2,3-dioxygenase activation and depressive symptoms in patients with coronary artery disease.
Coronary Disease
Plasma indoleamine 2,3-dioxygenase concentration is increased in hemodialysis patients and may contribute to the pathogenesis of coronary heart disease.
Crohn Disease
Ex vivo immunosuppressive effects of mesenchymal stem cells on Crohn's disease mucosal T cells are largely dependent on indoleamine 2,3-dioxygenase activity and cell-cell contact.
Indoleamine 2,3-dioxygenase expression in human inflammatory bowel disease.
Proteomic analysis of cytokine induced proteins in human intestinal epithelial cells: implications for inflammatory bowel diseases.
Cystic Fibrosis
Th17/Treg imbalance in murine cystic fibrosis is linked to indoleamine 2,3-dioxygenase deficiency but corrected by kynurenines.
Cytomegalovirus Infections
Thymosin alpha1: an endogenous regulator of inflammation, immunity, and tolerance.
Dementia
Frontal cortex indoleamine-2,3-dioxygenase activity is increased in HIV-1-associated dementia.
Dengue
Increased activity of indoleamine 2,3-dioxygenase in serum from acutely infected dengue patients linked to gamma interferon antiviral function.
Neopterin levels and Kyn/Trp ratios were significantly increased in dengue virus patients and subsequently decreased after recovery.
Diabetes Mellitus
Altered Indoleamine 2,3-Dioxygenase Production and Its Association to Inflammatory Cytokines in Peripheral Blood Mononuclear Cells Culture of Type 2 Diabetes Mellitus.
RAS inhibition modulates kynurenine levels in a CKD population with and without type 2 diabetes mellitus.
The modulation of enzyme indoleamine 2,3-dioxygenase from dendritic cells for the treatment of type 1 diabetes mellitus.
Diabetes Mellitus, Experimental
[Hormonal regulation of enzymatic activity. II. Changes of tryptophan peroxidase activity in the rat liver tissue, produced by the amount of glucose, alloxan diabetes and ethionine]
Diabetes Mellitus, Type 1
Effect of Probiotic Administration on Serum Tryptophan Metabolites in Pediatric Type 1 Diabetes Patients.
The kinetics of plasmacytoid dendritic cell accumulation in the pancreas of the NOD mouse during the early phases of insulitis.
The modulation of enzyme indoleamine 2,3-dioxygenase from dendritic cells for the treatment of type 1 diabetes mellitus.
Transient upregulation of indoleamine 2,3-dioxygenase in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes.
Diabetes Mellitus, Type 2
Altered Indoleamine 2,3-Dioxygenase Production and Its Association to Inflammatory Cytokines in Peripheral Blood Mononuclear Cells Culture of Type 2 Diabetes Mellitus.
Endoplasmic reticulum stress response and inflammatory cytokines in type 2 diabetic nephropathy: Role of indoleamine 2,3-dioxygenase and programmed death-1.
The contribution of gut bacterial metabolites in the human immune signaling pathway of non-communicable diseases.
Diabetic Nephropathies
Endoplasmic reticulum stress response and inflammatory cytokines in type 2 diabetic nephropathy: Role of indoleamine 2,3-dioxygenase and programmed death-1.
IDO1 as a new immune biomarker for diabetic nephropathy and its correlation with immune cell infiltration.
Increased indoleamine 2,3-dioxygenase activity in type 2 diabetic nephropathy.
Diabetic Retinopathy
Evaluation of indoleamine 2,3-dioxygenase expression and kynurenine pathway metabolites levels in serum samples of diabetic retinopathy patients.
Evaluation of the andrographolides role and its indoleamine 2,3-dioxygenase inhibitory potential and attendant molecular mechanism against STZ-induced diabetic rats.
Encephalitis
Astrocyte indoleamine 2,3-dioxygenase is induced by the TLR3 ligand poly(I:C): mechanism of induction and role in antiviral response.
Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis.
Encephalitis, Japanese
Blockage of indoleamine 2,3-dioxygenase regulates Japanese encephalitis via enhancement of type I/II IFN innate and adaptive T-cell responses.
Encephalomyelitis
Co-treatments to Boost IDO Activity and Inhibit Production of Downstream Catabolites Induce Durable Suppression of Experimental Autoimmune Encephalomyelitis.
Correction: The Synergistic Local Immunosuppressive Effects of Neural Stem Cells Expressing Indoleamine 2,3-Dioxygenase (IDO) in an Experimental Autoimmune Encephalomyelitis (EAE) Animal Model.
Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis.
Involvement of Indoleamine-2,3-Dioxygenase and Kynurenine Pathway in Experimental Autoimmune Encephalomyelitis in Mice.
Murine endometrial-derived mesenchymal stem cells suppress experimental autoimmune encephalomyelitis depending on indoleamine-2,3-dioxygenase expression.
The Synergistic Local Immunosuppressive Effects of Neural Stem Cells Expressing Indoleamine 2,3-Dioxygenase (IDO) in an Experimental Autoimmune Encephalomyelitis (EAE) Animal Model.
Encephalomyelitis, Autoimmune, Experimental
Co-treatments to Boost IDO Activity and Inhibit Production of Downstream Catabolites Induce Durable Suppression of Experimental Autoimmune Encephalomyelitis.
Correction: The Synergistic Local Immunosuppressive Effects of Neural Stem Cells Expressing Indoleamine 2,3-Dioxygenase (IDO) in an Experimental Autoimmune Encephalomyelitis (EAE) Animal Model.
Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis.
Involvement of Indoleamine-2,3-Dioxygenase and Kynurenine Pathway in Experimental Autoimmune Encephalomyelitis in Mice.
Murine endometrial-derived mesenchymal stem cells suppress experimental autoimmune encephalomyelitis depending on indoleamine-2,3-dioxygenase expression.
The Synergistic Local Immunosuppressive Effects of Neural Stem Cells Expressing Indoleamine 2,3-Dioxygenase (IDO) in an Experimental Autoimmune Encephalomyelitis (EAE) Animal Model.
Endometrial Neoplasms
Comparison of preoperative serum neopterin, periostin, indoleamine 2,3-dioxygenase, YKL-40, and tenascin-C levels with current tumor markers for early-stage endometrial cancer.
Expression of immune checkpoint molecules in endometrial carcinoma.
Indoleamine 2,3-dioxygenase in endometrial cancer: a targetable mechanism of immune resistance in mismatch repair-deficient and intact endometrial carcinomas.
Indoleamine 2,3-dioxygenase is a novel prognostic indicator for endometrial cancer.
Inverse correlation between tumoral indoleamine 2,3-dioxygenase expression and tumor-infiltrating lymphocytes in endometrial cancer: its association with disease progression and survival.
Overexpression of indoleamine 2,3-dioxygenase in human endometrial carcinoma cells induces rapid tumor growth in a mouse xenograft model.
Prognostic role of indoleamine 2,3-dioxygenase in endometrial carcinoma.
Endometriosis
Immunosuppressive macrophages induced by IDO1 promote the growth of endometrial stromal cells in endometriosis.
Indoleamine 2,3-dioxygenase suppresses the cytotoxicity of 1 NK cells in response to ectopic endometrial stromal cells in endometriosis.
Indoleamine 2,3-dioxygenase-1 (IDO1) in human endometrial stromal cells induces macrophage tolerance through interleukin-33 in the progression of endometriosis.
Menstrual blood-derived stromal stem cells from women with and without endometriosis reveal different phenotypic and functional characteristics.
Endotoxemia
Endotoxin-Induced Tryptophan Degradation along the Kynurenine Pathway: The Role of Indolamine 2,3-Dioxygenase and Aryl Hydrocarbon Receptor-Mediated Immunosuppressive Effects in Endotoxin Tolerance and Cancer and Its Implications for Immunoparalysis.
Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health.
Indoleamine-2,3-dioxygenase activity in experimental human endotoxemia.
Eosinophilia
Scleroderma, fasciitis, and eosinophilia associated with the ingestion of tryptophan.
Ependymoma
Tumor-infiltrating immune cell subpopulations and programmed death ligand 1 (PD-L1) expression associated with clinicopathological and prognostic parameters in ependymoma.
Epilepsy
Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy.
Adjuvant indoleamine 2,3-dioxygenase enzyme inhibition for comprehensive management of epilepsy and comorbid depression.
Adjuvant quercetin therapy for combined treatment of epilepsy and comorbid depression.
Evidence in support of using a neurochemistry approach to identify therapy for both epilepsy and associated depression.
Indoleamine-2,3-Dioxygenase 1 Deficiency Suppresses Seizures in Epilepsy.
Managing epilepsy-associated depression: Serotonin enhancers or serotonin producers?
Epilepsy, Generalized
Increased indoleamine 2,3-dioxygenase (IDO) activity in idiopathic generalized epilepsy.
Epilepsy, Temporal Lobe
Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy.
Epstein-Barr Virus Infections
Epstein-Barr Virus infection induces indoleamine 2,3-dioxygenase expression in human monocyte-derived macrophages through p38/MAPK and NF-?B pathways: impairment in T cell functions.
Exosomes-carrying Epstein-Barr virus-encoded small RNA-1 induces indoleamine 2, 3-dioxygenase expression in tumor-infiltrating macrophages of oral squamous-cell carcinomas and suppresses T-cell activity by activating RIG-I/IL-6/TNF-? pathway.
Esophageal Neoplasms
p38 predicts depression and poor outcome in esophageal cancer.
Esophageal Squamous Cell Carcinoma
Expression of New York esophageal squamous cell carcinoma 1 and its association with Foxp3 and indoleamine-2,3-dioxygenase in microenvironment of nonsmall cell lung cancer.
Involvement of indoleamine 2,3-dioxygenase in impairing tumor-infiltrating CD8 T-cell functions in esophageal squamous cell carcinoma.
[Study of indoleamine 2,3-dioxygenase expression in patients of esophageal squamous cell carcinoma]
Fatty Liver
Studies on tryptophan pyrrolase in carbon tetrachloride induced fatty liver. Tryptophan pyrrolase activity as a measure of the therapeutic effect of drugs on hepatic injury.
Fetal Growth Retardation
Endothelial indoleamine 2,3-dioxygenase-1 regulates the placental vascular tone and is deficient in intrauterine growth restriction and pre-eclampsia.
Fibrosarcoma
IL-4 and IL-13 regulate the induction of indoleamine 2,3-dioxygenase activity and the control of Toxoplasma gondii replication in human fibroblasts activated with IFN-gamma.
Flavivirus Infections
Flavivirus infection induces indoleamine 2,3-dioxygenase in human monocyte-derived macrophages via tumor necrosis factor and NF-?B.
Food Hypersensitivity
Low indoleamine 2,3-dioxygenase activity in persistent food allergy in children.
Gastrointestinal Neoplasms
The footprint of kynurenine pathway in every cancer: a new target for chemotherapy.
Gastrointestinal Stromal Tumors
Role of Immune Microenvironment in Gastrointestinal Stromal Tumors.
Gestational Trophoblastic Disease
Indoleamine 2,3-dioxygenase expression in gestational trophoblastic disease: implications for development of immunotherapeutic approaches.
Glioblastoma
Constitutive Expression of the Immunosuppressive Tryptophan Dioxygenase TDO2 in Glioblastoma Is Driven by the Transcription Factor C/EBP?.
Distinct effects of human glioblastoma immunoregulatory molecules programmed cell death ligand-1 (PDL-1) and indoleamine 2,3-dioxygenase (IDO) on tumour-specific T cell functions.
Establishment of T-helper type 1- and T-helper type 2-like human Toxoplasma antigen-specific T-cell clones.
Induction of toxoplasmostasis in a human glioblastoma by interferon gamma.
Inhibition of Indoleamine-2,3-dioxygenase (IDO) in Glioblastoma Cells by Oncolytic Herpes Simplex Virus.
Mathematical modelling of the synergistic combination of radiotherapy and indoleamine-2,3-dioxygenase (IDO) inhibitory immunotherapy against glioblastoma.
PCC0208009 enhances the anti-tumor effects of temozolomide through direct inhibition and transcriptional regulation of indoleamine 2,3-dioxygenase in glioma models.
The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma.
Glioma
Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma.
Expression of Indoleamine 2,3-dioxygenase and Correlation with Pathological Malignancy in Gliomas.
Glioma: Tryptophan Catabolite and Melatoninergic Pathways Link microRNA, 14-3- 3, Chromosome 4q35, Epigenetic Processes and other Glioma Biochemical Changes.
Indoleamine 2,3-dioxygenase as a new target for malignant glioma therapy.
Intratumoral oncolytic adenoviral treatment modulates the glioma microenvironment and facilitates systemic tumor-antigen-specific T cell therapy.
Investigation of the aryl hydrocarbon receptor and the intrinsic tumoral component of the kynurenine pathway of tryptophan metabolism in primary brain tumors.
PCC0208009 enhances the anti-tumor effects of temozolomide through direct inhibition and transcriptional regulation of indoleamine 2,3-dioxygenase in glioma models.
Simultaneous measurement of tryptophan and related compounds by liquid chromatography/electrospray ionization tandem mass spectrometry.
Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway.
Synergistic antitumor effect with indoleamine 2,3-dioxygenase inhibition and temozolomide in a murine glioma model.
The footprint of kynurenine pathway in every cancer: a new target for chemotherapy.
The Kynurenine/Tryptophan Ratio and Glioblastoma Patients Treated with Hsppc-96 Vaccine.
Glomerulonephritis, IGA
Indoleamine 2,3-Dioxygenase (IDO) Regulates Th17/Treg Immunity in Experimental IgA Nephropathy.
The therapeutic effect of dendritic cells expressing indoleamine 2,3-dioxygenase (IDO) on an IgA nephropathy mouse model.
Gout
Tryptophan catabolism in synovial fluid of various arthropathies and its relationship with inflammatory cytokines.
Graft vs Host Disease
A paradoxical pattern of indoleamine 2,3-dioxygenase expression in the colon tissues of patients with acute graft-versus-host disease.
IDO in Human Gut Graft-vs-Host Disease.
Increased plasma indoleamine 2,3-dioxygenase activity and interferon-? levels correlate with the severity of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
Indoleamine 2,3-dioxygenase expression in patients with acute graft-versus-host disease after allogeneic stem cell transplantation and in pregnant women: association with the induction of allogeneic immune tolerance?
Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality.
Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality.
Potential immunosuppressive function of plasma indoleamine 2,3-dioxygenase in patients with aGVHD after allo-HSCT.
Vascular alterations in a murine model of acute graft-versus-host disease are associated with decreased serum levels of adiponectin and an increased activity and vascular expression of indoleamine 2,3-dioxygenase.
Vascular Alterations in a Murine Model of Acute Graft-Versus-Host Disease Are Associated With Decreased Serum Levels of Adiponectin and an Increased Activity and Vascular Expression of Indoleamine 2,3-Dioxygenase.
Granuloma
Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection.
Granulomatous Disease, Chronic
Intact indoleamine 2,3-dioxygenase activity in human chronic granulomatous disease.
Role of tryptophan degradation in respiratory burst-independent antimicrobial activity of gamma interferon-stimulated human macrophages.
Hantavirus Infections
Indoleamine 2,3-dioxygenase activity is associated with regulatory T cell response in acute Puumala hantavirus infection.
Head and Neck Neoplasms
Inhibition of Indoleamine 2,3 Dioxygenase Does Not Improve Cancer-Related Symptoms in a Murine Model of Human Papilloma Virus-Related Head and Neck Cancer.
Heart Defects, Congenital
[Value of indoleamine 2,3-dioxygenase in diagnosis of systemic inflammatory response syndrome after cardiopulmonary bypass in children with congenital heart disease].
Hemangioma
Identifying potential regulators of infantile hemangioma progression through large-scale expression analysis: a possible role for the immune system and indoleamine 2,3 dioxygenase (IDO) during involution.
Immune response: A possible role in the pathophysiology of hemangioma.
Hematologic Neoplasms
Overexpression of indoleamine 2,3-dioxygenase correlates with regulatory T cell phenotype in acute myeloid leukemia patients with normal karyotype.
The footprint of kynurenine pathway in every cancer: a new target for chemotherapy.
Hemophilia A
Indoleamine 2,3-dioxygenase attenuates inhibitor development in gene-therapy-treated hemophilia A mice.
Hemorrhagic Fever with Renal Syndrome
High activity of indoleamine 2,3-dioxygenase is associated with renal insufficiency in Puumala hantavirus induced nephropathia epidemica.
Hepatic Encephalopathy
Role of the indoleamine-2,3-dioxygenase/kynurenine pathway of tryptophan metabolism in behavioral alterations in a hepatic encephalopathy rat model.
The relationship between plasma and brain quinolinic acid levels and the severity of hepatic encephalopathy in animal models of fulminant hepatic failure.
Hepatitis
Mesenchymal stem cells attenuate acute liver injury by altering ratio between interleukin 17 producing and regulatory natural killer T cells.
The autoimmune response elicited by mouse hepatitis virus (MHV-A59) infection is modulated by liver tryptophan-2,3-dioxygenase (TDO).
Upregulation of indoleamine 2,3-dioxygenase in hepatocyte during acute hepatitis caused by hepatitis B virus-specific cytotoxic T lymphocytes in vivo.
Hepatitis B
Indoleamine 2,3-dioxygenase is increased in hemodialysis patients and affects immune response to hepatitis B vaccination.
Indoleamine 2,3-dioxygenase mediates the antiviral effect of gamma interferon against hepatitis B virus in human hepatocyte-derived cells.
Indoleamine-2,3-dioxygenase as an effector and an indicator of protective immune responses in patients with acute hepatitis B.
Possible benefits of the targeting of indoleamine 2,3-dioxygenase (IDO) in hepatitis B vaccination.
Recombinant adenovirus with human indoleamine-2,3-dioxygenase and hepatitis B virus preS was constructed and expressed in HepG2 cells.
Upregulation of indoleamine 2,3-dioxygenase in hepatocyte during acute hepatitis caused by hepatitis B virus-specific cytotoxic T lymphocytes in vivo.
Hepatitis B, Chronic
[Immunosuppressive effect of indoleamine 2, 3-dioxygenase on T cells in patients with chronic hepatitis B]
[Indoleamine-2,3-dioxygenase and the immune microenvironment of chronic hepatitis B patients.]
Hepatitis C
Antiviral and Immunoregulatory Effects of Indoleamine-2,3-Dioxygenase in Hepatitis C Virus Infection.
Indolamine 2,3-dioxygenase expression by monocytes and dendritic cell populations in hepatitis C patients.
Indoleamine 2,3-dioxygenase expression and activity in patients with hepatitis C virus-induced liver cirrhosis.
Induction of indoleamine 2,3-dioxygenase in vivo by IFN-con1.
Lack of association of indoleamine 2,3-dioxygenase polymorphisms with interferon-alpha-related depression in hepatitis C.
Serotonin - kynurenine hypothesis of depression: historical overview and recent developments.
Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection.
Hepatitis C, Chronic
Alterations in the metabolism of tryptophan in patients with chronic hepatitis C six months after pegylated interferon-? 2a treatment.
Association of enhanced activity of indoleamine 2,3-dioxygenase in dendritic cells with the induction of regulatory T cells in chronic hepatitis C infection.
Herpes Simplex
Inhibition of human herpes simplex virus type 2 by interferon gamma and tumor necrosis factor alpha is mediated by indoleamine 2,3-dioxygenase.
Inhibition of Indoleamine-2,3-dioxygenase (IDO) in Glioblastoma Cells by Oncolytic Herpes Simplex Virus.
Role of indoleamine-2,3-dioxygenase in alpha/beta and gamma interferon-mediated antiviral effects against herpes simplex virus infections.
HIV Infections
Combination antiretroviral therapy and indoleamine 2,3-dioxygenase in HIV infections: challenges and new opportunities.
Drug abuse and neuropathogenesis of HIV infection: role of DC-SIGN and IDO.
Frontal cortex indoleamine-2,3-dioxygenase activity is increased in HIV-1-associated dementia.
How does indoleamine 2,3-dioxygenase contribute to HIV-mediated immune dysregulation.
Parameters of soluble immune activation in vivo correlate negatively with the proliferative capacity of peripheral blood mononuclear cells in vitro in HIV-infected patients.
Serum kynurenine-to-tryptophan ratio increases with progressive disease in HIV-infected patients.
Tryptophan depletion in context of the inflammatory and general nutritional status of a low-income South African HIV-infected population.
Hodgkin Disease
Indoleamine 2,3-dioxygenase (IDO) is frequently expressed in stromal cells of Hodgkin lymphoma and is associated with adverse clinical features: a retrospective cohort study.
Huntington Disease
Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease.
Indoleamine 2,3 Dioxygenase as a Potential Therapeutic Target in Huntington's Disease.
Indoleamine 2,3-dioxygenase as a novel therapeutic target for Huntington's disease.
Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).
Iron activates microglia and directly stimulates indoleamine-2,3-dioxygenase activity in the N171-82Q mouse model of Huntington's disease.
Hydatidiform Mole
Indoleamine 2,3-dioxygenase expression in gestational trophoblastic disease: implications for development of immunotherapeutic approaches.
Hyperbilirubinemia, Neonatal
Sn-protoporphyrin rapidly and markedly enhances the heme saturation of hepatic tryptophan pyrrolase. Evidence that this synthetic metalloporphyrin increases the functional content of heme in the liver.
Hyperglycemia
Fibroblast Cell-Based Therapy for Experimental Autoimmune Diabetes.
Hypersensitivity
Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors.
Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses.
Indoleamine 2,3-dioxygenase (IDO) in inflammation and allergy to Aspergillus.
Psoriasis is characterized by deficient negative immune regulation compared to transient delayed-type hypersensitivity reactions.
The indoleamine 2,3-dioxygenase (IDO) pathway controls allergy.
Thymosin alpha1: an endogenous regulator of inflammation, immunity, and tolerance.
Virus Infections Incite Pain Hypersensitivity by Inducing Indoleamine 2,3 Dioxygenase.
[DNAase I hypersensitivity of the 1,5'-flanking region of the tryptophan oxygenase gene in recombinant DNA and chromatin reconstituted with it]
Hypertension, Pulmonary
Endothelial Indoleamine 2,3-Dioxygenase Protects against Development of Pulmonary Hypertension.
Hyperthyroidism
Influence of non-steroidal anti-inflammatory compounds on the hepatic tryptophan pyrrolase activity in hypo- and hyperthyroid rats.
Role of thyroxine in the postnatal development of rat hepatic tryptophan oxygenase and ornithine aminotransferase.
Hypokinesia
The effect of space flight on the board of the satellite Cosmos 2044 on plasma hormone levels and liver enzyme activities of rats.
Hypotension
Regulation of vascular tone and blood pressure by singlet molecular oxygen in inflammation.
Immune Reconstitution Inflammatory Syndrome
Indoleamine 2,3-dioxygenase activity as a potential biomarker of immune suppression during visceral leishmaniasis.
Immune System Diseases
Indoleamine 2,3-Dioxygenase, Tryptophan Catabolism, and Mycobacterium avium subsp. paratuberculosis: a Model for Chronic Mycobacterial Infections.
Kynurenic acid, an IDO metabolite, controls TSG-6-mediated immunosuppression of human mesenchymal stem cells.
indoleamine 2,3-dioxygenase deficiency
Effects of indoleamine 2,3-dioxygenase deficiency on high-fat diet-induced hepatic inflammation.
Th17/Treg imbalance in murine cystic fibrosis is linked to indoleamine 2,3-dioxygenase deficiency but corrected by kynurenines.
Infections
A crucial role for tryptophan catabolism at the host/Candida albicans interface.
A First Plasmodium vivax Natural Infection Induces Increased Activity of the Interferon Gamma-Driven Tryptophan Catabolism Pathway.
A potential role for indoleamine 2,3-dioxygenase (IDO) in Rhodococcus equi infection.
Activation of the tryptophan/serotonin pathway is associated with severity and predicts outcomes in pneumonia: results of a long-term cohort study.
An observational cohort study of the kynurenine to tryptophan ratio in sepsis: association with impaired immune and microvascular function.
Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy.
Antioxidant activities of some tryptophan metabolites: possible implication for inflammatory diseases.
Antiviral and Immunoregulatory Effects of Indoleamine-2,3-Dioxygenase in Hepatitis C Virus Infection.
Association of enhanced activity of indoleamine 2,3-dioxygenase in dendritic cells with the induction of regulatory T cells in chronic hepatitis C infection.
Brain virus burden and indoleamine-2,3-dioxygenase expression during lentiviral infection of rhesus monkey are concomitantly lowered by 6-chloro-2',3'-dideoxyguanosine.
Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors.
Cytokines induce indoleamine 2,3-dioxygenase expression in human atheroma-asociated cells: implications for persistent Chlamydophila pneumoniae infection.
Decreased IDO1 Dependent Tryptophan Metabolism in Aged Lung during Influenza.
Early cytokine production is associated with protection from murine cerebral malaria.
Effects of Schistosoma mansoni infection on induction of tryptophan oxygenase in mouse livers.
Enhancement of innate immunity against Mycobacterium avium infection by immunostimulatory DNA is mediated by indoleamine 2,3-dioxygenase.
Expression of indoleamine 2,3-dioxygenase, tryptophan degradation, and kynurenine formation during in vivo infection with Toxoplasma gondii: induction by endogenous gamma interferon and requirement of interferon regulatory factor 1.
Expression of interferon regulatory factors and indoleamine 2,3-dioxygenase in Chlamydia trachomatis-infected synovial fibroblasts.
Free iron ions decrease indoleamine 2,3-dioxygenase expression and reduce IFNgamma-induced inhibition of Chlamydia trachomatis infection.
Helicobacter pylori-induced indoleamine 2,3-dioxygenase activity in vivo is regulated by TGFB1 and CTLA4 polymorphisms.
Heme oxygenase-1 activity is involved in the control of Toxoplasma gondii infection in the lung of BALB/c and C57BL/6 and in the small intestine of C57BL/6 mice.
Histoplasma capsulatum preferentially induces IDO in the lung.
HIV-1 Tat Protein Induces the Production of IDO in Human Monocyte Derived-Dendritic Cells through a Direct Mechanism: Effect on T Cells Proliferation.
Hypoxia abrogates antichlamydial properties of IFN-{gamma} in human fallopian tube cells in vitro and ex vivo.
Immunity and tolerance to Aspergillus fumigatus.
Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism.
Immunopathogenesis of cerebral malaria.
Impact of foetus and mother on IFN-gamma-induced indoleamine 2,3-dioxygenase and inducible nitric oxide synthase expression in murine placenta following Toxoplasma gondii infection.
Implications of interferon-induced tryptophan catabolism in cancer, auto-immune diseases and AIDS.
Increased expression of indoleamine 2,3-dioxygenase in murine malaria infection is predominantly localised to the vascular endothelium.
Increased mRNA expression of kynurenine pathway enzymes in human placentae exposed to bacterial endotoxin.
Indolamine 2,3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation.
Indoleamine 2,3-Dioxygenase (IDO) Activity During the Primary Immune Response to Influenza Infection Modifies the Memory T Cell Response to Influenza Challenge.
Indoleamine 2,3-dioxygenase activity is associated with regulatory T cell response in acute Puumala hantavirus infection.
Indoleamine 2,3-dioxygenase expression is associated with chronic rhinosinusitis: review of the evidence.
Indoleamine 2,3-dioxygenase expression regulates the survival and proliferation of Fusobacterium nucleatum in THP-1-derived macrophages.
Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host.
Indoleamine 2,3-dioxygenase is differentially expressed by different white blood cell populations of rhesus macaques (Macaca mulatta).
Indoleamine 2,3-Dioxygenase Is Involved in the Inflammation Response of Corneal Epithelial Cells to Aspergillus fumigatus Infections.
Indoleamine 2,3-dioxygenase is regulated by IFN-gamma in the mouse placenta during Listeria monocytogenes infection.
Indoleamine 2,3-Dioxygenase, Tryptophan Catabolism, and Mycobacterium avium subsp. paratuberculosis: a Model for Chronic Mycobacterial Infections.
Induction and role of indoleamine 2,3 dioxygenase in mouse models of influenza a virus infection.
Induction of indoleamine 2,3-dioxygenase by uropathogenic bacteria attenuates innate responses to epithelial infection.
Induction of indoleamine 2,3-dioxygenase in mouse lung during virus infection.
Influenza A virus infection induces indoleamine 2,3-dioxygenase (IDO) expression and modulates subsequent inflammatory mediators in nasal epithelial cells.
Influenza-induced expression of indoleamine 2,3-dioxygenase enhances interleukin-10 production and bacterial outgrowth during secondary pneumococcal pneumonia.
Inhibition of increased indoleamine 2,3-dioxygenase activity attenuates Toxoplasma gondii replication in the lung during acute infection.
Inhibition of indoleamine 2,3-dioxygenase enhances the T-cell response to influenza virus infection.
Interferon-beta induction by Chlamydia pneumoniae in human smooth muscle cells.
Interplay between IDO1 and iNOS in human retinal pigment epithelial cells.
Intratumoral oncolytic adenoviral treatment modulates the glioma microenvironment and facilitates systemic tumor-antigen-specific T cell therapy.
Isolating vessels from the mouse brain for gene expression analysis using laser capture microdissection.
L-tryptophan-L-kynurenine pathway metabolism accelerated by Toxoplasma gondii infection is abolished in gamma interferon-gene-deficient mice: cross-regulation between inducible nitric oxide synthase and indoleamine-2,3-dioxygenase.
Leishmania major attenuates host immunity by stimulating local indoleamine 2,3-dioxygenase expression.
Lysophosphatidylcholine exacerbates Leishmania major-dendritic cell infection through interleukin-10 and a burst in arginase1 and indoleamine 2,3-dioxygenase activities.
Murine Coronavirus Infection Activates the Aryl Hydrocarbon Receptor in an Indoleamine 2,3-Dioxygenase-Independent Manner, Contributing to Cytokine Modulation and Proviral TCDD-Inducible-PARP Expression.
Neopterin in HIV-1 infection.
Potentiation of interferon-mediated inhibition of Chlamydia infection by interleukin-1 in human macrophage cultures.
Protective role of Indoleamine 2,3 dioxygenase in Respiratory Syncytial Virus associated immune response in airway epithelial cells.
Pulmonary paracoccidioidomycosis in AhR deficient hosts is severe and associated with defective Treg and Th22 responses.
Recurrent headache as the main symptom of acquired cerebral toxoplasmosis in nonhuman immunodeficiency virus-infected subjects with no lymphadenopathy: the parasite may be responsible for the neurogenic inflammation postulated as a cause of different types of headaches.
Regulation of kynurenine biosynthesis during influenza virus infection.
Restriction of Chlamydia pneumoniae replication in human dendritic cell by activation of indoleamine 2,3-dioxygenase.
Role of human brain microvascular endothelial cells during central nervous system infection. Significance of indoleamine 2,3-dioxygenase in antimicrobial defence and immunoregulation.
Schistosoma mansoni and Schistosoma japonicum: effects of infection on induction of tryptophan oxygenase in mouse livers.
Serum tryptophan and its metabolites in female dogs undergoing ovariohysterectomy as treatment of pyometra or as elective spay surgery.
Severe Tryptophan Starvation Blocks Onset of Conventional Persistence and Reduces Reactivation of Chlamydia trachomatis.
Systemic treatment with CpG-B after sublethal rickettsial infection induces mouse death through indoleamine 2,3-dioxygenase (IDO).
Th17 and regulatory T cells: implications for AIDS pathogenesis.
The autoimmune response elicited by mouse hepatitis virus (MHV-A59) infection is modulated by liver tryptophan-2,3-dioxygenase (TDO).
The end of the road for the tryptophan depletion concept in pregnancy and infection.
The IDO1-induced kynurenines play a major role in the antimicrobial effect of human myeloid cells against Listeria monocytogenes.
Tolerogenic Plasmacytoid Dendritic Cells Control Paracoccidioides brasiliensis Infection by Inducting Regulatory T Cells in an IDO-Dependent Manner.
Trypanosoma cruzi-induced depressive-like behavior is independent of meningoencephalitis but responsive to parasiticide and TNF-targeted therapeutic interventions.
Tryptophan Breakdown in Patients with HCV Infection is Influenced by IL28B Polymorphism.
Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?
Two New Tryptophan Derivatives from the Seed Kernels of Entada rheedei: Effects on Cell Viability and HIV Infectivity.
Vascular allografts are resistant to methicillin-resistant Staphylococcus aureus infection by indoleamine 2,3-dioxygenase in rat aortic transplant model.
Inflammatory Bowel Diseases
Indoleamine 2,3-dioxygenase and regulatory t cells in intestinal mucosa in children with inflammatory bowel disease.
Indoleamine 2,3-dioxygenase expression in human inflammatory bowel disease.
Overexpression of indoleamine 2,3-dioxygenase in human inflammatory bowel disease.
The contribution of gut bacterial metabolites in the human immune signaling pathway of non-communicable diseases.
Influenza, Human
Assessment of neopterin and indoleamine 2,3-dioxygenase activity in patients with seasonal influenza: A pilot study.
Attenuation of pathogenic immune responses during infection with human and simian immunodeficiency virus (HIV/SIV) by the tetracycline derivative minocycline.
Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity.
Decreased IDO1 Dependent Tryptophan Metabolism in Aged Lung during Influenza.
Drug analog inhibition of indoleamine 2,3-dioxygenase (IDO) activity modifies pattern recognition receptor expression and proinflammatory cytokine responses early during influenza virus infection.
Increased Indoleamine-2,3-Dioxygenase Activity Is Associated With Poor Clinical Outcome in Adults Hospitalized With Influenza in the INSIGHT FLU003Plus Study.
Indoleamine 2,3-Dioxygenase (IDO) Activity During the Primary Immune Response to Influenza Infection Modifies the Memory T Cell Response to Influenza Challenge.
Induction and role of indoleamine 2,3 dioxygenase in mouse models of influenza a virus infection.
Induction of indoleamine 2,3-dioxygenase in mouse lung during virus infection.
Influenza A virus infection induces indoleamine 2,3-dioxygenase (IDO) expression and modulates subsequent inflammatory mediators in nasal epithelial cells.
Influenza virus induces expression of antioxidant genes in human epithelial cells.
Influenza-induced expression of indoleamine 2,3-dioxygenase enhances interleukin-10 production and bacterial outgrowth during secondary pneumococcal pneumonia.
Inhibition of indoleamine 2,3-dioxygenase enhances the T-cell response to influenza virus infection.
Insulin Resistance
Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health.
Serotonin - kynurenine hypothesis of depression: historical overview and recent developments.
Intestinal Diseases
Indoleamine 2,3 dioxygenase in intestinal disease.
Iron Deficiencies
Current Understanding of the Mechanisms Underlying Immune Evasion From PD-1/PD-L1 Immune Checkpoint Blockade in Head and Neck Cancer.
Rat liver tryptophan pyrrolase activity in iron deficiency.
Utilization of dietary tryptophan in iron-deficient rats.
Irritable Bowel Syndrome
Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort.
Ischemic Stroke
Serum indoleamine 2,3-dioxygenase and kynurenine aminotransferase enzyme activity in patients with ischemic stroke.
The novel targets of DL-3-n-butylphthalide predicted by similarity ensemble approach in combination with molecular docking study.
Keratitis
Expression of indoleamine 2,3-dioxygenase in a murine model of Aspergillus fumigatus keratitis.
Indoleamine 2,3-Dioxygenase Regulates Macrophage Recruitment, Polarization and Phagocytosis in Aspergillus Fumigatus Keratitis.
Latent Infection
Biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients.
Leishmaniasis
Indoleamine 2,3-dioxygenase (IDO) induced by Leishmania infection of human dendritic cells.
The role of indoleamine 2, 3 dioxygenase in regulating host immunity to leishmania infection.
Leishmaniasis, Visceral
Indoleamine 2,3-dioxygenase activity as a potential biomarker of immune suppression during visceral leishmaniasis.
Leprosy, Lepromatous
Indoleamine 2,3-dioxygenase and iron are required for Mycobacterium leprae survival.
Leukemia
Adipose tissue-derived stromal cells retain immunosuppressive and angiogenic activity after coculture with cord blood hematopoietic precursors.
Ex Vivo Induced Regulatory Human/Murine Mesenchymal Stem Cells as Immune Modulators.
Expression of indoleamine 2,3-dioxygenase in acute myeloid leukemia and the effect of its inhibition on cultured leukemia blast cells.
Forced expression of indoleamine-2,3-dioxygenase in human umbilical cord-derived mesenchymal stem cells abolishes their anti-apoptotic effect on leukemia cell lines in vitro.
IFN-? and indoleamine 2,3-dioxygenase signaling between donor dendritic cells and T cells regulates graft versus host and graft versus leukemia activity.
Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair leukemia-specific immune response by inducing potent T regulatory cells.
Regulatory T cells induce a privileged tolerant microenvironment at the fetal-maternal interface.
Synergistic effects of phorbol ester and INF-gamma on the induction of indoleamine 2,3-dioxygenase in THP-1 monocytic leukemia cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Chronic Lymphocytic Leukemia Nurse-like cells express the hepatocyte growth factor receptor (c-MET) and indoleamine 2,3-dioxygenase and display features of immunosuppressive type 2 skewed macrophages.
Indoleamine 2,3-Dioxygenase Activity and Expression in Patients With Chronic Lymphocytic Leukemia.
Leukemia, Myeloid, Acute
A novel immunohistochemical score to predict early mortality in acute myeloid leukemia patients based on indoleamine 2,3 dioxygenase expression.
Acute myeloid leukemia cells constitutively express the immunoregulatory enzyme indoleamine 2,3-dioxygenase.
Expression of indoleamine 2,3-dioxygenase in acute myeloid leukemia and the effect of its inhibition on cultured leukemia blast cells.
Expression of indoleamine 2,3-dioxygenase in leukemic cells indicates an unfavorable prognosis in acute myeloid leukemia patients with intermediate-risk cytogenetics.
High INDO (indoleamine 2,3-dioxygenase) mRNA level in blasts of acute myeloid leukemic patients predicts poor clinical outcome.
Hydrogen-Peroxide Synthesis and LDL-Uptake Controls Immunosuppressive Properties in Monocyte-Derived Dendritic Cells.
Indoleamine 2,3-dioxygenase activity of acute myeloid leukemia cells can be measured from patients' sera by HPLC and is inducible by IFN-gamma.
Indoleamine 2,3-dioxygenase and regulatory T cells in acute myeloid leukemia.
Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair leukemia-specific immune response by inducing potent T regulatory cells.
Investigating the Role of Indoleamine 2,3-Dioxygenase in Acute Myeloid Leukemia: A Systematic Review.
Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25- into CD25+ T regulatory cells.
Overexpression of indoleamine 2,3-dioxygenase correlates with regulatory T cell phenotype in acute myeloid leukemia patients with normal karyotype.
Prognostic value of the combination of serum l-kynurenine level and indoleamine 2,3-dioxygenase mRNA expression in acute myeloid leukemia.
Role of indoleamine 2,3-dioxygenase in acute myeloid leukemia.
[Expression and Activity Regulation of Indoleamine 2,3-Dioxygenase in Acute Myeloid Leukemia Cells].
Lichen Planus, Oral
Interferon-? regulates the function of mesenchymal stem cells from oral lichen planus via indoleamine 2,3-dioxygenase activity.
Listeriosis
Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection.
Liver Cirrhosis
Indoleamine 2,3-dioxygenase expression and activity in patients with hepatitis C virus-induced liver cirrhosis.
The Deficiency of Indoleamine 2,3-Dioxygenase Aggravates the CCl4-Induced Liver Fibrosis in Mice.
Liver Cirrhosis, Biliary
1-Methyl tryptophan, an indoleamine 2,3-dioxygenase inhibitor, attenuates cardiac and hepatic dysfunction in rats with biliary cirrhosis.
Impaired indoleamine 2,3-dioxygenase production contributes to the development of autoimmunity in primary biliary cirrhosis.
Potential role of indoleamine 2,3-dioxygenase in primary biliary cirrhosis.
Liver Diseases
A narrative review of the roles of indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in liver diseases.
[Tryptophan metabolism in liver diseases: a pharmacokinetic and enzymatic study]
Liver Neoplasms
Skin delivery of short hairpin RNA of indoleamine 2,3 dioxygenase induces antitumor immunity against orthotopic and metastatic liver cancer.
Liver Neoplasms, Experimental
Messenger RNA activities for two liver enzymes, tyrosine aminotransferase and tryptophan oxygenase, in Morris hepatoma 5123C and 9618A and in HTC cells. Correlation with enzyme activities.
Pretranslational control of tryptophan oxygenase levels in Morris hepatoma and host liver.
Lung Neoplasms
Computational study on new natural compound inhibitors of indoleamine 2,3-dioxygenase 1.
Expression of New York esophageal squamous cell carcinoma 1 and its association with Foxp3 and indoleamine-2,3-dioxygenase in microenvironment of nonsmall cell lung cancer.
Feiji Recipe inhibits the growth of lung cancer by modulating T-cell immunity through indoleamine-2,3-dioxygenase pathway in an orthotopic implantation model.
Ganoderic acid Me induces the apoptosis of competent T cells and increases the proportion of Treg cells through enhancing the expression and activation of indoleamine 2,3-dioxygenase in mouse lewis lung cancer cells.
GBP1 Facilitates Indoleamine 2,3-Dioxygenase Extracellular Secretion to Promote the Malignant Progression of Lung Cancer.
High indoleamine-2,3-dioxygenase 1 (IDO) activity is linked to primary resistance to immunotherapy in non-small cell lung cancer (NSCLC).
IDO Immune Status after Chemoradiation May Predict Survival in Lung Cancer Patients.
Indoleamine 2,3-Dioxygenase (IDO) Expression in Lung Cancer.
Indoleamine 2,3-dioxygenase activity and clinical outcome following induction chemotherapy and concurrent chemoradiation in Stage III non-small cell lung cancer.
Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironment.
Indoleamine-2,3-Dioxygenase in Non-Small Cell Lung Cancer: A Targetable Mechanism of Immune Resistance Frequently Coexpressed With PD-L1.
Induction of indoleamine 2,3-dioxygenase (IDO) enzymatic activity contributes to interferon-gamma induced apoptosis and death receptor 5 expression in human non-small cell lung cancer cells.
Long-lasting disease stabilization in the absence of toxicity in metastatic lung cancer patients vaccinated with an epitope derived from indoleamine 2,3 dioxygenase.
NK cell-based therapeutics for lung cancer.
Revisiting IDO and its value as a predictive marker for anti-PD-1 resistance.
The footprint of kynurenine pathway in every cancer: a new target for chemotherapy.
Lupus Erythematosus, Systemic
Indoleamine 2,3-dioxygenase activity is increased in patients with systemic lupus erythematosus and predicts disease activation in the sunny season.
Indoleamine-2,3-dioxygenase in murine and human systemic lupus erythematosus: Down-regulation by the tolerogeneic peptide hCDR1.
Lymphatic Metastasis
Relationship between indoleamine 2,3-dioxygenase activity and lymphatic invasion propensity of colorectal carcinoma.
Lymphoma
Immunohistochemical Features of Indoleamine 2,3-Dioxygenase (IDO) in Various Types of Lymphoma: A Single Center Experience.
NK cell-based therapeutics for lung cancer.
Lymphoma, B-Cell
IDO, TDO, and AHR overexpression is associated with poor outcome in diffuse large B-cell lymphoma patients in the rituximab era.
Indoleamine 2,3-dioxygenase expression and serum kynurenine concentrations in patients with diffuse large B-cell lymphoma.
Indoleamine 2,3-dioxygenase in tumor tissue indicates prognosis in patients with diffuse large B-cell lymphoma treated with R-CHOP.
Lymphoma, Large B-Cell, Diffuse
IDO, TDO, and AHR overexpression is associated with poor outcome in diffuse large B-cell lymphoma patients in the rituximab era.
Indoleamine 2,3-dioxygenase expression and serum kynurenine concentrations in patients with diffuse large B-cell lymphoma.
Indoleamine 2,3-dioxygenase in tumor tissue indicates prognosis in patients with diffuse large B-cell lymphoma treated with R-CHOP.
Lymphoma, Non-Hodgkin
Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice.
Malaria
Immunopathogenesis of cerebral malaria.
Increased expression of indoleamine 2,3-dioxygenase in murine malaria infection is predominantly localised to the vascular endothelium.
Isolating vessels from the mouse brain for gene expression analysis using laser capture microdissection.
Malaria, Cerebral
Increased expression of indoleamine 2,3-dioxygenase in murine malaria infection is predominantly localised to the vascular endothelium.
Massive Hepatic Necrosis
Kynurenine production mediated by indoleamine 2,3-dioxygenase aggravates liver injury in HBV-specific CTL-induced fulminant hepatitis.
Mastitis
Tryptophan, kynurenine, kynurenic acid concentrations and indoleamine 2,3-dioxygenase activity in serum and milk of dairy cows with subclinical mastitis caused by coagulase-negative staphylococci.
Melanoma
Characterization of the in vivo immune network of IDO, tryptophan metabolism, PD-L1, and CTLA-4 in circulating immune cells in melanoma.
Clinical, Genetic and Innate Immunity Characteristics of Melanoma in Organ Transplant Recipients.
Combinatorial antitumor effects of indoleamine 2,3-dioxygenase inhibitor NLG919 and paclitaxel in a murine B16-F10 melanoma model.
Computational study on new natural compound inhibitors of indoleamine 2,3-dioxygenase 1.
Discovery of Potent Competitive Inhibitors of Indoleamine 2,3-Dioxygenase with in Vivo Pharmacodynamic Activity and Efficacy in a Mouse Melanoma Model.
Effect of indoleamine 2,3-dioxygenase expressed by fetal fibroblasts on melanoma cells.
Enzyme activities and metabolites along the kynurenine pathway in mice with Harding-Passey melanoma.
Expression of immune checkpoint receptors Indoleamine 2,3-dioxygenase and T cell Ig and ITIM domain in metastatic versus nonmetastatic choroidal melanoma.
Expression of indoleamine 2,3-dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival.
FoxP3 and indoleamine 2,3-dioxygenase immunoreactivity in sentinel nodes from melanoma patients.
From Melanoma Development to RNA-Modified Dendritic Cell Vaccines: Highlighting the Lessons From the Past.
Immunogenic camptothesome nanovesicles comprising sphingomyelin-derived camptothecin bilayers for safe and synergistic cancer immunochemotherapy.
Indoleamine 2,3 dioxygenase as a prognostic and follow-up marker in melanoma. A comparative study with LDH and S100B.
Indoleamine 2,3-dioxygenase and survivin peptide vaccine combined with temozolomide in metastatic melanoma.
Indoleamine 2,3-Dioxygenase Expression in Primary Cutaneous Melanoma Correlates with Breslow Thickness and Is of Significant Prognostic Value for Progression-Free Survival.
Indoleamine 2,3-dioxygenase in melanoma progression and BRAF inhibitor resistance.
Indoleamine 2,3-dioxygenase, a new prognostic marker in sentinel lymph nodes of melanoma patients.
Inter- and intra-patient heterogeneity of indoleamine 2,3-dioxygenase expression in primary and metastatic melanoma cells and the tumor microenvironment.
Intratumoral immune cell infiltrates, FoxP3, and indoleamine 2,3-dioxygenase in patients with melanoma undergoing CTLA4 blockade.
Macrophages/Microglia Represent the Major Source of Indolamine 2,3-Dioxygenase Expression in Melanoma Metastases of the Brain.
Mechanisms of local immunosuppression in cutaneous melanoma.
Molecular analysis of melanoma-induced sentinel lymph node immune dysfunction.
Occurrence of indoleamine 2,3-dioxygenase in human cutaneous malignant melanoma.
PD-L1 blockade for cancer treatment: MEDI4736.
Peritumoral indoleamine 2,3-dioxygenase expression in melanoma: an early marker of resistance to immune control?
Psoriasis is characterized by deficient negative immune regulation compared to transient delayed-type hypersensitivity reactions.
Safety, immune and clinical responses in metastatic melanoma patients vaccinated with a long peptide derived from indoleamine 2,3-dioxygenase in combination with ipilimumab.
Smart Nanovesicle-Mediated Immunogenic Cell Death through Tumor Microenvironment Modulation for Effective Photodynamic Immunotherapy.
Synergistic Transcutaneous Immunotherapy Enhances Antitumor Immune Responses through Delivery of Checkpoint Inhibitors.
T and NK cells: two sides of tumor immunoevasion.
The footprint of kynurenine pathway in every cancer: a new target for chemotherapy.
The prognostic significance of indoleamine-2,3-dioxygenase and the receptors for transforming growth factor ? and interferon ? in metastatic lymph nodes in malignant melanoma.
The role of FoxP3+ regulatory T cells and IDO+ immune and tumor cells in malignant melanoma - an immunohistochemical study.
Tryptophan protects human melanoma cells against gamma-interferon and tumour necrosis factor-alpha: a unifying mechanism of action.
Type III TGF-? receptor downregulation generates an immunotolerant tumor microenvironment.
Variable indoleamine 2,3-dioxygenase expression in acral / mucosal melanoma and its possible link to immunotherapy.
[Potential endogenous immunological self-protection of uveal melanoma by indoleamine 2,3-dioxygenase]
Meningitis, Pneumococcal
Inhibition of indoleamine 2,3-dioxygenase prevented cognitive impairment in adult Wistar rats subjected to pneumococcal meningitis.
Mesothelioma
High BIN1 expression has a favorable prognosis in malignant pleural mesothelioma and is associated with tumor infiltrating lymphocytes.
The usefulness of biomarkers in diagnosis of asbestos-induced malignant pleural mesothelioma.
Mesothelioma, Malignant
High BIN1 expression has a favorable prognosis in malignant pleural mesothelioma and is associated with tumor infiltrating lymphocytes.
Metabolic Diseases
Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health.
Metabolic Syndrome
Lipopolysaccharide-induced brain activation of the indoleamine 2,3-dioxygenase and depressive-like behavior are impaired in a mouse model of metabolic syndrome.
Miosis
[Effect of ethyl-p-nitrophenyl phenylphosphonothiate (EPN) on tryptophan pyrrolase activity in relation to miosis and change in serum cholinesterase activities]
Mouth Neoplasms
Indoleamine 2,3-dioxygenase, an immunomodulatory protein, is suppressed by (-)-epigallocatechin-3-gallate via blocking of gamma-interferon-induced JAK-PKC-delta-STAT1 signaling in human oral cancer cells.
Multiple Myeloma
Multiple myeloma cell-derived IL-32? increases the immunosuppressive function of macrophages by promoting indoleamine 2,3-dioxygenase (IDO) expression.
Multiple Sclerosis
A putative mechanism on remission of multiple sclerosis during pregnancy: estrogen-induced indoleamine 2,3-dioxygenase by dendritic cells.
Co-treatments to Boost IDO Activity and Inhibit Production of Downstream Catabolites Induce Durable Suppression of Experimental Autoimmune Encephalomyelitis.
Kynurenines and Multiple Sclerosis: The Dialogue between the Immune System and the Central Nervous System.
Multiple Sclerosis, Relapsing-Remitting
Indoleamine 2,3 Dioxygenase (IDO) Expression and Activity in Relapsing-Remitting Multiple Sclerosis.
Muscular Dystrophies, Limb-Girdle
Human iPSC-derived mesoangioblasts, like their tissue-derived counterparts, suppress T cell proliferation through IDO- and PGE-2-dependent pathways.
Myelodysplastic Syndromes
A Phase II Study to Determine the Safety and Efficacy of the Oral Inhibitor of Indoleamine 2,3-Dioxygenase (IDO) Enzyme INCB024360 in Patients with Myelodysplastic Syndromes.
Prognostic value of indoleamine 2,3 dioxygenase in patients with higher-risk myelodysplastic syndromes treated with azacytidine.
Myocardial Ischemia
Indoleamine 2,3-dioxygenase and ischemic heart disease: a Mendelian Randomization study.
Myocarditis
Absence of kynurenine 3-monooxygenase reduces mortality of acute viral myocarditis in mice.
Nasal Polyps
Indoleamine 2,3-dioxygenase expression is associated with chronic rhinosinusitis with nasal polyps and antrochoanal polyps.
Relationships of indoleamine 2,3-dioxygenase activity and cofactors with asthma and nasal polyps.
Nasopharyngeal Carcinoma
Bortezomib Relieves Immune Tolerance in Nasopharyngeal Carcinoma via STAT1 Suppression and Indoleamine 2,3-Dioxygenase Downregulation.
Expression of indoleamine 2,3-dioxygenase in nasopharyngeal carcinoma impairs the cytolytic function of peripheral blood lymphocytes.
Prognostic value of indoleamine 2,3-dioxygenase activity and expression in nasopharyngeal carcinoma.
Sodium butyrate inhibits interferon-gamma induced indoleamine 2,3-dioxygenase expression via STAT1 in nasopharyngeal carcinoma cells.
Neoplasm Metastasis
Cancer/stroma interplay via cyclooxygenase-2 and indoleamine 2,3-dioxygenase promotes breast cancer progression.
Enhanced cancer therapy through synergetic photodynamic/immune checkpoint blockade mediated by a liposomal conjugate comprised of porphyrin and IDO inhibitor.
Feiji Recipe inhibits the growth of lung cancer by modulating T-cell immunity through indoleamine-2,3-dioxygenase pathway in an orthotopic implantation model.
Immunogenic camptothesome nanovesicles comprising sphingomyelin-derived camptothecin bilayers for safe and synergistic cancer immunochemotherapy.
Immunological and nonimmunological effects of indoleamine 2,3-dioxygenase on breast tumor growth and spontaneous metastasis formation.
Immunological environment in colorectal cancer: a computer-aided morphometric study of whole slide digital images derived from tissue microarray.
Indoleamine 2,3-Dioxygenase and Its Therapeutic Inhibition in Cancer.
Indoleamine 2,3-dioxygenase promotes peritoneal metastasis of ovarian cancer by inducing an immunosuppressive environment.
Macrophages/Microglia Represent the Major Source of Indolamine 2,3-Dioxygenase Expression in Melanoma Metastases of the Brain.
Mechanisms of local immunosuppression in cutaneous melanoma.
Relationship between indoleamine 2,3-dioxygenase activity and lymphatic invasion propensity of colorectal carcinoma.
The prognostic significance of indoleamine-2,3-dioxygenase and the receptors for transforming growth factor ? and interferon ? in metastatic lymph nodes in malignant melanoma.
Ultrasound-Driven Biomimetic Nanosystem Suppresses Tumor Growth and Metastasis through Sonodynamic Therapy, CO Therapy, and Indoleamine 2,3-Dioxygenase Inhibition.
Neoplasms
(-)-Epigallocatechin gallate inhibits the expression of indoleamine 2,3-dioxygenase in human colorectal cancer cells.
(-)-Epigallocatechin gallate suppresses indoleamine 2,3-dioxygenase expression in murine dendritic cells: evidences for the COX-2 and STAT1 as potential targets.
A Cisplatin-Loaded Immunochemotherapeutic Nanohybrid Bearing Immune Checkpoint Inhibitors for Enhanced Cervical Cancer Therapy.
A crucial role for tryptophan catabolism at the host/Candida albicans interface.
A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors.
A highly efficient modality to block the degradation of tryptophan for cancer immunotherapy: locked nucleic acid-modified antisense oligonucleotides to inhibit human indoleamine 2,3-dioxygenase 1/tryptophan 2,3-dioxygenase expression.
A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase.
A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies.
A new glucocorticoid receptor detected in host rat liver but not in various hepatomas.
A novel cancer therapy by skin delivery of indoleamine 2,3-dioxygenase siRNA.
A Pt(IV) Pro-drug Preferentially Targets Indoleamine-2,3-dioxygenase, Providing Enhanced Ovarian Cancer Immuno-Chemotherapy.
A road less traveled paved by IDO silencing: Harnessing the antitumor activity of neutrophils.
Accelerated rejection of the second transplants of immunogenic tumor in mice under inhibition of indoleamine 2,3-dioxygenase activity by ethyl pyruvate.
Accumulation of an endogenous tryptophan-derived metabolite in colorectal and breast cancers.
Adipose-derived stem cells induced dendritic cells undergo tolerance and inhibit Th1 polarization.
Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma.
AG490, a Jak2 inhibitor, suppressed the progression of murine ovarian cancer.
Alteration in Gene Pair Correlations in Tryptophan Metabolism as a Hallmark in Cancer Diagnosis.
Alterations of serum levels of plasminogen, TNF-?, and IDO in granulomatosis with polyangiitis patients.
An albumin-bound drug conjugate of paclitaxel and indoleamine-2,3-dioxygenase inhibitor for enhanced cancer chemo-immunotherapy.
An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy.
Analysis of indoleamine 2-3 dioxygenase (IDO1) expression in breast cancer tissue by immunohistochemistry.
Arid5a: A Missing Link between EMT and Tumoral Immune Resistance.
Association between Cyclooxygenase-2 and Indoleamine 2,3-Dioxygenase Expression in Breast Cancer Patients from Pakistan.
Association between IDO activity and prognosis in patients with non-small cell lung cancer after radiotherapy.
Association between peripheral blood markers and immune-related factors on tumor cells in patients with resected primary lung adenocarcinoma.
Astragaloside IV inhibits progression of lung cancer by mediating immune function of Tregs and CTLs by interfering with IDO.
Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3.
Bortezomib Relieves Immune Tolerance in Nasopharyngeal Carcinoma via STAT1 Suppression and Indoleamine 2,3-Dioxygenase Downregulation.
Breast Cancer Chemo-immunotherapy through Liposomal Delivery of an Immunogenic Cell Death Stimulus Plus Interference in the IDO-1 Pathway.
Caffeic acid phenethyl ester protects against photothrombotic cortical ischemic injury in mice.
Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors.
Cancer prevention and therapy through the modulation of the tumor microenvironment.
Cancer/stroma interplay via cyclooxygenase-2 and indoleamine 2,3-dioxygenase promotes breast cancer progression.
Canine mast cell tumour cells regulate tryptophan catabolism via the expression of indoleamine 2,3-dioxygenase.
Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms.
Catalytic activity of human indoleamine 2,3-dioxygenase (hIDO1) at low oxygen.
CD4 responses against IDO.
CD4/CD8 + T cells, DC subsets, Foxp3, and IDO expression are predictive indictors of gastric cancer prognosis.
Cell-Based Identification of New IDO1 Modulator Chemotypes.
Central role of IFNgamma-indoleamine 2,3-dioxygenase axis in regulation of interleukin-12-mediated antitumor immunity.
Changes in the levels of thioredoxin and indoleamine-2,3-dioxygenase activity in plasma of patients with colorectal cancer treated with chemotherapy.
Characterization of immune infiltration in sarcomatoid hepatocellular carcinoma.
Characterization of the in vivo immune network of IDO, tryptophan metabolism, PD-L1, and CTLA-4 in circulating immune cells in melanoma.
Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy.
Chemo-Immunotherapy: Role of Indoleamine 2,3-Dioxygenase in Defining Immunogenic Versus Tolerogenic Cell Death in the Tumor Microenvironment.
Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase.
Chrysin promotes attenuation of depressive-like behavior and hippocampal dysfunction resulting from olfactory bulbectomy in mice.
Clinical Significance of Program Death Ligand-1 and Indoleamine-2,3-Dioxygenase Expression in Colorectal Carcinoma.
Clinical, Genetic and Innate Immunity Characteristics of Melanoma in Organ Transplant Recipients.
Cloning and expression of a cDNA encoding mouse indoleamine 2,3-dioxygenase.
Co-delivery of anionic epitope/CpG vaccine and IDO inhibitor by self-assembled cationic liposomes for combination melanoma immunotherapy.
Combination immunotherapy and radiation therapy strategies for pancreatic cancer-targeting multiple steps in the cancer immunity cycle.
Combinatorial antitumor effects of indoleamine 2,3-dioxygenase inhibitor NLG919 and paclitaxel in a murine B16-F10 melanoma model.
Comparison of preoperative serum neopterin, periostin, indoleamine 2,3-dioxygenase, YKL-40, and tenascin-C levels with current tumor markers for early-stage endometrial cancer.
Comparison study of different indoleamine-2,3 dioxygenase inhibitors from the perspective of pharmacodynamic effects.
Computational study on new natural compound inhibitors of indoleamine 2,3-dioxygenase 1.
Correlation Patterns Among B7 Family Ligands and Tryptophan Degrading Enzymes in Hepatocellular Carcinoma.
Critical role of indoleamine 2,3-dioxygenase in tumor resistance to repeated treatments with targeted IFNgamma.
Current Understanding of the Mechanisms Underlying Immune Evasion From PD-1/PD-L1 Immune Checkpoint Blockade in Head and Neck Cancer.
Dendritic cell vaccination against ovarian cancer - tipping the Treg/T(H)17 balance to therapeutic advantage?
Depression-like behavior, hyperglycemia, oxidative stress, and neuroinflammation presented in diabetic mice are reversed by the administration of 1-methyl-3-(phenylselanyl)-1H-indole.
Design and automated production of 11C-alpha-methyl-l-tryptophan (11C-AMT).
Design and Synthesis of Indoleamine 2,3-Dioxygenase 1 Inhibitors and Evaluation of Their Use as Anti-Tumor Agents.
Design, synthesis and antitumor study of a series of N-Cyclic sulfamoylaminoethyl substituted 1,2,5-oxadiazol-3-amines as new indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors.
Design, Synthesis and Biological Evaluation of Novel 1,2,5-Oxadiazol-3- Carboximidamide Derivatives as Indoleamine 2, 3-Dioxygenase 1 (IDO1) Inhibitors.
Determination of kynurnine and tryptophan, biomarkers of indoleamine 2,3-dioxygenase by LC-MS/MS in plasma and tumor.
Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase.
Different effects of tryptophan 2,3-dioxygenase inhibition on SK-Mel-28 and HCT-8 cancer cell lines.
Differential effects of the tryptophan metabolite3-hydroxyanthranilic acid on the proliferation of human CD8(+) T cells induced by TCR triggering or homeostatic cytokines.
Differential induction of indoleamine-2,3-dioxygenase (IDO) by interferon-gamma in human gynecologic cancer cells.
Differential regulation of human indoleamine 2,3-dioxygenase gene expression by interferons-gamma and -alpha. Analysis of the regulatory region of the gene and identification of an interferon-gamma-inducible DNA-binding factor.
Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors.
Discovery of 5-(pyridin-3-yl)-1H-indole-4,7-diones as indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.
Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate.
Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy.
Discovery of indoleamine 2,3-dioxygenase inhibitors using machine learning based virtual screening.
Discovery of potent indoleamine 2,3-dioxygenase (IDO) inhibitor from alkaloids in Picrasma quassioides by virtual screening and in vitro evaluation.
Discovery of Tryptanthrin Derivatives as Potent Inhibitors of Indoleamine 2, 3-Dioxygenase with Therapeutic Activity in LLC tumor-bearing Mice.
DNA regulatory elements for steroid hormones.
Do regulatory T-cells play a role in AIDS pathogenesis?
Downregulation of indoleamine-2,3-dioxygenase in cervical cancer cells suppresses tumor growth by promoting natural killer cell accumulation.
Dual biological effects of the cytokines interleukin-10 and interferon-?.
Dual effects of indoleamine 2,3-dioxygenase inhibitors on the therapeutic effects of cyclophosphamide and cycloplatam on Ehrlich ascites tumor in mice.
Dual Function of Nitric Oxide in Carcinogenesis, Reappraisal.
Dual functional immunostimulatory polymeric prodrug carrier with pendent indoximod for enhanced cancer immunochemotherapy.
Dual-functional conjugates improving cancer immunochemotherapy by inhibiting tubulin polymerization and indoleamine-2,3-dioxygenase.
Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion.
Early Carcinogenesis Involves the Establishment of Immune Privilege via Intrinsic and Extrinsic Regulation of Indoleamine 2,3-dioxygenase-1: Translational Implications in Cancer Immunotherapy.
Effect of basic protein from tumor tissue on liver tryptophan pyrrolase activity.
Effect of the association of 1-methyl-DL-tryptophan with paclitaxel on the expression of indoleamine 2,3-dioxygenase in cultured cancer cells from patients with breast cancer.
Effects of pentoxifylline, 7-nitroindazole, and imipramine on tumor necrosis factor-? and indoleamine 2,3-dioxygenase enzyme activity in the hippocampus and frontal cortex of chronic mild-stress-exposed rats.
Electric Pulse Responsive Magnetic Nanoclusters Loaded with Indoleamine 2,3-Dioxygenase Inhibitor for Synergistic Immuno-Ablation Cancer Therapy.
Emerging Strategies in Systemic Therapy for the Treatment of Melanoma.
Endotoxin-Induced Tryptophan Degradation along the Kynurenine Pathway: The Role of Indolamine 2,3-Dioxygenase and Aryl Hydrocarbon Receptor-Mediated Immunosuppressive Effects in Endotoxin Tolerance and Cancer and Its Implications for Immunoparalysis.
Engineering a photosensitizer nanoplatform for amplified photodynamic immunotherapy via tumor microenvironment modulation.
Enhanced cancer therapy through synergetic photodynamic/immune checkpoint blockade mediated by a liposomal conjugate comprised of porphyrin and IDO inhibitor.
Enhancement of indoleamine 2,3-dioxygenase activity in cancer patients receiving interferon-beta Ser.
Eosinophil granulocytes account for indoleamine 2,3-dioxygenase-mediated immune escape in human non-small cell lung cancer.
Epithelial-to-mesenchymal transition (EMT) induced by inflammatory priming elicits mesenchymal stromal cell-like immune-modulatory properties in cancer cells.
Evaluation of L-1-[18F]Fluoroethyl-Tryptophan for PET Imaging of Cancer.
Exploration of good and bad structural fingerprints for inhibition of indoleamine-2,3-dioxygenase enzyme in cancer immunotherapy using Monte Carlo optimization and Bayesian classification QSAR modeling.
Expression and prognostic impact of indoleamine 2,3-dioxygenase in oral squamous cell carcinomas.
Expression and Prognostic Value of Indoleamine 2,3-dioxygenase in Pancreatic Cancer.
Expression of Indoleamine 2,3-dioxygenase and Correlation with Pathological Malignancy in Gliomas.
Expression of indoleamine 2,3-dioxygenase and infiltration of FOXP3+ regulatory T cells are associated with aggressive features of papillary thyroid microcarcinoma.
Expression of indoleamine 2,3-dioxygenase in tumor endothelial cells correlates with long-term survival of patients with renal cell carcinoma.
Expression of indoleamine 2,3-dioxygenase predicts shorter survival in patients with vulvar squamous cell carcinoma (vSCC) not influencing on the recruitment of FOXP3-expressing regulatory T cells in cancer nests.
Expression of PD-L1, PD-L2, and IDO1 on tumor cells and density of CD8-positive tumor-infiltrating lymphocytes in early-stage lung adenocarcinoma according to histological subtype.
Expression of Programmed cell death protein 1 (PD-1) and Indoleamine 2,3-dioxygenase (IDO) in the tumor microenvironment and in tumor-draining lymph nodes of breast cancer.
Expression profile of the human IDO1 protein, a cancer drug target involved in tumoral immune resistance.
First-in-Human Phase I Study of the Oral Inhibitor of Indoleamine 2,3-Dioxygenase-1 Epacadostat (INCB024360) in Patients with Advanced Solid Malignancies.
Fish oil ameliorates sickness behavior induced by lipopolysaccharide in aged mice through the modulation of kynurenine pathway.
Flavivirus infection induces indoleamine 2,3-dioxygenase in human monocyte-derived macrophages via tumor necrosis factor and NF-?B.
Fludarabine downregulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism.
Focus on TILs: Prognostic significance of tumor infiltrating lymphocytes in human bladder cancer.
Forkhead box P3 and indoleamine 2,3-dioxygenase co-expression in Pakistani triple negative breast cancer patients.
FoxP3 and IDO in Canine Melanocytic Tumors.
FOXP3+ regulatory T cells and tumoral indoleamine 2,3-dioxygenase expression predicts the carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas.
FoxP3, CTLA-4, and IDO in Canine Melanocytic Tumors.
From Melanoma Development to RNA-Modified Dendritic Cell Vaccines: Highlighting the Lessons From the Past.
Fully automated radiosynthesis of N(1)-[(18)F]fluoroethyl-tryptophan and study of its biological activity as a new potential substrate for indoleamine 2,3-dioxygenase PET imaging.
Functional expression cloning identifies COX-2 as a suppressor of antigen-specific cancer immunity.
Gene silencing of indoleamine 2,3-dioxygenase hinders tumor growth through angiogenesis inhibition.
Genomic and Immunologic Correlates of Indoleamine 2,3-Dioxygenase Pathway Expression in Cancer.
Glycogen Synthase Kinase-3? (GSK-3?) Inhibition Enhances Dendritic Cell-based Cancer Vaccine Potency via Suppression of Interferon-?-induced Indoleamine 2,3-Dioxygenase Expression.
Haemophilus ducreyi Lipooligosaccharides Induce Expression of the Immunosuppressive Enzyme Indoleamine 2,3-Dioxygenase via Type I Interferons and Tumor Necrosis Factor Alpha in Human Dendritic Cells.
Heme-binding-mediated negative regulation of the tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) by IDO2.
Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation.
High expression of indoleamine 2,3-dioxygenase in the tumour is associated with medullary features and favourable outcome in basal-like breast carcinoma.
High INDO (indoleamine 2,3-dioxygenase) mRNA level in blasts of acute myeloid leukemic patients predicts poor clinical outcome.
High Indoleamine 2,3-Dioxygenase Is Correlated With Microvessel Density and Worse Prognosis in Breast Cancer.
Highlights at the gate of tryptophan catabolism: a review on the mechanisms of activation and regulation of indoleamine 2,3-dioxygenase (IDO), a novel target in cancer disease.
Host indoleamine 2,3-dioxygenase: contribution to systemic acquired tumor tolerance.
HPV16 E2 protein promotes innate immunity by modulating immunosuppressive status.
Human iPSC-derived mesoangioblasts, like their tissue-derived counterparts, suppress T cell proliferation through IDO- and PGE-2-dependent pathways.
Human mesenchymal stem cells derived from umbilical cord and bone marrow exert immunomodulatory effects in different mechanisms.
Human Mesenchymal Stem Cells Overexpressing the IL-33 Antagonist Soluble IL-1 Receptor-Like-1 Attenuate Endotoxin-Induced Acute Lung Injury.
Human MSC suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation.
Hydroxyamidine inhibitors of indoleamine-2,3-dioxygenase potently suppress systemic tryptophan catabolism and the growth of IDO-expressing tumors.
Identification of Potent Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors Based on a Phenylimidazole Scaffold.
Identification of potent virtual leads to design novel indoleamine 2,3-dioxygenase inhibitors: pharmacophore modeling and molecular docking studies.
IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-kappaB activation.
IDO Downregulation Induces Sensitivity to Pemetrexed, Gemcitabine, FK866, and Methoxyamine in Human Cancer Cells.
IDO expression by human B lymphocytes in response to T lymphocyte stimuli and TLR engagement is biologically inactive.
IDO expression in breast cancer: an assessment of 281 primary and metastatic cases with comparison to PD-L1.
IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan.
IDO Is a Nodal Pathogenic Driver of Lung Cancer and Metastasis Development.
IDO, TDO, and AHR overexpression is associated with poor outcome in diffuse large B-cell lymphoma patients in the rituximab era.
IDO-inhibitor potentiated immunogenic chemotherapy abolishes primary tumor growth and eradicates metastatic lesions by targeting distinct compartments within tumor microenvironment.
IDO-Mediated Tryptophan Degradation in the Pathogenesis of Malignant Tumor Disease.
IDO1 and kynurenine pathway metabolites activate PI3K-Akt signaling in the neoplastic colon epithelium to promote cancer cell proliferation and inhibit apoptosis.
IDO1 Expression Increased After Neoadjuvant Therapy Predicts Poor Pathologic Response and Prognosis in Esophageal Squamous Cell Carcinoma.
IDO1 impairs NK cell cytotoxicity by decreasing NKG2D/NKG2DLs via promoting miR-18a.
IDO1-Targeted Therapy Does Not Control Disease Development in the Eµ-TCL1 Mouse Model of Chronic Lymphocytic Leukemia.
IFN-gamma is the inducer of indoleamine 2,3-dioxygenase in allografted tumor cells undergoing rejection.
Imaging Correlates of Differential Expression of Indoleamine 2,3-Dioxygenase in Human Brain Tumors.
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido.
Immune escape as a fundamental trait of cancer: focus on IDO.
Immune modulation in corneal transplantation.
Immune regulatory effects of simvastatin on regulatory T cell-mediated tumour immune tolerance.
Immune responses regulation following antitumor dendritic cell-based prophylactic, concurrent, and therapeutic vaccination.
Immunobiochemical pathways of neopterin formation and tryptophan breakdown via indoleamine 2,3-dioxygenase correlate with circulating tumor cells in ovarian cancer patients- A study of the OVCAD consortium.
Immunogenic camptothesome nanovesicles comprising sphingomyelin-derived camptothecin bilayers for safe and synergistic cancer immunochemotherapy.
Immunohistochemical evaluation of immune cell infiltration in canine gliomas.
Immunological and nonimmunological effects of indoleamine 2,3-dioxygenase on breast tumor growth and spontaneous metastasis formation.
Immunological effects of levamisole in vitro.
Immunological environment in colorectal cancer: a computer-aided morphometric study of whole slide digital images derived from tissue microarray.
Immunoregulatory effects on T lymphocytes by human mesenchymal stromal cells isolated from bone marrow, amniotic fluid, and placenta.
Immunosuppression routed via the kynurenine pathway: a biochemical and pathophysiologic approach.
Immunotherapeutic suppression of indoleamine 2,3-dioxygenase and tumor growth with ethyl pyruvate.
Impaired expression of indoleamine 2, 3-dioxygenase in monocyte-derived dendritic cells in response to Toll-like receptor-7/8 ligands.
Improved Radiosynthesis and Biological Evaluations of L- and D-1-[
In vivo metabolism of tryptophan in meningiomas is mediated by indoleamine 2,3-dioxygenase 1.
Increased Activity of the Immunoregulatory Enzyme Indoleamine-2,3-Dioxygenase (IDO) with Consecutive Tryptophan Depletion Predicts Death in Patients with Neuroendocrine Neoplasia.
Increased tryptophan transport in epileptogenic dysembryoplastic neuroepithelial tumors.
Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors.
Indoleamine 2,3 dioxygenase as a prognostic and follow-up marker in melanoma. A comparative study with LDH and S100B.
Indoleamine 2,3-dioxygenase (IDO) activity influence tumor growth in the TRAMP prostate cancer model.
Indoleamine 2,3-Dioxygenase (IDO) Expression in Lung Cancer.
Indoleamine 2,3-Dioxygenase (IDO) Inhibition as a Strategy to Augment Cancer Immunotherapy.
Indoleamine 2,3-dioxygenase (Ido) inhibitors and their nanomedicines for cancer immunotherapy.
Indoleamine 2,3-dioxygenase (IDO): Biology and Target in Cancer Immunotherapies.
Indoleamine 2,3-Dioxygenase Activity-Induced Acceleration of Tumor Growth, and Protein Kinases-Related Novel Therapeutics Regimens.
Indoleamine 2,3-dioxygenase Affects the Aggressiveness of Intraductal Papillary Mucinous Neoplasms Through Foxp3+CD4+CD25+ T Cells in Peripheral Blood.
Indoleamine 2,3-dioxygenase and ischemic heart disease: a Mendelian Randomization study.
Indoleamine 2,3-Dioxygenase and Its Therapeutic Inhibition in Cancer.
Indoleamine 2,3-dioxygenase and survivin peptide vaccine combined with temozolomide in metastatic melanoma.
Indoleamine 2,3-dioxygenase as a modifier of pathogenic inflammation in cancer and other inflammation-associated diseases.
Indoleamine 2,3-dioxygenase as a new target for malignant glioma therapy.
Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection.
Indoleamine 2,3-dioxygenase expression and overall survival in patients diagnosed with breast cancer in Pakistan.
Indoleamine 2,3-dioxygenase expression in early keratocyte neoplasia of the lower lip correlates to the degree of cell atypia.
Indoleamine 2,3-dioxygenase expression in gestational trophoblastic disease: implications for development of immunotherapeutic approaches.
Indoleamine 2,3-dioxygenase expression in human cancers: clinical and immunologic perspectives.
Indoleamine 2,3-Dioxygenase Expression in Primary Cutaneous Melanoma Correlates with Breslow Thickness and Is of Significant Prognostic Value for Progression-Free Survival.
Indoleamine 2,3-dioxygenase expression is associated with chronic rhinosinusitis: review of the evidence.
Indoleamine 2,3-Dioxygenase Expression Pattern in the Tumor Microenvironment Predicts Clinical Outcome in Early Stage Cervical Cancer.
Indoleamine 2,3-dioxygenase expression predicts impaired survival of invasive cervical cancer patients treated with radical hysterectomy.
Indoleamine 2,3-dioxygenase in cancer: targeting pathological immune tolerance with small-molecule inhibitors.
Indoleamine 2,3-dioxygenase in immune suppression and cancer.
Indoleamine 2,3-dioxygenase in melanoma progression and BRAF inhibitor resistance.
Indoleamine 2,3-dioxygenase in tumor induced tolerance.
Indoleamine 2,3-dioxygenase in tumor tissue indicates prognosis in patients with diffuse large B-cell lymphoma treated with R-CHOP.
Indoleamine 2,3-dioxygenase inhibitors: a patent review (2008 - 2012).
Indoleamine 2,3-dioxygenase inhibitors: potential treatment for cancer, sepsis, and more.
Indoleamine 2,3-dioxygenase inhibitory activity of derivatives of marine alkaloid tsitsikammamine A.
Indoleamine 2,3-dioxygenase is differentially expressed by different white blood cell populations of rhesus macaques (Macaca mulatta).
Indoleamine 2,3-Dioxygenase Is Not a Pivotal Regulator Responsible for Suppressing Allergic Airway Inflammation through Adipose-Derived Stem Cells.
Indoleamine 2,3-Dioxygenase Is the Anticancer Target for a Novel Series of Potent Naphthoquinone-Based Inhibitors.
Indoleamine 2,3-dioxygenase mediates immune-independent human tumor cell resistance to olaparib, gamma radiation, and cisplatin.
Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer.
Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironment.
Indoleamine 2,3-dioxygenase regulates T cell activity through Vav1/Rac pathway.
Indoleamine 2,3-dioxygenase, Tregs and cancer.
Indoleamine 2,3-dioxygenase: As a potential prognostic marker and immunotherapeutic target for hepatocellular carcinoma.
Indoleamine-2,3-dioxygenase (IDO) metabolic activity is detrimental for cervical cancer patient survival.
Indoleamine-2,3-dioxygenase and Interleukin-6 associated with tumor response to neoadjuvant chemotherapy in breast cancer.
Induction of indoleamine 2,3-dioxygenase in tumor cells transplanted into allogeneic mouse: interferon-gamma is the inducer.
Induction of indoleamine-2,3 dioxygenase in bone marrow stromal cells inhibits myeloma cell growth.
Infiltrating T cells increase IDO1 expression in glioblastoma and contribute to decreased patient survival.
Inflammatory Reprogramming with IDO1 Inhibitors: Turning Immunologically Unresponsive 'Cold' Tumors 'Hot'.
Inflammatory stimuli reduce survival of serotonergic neurons and induce neuronal expression of indoleamine 2,3-dioxygenase in rat dorsal raphe nucleus organotypic brain slices.
Influence of Donor's Age on Immunomodulatory Properties of Canine Adipose Tissue-Derived Mesenchymal Stem Cells.
Inhibition of human herpes simplex virus type 2 by interferon gamma and tumor necrosis factor alpha is mediated by indoleamine 2,3-dioxygenase.
Inhibition of Indoleamine 2,3 Dioxygenase Does Not Improve Cancer-Related Symptoms in a Murine Model of Human Papilloma Virus-Related Head and Neck Cancer.
Inhibition of indoleamine 2,3-dioxygenase activity enhances the anti-tumour effects of a Toll-like receptor 7 agonist in an established cancer model.
Inhibition of Indoleamine 2,3-Dioxygenase Enhances the Therapeutic Efficacy of Immunogenic Chemotherapeutics in Breast Cancer.
Inhibition of indoleamine 2,3-dioxygenase in human macrophages inhibits interferon-gamma-induced bacteriostasis but does not abrogate toxoplasmastasis.
Inhibition of indoleamine 2,3-dioxygenase suppresses NK cell activity and accelerates tumor growth.
Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy.
Inhibition of Indoleamine-2,3-dioxygenase (IDO) in Glioblastoma Cells by Oncolytic Herpes Simplex Virus.
Inhibition of Tryptophan-Dioxygenase Activity Increases the Antitumor Efficacy of Immune Checkpoint Inhibitors.
Inhibitor of indoleamine-2,3-dioxygenase 1-methyl-D-tryptophan can stimulate the growth of immunogenic tumors.
Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees?
Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).
Inhibitory effects of a selective prostaglandin E2 receptor antagonist RQ-15986 on inflammation-related colon tumorigenesis in APC-mutant rats.
Injectable Bioresponsive Gel Depot for Enhanced Immune Checkpoint Blockade.
Insights from the predicted structural analysis of carborane substituted withaferin A with Indoleamine - 2,3-dioxygenase as a potent inhibitor.
Inter- and intra-patient heterogeneity of indoleamine 2,3-dioxygenase expression in primary and metastatic melanoma cells and the tumor microenvironment.
Interferon enhances tryptophan metabolism by inducing pulmonary indoleamine 2,3-dioxygenase: its possible occurrence in cancer patients.
Interferon-? and Tumor Necrosis Factor-? Polarize Bone Marrow Stromal Cells Uniformly to a Th1 Phenotype.
Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin.
Intralesional expression of mRNA of interferon- gamma , tumor necrosis factor- alpha , interleukin-10, nitric oxide synthase, indoleamine-2,3-dioxygenase, and RANTES is a major immune effector in Mediterranean spotted fever rickettsiosis.
Intratumoral oncolytic adenoviral treatment modulates the glioma microenvironment and facilitates systemic tumor-antigen-specific T cell therapy.
Investigation of the absolute bioavailability and human mass balance of navoximod, a novel IDO1 inhibitor.
Ketamine's effect on inflammation and kynurenine pathway in depression: A systematic review.
Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling.
l-Kynurenine-induced apoptosis in human NK cells is mediated by reactive oxygen species.
Lack of microbicidal response in human macrophages infected with Parachlamydia acanthamoebae.
Levo- but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cells.
Limitations and Off-Target Effects of Tryptophan-Related IDO Inhibitors in Cancer Treatment.
Liposomal Delivery of Mitoxantrone and a Cholesteryl Indoximod Prodrug Provides Effective Chemo-immunotherapy in Multiple Solid Tumors.
Localization of indoleamine 2,3-dioxygenase in human esophageal squamous cell carcinomas.
Low dose Zebularine treatment enhances immunogenicity of tumor cells.
Low expression of Bin1, along with high expression of IDO in tumor tissue and draining lymph nodes, are predictors of poor prognosis for esophageal squamous cell cancer patients.
Low Levels of Serum Tryptophan Underlie Skeletal Muscle Atrophy.
Low-dose X-ray radiotherapy-radiodynamic therapy via nanoscale metal-organic frameworks enhances checkpoint blockade immunotherapy.
Manipulation of indoleamine 2,3-dioxygenase (IDO) for clinical transplantation: promises and challenges.
Marrying immunotherapy with chemotherapy: why say IDO?
Matrix metalloproteinase inhibitors attenuate neuroinflammation following focal cerebral ischemia in mice.
Mechanisms involved in synergistic anticancer immunity of anti-4-1BB and anti-CD4 therapy.
Mechanisms of Intrinsic Tumor Resistance to Immunotherapy.
Mediating the death of dormant tumor cells.
Melatonin in cancer patients and in tumor-bearing animals.
Mesenchymal Stromal Cells Affect Disease Outcomes via Macrophage Polarization.
Mesenchymal stromal cells as vehicles of tetravalent bispecific Tandab (CD3/CD19) for the treatment of B cell lymphoma combined with IDO pathway inhibitor D-1-methyl-tryptophan.
Metabolomic Analysis of Gastric Cancer Progression within the Correa's Cascade Using Ultraperformance Liquid Chromatography-Mass Spectrometry.
Metabolomic Analysis of the Effects of Leptin Replacement Therapy in Patients with Lipodystrophy.
Minireview, The oxidative stress-induced niacin sink (OSINS) model for HIV pathogenesis.
MiR-218 produces anti-tumor effects on cervical cancer cells in vitro.
Modularly Designed Peptide Nanoprodrug Augments Antitumor Immunity of PD-L1 Checkpoint Blockade by Targeting Indoleamine 2,3-Dioxygenase.
Modulating Tumor Immunology by Inhibiting Indoleamine 2,3-Dioxygenase (IDO): Recent Developments and First Clinical Experiences.
Modulation of dendritic cell maturation and function by siRNA-bearing 5'-triphosphate.
Modulation of tumor tolerance in primary central nervous system malignancies.
Molecular docking and dynamic simulation studies evidenced plausible immunotherapeutic anticancer property by Withaferin A targeting indoleamine 2,3-dioxygenase.
Multiple aberrations in shared inflammatory and oxidative & nitrosative stress (IO&NS) pathways explain the co-association of depression and cardiovascular disorder (CVD), and the increased risk for CVD and due mortality in depressed patients.
Myeloid CD11c+ S100+ dendritic cells express indoleamine 2,3-dioxygenase at the inflammatory border to invasive lower lip squamous cell carcinoma.
Myeloid differentiation primary response protein 88 blockade upregulates indoleamine 2,3-dioxygenase expression in rheumatoid synovial fibroblasts.
Nanoconjugates to enhance PDT-mediated cancer immunotherapy by targeting the indoleamine-2,3-dioxygenase pathway.
Nanoenabled Reversal of IDO1-Mediated Immunosuppression Synergizes with Immunogenic Chemotherapy for Improved Cancer Therapy.
Nanomedicine and cancer immunotherapy: focus on indoleamine 2,3-dioxygenase inhibitors.
Nanosensor detection of an immunoregulatory tryptophan influx/kynurenine efflux cycle.
Neopterin formation and tryptophan degradation by a human myelomonocytic cell line (THP-1) upon cytokine treatment.
Neuroprotective effects of human umbilical cord-derived mesenchymal stem cells on periventricular leukomalacia-like brain injury in neonatal rats.
NF-kappa B activation contributes to indoleamine dioxygenase transcriptional synergy induced by IFN-gamma and tumor necrosis factor-alpha.
Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery.
NK cell-based therapeutics for lung cancer.
NK Cell-Dependent Growth Inhibition of Lewis Lung Cancer by Yu-Ping-Feng, an Ancient Chinese Herbal Formula.
No significant effects of Poly(I:C) on human umbilical cord-derived mesenchymal stem cells in the treatment of B6.MRL-Fas(lpr) mice.
Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan.
NO• /RUNX3/kynurenine metabolic signaling enhances disease aggressiveness in pancreatic cancer.
O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1.
Off-tumor IDO1 target engagements determine the cancer-immune set point and predict the immunotherapeutic efficacy.
Oral Probiotics Ameliorate the Behavioral Deficits Induced by Chronic Mild Stress in Mice via the Gut Microbiota-Inflammation Axis.
Ovarian Tumor Ascites CD14+ Cells Suppress Dendritic Cell-activated CD4+ T-cell Responses Through IL-10 Secretion and Indoleamine 2,3-Dioxygenase.
Overcoming Chemoimmunotherapy-Induced Immunosuppression by Assemblable and Depot Forming Immune Modulating Nanosuspension.
Overcoming immune resistance in the tumor microenvironment by blockade of indoleamine 2,3-dioxygenase and programmed death ligand 1.
Overcoming T Cell Exhaustion via Immune Checkpoint Modulation with a Dendrimer-Based Hybrid Nanocomplex.
Overexpression of indoleamine 2,3-dioxygenase in human endometrial carcinoma cells induces rapid tumor growth in a mouse xenograft model.
p38 predicts depression and poor outcome in esophageal cancer.
Pathways of immune exclusion in metastatic osteosarcoma are associated with inferior patient outcomes.
PCC0208009 enhances the anti-tumor effects of temozolomide through direct inhibition and transcriptional regulation of indoleamine 2,3-dioxygenase in glioma models.
PD-1 Blockade Cellular Vesicles for Cancer Immunotherapy.
PEG-Poly(1-Methyl-l-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase.
Peritumoral indoleamine 2,3-dioxygenase expression in melanoma: an early marker of resistance to immune control?
pH-Sensitive Molecular-Switch-Containing Polymer Nanoparticle for Breast Cancer Therapy with Ferritinophagy-Cascade Ferroptosis and Tumor Immune Activation.
Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors.
Phase II trial of the IDO pathway inhibitor indoximod plus pembrolizumab for the treatment of patients with advanced melanoma.
Phenyl Benzenesulfonylhydrazides Exhibit Selective Indoleamine 2,3-Dioxygenase Inhibition with Potent in Vivo Pharmacodynamic Activity and Antitumor Efficacy.
Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy.
Physical state, expression and regulation of two glucocorticoid-controlled genes on bovine papilloma virus vectors.
PI3Kgamma Inhibitor Attenuates Immunosuppressive Effect of Poly(l-Glutamic Acid)-Combretastatin A4 Conjugate in Metastatic Breast Cancer.
Placenta-derived multipotent mesenchymal stromal cells: a promising potential cell-based therapy for canine inflammatory brain disease.
Plasmon-Driven Catalytic Chemotherapy Augments Cancer Immunotherapy through Induction of Immunogenic Cell Death and Blockage of IDO Pathway.
Predictive and prognostic role of serum neopterin and tryptophan breakdown in prostate cancer.
Prevention of spontaneous tumor development in a ret transgenic mouse model by ret peptide vaccination with indoleamine 2,3-dioxygenase inhibitor 1-methyl tryptophan.
Prognostic Implications of the Immune Tumor Microenvironment in Patients With Pancreatic and Gastrointestinal Neuroendocrine Tumors.
Prognostic role of indoleamine 2,3-dioxygenase in endometrial carcinoma.
Prognostic value of indoleamine 2,3-dioxygenase activity and expression in nasopharyngeal carcinoma.
Prognostic Value of the Neo-Immunoscore in Renal Cell Carcinoma.
Proposed mechanisms for oligonucleotide IMT504 induced diabetes reversion in a mouse model of immunodependent diabetes.
Prostaglandin D2 is a novel repressor of IFN? induced indoleamine-2,3-dioxygenase via the DP1 receptor and cAMP pathway.
Prostate cancer immunotherapy yields superior long-term survival in TRAMP mice when administered at an early stage of carcinogenesis prior to the establishment of tumor-associated immunosuppression at later stages.
Quantification of tryptophan transport and metabolism in lung tumors using PET.
Rational design of a minimalist nanoplatform to maximize immunotherapeutic efficacy: Four birds with one stone.
Rational design of indoleamine 2,3-dioxygenase inhibitors.
Recent discovery of indoleamine-2,3-dioxygenase 1 inhibitors targeting cancer immunotherapy.
Redox-Activated Porphyrin-Based Liposome Remote-Loaded with Indoleamine 2,3-Dioxygenase (IDO) Inhibitor for Synergistic Photoimmunotherapy through Induction of Immunogenic Cell Death and Blockage of IDO Pathway.
Regulatory T cells move in when gliomas say "I Do".
Relationship between indoleamine 2,3-dioxygenase activity and lymphatic invasion propensity of colorectal carcinoma.
Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice.
Resveratrol suppresses tumor progression via the regulation of indoleamine 2,3-dioxygenase.
Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme.
Review of 10 years of research on breast cancer patients: Focus on indoleamine 2,3-dioxygenase.
Role of Immune Microenvironment in Gastrointestinal Stromal Tumors.
Role of indoleamine 2,3-dioxygenase in acute myeloid leukemia.
Role of indoleamine 2,3-dioxygenase in testicular immune-privilege.
Safety, immune and clinical responses in metastatic melanoma patients vaccinated with a long peptide derived from indoleamine 2,3-dioxygenase in combination with ipilimumab.
Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells.
Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Coupled with Enzymatic Depletion of Tumor Hyaluronan Induces Complete Regression of Aggressive Pancreatic Tumors.
Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy.
Serial transplants of DMBA-induced mammary tumors in Fischer rats as a model system for human breast cancer. VI. The role of different forms of tumor-associated stress for the regulation of pineal melatonin secretion.
Serum from Asthmatic Mice Potentiates the Therapeutic Effects of Mesenchymal Stromal Cells in Experimental Allergic Asthma.
Serum Tryptophan and Kynurenine Concentrations as Parameters for Indoleamine 2,3-Dioxygenase Activity in Patients With Endometrial, Ovarian, and Vulvar Cancer.
Shaping the glioma immune microenvironment through tryptophan metabolism.
Silencing of indoleamine 2,3-dioxygenase enhances dendritic cell immunogenicity and antitumour immunity in cancer patients.
Smart Nanovesicle-Mediated Immunogenic Cell Death through Tumor Microenvironment Modulation for Effective Photodynamic Immunotherapy.
Specific changes in faecal microbiota are associated with familial Mediterranean fever.
Spontaneous Cytotoxic T-Cell Reactivity against Indoleamine 2,3-Dioxygenase-2.
Structural Basis of Selective Human Indoleamine-2,3-dioxygenase 1 (hIDO1) Inhibition.
Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase.
Structure-activity relationship and enzyme kinetic studies on 4-aryl-1H-1,2,3-triazoles as indoleamine 2,3-dioxygenase (IDO) inhibitors.
Structure-activity Relationship of Indomethacin Derivatives as IDO1 Inhibitors.
Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors.
Studies on liver tryptophan pyrrolase of tumor bearing rats.
Studies on tryptophan pyrrolase activity in tumour bearing mice.
Substrate binding in human indoleamine 2,3-dioxygenase 1: A spectroscopic analysis.
Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer.
Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway.
Synthesis and biological evaluation of novel tryptoline derivatives as indoleamine 2,3-dioxygenase (IDO) inhibitors.
Synthesis and evaluation of 6-[18F]fluoro-3-(pyridin-3-yl)-1H-indole as potential PET tracer for targeting tryptophan 2, 3-dioxygenase (TDO).
Synthesis of 5-[(18)F]Fluoro-?-methyl Tryptophan: New Trp Based PET Agents.
Target exposure and pharmacodynamics study of the indoleamine 2,3-dioxygenase-1 (IDO-1) inhibitor epacadostat in the CT26 mouse tumor model.
Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function.
Targeting Indoleamine 2,3-Dioxygenase in Cancer Models Using the Novel Small Molecule Inhibitor NTRC 3883-0.
Targeting indoleamine-2,3-dioxygenase in cancer: Scientific rationale and clinical evidence.
Targeting Interleukin(IL)-30/IL-27p28 signaling in cancer stem-like cells and host environment synergistically inhibits prostate cancer growth and improves survival.
Targeting myeloid-derived suppressor cells with colony stimulating factor-1 receptor blockade can reverse immune resistance to immunotherapy in indoleamine 2,3-dioxygenase-expressing tumors.
Targeting the indoleamine 2,3-dioxygenase pathway in cancer.
TDO2 Promotes the EMT of Hepatocellular Carcinoma Through Kyn-AhR Pathway.
The additional facet of immunoscore: immunoprofiling as a possible predictive tool for cancer treatment.
The Combined Use of Melatonin and an Indoleamine 2,3-Dioxygenase-1 Inhibitor Enhances Vaccine-Induced Protective Cellular Immunity to HPV16-Associated Tumors.
The complex roles of efferocytosis in cancer development, metastasis, and treatment.
The contribution of gut bacterial metabolites in the human immune signaling pathway of non-communicable diseases.
The Correlation Between the Subsets of Tumor Infiltrating Memory T Cells and the Expression of Indoleamine 2,3-Dioxygenase in Gastric Cancer.
The efficacy of indoximod upon stimulation with pro-inflammatory cytokines in triple-negative breast cancer cells.
The equine alveolar macrophage: Functional and phenotypic comparisons with peritoneal macrophages.
The footprint of kynurenine pathway in every cancer: a new target for chemotherapy.
The hepatocyte growth factor antagonist NK4 inhibits indoleamine-2,3-dioxygenase expression via the c-Met-phosphatidylinositol 3-kinase-AKT signaling pathway.
The immune system strikes back: cellular immune responses against indoleamine 2,3-dioxygenase.
The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression.
The immunoregulatory mechanisms of carcinoma for its survival and development.
The immunotherapeutic role of indoleamine 2,3-dioxygenase in head and neck squamous cell carcinoma: A systematic review.
The importance of cytokines and autoantibodies in depression.
The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma.
The indoleamine-2,3-dioxygenase (IDO) inhibitor 1-methyl-D-tryptophan upregulates IDO1 in human cancer cells.
The Kynurenine/Tryptophan Ratio and Glioblastoma Patients Treated with Hsppc-96 Vaccine.
The paradoxical patterns of expression of indoleamine 2,3-dioxygenase in colon cancer.
The potential of targeting indoleamine 2,3-dioxygenase for cancer treatment.
The rapid antidepressant effect of ketamine in rats is associated with down-regulation of pro-inflammatory cytokines in the hippocampus.
The rationale of indoleamine 2,3-dioxygenase inhibition for cancer therapy.
The Role of Congenital Cytomegalovirus Infection in Adverse Birth Outcomes: A Review of the Potential Mechanisms.
The role of FoxP3+ regulatory T cells and IDO+ immune and tumor cells in malignant melanoma - an immunohistochemical study.
The role of IDO in brain tumor immunotherapy.
The Role of Indoleamine 2,3-Dioxygenase in Diethylnitrosamine-Induced Liver Carcinogenesis.
The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy.
The role of plasma IDO activity as a diagnostic marker of patients with colorectal cancer.
The safety and tolerability of epacadostat alone and in combination with pembrolizumab in patients with advanced solid tumors: results from a first-in-Japanese phase I study (KEYNOTE-434).
The specific targeting of immune regulation: T-cell responses against Indoleamine 2,3-dioxygenase.
The subsets of dendritic cells and memory T cells correspond to indoleamine 2,3-dioxygenase in stomach tumor microenvironment.
The targeting of indoleamine 2,3 dioxygenase -mediated immune escape in cancer.
Therapeutic cancer vaccines.
Transcriptional activation of indoleamine dioxygenase by interleukin 1 and tumor necrosis factor alpha in interferon-treated epithelial cells.
Treg Destabilization and Reprogramming: Implications for Cancer Immunotherapy.
Tryptamine and dimethyltryptamine inhibit indoleamine 2,3 dioxygenase and increase the tumor-reactive effect of peripheral blood mononuclear cells.
Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion.
Tryptophan catabolism increases in breast cancer patients compared to healthy controls without affecting the cancer outcome or response to chemotherapy.
Tryptophan catabolites along the indoleamine 2,3-dioxygenase pathway as a biological link between depression and cancer.
Tryptophan conjugated magnetic nanoparticles for targeting tumors overexpressing indoleamine 2,3 dioxygenase (IDO) and L-type amino acid transporter.
Tryptophan degradation in transplanted tumor cells undergoing rejection.
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond.
Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma.
Tryptophan pyrrolase, kynureninase and kynurenine transaminase activities of human renal tumours.
Tumor cellular proliferation is associated with enhanced immune checkpoint expression in stage I non-small cell lung cancer.
Tumor immune escape mediated by indoleamine 2,3-dioxygenase.
Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs.
Tumor microenvironment-responsive prodrug nanoplatform via co-self-assembly of photothermal agent and IDO inhibitor for enhanced tumor penetration and cancer immunotherapy.
Tumor-associated dendritic cells: molecular mechanisms to suppress antitumor immunity.
Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner.
Tumor-infiltrating immune cell subpopulations and programmed death ligand 1 (PD-L1) expression associated with clinicopathological and prognostic parameters in ependymoma.
Tumour necrosis factor-alpha and lipopolysaccharide enhance interferon-induced tryptophan degradation and pteridine synthesis in human cells.
Turn Off the IDO: Will Clinical Trials Be Successful?
Type III TGF-? receptor downregulation generates an immunotolerant tumor microenvironment.
Tyrosine kinase inhibitors modulate dendritic cell activity via confining c-Kit signaling and tryptophan metabolism.
Ultrasound-Driven Biomimetic Nanosystem Suppresses Tumor Growth and Metastasis through Sonodynamic Therapy, CO Therapy, and Indoleamine 2,3-Dioxygenase Inhibition.
Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors.
Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells.
Use of quantitative real-time PCR to determine the local inflammatory response in the intestinal mucosa and muscularis of horses undergoing small intestinal resection.
Vascular allografts are resistant to methicillin-resistant Staphylococcus aureus through indoleamine 2,3-dioxygenase in a murine model.
Zinc protoporphyrin IX stimulates tumor immunity by disrupting the immunosuppressive enzyme indoleamine 2,3-dioxygenase.
[A new mechanism of tumor resistance to the immune system, based on tryptophan breakdown by indoleamine 2,3-dioxygenase]
[Clinical Application of Immunosuppressive Factors in Cancer Diagnosis and Therapy].
[Curcumin inhibiting the expression of indoleamine 2,3-dioxygenase induced by IFN-gamma in cancer cells]
[Induction of indoleamine 2,3-dioxygenase after bacterial endotoxin treatment, viral infection or tumor transplantation, and its physiological significance]
[Preparation of anti-human indoleamine 2,3-dioxygenase polyclonal antibody]
Neoplasms, Squamous Cell
Low expression of Bin1, along with high expression of IDO in tumor tissue and draining lymph nodes, are predictors of poor prognosis for esophageal squamous cell cancer patients.
Neoplastic Cells, Circulating
Immunobiochemical pathways of neopterin formation and tryptophan breakdown via indoleamine 2,3-dioxygenase correlate with circulating tumor cells in ovarian cancer patients- A study of the OVCAD consortium.
Nervous System Diseases
Discovery of Tryptanthrin Derivatives as Potent Inhibitors of Indoleamine 2, 3-Dioxygenase with Therapeutic Activity in LLC tumor-bearing Mice.
IFN-gamma-induced IDO and WRS expression in microglia is differentially regulated by IL-4.
Pharmacokinetics of 1-methyl-L-tryptophan after single and repeated subcutaneous application in a porcine model.
The Effect of IDO on Neural Progenitor Cell Survival Under Oxygen Glucose Deprivation.
Neuralgia
Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice.
Pharmacological Inhibition of Indoleamine 2,3-Dioxygenase-2 and Kynurenine 3-Monooxygenase, Enzymes of the Kynurenine Pathway, Significantly Diminishes Neuropathic Pain in a Rat Model.
Neuroblastoma
Metabolism of L-tryptophan to kynurenate and quinolinate in the central nervous system: effects of 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
Neurodegenerative Diseases
Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).
The role of indoleamine 2,3-dioxygenase in a mouse model of neuroinflammation-induced depression.
The Synergistic Local Immunosuppressive Effects of Neural Stem Cells Expressing Indoleamine 2,3-Dioxygenase (IDO) in an Experimental Autoimmune Encephalomyelitis (EAE) Animal Model.
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond.
Neuroendocrine Tumors
Prognostic Implications of the Immune Tumor Microenvironment in Patients With Pancreatic and Gastrointestinal Neuroendocrine Tumors.
Neuroinflammatory Diseases
Electroacupuncture Relieves LPS-Induced Depression-Like Behaviour in Rats Through IDO-Mediated Tryptophan-Degrading Pathway.
Fish oil ameliorates sickness behavior induced by lipopolysaccharide in aged mice through the modulation of kynurenine pathway.
Increased indoleamine 2,3-dioxygenase (IDO) activity in idiopathic generalized epilepsy.
Inflammatory stimuli reduce survival of serotonergic neurons and induce neuronal expression of indoleamine 2,3-dioxygenase in rat dorsal raphe nucleus organotypic brain slices.
Mastocytosis in adulthood and neuropsychiatric disorders.
Neuroinflammation and Depression: The Role of Indoleamine 2,3-dioxygenase (IDO) as a Molecular Pathway.
Non-alcoholic Fatty Liver Disease
The contribution of gut bacterial metabolites in the human immune signaling pathway of non-communicable diseases.
Obesity
Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: Focus on brain indoleamine 2,3-dioxygenase activation.
Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health.
Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone.
Osteoarthritis
Distribution of myeloid dendritic cells and plasmacytoid dendritic cells in the synovial tissues of rheumatoid arthritis.
The role of indoleamine 2,3 dioxygenase 1 in the osteoarthritis.
Tryptophan catabolism in synovial fluid of various arthropathies and its relationship with inflammatory cytokines.
Osteosarcoma
Interleukin-12 and interleukin-18 induce indoleamine 2,3-dioxygenase (IDO) activity in human osteosarcoma cell lines independently from interferon-gamma.
Prognostic value of indoleamine 2,3-dioxygenase expression in high grade osteosarcoma.
Ovarian Neoplasms
A Pt(IV) Pro-drug Preferentially Targets Indoleamine-2,3-dioxygenase, Providing Enhanced Ovarian Cancer Immuno-Chemotherapy.
A randomised, open-label, phase 2 study of the IDO1 inhibitor epacadostat (INCB024360) versus tamoxifen as therapy for biochemically recurrent (CA-125 relapse)-only epithelial ovarian cancer, primary peritoneal carcinoma, or fallopian tube cancer.
Computational study on new natural compound inhibitors of indoleamine 2,3-dioxygenase 1.
Correction to "A Pt(IV) Pro-drug Preferentially Targets Indoleamine-2,3-dioxygenase, Providing Enhanced Ovarian Cancer Immuno-Chemotherapy".
IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation.
Immunobiochemical pathways of neopterin formation and tryptophan breakdown via indoleamine 2,3-dioxygenase correlate with circulating tumor cells in ovarian cancer patients- A study of the OVCAD consortium.
Increased synthesis of indoleamine-2,3-dioxygenase protein is positively associated with impaired survival in patients with serous-type, but not with other types of, ovarian cancer.
Indoleamine 2,3-dioxygenase and immune tolerance in ovarian cancer.
Indoleamine 2,3-dioxygenase promotes peritoneal dissemination of ovarian cancer through inhibition of natural killercell function and angiogenesis promotion.
Indoleamine 2,3-dioxygenase promotes peritoneal metastasis of ovarian cancer by inducing an immunosuppressive environment.
Indoleamine 2,3-dioxygenase serves as a marker of poor prognosis in gene expression profiles of serous ovarian cancer cells.
Indoleamine-2,3-dioxygenase, an immunosuppressive enzyme that inhibits natural killer cell function, as a useful target for ovarian cancer therapy.
Ovarian Tumor Ascites CD14+ Cells Suppress Dendritic Cell-activated CD4+ T-cell Responses Through IL-10 Secretion and Indoleamine 2,3-Dioxygenase.
Signaling Circuits and Regulation of Immune Suppression by Ovarian Tumor-Associated Macrophages.
Tryptophan catabolism in epithelial ovarian carcinoma.
Pancreatic Neoplasms
Combination immunotherapy and radiation therapy strategies for pancreatic cancer-targeting multiple steps in the cancer immunity cycle.
Expression and Prognostic Value of Indoleamine 2,3-dioxygenase in Pancreatic Cancer.
NO• /RUNX3/kynurenine metabolic signaling enhances disease aggressiveness in pancreatic cancer.
The footprint of kynurenine pathway in every cancer: a new target for chemotherapy.
Pancreatitis
Autoimmune Pancreatitis Type 2: Diagnostic Utility of PD-L1 Immunohistochemistry.
Fatal pancreatitis in simian immunodeficiency virus SIV(mac251)-infected macaques treated with 2',3'-dideoxyinosine and stavudine following cytotoxic-T-lymphocyte-associated antigen 4 and indoleamine 2,3-dioxygenase blockade.
Indoleamine 2,3-dioxygenase is upregulated in the brain of rats with acute pancreatitis.
Papilloma
Inhibition of Indoleamine 2,3 Dioxygenase Does Not Improve Cancer-Related Symptoms in a Murine Model of Human Papilloma Virus-Related Head and Neck Cancer.
Papillomavirus Infections
Indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase expression in HPV infection, SILs, and cervical cancer.
Paracoccidioidomycosis
Regulatory T cells in paracoccidioidomycosis.
Paralysis
Poliovirus induces indoleamine-2,3-dioxygenase and quinolinic acid synthesis in macaque brain.
Paraparesis, Spastic
Central nervous system activation of the indoleamine-2,3-dioxygenase pathway in human T cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis.
Paratuberculosis
Indoleamine 2,3-Dioxygenase, Tryptophan Catabolism, and Mycobacterium avium subsp. paratuberculosis: a Model for Chronic Mycobacterial Infections.
Parkinson Disease
X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.
Pellagra
Niacin metabolism and indoleamine 2,3-dioxygenase activation in malnourished patients with flaky paint dermatosis.
Tryptophan metabolism in patients with pellagra: problem of vitamin B 6 enzyme activity and feedback control of tryptophan pyrrolase enzyme.
Peritonitis
Blockade of indoleamine 2,3-dioxygenase reduces mortality from peritonitis and sepsis in mice by regulating functions of CD11b+ peritoneal cells.
Persistent Infection
IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-kappaB activation.
Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host.
Zinc protoporphyrin IX stimulates tumor immunity by disrupting the immunosuppressive enzyme indoleamine 2,3-dioxygenase.
Placenta Accreta
Indoleamine 2,3-dioxygenase and trophoblast invasion in caesarean scar pregnancy: Implications for the aetiopathogenesis of placenta accreta spectrum.
Pneumonia
Is tryptophan catabolism increased under indoleamine 2,3 dioxygenase activity during chronic lung inflammation in pigs?
Serum activity of indoleamine 2,3-dioxygenase predicts prognosis of community-acquired pneumonia.
Th17/Treg imbalance in murine cystic fibrosis is linked to indoleamine 2,3-dioxygenase deficiency but corrected by kynurenines.
Pneumonia, Pneumococcal
Influenza-induced expression of indoleamine 2,3-dioxygenase enhances interleukin-10 production and bacterial outgrowth during secondary pneumococcal pneumonia.
Pneumonia, Viral
Antioxidant activities of some tryptophan metabolites: possible implication for inflammatory diseases.
Porphyrias
Effects of acute carbamazepine administration on haem metabolism in rat liver.
Glucose effect on tryptophan oxygenase and tyrosine aminotransferase induction after allylisopropylacetamide-induced porphyria in the rat.
The activation and induction of tryptophan pyrrolase during experimental porphyria and by amino-triazole.
Tryptophan pyrrolase, the regulatory free haem and hepatic porphyrias. Early depletion of haem by clinical and experimental exacerbators of porphyria.
Tryptophan pyrrolase, tryptophan and tyrosine transaminase changes during allylisopropylacetamide-induced porphyria in the rat.
[Behavior of hepatic tryptophan pyrrolase in porphyria induced with DDC in rats]
Porphyrias, Hepatic
Heme utilization by rat liver tryptophan pyrrolase as a screening test for exacerbation of hepatic porphyrias by drugs.
Reduction of the C2 and C4 vinyl groups of Sn-protoporphyrin to form Sn-mesoporphyrin markedly enhances the ability of the metalloporphyrin to inhibit in vivo heme catabolism.
Regulation of rat liver tryptophan pyrrolase by its cofactor haem: Experiments with haematin and 5-aminolaevulinate and comparison with the substrate and hormonal mechanisms.
Tryptophan pyrrolase, the regulatory free haem and hepatic porphyrias. Early depletion of haem by clinical and experimental exacerbators of porphyria.
Pre-Eclampsia
Decreased tryptophan catabolism by placental indoleamine 2,3-dioxygenase in preeclampsia.
Endothelial indoleamine 2,3-dioxygenase-1 regulates the placental vascular tone and is deficient in intrauterine growth restriction and pre-eclampsia.
Genetic Variation in the Indoleamine 2,3-Dioxygenase Gene in Pre-eclampsia (Reply).
Genetic Variation in the Indoleamine 2,3-Dioxygenase Gene in Pre-eclampsia.
Indoleamine 2,3-Dioxygenase Gene in Pre-eclampsia.
Mouse model for allogeneic immune reaction against fetus recapitulates human pre-eclampsia.
Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes.
Reduced expression of indoleamine 2,3-dioxygenase participates in pathogenesis of preeclampsia via regulatory T cells.
Prostatic Neoplasms
Expression of immunomodulating genes in prostate cancer and benign prostatic tissue.
Expression of Indoleamine 2,3-Dioxygenase Induced by IFN-? and TNF-? as Potential Biomarker of Prostate Cancer Progression.
High expression of indoleamine 2,3-dioxygenase gene in prostate cancer.
Increased indoleamine 2,3-dioxygenase activity and expression in prostate cancer following targeted immunotherapy.
Indoleamine 2,3-dioxygenase (IDO) activity influence tumor growth in the TRAMP prostate cancer model.
Indoleamine 2,3-dioxygenase expression in the prognosis of the localized prostate cancer.
Prostate cancer immunotherapy yields superior long-term survival in TRAMP mice when administered at an early stage of carcinogenesis prior to the establishment of tumor-associated immunosuppression at later stages.
Small Molecules for Immunomodulation in Cancer.
The footprint of kynurenine pathway in every cancer: a new target for chemotherapy.
The Prognostic Value of Indoleamine-2,3-Dioxygenase Gene Expression in Urine of Prostate Cancer Patients Undergoing Radical Prostatectomy as First Treatment of Choice.
Tumor-associated dendritic cells: molecular mechanisms to suppress antitumor immunity.
Proteinuria
RAS inhibition modulates kynurenine levels in a CKD population with and without type 2 diabetes mellitus.
Psoriasis
Immune cells from Psoriasis patients are defective to induce Indoleamine 2,3-dioxygenase expression in response to inflammatory stimuli.
Indoleamine 2,3-dioxygenase in psoriasis: a defective mechanism.
Psoriasis is characterized by deficient negative immune regulation compared to transient delayed-type hypersensitivity reactions.
The efficacy of in vivo administration of Apremilast on mesenchymal stem cells derived from psoriatic patients.
Pulmonary Disease, Chronic Obstructive
Decreased indoleamine 2,3-dioxygenase activity and IL-10/IL-17A ratio in patients with COPD.
Dysregulation of the Tryptophan Pathway Evidences Gender Differences in COPD.
Purpura, Thrombocytopenic, Idiopathic
Decreased indoleamine 2,3-dioxygenase expression in dendritic cells and role of indoleamine 2,3-dioxygenase-expressing dendritic cells in immune thrombocytopenia.
Rectal Neoplasms
Prognostic value of tumour-infiltrating CD8+?lymphocytes in rectal cancer after neoadjuvant chemoradiation: is indoleamine-2,3-dioxygenase (IDO1) a friend or foe?
Renal Insufficiency
High activity of indoleamine 2,3-dioxygenase is associated with renal insufficiency in Puumala hantavirus induced nephropathia epidemica.
Renal Insufficiency, Chronic
Correlation of Indoleamine-2,3-Dioxygenase and Chronic Kidney Disease: A Pilot Study.
Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms.
RAS inhibition modulates kynurenine levels in a CKD population with and without type 2 diabetes mellitus.
Reperfusion Injury
Indoleamine 2,3 dioxygenase (ido)expression in renal tubular epithelial cells contributes to renal ischemia reperfusion injury.
Indoleamine 2,3-dioxygenase expression promotes renal ischemia-reperfusion injury.
Indoleamine 2,3-dioxygenase inhibition alters the non-coding RNA transcriptome following renal ischemia-reperfusion injury.
Nonviral gene delivery with indoleamine 2,3-dioxygenase targeting pulmonary endothelium protects against ischemia-reperfusion injury.
Role of indoleamine 2,3-dioxygenase in ischemia-reperfusion injury of renal tubular epithelial cells.
The protective effect of 1-methyltryptophan isomers in renal ischemia-reperfusion injury is not exclusively dependent on indolamine 2,3-dioxygenase inhibition.
The role of indoleamine 2,3 dioxygenase in beneficial effects of stem cells in hind limb ischemia reperfusion injury.
Respiratory Syncytial Virus Infections
Respiratory Syncytial Virus Infection Reduces Kynurenic Acid Production and Reverses Th17/Treg Balance by Modulating Indoleamine 2,3-Dioxygenase (IDO) Molecules in Plasmacytoid Dendritic Cells.
Rheumatic Diseases
Emerging Concepts on Inhibitors of Indoleamine 2,3-Dioxygenase in Rheumatic Diseases.
Rhinitis, Allergic
Indoleamine 2,3-dioxygenase expression in patients with allergic rhinitis: a case-control study.
Rhinitis, Allergic, Seasonal
Specific Immunotherapy Normalizes Tryptophan Concentrations in Patients with Allergic Rhinitis.
Rickettsia Infections
Intralesional expression of mRNA of interferon- gamma , tumor necrosis factor- alpha , interleukin-10, nitric oxide synthase, indoleamine-2,3-dioxygenase, and RANTES is a major immune effector in Mediterranean spotted fever rickettsiosis.
Sarcoma
DNA regulatory elements for steroid hormones.
IDO Targeting in Sarcoma: Biological and Clinical Implications.
Sarcoma, Ewing
Indoleamine-2,3-dioxygenase in an immunotherapy model for Ewing sarcoma.
Schistosomiasis mansoni
Effects of Schistosoma mansoni infection on induction of tryptophan oxygenase in mouse livers.
Scleroderma, Systemic
Indoleamine 2,3 dioxygenase gene polymorphisms correlate with CD8+ Treg impairment in systemic sclerosis.
The role of B7 family costimulatory molecules and indoleamine 2,3-dioxygenase in primary Sjögren's syndrome and systemic sclerosis.
Scrub Typhus
Activation of Indoleamine 2,3-Dioxygenase in Patients with Scrub Typhus and Its Role in Growth Restriction of Orientia tsutsugamushi.
Seizures
Alzheimer's and seizures: interleukin-18, indoleamine 2,3-dioxygenase and quinolinic Acid.
Indoleamine-2,3-Dioxygenase 1 Deficiency Suppresses Seizures in Epilepsy.
Prevention by cycloheximide of the audiogenic seizures and tryptophan metabolic disturbances of ethanol withdrawal in rats.
Tryptophan pyrrolase activity in rats subjected to electric convulsions.
Sepsis
Blockade of indoleamine 2,3-dioxygenase reduces mortality from peritonitis and sepsis in mice by regulating functions of CD11b+ peritoneal cells.
Effect of 1-methyl-D-tryptophan and adoptive transfer of dendritic cells on polymicrobial sepsis induced by cecal content injection.
Endotoxin-Induced Tryptophan Degradation along the Kynurenine Pathway: The Role of Indolamine 2,3-Dioxygenase and Aryl Hydrocarbon Receptor-Mediated Immunosuppressive Effects in Endotoxin Tolerance and Cancer and Its Implications for Immunoparalysis.
Enhanced indoleamine 2,3-dioxygenase activity in patients with severe sepsis and septic shock.
Indoleamine 2,3-dioxygenase inhibitors: potential treatment for cancer, sepsis, and more.
Inhibition of indoleamine 2,3-dioxygenase 1/2 prevented cognitive impairment and energetic metabolism changes in the hippocampus of adult rats subjected to polymicrobial sepsis.
Mitochondria-Rich Fraction Isolated From Mesenchymal Stromal Cells Reduces Lung and Distal Organ Injury in Experimental Sepsis.
Regulation of vascular tone and blood pressure by singlet molecular oxygen in inflammation.
Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock.
Shock, Septic
Blockade of indoleamine 2,3-dioxygenase protects mice against lipopolysaccharide-induced endotoxin shock.
Enhanced indoleamine 2,3-dioxygenase activity in patients with severe sepsis and septic shock.
Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock.
Simian Acquired Immunodeficiency Syndrome
Cerebral cortex and lung indoleamine-2,3-dioxygenase activity is increased in type-D retrovirus infected macaques.
Increased ratio of quinolinic acid to kynurenic acid in cerebrospinal fluid of D retrovirus-infected rhesus macaques: relationship to clinical and viral status.
Skin Diseases
Effect of psoralen-induced photodermatitis on tryptophan metabolism in rats.
Immunotolerant indoleamine-2,3-dioxygenase increases in condyloma acuminata.
Niacin metabolism and indoleamine 2,3-dioxygenase activation in malnourished patients with flaky paint dermatosis.
Sleep Deprivation
Enzyme activity in sleep and sleep deprivation.
Small Cell Lung Carcinoma
NK cell-based therapeutics for lung cancer.
Squamous Cell Carcinoma of Head and Neck
Exosomes-carrying Epstein-Barr virus-encoded small RNA-1 induces indoleamine 2, 3-dioxygenase expression in tumor-infiltrating macrophages of oral squamous-cell carcinomas and suppresses T-cell activity by activating RIG-I/IL-6/TNF-? pathway.
Expression and prognostic impact of indoleamine 2,3-dioxygenase in oral squamous cell carcinomas.
Human papilloma virus specific immunogenicity and dysfunction of CD8+ T cells in head and neck cancer.
Interferon gamma-induced apoptosis of head and neck squamous cell carcinoma is connected to indoleamine-2,3-dioxygenase via mitochondrial and ER stress-associated pathways.
Targeting the IDO-BCL2A1-Cytochrome c Pathway Promotes Apoptosis in Oral Squamous Cell Carcinoma.
The immunotherapeutic role of indoleamine 2,3-dioxygenase in head and neck squamous cell carcinoma: A systematic review.
Tumoral indoleamine 2,3-dioxygenase expression predicts poor outcome in laryngeal squamous cell carcinoma.
Staphylococcal Infections
The induction of host tryptophan oxygenase by staphylococcal infection. 1.
Vascular allografts are resistant to methicillin-resistant Staphylococcus aureus infection by indoleamine 2,3-dioxygenase in rat aortic transplant model.
Starvation
Accumulation of an endogenous tryptophan-derived metabolite in colorectal and breast cancers.
An insight into the early mechanisms of allergen-specific immunotherapy.
Analysis of transcription factors regulating induction of indoleamine 2,3-dioxygenase by IFN-gamma.
Changes in rat liver weight and specific activity of hepatic tryptophan dioxygenase in different stages of fasting.
Glycogen Synthase Kinase-3? (GSK-3?) Inhibition Enhances Dendritic Cell-based Cancer Vaccine Potency via Suppression of Interferon-?-induced Indoleamine 2,3-Dioxygenase Expression.
Indoleamine 2,3-Dioxygenase (IDO) Regulates Th17/Treg Immunity in Experimental IgA Nephropathy.
Indoleamine 2,3-dioxygenase and regulatory function: tryptophan starvation and beyond.
Nanosensor detection of an immunoregulatory tryptophan influx/kynurenine efflux cycle.
Possible involvement of the enhanced tryptophan pyrrolase activity in the corticosterone- and starvation-induced increases in concentrations of nicotinamide-adenine dinucleotides (phosphates) in rat liver.
Tryptophan Codon-Dependent Transcription in Chlamydia pneumoniae during Gamma Interferon-Mediated Tryptophan Limitation.
Tryptophan pyrrolase gene expression in an alcohol preferring and non-preferring mouse strain.
Tryptophan pyrrolase in haem regulation. The mechanisms of enhancement of rat liver 5-aminolaevulinate synthase activity by starvation and of the glucose effect on induction of the enzyme by 2-allyl-2-isopropylacetamide.
Stomach Neoplasms
Development of simultaneous analysis of tryptophan metabolites in serum and gastric juice - an investigation towards establishing a biomarker test for gastric cancer diagnosis.
Immunoactivative role of indoleamine 2,3?dioxygenase in gastric cancer cells in vitro.
The Correlation Between the Subsets of Tumor Infiltrating Memory T Cells and the Expression of Indoleamine 2,3-Dioxygenase in Gastric Cancer.
The Impact of Indoleamine 2,3-dioxygenase (IDO) Expression on Stage III Gastric Cancer.
Stroke
The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines.
Thyroid Neoplasms
Indoleamine-2,3-Dioxygenase in Thyroid Cancer Cells Suppresses Natural Killer Cell Function by Inhibiting NKG2D and NKp46 Expression via STAT Signaling Pathways.
[Indoleamine 2,3-Dioxygenase Activity during I131-Radioisotope Therapy for Metastatic Thyroid Cancer].
[Study of indoleamine 2,3-dioxygenase expression in patients of thyroid cancer].
Tics
BRAF and NRAS mutations and antitumor immunity in Korean malignant melanomas and their prognostic relevance: Gene set enrichment analysis and CIBERSORT analysis.
Exclusion of the 5-HT1A serotonin neuroreceptor and tryptophan oxygenase genes in a large British kindred multiply affected with Tourette's syndrome, chronic motor tics, and obsessive-compulsive behavior.
Tourette Syndrome
Exclusion of the 5-HT1A serotonin neuroreceptor and tryptophan oxygenase genes in a large British kindred multiply affected with Tourette's syndrome, chronic motor tics, and obsessive-compulsive behavior.
Toxoplasmosis
Heme oxygenase-1 activity is involved in the control of Toxoplasma gondii infection in the lung of BALB/c and C57BL/6 and in the small intestine of C57BL/6 mice.
Impact of foetus and mother on IFN-gamma-induced indoleamine 2,3-dioxygenase and inducible nitric oxide synthase expression in murine placenta following Toxoplasma gondii infection.
Indoleamine 2,3-Dioxygenase Activity During Acute Toxoplasmosis and the Suppressed T Cell Proliferation in Mice.
L-tryptophan-L-kynurenine pathway metabolism accelerated by Toxoplasma gondii infection is abolished in gamma interferon-gene-deficient mice: cross-regulation between inducible nitric oxide synthase and indoleamine-2,3-dioxygenase.
Modulation of host HIF-1? activity and the tryptophan pathway contributes to the anti-
Triple Negative Breast Neoplasms
Forkhead box P3 and indoleamine 2,3-dioxygenase co-expression in Pakistani triple negative breast cancer patients.
Trophoblastic Neoplasms
Indoleamine 2,3-dioxygenase expression in gestational trophoblastic disease: implications for development of immunotherapeutic approaches.
Tuberculosis
Evolutionary Views of Tuberculosis: Indoleamine 2,3-Dioxygenase Catalyzed Nicotinamide Synthesis Reflects Shifts in Macrophage Metabolism: Indoleamine 2,3-Dioxygenase Reflects Altered Macrophage Metabolism During Tuberculosis Pathogenesis.
Gene expression in HIV-1/Mycobacterium tuberculosis co-infected macrophages is dominated by M. tuberculosis.
Plasma indoleamine 2,3-dioxygenase activity as a potential biomarker for early diagnosis of multidrug-resistant tuberculosis in tuberculosis patients.
Tuberculosis, Multidrug-Resistant
Plasma indoleamine 2,3-dioxygenase activity as a potential biomarker for early diagnosis of multidrug-resistant tuberculosis in tuberculosis patients.
Tuberculosis, Pleural
Indoleamine 2,3-dioxygenase in the pathogenesis of tuberculous pleurisy.
Tuberculosis, Pulmonary
Serum indoleamine 2,3-dioxygenase activity predicts prognosis of pulmonary tuberculosis.
Urinary Bladder Neoplasms
Role of Indoleamine-2,3-Dioxygenase Inhibitors in Salvage Therapy for Non-Muscle Invasive Bladder Cancer.
Uterine Cervical Neoplasms
Cell intrinsic & extrinsic factors in cervical carcinogenesis.
Correlation between indoleamine 2,3 dioxygenase mRNA and CDKN2A/p16 mRNA: a combined strategy to cervical cancer diagnosis.
Downregulation of indoleamine-2,3-dioxygenase in cervical cancer cells suppresses tumor growth by promoting natural killer cell accumulation.
Indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase expression in HPV infection, SILs, and cervical cancer.
Indoleamine 2,3-Dioxygenase Expression Pattern in the Tumor Microenvironment Predicts Clinical Outcome in Early Stage Cervical Cancer.
Indoleamine 2,3-dioxygenase expression predicts impaired survival of invasive cervical cancer patients treated with radical hysterectomy.
Indoleamine-2,3-dioxygenase (IDO) metabolic activity is detrimental for cervical cancer patient survival.
MiR-218 produces anti-tumor effects on cervical cancer cells in vitro.
Neem leaf glycoprotein overcomes indoleamine 2,3 dioxygenase mediated tolerance in dendritic cells by attenuating hyperactive regulatory T cells in cervical cancer stage IIIB patients.
Systemic Changes of Tryptophan Catabolites via the Indoleamine-2,3-dioxygenase Pathway in Primary Cervical Cancer.
Vaccinia
Role of Indoleamine 2,3-Dioxygenase in Antiviral Activity of Interferon-gamma Against Vaccinia Virus.
Vasculitis
Mollaret meningitis may be caused by reactivation of latent cerebral toxoplasmosis.
Viremia
Primary infection with simian immunodeficiency virus: plasmacytoid dendritic cell homing to lymph nodes, type I interferon, and immune suppression.
Virus Diseases
Antiviral and Immunoregulatory Effects of Indoleamine-2,3-Dioxygenase in Hepatitis C Virus Infection.
Drug analog inhibition of indoleamine 2,3-dioxygenase (IDO) activity modifies pattern recognition receptor expression and proinflammatory cytokine responses early during influenza virus infection.
Identification of potent virtual leads to design novel indoleamine 2,3-dioxygenase inhibitors: pharmacophore modeling and molecular docking studies.
Indoleamine 2,3-Dioxygenase in Hematopoietic Stem Cell-Derived Cells Suppresses Rhinovirus-Induced Neutrophilic Airway Inflammation by Regulating Th1- and Th17-Type Responses.
Indoleamine 2,3-Dioxygenase Is the Anticancer Target for a Novel Series of Potent Naphthoquinone-Based Inhibitors.
Induction and role of indoleamine 2,3 dioxygenase in mouse models of influenza a virus infection.
Induction of indoleamine 2,3-dioxygenase in mouse lung during virus infection.
Influenza A virus infection induces indoleamine 2,3-dioxygenase (IDO) expression and modulates subsequent inflammatory mediators in nasal epithelial cells.
Influenza virus induces expression of antioxidant genes in human epithelial cells.
Inhibition of indoleamine 2,3-dioxygenase enhances the T-cell response to influenza virus infection.
Interferons: Reprogramming the Metabolic Network against Viral Infection.
l-Kynurenine-induced apoptosis in human NK cells is mediated by reactive oxygen species.
Low serum tryptophan levels, reduced macrophage IDO activity and high frequency of psychopathology in HCV patients.
O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1.
Regulatory T-cell markers, indoleamine 2,3-dioxygenase, and virus levels in spleen and gut during progressive simian immunodeficiency virus infection.
Respiratory Syncytial Virus Infection Reduces Kynurenic Acid Production and Reverses Th17/Treg Balance by Modulating Indoleamine 2,3-Dioxygenase (IDO) Molecules in Plasmacytoid Dendritic Cells.
Role of indoleamine-2,3-dioxygenase in alpha/beta and gamma interferon-mediated antiviral effects against herpes simplex virus infections.
Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase.
Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection.
Virus Infections Incite Pain Hypersensitivity by Inducing Indoleamine 2,3 Dioxygenase.
[Induction of indoleamine 2,3-dioxygenase after bacterial endotoxin treatment, viral infection or tumor transplantation, and its physiological significance]
Vitamin B 6 Deficiency
Oral contraceptives and depression: impact, prevalence and cause.
Vitiligo
Abnormal tryptophan pyrrolase and amino acids related to melanogenesis in vitiligo.
Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 2: epidermal H2O2/ONOO--mediated stress in vitiligo hampers indoleamine 2,3-dioxygenase and aryl hydrocarbon receptor-mediated immune response signaling.
[Tryptophan metabolism in vitiligo]
Vulvar Neoplasms
Serum Tryptophan and Kynurenine Concentrations as Parameters for Indoleamine 2,3-Dioxygenase Activity in Patients With Endometrial, Ovarian, and Vulvar Cancer.
Warts
Psoriasis is characterized by deficient negative immune regulation compared to transient delayed-type hypersensitivity reactions.