Information on EC 1.13.11.14 - 2,3-dihydroxybenzoate 3,4-dioxygenase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.13.11.14
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RECOMMENDED NAME
GeneOntology No.
2,3-dihydroxybenzoate 3,4-dioxygenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2,3-dihydroxybenzoate + O2 = 3-carboxy-2-hydroxymuconate semialdehyde
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
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oxidation
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redox reaction
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reduction
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
2,3-dihydroxybenzoate degradation
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Benzoate degradation
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Microbial metabolism in diverse environments
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SYSTEMATIC NAME
IUBMB Comments
2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (decyclizing)
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CAS REGISTRY NUMBER
COMMENTARY hide
9032-31-9
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
RW611
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Manually annotated by BRENDA team
RW611
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,3-dihydroxy-p-toluate + O2
2,6-dioxo-4-heptenoic acid + CO2
show the reaction diagram
2,3-dihydroxybenzoate + O2
CO2 + alpha-hydroxymuconic semialdehyde
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2,3-dihydroxybenzoate + O2
CO2 + alpha-hydroxymuconic semialdehyde
show the reaction diagram
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,3,4-Trihydroxybenzoate
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competitive inhibitor
3-chlorocatechol
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non-competitive inhibitor
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.003
2,3-Dihydroxy-p-toluate
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0.0054 - 0.023
2,3-Dihydroxybenzoate
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.006
2,3,4-Trihydroxybenzoate
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0.057
3-chlorocatechol
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.095
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growth on 2,3-dihydroxybenzoate
0.135
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growth on glucose
0.261
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specific activity in cell-free extract after growth on 2,3-dihydroxybenzoate
0.264
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specific activity in cell-free extract after growth on phthalate
0.355
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specific activity in cell-free extract after growth on succinate
0.508
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specific activity in cell-free extract after growth on 2-sulfobenzoate
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.6
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assay at