Information on EC 1.11.1.3 - fatty-acid peroxidase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.11.1.3
-
RECOMMENDED NAME
GeneOntology No.
fatty-acid peroxidase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
palmitate + 2 H2O2 = pentadecanal + CO2 + 3 H2O
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
hexadecanoate:hydrogen-peroxide oxidoreductase
Acts on long-chain fatty acids from dodecanoic to octadecanoic acid.
CAS REGISTRY NUMBER
COMMENTARY hide
9029-52-1
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
Carthamus tintorius
-
-
-
Manually annotated by BRENDA team
no activity in Glycine max
-
-
-
Manually annotated by BRENDA team
no activity in Helianthus annuus
-
-
-
Manually annotated by BRENDA team
no activity in Lupinus luteus
-
-
-
Manually annotated by BRENDA team
no activity in Rattus norvegicus
-
-
-
Manually annotated by BRENDA team
no activity in Ricinus communis
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
lauric acid + H2O2
undecanal + CO2 + H2O
show the reaction diagram
-
-
-
-
?
palmitate + H2O2
pentadecanal + CO2 + H2O
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
palmitate + H2O2
pentadecanal + CO2 + H2O
show the reaction diagram
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,2,4-Triazole
-
-
CO
-
light-dependent inhibition
cyanide
-
-
imidazole
-
-
additional information
-
imidazole derivates are also inhibitory, weaker inhibition than imidazole
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.055
lauric acid
-
-
0.0009
palmitate
-
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0002
imidazole
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2.9
-
purified enzyme with lauric acid as substrate
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.8 - 8
-
highest activity
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
taken from germinating peanut
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
50000
-
alpha,beta, 1 * 70000 + 1 * 50000, 70 kD subunit shows EC 1.11.1.3 activity, 50 kD subunit shows NAD+ oxidoreductase activity
70000
-
alpha,beta, 1 * 70000 + 1 * 50000, 70 kD subunit shows EC 1.11.1.3 activity, 50 kD subunit shows NAD+ oxidoreductase activity
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
-
alpha,beta, 1 * 70000 + 1 * 50000, 70 kD subunit shows EC 1.11.1.3 activity, 50 kD subunit shows NAD+ oxidoreductase activity
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
55
-
only traces of activity after 5 min
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-5°C, 3 month, 10% loss of activity
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE