Information on EC 1.1.5.B1 - quinoprotein inositol dehydrogenase

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The expected taxonomic range for this enzyme is: Gluconobacter oxydans

EC NUMBER
COMMENTARY hide
1.1.5.B1
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
quinoprotein inositol dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
myo-inositol + pyrroloquinoline quinone = 2,4,6/3,5-pentahydroxycyclohexanone + pyrroloquinoline quinol
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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-
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SYSTEMATIC NAME
IUBMB Comments
myo-inositol:quinone 2-oxidoreductase
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain ATCC 621H, DSM 2343, gene GOX1857
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
allo-inositol + 2,6-dichlorophenol indophenol
?
show the reaction diagram
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i.e. 1,2,3,4/5,6-cyclohexanehexol
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?
D-sorbitol + 2,6-dichlorophenol indophenol
?
show the reaction diagram
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-
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?
muco-inositol + 2,6-dichlorophenol indophenol
?
show the reaction diagram
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i.e. 1,2,4,5/3,6-cyclohexanehexol
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-
?
myo-inositol + 2,6-dichlorophenol indophenol
?
show the reaction diagram
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-
-
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?
additional information
?
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substrate specificity, overview
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyrroloquinoline quinone
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dependent on
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
D-glucose suppresses the enzyme, D-mannitol suppresses enzyme induction by myo-inositol, overview
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
myo-inositol induces the enzyme maximally at 33 mM, but is slightly suppressing at higher concentrations, allo-inositol, muco-inositol, and D-sorbitol also induces the enzyme, D-mannitol suppresses enzyme induction by myo-inositol, overview
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.09
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D-sorbitol induced wild-type strain, crude extract
0.6
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membrane fraction of induced wild-type cells
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
gene GOX1857, DNA and amino acid sequence determination and analysis, expression of wild-type and mutant enzymes in Escherichia coli
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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construction of a GOX1857 disruption mutant strain DW1, which is inactive with myo-inositol and unable to grow with myo-inositol as the sole energy source