Information on EC 1.1.5.7 - cyclic alcohol dehydrogenase (quinone)

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The expected taxonomic range for this enzyme is: Gluconobacter frateurii

EC NUMBER
COMMENTARY hide
1.1.5.7
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RECOMMENDED NAME
GeneOntology No.
cyclic alcohol dehydrogenase (quinone)
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a cyclic alcohol + a quinone = a cyclic ketone + a quinol
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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SYSTEMATIC NAME
IUBMB Comments
cyclic alcohol:quinone oxidoreductase
This enzyme oxidizes a wide variety of cyclic alcohols. Some minor enzyme activity is found with aliphatic secondary alcohols and sugar alcohols, but not primary alcohols. The enzyme is unable to catalyse the reverse reaction of cyclic ketones or aldehydes to cyclic alcohols. This enzyme differs from EC 1.1.5.5, alcohol dehydrogenase (quinone), which shows activity with ethanol [1].
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
CHM 9
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(1R,2R)-trans-1,2-cyclohexanediol + pyrroloquinoline quinone
?
show the reaction diagram
(1S,2S)-trans-1,2-cyclohexanediol + pyrroloquinoline quinone
?
show the reaction diagram
(2R,3R)-2,3-butanediol + pyrroloquinoline quinone
?
show the reaction diagram
-
41% of the activity compared to cyclopentanol
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ir
1,2-butanediol + pyrroloquinoline quinone
?
show the reaction diagram
-
63% of the activity compared to cyclopentanol
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ir
1,3-butanediol + pyrroloquinoline quinone
?
show the reaction diagram
-
12% of the activity compared to cyclopentanol
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ir
1,3-cyclopentanediol + pyrroloquinoline quinone
?
show the reaction diagram
-
73% of the activity compared to cyclopentanol
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ir
1,4-cyclohexanediol + pyrroloquinoline quinone
?
show the reaction diagram
-
14% of the activity compared to cyclopentanol
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ir
2,3-butanediol + pyrroloquinoline quinone
?
show the reaction diagram
-
186% of the activity compared to cyclopentanol
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ir
2,4-pentanediol + pyrroloquinoline quinone
?
show the reaction diagram
-
16% of the activity compared to cyclopentanol
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ir
2-butanol + pyrroloquinoline quinone
butane-2-one + reduced pyrroloquinoline quinone
show the reaction diagram
2-hexanol + pyrroloquinoline quinone
2-hexanone + pyrroloquinoline quinol
show the reaction diagram
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10% of the activity compared to cyclopentanol
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ir
2-methyl-2,4-pentanediol + pyrroloquinoline quinone
?
show the reaction diagram
-
17% of the activity compared to cyclopentanol
-
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ir
2-propanol + pyrroloquinoline quinone
acetone + pyrroloquinoline quinol
show the reaction diagram
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17% of the activity compared to cyclopentanol
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ir
3-pentanol + pyrroloquinoline quinone
3-pentanone + pyrroloquinoline quinol
show the reaction diagram
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74% of the activity compared to cyclopentanol
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ir
cis-1,2-cyclohexanediol + pyrroloquinoline quinone
?
show the reaction diagram
-
88% of the activity compared to cyclopentanol
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ir
cis-1,2-cyclopentanediol + pyrroloquinoline quinone
?
show the reaction diagram
-
181% of the activity compared to cyclopentanol
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ir
cis-4-cyclopentene-1,3-diol + pyrroloquinoline quinone
?
show the reaction diagram
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32% of the activity compared to cyclopentanol
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ir
cyclobutanol + pyrroloquinoline quinone
cyclobutanone + pyrroloquinoline quinol
show the reaction diagram
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73% of the activity compared to cyclopentanol
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ir
cyclohexanol + pyrroloquinoline quinone
cyclohexanone + pyrroloquinoline quinol
show the reaction diagram
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73% of the activity compared to cyclopentanol
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ir
cyclooctanol + pyrroloquinoline quinone
cyclooctanone + pyrroloquinoline quinol
show the reaction diagram
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137% of the activity compared to cyclopentanol
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ir
cyclopentanol + pyrroloquinoline quinone
cyclopentanone + pyrroloquinoline quinol
show the reaction diagram
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only pyrroloquinoline quinone is effective as electron acceptor, no activity with FAD, FMN and NAD(P)+
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ir
D-arabitol + pyrroloquinoline quinone
?
show the reaction diagram
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78% of the activity compared to cyclopentanol
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ir
D-mannitol + pyrroloquinoline quinone
?
show the reaction diagram
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25% of the activity compared to cyclopentanol
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ir
D-sorbitol + pyrroloquinoline quinone
?
show the reaction diagram
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34% of the activity compared to cyclopentanol
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ir
glycerol + pyrroloquinoline quinone
?
show the reaction diagram
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59% of the activity compared to cyclopentanol
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ir
meso-erythritol + pyrroloquinoline quinone
?
show the reaction diagram
-
100% of the activity compared to cyclopentanol
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ir
ribitol + pyrroloquinoline quinone
?
show the reaction diagram
-
34% of the activity compared to cyclopentanol
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ir
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyrroloquinoline quinone
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only pyrroloquinoline quinone is effective as electron acceptor, no activity with FAD, FMN and NAD(P)+
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
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addition of pyrroloquinoline quinone and Ca2+ converts the apo-enzyme to the holoenzyme
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1
Cyclopentanol
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pH 5.5, 25°C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
83000
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x * 83000, SDS-PAGE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE