Information on EC 1.1.5.11 - 1-butanol dehydrogenase (quinone)

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.1.5.11
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RECOMMENDED NAME
GeneOntology No.
1-butanol dehydrogenase (quinone)
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
butan-1-ol + a quinone = butanal + a quinol
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
butane degradation
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SYSTEMATIC NAME
IUBMB Comments
butan-1-ol:quinone oxidoreductase
This periplasmic quinoprotein alcohol dehydrogenase, characterized from the bacterium Thauera butanivorans, is involved in butane degradation. It contains a pyrroloquinoline quinone (PQQ) prosthetic group. cf. EC 1.1.2.9, 1-butanol dehydrogenase (cytochrome c).
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-octanol + a quinone
octanal + a quinol
show the reaction diagram
1-pentanol + a quinone
pentanal + a quinol
show the reaction diagram
1-propanol + a quinone
propanal + a quinol
show the reaction diagram
2-butanol + a quinone
2-butanone + a quinol
show the reaction diagram
butan-1-ol + a quinone
butanal + a quinol
show the reaction diagram
butan-2-ol + a quinone
2-butanone + a quinol
show the reaction diagram
butyraldehyde + a quinol
1-butanol + a quinone
show the reaction diagram
butyraldehyde + a quinol
?
show the reaction diagram
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25% activity compared to butan-2-ol
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?
ethanol + a quinone
acetaldehyde + a quinol
show the reaction diagram
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0.7% activity compared to butan-2-ol
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?
methanol + a quinone
formaldehyde + a quinol
show the reaction diagram
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0.7% activity compared to butan-2-ol
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?
octan-2-ol + a quinone
2-octanone + a quinol
show the reaction diagram
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15% activity compared to butan-2-ol
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-
?
pentan-2-ol + a quinone
2-pentanone + a quinol
show the reaction diagram
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61% activity compared to butan-2-ol
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?
propan-2-ol + a quinone
acetone + a quinol
show the reaction diagram
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0.7% activity compared to butan-2-ol
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-
?
propionaldehyde + a quinol
?
show the reaction diagram
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33% activity compared to butan-2-ol
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?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
butan-1-ol + a quinone
butanal + a quinol
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyrroloquinoline quinone
additional information
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NAD+-independent
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
acetic acid
about 20% residual activity at 8% (v/v) acetic acid
antimycin A
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3% inhibition at 1 mM
Salicylhydroxamic acid
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5% inhibition at 3 mM
additional information
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not inhibited by cyanide (1 mM)
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.662
2-butanol
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at pH 7.0 and 30°C
0.0017
butan-1-ol
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at pH 7.0 and 30°C
0.369
Butyraldehyde
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at pH 7.0 and 30°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
10 - 40
more than 60% activity between 10 and 40°C, no activity at 50°C
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.2
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calculated from amino acid sequence
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
DEAE Toyopearl column chromatography, CM Toyopearl column chromatography, and hydroxyapatite column chromatography
Q-Sepharose column chromatography and Superose 6 gel filtration
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the enzyme's mRNAs is induced when the cell's 1-butanol oxidation activity is induced