Information on EC 1.1.2.6 - polyvinyl alcohol dehydrogenase (cytochrome)

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.1.2.6
-
RECOMMENDED NAME
GeneOntology No.
polyvinyl alcohol dehydrogenase (cytochrome)
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
polyvinyl alcohol + ferricytochrome c = oxidized polyvinyl alcohol + ferrocytochrome c + H+
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
polyvinyl alcohol degradation
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-
SYSTEMATIC NAME
IUBMB Comments
polyvinyl alcohol:ferricytochrome-c oxidoreductase
A quinoprotein. The enzyme is involved in bacterial polyvinyl alcohol degradation. Some Gram-negative bacteria degrade polyvinyl alcohol by importing it into the periplasmic space, where it is oxidized by polyvinyl alcohol dehydrogenase, an enzyme that is coupled to the respiratory chain via cytochrome c. The enzyme contains a pyrroloquinoline quinone cofactor.
CAS REGISTRY NUMBER
COMMENTARY hide
119940-13-5
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain 113P3
-
-
Manually annotated by BRENDA team
strain 113P3
SwissProt
Manually annotated by BRENDA team
strain 113P3
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1,2-cyclohexanediol + oxidized 2,6-dichlorophenolindophenol
?
show the reaction diagram
1,3-butanediol + oxidized 2,6-dichlorophenolindophenol
?
show the reaction diagram
1,3-cyclohexanediol + oxidized 2,6-dichlorophenolindophenol
?
show the reaction diagram
1,3-cyclohexanedione + reduced 2,6-dichlorophenolindophenol
?
show the reaction diagram
2,4-pentanediol + oxidized 2,6-dichlorophenolindophenol
?
show the reaction diagram
polyvinyl alcohol + 2 ferricytochrome c
polyvinyl alcohol containing oxo-groups + 2 ferrocytochrome c + 2 H+
show the reaction diagram
-
the enzyme is involved in polyvinyl alcohol degradation
-
-
?
polyvinyl alcohol + acceptor
polyvinyl alcohol containing beta-dioxo groups + reduced acceptor
show the reaction diagram
polyvinyl alcohol + acceptor
polyvinyl alcohol containing oxo-groups + reduced acceptor
show the reaction diagram
-
pyrroloquinoline quinone-dependent polyvinyl alcohol dehydrogenase requires pyrroloquinoline quinone for polyvinyl alcohol dehydrogenation with phenazine methosulfate, phenazine ethosulfate, and 2,6-dichlorophenolindophenol as electron acceptors
-
-
?
polyvinyl alcohol + ferricytochrome c
polyvinyl alcohol containing oxo-groups + ferrocytochrome c + 2 H+
show the reaction diagram
polyvinyl alcohol + ferricytochrome c
polyvinyl alcohol containing oxo-groups + ferrocytochrome c + H+
show the reaction diagram
polyvinyl alcohol + oxidized 2,6-dichlorophenolindophenol
polyvinyl alcohol containing oxo-groups + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
polyvinyl alcohol + oxidized acceptor
polyvinyl alcohol containing oxo-groups + reduced acceptor
show the reaction diagram
-
reaction in bacterial polyvinyl alcohol degradation, couples polyvinyl alcohol dehydrogenation to cytochrome reduction
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
polyvinyl alcohol + 2 ferricytochrome c
polyvinyl alcohol containing oxo-groups + 2 ferrocytochrome c + 2 H+
show the reaction diagram
-
the enzyme is involved in polyvinyl alcohol degradation
-
-
?
polyvinyl alcohol + ferricytochrome c
polyvinyl alcohol containing oxo-groups + ferrocytochrome c + H+
show the reaction diagram
polyvinyl alcohol + oxidized acceptor
polyvinyl alcohol containing oxo-groups + reduced acceptor
show the reaction diagram
-
reaction in bacterial polyvinyl alcohol degradation, couples polyvinyl alcohol dehydrogenation to cytochrome reduction
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cytochrome c
-
cytochrome c involved in the pva operon is a physiological primary electron acceptor for polyvinyl-alcohol dehydrogenase
pyrroloquinoline quinone
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
EDTA
-
1 mM, complete inhibition
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
additional information
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effect of saponification degree and ethylene contents of polyvinyl acohol-related polymers, effect of polymerization degree of polyvinyl acohol-related polymers, effect on tacticity of polyvinyl acohol-related polymers, Km-values in mg/ml
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
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assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
67000
-
gel filtration
68045
-
x * 68045, calculated from sequence
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
recombinant enzyme
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
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pva operon, DNA and amino acid sequence determination and analysis of the complete operon in strain 113P3, genetic organization, overview
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recombinant PVADH tagged with hexahistidine is expressed in Escherichia coli. The three genes encoding oxidized polyvinyl alcohol hydrolase (EC 3.7.1.7), poly(vinyl alcohol) dehydrogenase and cytochrome c are expressed constitutively and form an operon