Information on EC 1.1.1.98 - (R)-2-hydroxy-fatty-acid dehydrogenase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.1.1.98
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RECOMMENDED NAME
GeneOntology No.
(R)-2-hydroxy-fatty-acid dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(R)-2-hydroxystearate + NAD+ = 2-oxostearate + NADH + H+
show the reaction diagram
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-
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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-
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redox reaction
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-
-
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reduction
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-
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SYSTEMATIC NAME
IUBMB Comments
(R)-2-hydroxystearate:NAD+ oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY hide
37250-32-1
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
three different forms: HAOX1, HAOX2, HAOX3
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-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-2-hydroxy fatty acid + NAD+
2-keto fatty acid + NADH + H+
show the reaction diagram
D-2-hydroxystearate + NAD+
2-oxostearate + NADH + H+
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-2-hydroxy fatty acid + NAD+
2-keto fatty acid + NADH + H+
show the reaction diagram
-
intermediate product in the alpha-oxidation of normal and/or branched long-chain fatty acids
-
?
D-2-hydroxystearate + NAD+
2-oxostearate + NADH + H+
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
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assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
HAOX1 and HAOX2
Manually annotated by BRENDA team
-
HAOX1 and, exclusively, HAOX3
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
His-tagged protein
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
three different genes, HAOX1, HAOX2, HAOX3, coding for 3 different 2-hydroxy acid oxidases, overexpression in Escherichia coli strain DH10B as His-tagged protein and in human skin fibroblasts GM5756-T cells as c-myc-tagged protein
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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overexpression of HAOX1, HAOX2, HAOX3 in Escherichia coli strain DH10B as His-tagged proteins and in human skin fibroblasts GM5756-T cells as c-myc-tagged proteins