Information on EC 1.1.1.7 - propanediol-phosphate dehydrogenase

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The expected taxonomic range for this enzyme is: Oryctolagus cuniculus

EC NUMBER
COMMENTARY hide
1.1.1.7
-
RECOMMENDED NAME
GeneOntology No.
propanediol-phosphate dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
propane-1,2-diol 1-phosphate + NAD+ = hydroxyacetone phosphate + NADH + H+
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
propane-1,2-diol-1-phosphate:NAD+ oxidoreductase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9028-15-3
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
hydroxyacetone phosphate + NADH
propane-1,2-diol-1-phosphate + NAD+
show the reaction diagram
-
-
-
-
r
propane-1,2-diol-1-phosphate + NAD+
hydroxyacetone phosphate + NADH
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
propane-1,2-diol-1-phosphate + NAD+
hydroxyacetone phosphate + NADH
show the reaction diagram
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Hydroxyacetone phosphate
-
product inhibition, competitive
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4.4
DL-propane-1,2-diol 1-phosphate
-
-
0.1 - 5.5
Hydroxyacetone phosphate
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.3
-
0.1-0.43
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.7
-
hydroxyacetone phosphate reduction
additional information
-
dehydrogenation of propane-1,2-diol 1-phosphate has alkaline pH-optimum
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.4 - 9.6
-
hydroxyacetone phosphate reduction, values strongly dependent on buffer system
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, dialyzed against distilled water for 12-24 h
-
4°C, dialyzed against Tris-buffer, pH 7.7, 80% loss of activity in 1 month
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE