Information on EC 1.1.1.408 - 4-phospho-D-threonate 3-dehydrogenase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.1.1.408
-
RECOMMENDED NAME
GeneOntology No.
4-phospho-D-threonate 3-dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-dehydro-4-phospho-D-erythronate = glycerone phosphate + CO2
show the reaction diagram
(1b), spontaneous
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-
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4-phospho-D-threonate + NAD+ = 3-dehydro-4-phospho-D-erythronate + NADH + H+
show the reaction diagram
(1a)
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-
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4-phospho-D-threonate + NAD+ = glycerone phosphate + CO2 + NADH + H+
show the reaction diagram
overall reaction
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-
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SYSTEMATIC NAME
IUBMB Comments
4-phospho-D-threonate:NAD+ 3-oxidoreductase
The enzyme, characterized from bacteria, is involved in a pathway for D-threonate catabolism.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-dehydro-4-phospho-D-erythronate
glycerone phosphate + CO2
show the reaction diagram
4-hydroxy-L-threonine 4-phosphate + NAD+
3-amino-2-oxopropyl phosphate + CO2 + NADH + H+
show the reaction diagram
4-phospho-D-erythronate + NAD+
glycerone phosphate + CO2 + NADH + H+
show the reaction diagram
4-phospho-D-threonate + NAD+
3-dehydro-4-phospho-D-erythronate + NADH + H+
show the reaction diagram
4-phospho-D-threonate + NAD+
glycerone phosphate + CO2 + NADH + H+
show the reaction diagram
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.19 - 0.2
4-hydroxy-L-threonine 4-phosphate
-
0.054 - 0.12
4-phospho-D-threonate
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.35 - 0.37
4-hydroxy-L-threonine 4-phosphate
-
3.4 - 8.9
4-phospho-D-threonate
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.8 - 1.9
4-hydroxy-L-threonine 4-phosphate
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29 - 160
4-phospho-D-threonate