Information on EC 1.1.1.396 - bacteriochlorophyllide a dehydrogenase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.1.1.396
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RECOMMENDED NAME
GeneOntology No.
bacteriochlorophyllide a dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD+ = bacteriochlorophyllide a + NADH + H+
show the reaction diagram
(1)
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3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD+ = 3-acetyl-3-devinylchlorophyllide a + NADH + H+
show the reaction diagram
(2)
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
bacteriochlorophyll a biosynthesis
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bacteriochlorophyll b biosynthesis
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Biosynthesis of secondary metabolites
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Porphyrin and chlorophyll metabolism
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SYSTEMATIC NAME
IUBMB Comments
3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide-a:NAD+ oxidoreductase (bacteriochlorophyllide a-forming)
The enzyme, together with EC 1.3.7.15, chlorophyllide-a reductase, and EC 4.2.1.165, chlorophyllide-a 31-hydratase, is involved in the conversion of chlorophyllide a to bacteriochlorophyllide a. The enzymes can act in multiple orders, resulting in the formation of different intermediates, but the final product of the cumulative action of the three enzymes is always bacteriochlorophyllide a. The enzyme oxidizes a hydroxyl group on ring A, converting it to an oxo group.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-devinyl-2-(1-hydroxyethyl)chlorophyllide a + NAD+
2-acetyl-2-devinylchlorophyllide a + NADH + H+
show the reaction diagram
3,13-dihydroxy-pheophorbide a + NAD+
3-acetyl-13-hydroxy-pheophorbide a + NADH + H+
show the reaction diagram
3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD+
bacteriochlorophyllide a + NADH + H+
show the reaction diagram
3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD+
3-acetyl-3-devinylchlorophyllide a + NADH + H+
show the reaction diagram
3-hydroxyethyl chlorophyllide a + NAD+
bacteriopheophorbide a + NADH + H+
show the reaction diagram
bacteriopheophorbide a + NAD+
3-hydroxyethyl-bycteriopheophorbide a + NADH + H+
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2-devinyl-2-(1-hydroxyethyl)chlorophyllide a + NAD+
2-acetyl-2-devinylchlorophyllide a + NADH + H+
show the reaction diagram
3,13-dihydroxy-pheophorbide a + NAD+
3-acetyl-13-hydroxy-pheophorbide a + NADH + H+
show the reaction diagram
3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD+
bacteriochlorophyllide a + NADH + H+
show the reaction diagram
3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD+
3-acetyl-3-devinylchlorophyllide a + NADH + H+
show the reaction diagram
3-hydroxyethyl chlorophyllide a + NAD+
bacteriopheophorbide a + NADH + H+
show the reaction diagram
bacteriopheophorbide a + NAD+
3-hydroxyethyl-bycteriopheophorbide a + NADH + H+
show the reaction diagram
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
glutathione-agarose column chromatography, and gel filtration
nickel column chromatography
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
atmospheric oxygen tension (20% 02) reduces the expression of the enzyme compared with low oxygen tension (2% 02)
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E46A
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inactive
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E68A
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inactive
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H141A
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inactive
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Y67A
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inactive
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