Information on EC 1.1.1.395 - 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.1.1.395
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RECOMMENDED NAME
GeneOntology No.
3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 3alpha-hydroxy bile acid CoA ester + NAD+ = a 3-oxo bile acid CoA ester + NADH + H+
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
bile acids degradation
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SYSTEMATIC NAME
IUBMB Comments
3alpha-hydroxy-bile-acid-CoA-ester:NAD+ 3-oxidoreductase
This bacterial enzyme is involved in the 7-dehydroxylation process associated with bile acid degradation. The enzyme has very little activity with unconjugated bile acid substrates. It has similar activity with choloyl-CoA, chenodeoxycholoyl-CoA, deoxycholoyl-CoA, and lithocholoyl-CoA.