Information on EC 1.1.1.371 - scyllo-inositol 2-dehydrogenase (NADP+)

for references in articles please use BRENDA:EC1.1.1.371
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The expected taxonomic range for this enzyme is: Bacillus subtilis

EC NUMBER
COMMENTARY hide
1.1.1.371
-
RECOMMENDED NAME
GeneOntology No.
scyllo-inositol 2-dehydrogenase (NADP+)
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
scyllo-inositol + NADP+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
show the reaction diagram
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-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Inositol phosphate metabolism
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Microbial metabolism in diverse environments
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-
SYSTEMATIC NAME
IUBMB Comments
scyllo-inositol:NADP+ 2-oxidoreductase
The enzyme, found in the bacterium Bacillus subtilis, has no activity with NAD+ [cf. EC 1.1.1.370, scyllo-inositol 2-dehydrogenase (NAD+)].
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADP+
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.68
2,4,6/3,5-pentahydroxycyclohexanone
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pH 7.5, 37C
0.096
NADP+
-
pH 7.5, 37C
0.027
NADPH
-
pH 7.5, 37C
34.3
scyllo-Inositol
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pH 7.5, 37C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
PDB
SCOP
CATH
ORGANISM
UNIPROT
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli as a C-terminally His6-tagged fusion protein
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gene iolW, DNA and amino acid sequence determination and analysis, the gene belongs to the Gfo/Idh/MocA family; gene yulF, DNA and amino acid sequence determination and analysis, the gene belongs to the Gfo/Idh/MocA family, recombinant expression of His6-tagged YulF
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
induced during growth on scyllo-inositol