Information on EC 1.1.1.366 - L-idonate 5-dehydrogenase (NAD+)

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The expected taxonomic range for this enzyme is: Vitis vinifera

EC NUMBER
COMMENTARY hide
1.1.1.366
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RECOMMENDED NAME
GeneOntology No.
L-idonate 5-dehydrogenase (NAD+)
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-idonate + NAD+ = 5-dehydro-D-gluconate + NADH + H+
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
L-ascorbate degradation IV
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ketogluconate metabolism
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SYSTEMATIC NAME
IUBMB Comments
L-idonate:NAD+ oxidoreductase
Involved in the catabolism of ascorbate (vitamin C) to tartrate. No activity is observed with NADP+ (cf. EC 1.1.1.264, L-idonate 5-dehydrogenase).
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SwissProt
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-idonate + NAD+
5-dehydro-D-gluconate + NADH + H+
show the reaction diagram
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-
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r
sorbitol + NAD+
?
show the reaction diagram
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when sorbitol is tested as a substrate, NAD+ reduction occurs but at a very low rate
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r
additional information
?
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no activity with NADPH and NADP+
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-idonate + NAD+
5-dehydro-D-gluconate + NADH + H+
show the reaction diagram
-
-
-
-
r
sorbitol + NAD+
?
show the reaction diagram
-
when sorbitol is tested as a substrate, NAD+ reduction occurs but at a very low rate
-
-
r
additional information
?
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-
no activity with NADPH and NADP+
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-
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
40000
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x * 40000, SDS-PAGE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
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x * 40000, SDS-PAGE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) pLysS cells
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IdnDh gene, quantitative expression analysis on transcriptional and translational levels in fruits of different stages