Information on EC 1.1.1.366 - L-idonate 5-dehydrogenase (NAD+)

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The expected taxonomic range for this enzyme is: Vitis vinifera

EC NUMBER
COMMENTARY hide
1.1.1.366
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RECOMMENDED NAME
GeneOntology No.
L-idonate 5-dehydrogenase (NAD+)
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-idonate + NAD+ = 5-dehydro-D-gluconate + NADH + H+
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
L-ascorbate degradation IV
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ketogluconate metabolism
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SYSTEMATIC NAME
IUBMB Comments
L-idonate:NAD+ oxidoreductase
Involved in the catabolism of ascorbate (vitamin C) to tartrate. No activity is observed with NADP+ (cf. EC 1.1.1.264, L-idonate 5-dehydrogenase).
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SwissProt
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-idonate + NAD+
5-dehydro-D-gluconate + NADH + H+
show the reaction diagram
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r
sorbitol + NAD+
?
show the reaction diagram
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when sorbitol is tested as a substrate, NAD+ reduction occurs but at a very low rate
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r
additional information
?
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no activity with NADPH and NADP+
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-idonate + NAD+
5-dehydro-D-gluconate + NADH + H+
show the reaction diagram
-
-
-
-
r
sorbitol + NAD+
?
show the reaction diagram
-
when sorbitol is tested as a substrate, NAD+ reduction occurs but at a very low rate
-
-
r
additional information
?
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no activity with NADPH and NADP+
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-
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
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x * 40000, SDS-PAGE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) pLysS cells
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IdnDh gene, quantitative expression analysis on transcriptional and translational levels in fruits of different stages