Information on EC 1.1.1.32 - mevaldate reductase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)

The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.1.1.32
-
RECOMMENDED NAME
GeneOntology No.
mevaldate reductase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(R)-mevalonate + NAD+ = mevaldate + NADH + H+
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
(R)-mevalonate:NAD+ oxidoreductase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9028-33-5
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
(R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
show the reaction diagram
(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADPH
(R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NADP+
show the reaction diagram
(S)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
(S)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
(R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
show the reaction diagram
(S)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
(S)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(R,S)-mevaldate
-
20 mM or higher
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4
(R)-mevaldic acid
-
-
0.003
NADH
-
-
0.09
NADPH
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.2
-
partially purified liver enzyme
0.63
-
partially purified liver enzyme
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.4
-
-
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4.6 - 6.9
-
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ammonium sulfate precipitation, calcium phosphate gel, DEAE-cellulose, bentonite precipitation
-