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(R)-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
(R)-3-hydroxyisobutyrate + NAD+
methylmalonate semialdehyde + NADH + H+
-
-
-
-
r
(S)-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
(S)-3-hydroxyisobutyrate + NAD+
methylmalonate semialdehyde + NADH + H+
100% activity
-
-
?
(S)-3-hydroxyisobutyrate + NADP+
2-methyl-3-oxopropanoate + NADPH + H+
-
-
-
?
(S)-beta-hydroxyisobutyrate + NADP+
2-methyl-3-oxopropanoate + NADPH + H+
-
-
-
-
r
(S)-methyl-3-hydroxy-2-methylpropionate + NAD+
?
1.2% activity compared to (S)-3-hydroxyisobutyrate
-
-
?
2-methyl-D,L-serine + NAD+
?
3-hydroxy-2-methylpropanoate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
3-hydroxy-2-methylpropanoate + NADP+
2-methyl-3-oxopropanoate + NADPH + H+
3-hydroxyisobutyrate + NAD+
methylmalonate semialdehyde + NADH + H+
-
-
-
-
r
3-hydroxyisobutyric acid + NAD+
methylmalonic semialdehyde + NADH
-
-
-
-
r
3-hydroxypropanoate + NAD(P)+
?
3-hydroxypropanoate + NAD+
?
3-hydroxypropanoate + NAD+
malonate semialdehyde + NADH + H+
-
-
-
-
r
3-hydroxypropanoate + NADP+
malonate semialdehyde + NADPH + H+
-
-
-
-
r
3-hydroxypropanoic acid + NAD+
3-oxopropanoate + NADH + H+
substrate with much less efficiency compared to (S)-3-hydroxyisobutyrate
-
-
?
3-hydroxypropionate + NAD+
3-oxopropanoate + NADH + H+
-
-
-
-
?
3-hydroxypropionate + NAD+
malonate semialdehyde + NADH + H+
13% activity compared to (S)-3-hydroxyisobutyrate
-
-
?
3-hydroxypropionic acid + NAD+
malonate semialdehyde + NADH + H+
D,L-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropionate + NADH
-
-
-
-
?
D,L-3-hydroxyisobutyrate + NAD+
D-2-methyl-3-oxopropionate + NADH
D,L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
D-3-hydroxyisobutyrate + NAD+
(S)-methylmalonate semialdehyde + NADH + H+
-
-
-
-
r
D-3-hydroxyisobutyrate + NAD+
methylmalonate semialdehyde + NADH + H+
-
-
-
-
r
DL-3-hydroxyisobutyrate + NAD+
methylmalonate semialdehyde + NADH + H+
-
-
-
-
r
L-3-hydroxyisobutyrate + NAD+
(S)-methylmalonate semialdehyde + NADH + H+
-
-
-
-
r
L-3-hydroxyisobutyrate + NAD+
3-oxoisobutyrate + NADH
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
L-3-hydroxyisobutyrate + NAD+
methylmalonate semialdehyde + NADH + H+
-
-
-
-
r
L-serine + NAD+
3-oxo-L-alanine + NADH + H+
methyl (2S)-3-hydroxy-2-methylpropanoate + NAD+
methyl (2S)-2-methyl-3-oxopropanoate + NADH + H+
methyl DL-serine + NAD+
methyl 3-oxo-DL-alanine + NADH + H+
additional information
?
-
(R)-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
2% activity compared to (S)-3-hydroxyisobutyrate
-
-
?
(R)-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
substrate with much less efficiency compared to (S)-3-hydroxyisobutyrate
-
-
?
(R)-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
substrate with much less efficiency compared to (S)-3-hydroxyisobutyrate
-
-
?
(S)-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
-
-
-
?
(S)-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
-
the enzyme is very specific to (S)-3-hydroxyisobutyrate
-
-
?
(S)-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
the enzyme is specific to (S)-3-hydroxyisobutyrate and prefers NAD+ as cofactor
-
-
?
(S)-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
the enzyme is specific to (S)-3-hydroxyisobutyrate
-
-
?
(S)-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
the enzyme is specific to (S)-3-hydroxyisobutyrate and prefers NAD+ as cofactor
-
-
?
(S)-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
the enzyme is specific to (S)-3-hydroxyisobutyrate
-
-
?
(S)-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
-
the enzyme is very specific to (S)-3-hydroxyisobutyrate
-
-
?
(S)-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
-
the enzyme is very specific to (S)-3-hydroxyisobutyrate
-
-
?
2-methyl-D,L-serine + NAD+
?
-
-
-
-
?
2-methyl-D,L-serine + NAD+
?
-
-
-
-
?
3-hydroxy-2-methylpropanoate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
-
-
-
?
3-hydroxy-2-methylpropanoate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
-
-
-
-
r
3-hydroxy-2-methylpropanoate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
-
-
-
-
r
3-hydroxy-2-methylpropanoate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
-
-
-
-
?
3-hydroxy-2-methylpropanoate + NADP+
2-methyl-3-oxopropanoate + NADPH + H+
-
-
-
-
r
3-hydroxy-2-methylpropanoate + NADP+
2-methyl-3-oxopropanoate + NADPH + H+
-
-
-
-
r
3-hydroxypropanoate + NAD(P)+
?
-
is more active with NADP+ than NAD+
-
-
?
3-hydroxypropanoate + NAD(P)+
?
-
is more active with NADP+ than NAD+
-
-
?
3-hydroxypropanoate + NAD+
?
-
-
-
-
?
3-hydroxypropanoate + NAD+
?
-
-
-
-
?
3-hydroxypropanoate + NAD+
?
-
-
-
-
?
3-hydroxypropionic acid + NAD+
malonate semialdehyde + NADH + H+
-
-
-
-
r
3-hydroxypropionic acid + NAD+
malonate semialdehyde + NADH + H+
-
-
-
-
r
D,L-3-hydroxyisobutyrate + NAD+
D-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
D,L-3-hydroxyisobutyrate + NAD+
D-2-methyl-3-oxopropionate + NADH
-
strain IFO 0750
-
-
?
D,L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
strain IFO 1542
-
-
?
D,L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
D,L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
Nocardia lyena
-
-
-
-
?
D,L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
D,L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
Pseudomonas dacunhae
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
3-oxoisobutyrate + NADH
high stereospecificity
-
-
r
L-3-hydroxyisobutyrate + NAD+
3-oxoisobutyrate + NADH
high stereospecificity
-
-
r
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
Corynebacterium hydrocarbons
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
r
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
L-serine + NAD+
3-oxo-L-alanine + NADH + H+
-
-
-
-
r
L-serine + NAD+
3-oxo-L-alanine + NADH + H+
-
-
-
-
r
L-serine + NAD+
3-oxo-L-alanine + NADH + H+
-
-
-
-
r
L-serine + NAD+
?
substrate with much less efficiency compared to (S)-3-hydroxyisobutyrate
-
-
?
L-serine + NAD+
?
substrate with much less efficiency compared to (S)-3-hydroxyisobutyrate
-
-
?
L-serine + NAD+
?
-
-
-
-
?
L-serine + NAD+
?
-
-
-
-
?
methyl (2S)-3-hydroxy-2-methylpropanoate + NAD+
methyl (2S)-2-methyl-3-oxopropanoate + NADH + H+
-
-
-
-
r
methyl (2S)-3-hydroxy-2-methylpropanoate + NAD+
methyl (2S)-2-methyl-3-oxopropanoate + NADH + H+
-
-
-
-
r
methyl DL-serine + NAD+
methyl 3-oxo-DL-alanine + NADH + H+
-
-
-
-
r
methyl DL-serine + NAD+
methyl 3-oxo-DL-alanine + NADH + H+
-
-
-
-
r
additional information
?
-
-
no activity with (R)-methyl-3-hydroxy-2-methylpropionate, glycerate, serine, beta-hydroxypyruvate, threonine, 2-hydroxybutyrate, malate, glycolate, beta-hydroxybutyrate, lactate, and 6-phosphogluconate. NADP+ is not a suitable cofactor. Also, FAD, oxidized cytochrome c, as well as the artificial electron acceptors phenazine methosulfate and dichlorophenol indophenol cannot be reduced by the enzyme
-
-
-
additional information
?
-
no activity with (R)-methyl-3-hydroxy-2-methylpropionate, glycerate, serine, beta-hydroxypyruvate, threonine, 2-hydroxybutyrate, malate, glycolate, beta-hydroxybutyrate, lactate, and 6-phosphogluconate. NADP+ is not a suitable cofactor. Also, FAD, oxidized cytochrome c, as well as the artificial electron acceptors phenazine methosulfate and dichlorophenol indophenol cannot be reduced by the enzyme
-
-
-
additional information
?
-
-
MmsB from Bacillus cereus exhibits 3-hydroxyisobutyrate dehydrogenase as well as 3-hydroxypropionate dehydrogenase activity, EC 1.1.1.59
-
-
?
additional information
?
-
-
wide substrate specificity of the 3-HIBADH
-
-
?
additional information
?
-
-
no activity with NADP+, DL-glycerate, (R)-3-hydroxyisobutyrate, L-threonine, D-threonine, and D-serine
-
-
?
additional information
?
-
-
MmsB from Bacillus cereus exhibits 3-hydroxyisobutyrate dehydrogenase as well as 3-hydroxypropionate dehydrogenase activity, EC 1.1.1.59
-
-
?
additional information
?
-
-
wide substrate specificity of the 3-HIBADH
-
-
?
additional information
?
-
no activity with D-serine, (S)-3-hydroxyisobutyrate methyl ester, (R)-3-hydroxyisobutyrate methyl ester, L-threonine and D-threonine
-
-
-
additional information
?
-
-
no activity with D-serine, (S)-3-hydroxyisobutyrate methyl ester, (R)-3-hydroxyisobutyrate methyl ester, L-threonine and D-threonine
-
-
-
additional information
?
-
no activity with D-serine, (S)-3-hydroxyisobutyrate methyl ester, (R)-3-hydroxyisobutyrate methyl ester, L-threonine and D-threonine
-
-
-
additional information
?
-
-
no activity with (R)-3-hydroxyisobutyrate
-
-
?
additional information
?
-
-
no activity with (R)-3-hydroxyisobutyrate
-
-
?
additional information
?
-
-
the enzyme catalyzes the rate-limiting step in the irreversible degradative pathway for the carbon skeleton of valine and the other branched-chain amino acids
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(S)-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
3-hydroxy-2-methylpropanoate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
3-hydroxy-2-methylpropanoate + NADP+
2-methyl-3-oxopropanoate + NADPH + H+
D,L-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropionate + NADH
-
-
-
-
?
D,L-3-hydroxyisobutyrate + NAD+
D-2-methyl-3-oxopropionate + NADH
D,L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
additional information
?
-
(S)-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
-
-
-
?
(S)-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
the enzyme is specific to (S)-3-hydroxyisobutyrate and prefers NAD+ as cofactor
-
-
?
(S)-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
the enzyme is specific to (S)-3-hydroxyisobutyrate and prefers NAD+ as cofactor
-
-
?
3-hydroxy-2-methylpropanoate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
-
-
-
?
3-hydroxy-2-methylpropanoate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
-
-
-
-
r
3-hydroxy-2-methylpropanoate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
-
-
-
-
r
3-hydroxy-2-methylpropanoate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
-
-
-
-
?
3-hydroxy-2-methylpropanoate + NADP+
2-methyl-3-oxopropanoate + NADPH + H+
-
-
-
-
r
3-hydroxy-2-methylpropanoate + NADP+
2-methyl-3-oxopropanoate + NADPH + H+
-
-
-
-
r
D,L-3-hydroxyisobutyrate + NAD+
D-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
D,L-3-hydroxyisobutyrate + NAD+
D-2-methyl-3-oxopropionate + NADH
-
strain IFO 0750
-
-
?
D,L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
strain IFO 1542
-
-
?
D,L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
D,L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
Nocardia lyena
-
-
-
-
?
D,L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
D,L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
Pseudomonas dacunhae
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
Corynebacterium hydrocarbons
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
r
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
-
-
-
-
?
additional information
?
-
-
MmsB from Bacillus cereus exhibits 3-hydroxyisobutyrate dehydrogenase as well as 3-hydroxypropionate dehydrogenase activity, EC 1.1.1.59
-
-
?
additional information
?
-
-
MmsB from Bacillus cereus exhibits 3-hydroxyisobutyrate dehydrogenase as well as 3-hydroxypropionate dehydrogenase activity, EC 1.1.1.59
-
-
?
additional information
?
-
-
the enzyme catalyzes the rate-limiting step in the irreversible degradative pathway for the carbon skeleton of valine and the other branched-chain amino acids
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Worral, E.B.; Gassain, S.; Cox, D.J.; Sugden, M.C.; Palmer, T.N.
3-Hydroxyisobutyrate dehydrogenase, an impurity in commercial 3-hydroxybutyrate dehydrogenase
Biochem. J.
241
297-300
1987
Cereibacter sphaeroides
brenda
Rougraff, P.M.; Paxton, R.; Kuntz, M.J.; Crabb, D.W.; Harris, R.A
Purification and characterization of 3-hydroxyisobutyrate dehydrogenase from rat liver
J. Biol. Chem.
263
327-331
1988
Oryctolagus cuniculus
brenda
Hasegawa, J
Distribution in organisms and stereospecificity of beta-hydroxyisobutyrate dehydrogenase
Agric. Biol. Chem.
45
2899-2901
1981
Bos taurus, Candida parapsilosis, Diutina rugosa, Corynebacterium hydrocarbons, Tsukamurella paurometabola, Oryctolagus cuniculus, Galactomyces reessii, Micrococcus flavus, Micrococcus luteus, Nocardia lyena, Pseudomonas aeruginosa, Pseudomonas dacunhae, Rhodotorula mucilaginosa, Sus scrofa, Aciculoconidium aculeatum
-
brenda
Hasegawa, J
Purification, crystallization and some properties of beta-hydroxyisobutyrate dehydrogenase from candida rugosa IFO 0750
Agric. Biol. Chem.
45
2805-2814
1981
Diutina rugosa
-
brenda
De Paul Marshall, V.; Sokatch, J.R.
Regulation of valine catabolism in Pseudomonas putida
J. Bacteriol.
110
1073-1081
1972
Pseudomonas putida
brenda
Robinson, W.G.; Coon, M.J.
The purification and properties of beta-hydroxyisobutyrate dehydrogenase
J. Biol. Chem.
225
511-521
1956
Sus scrofa
brenda
Hawes, J.W.; Crabb, D.W.; Chan, R.J.; Rougraff, P.M.; Paxton, R.; Harris, R.A.
Mammalien 3-hydroxyisobutyrate dehydrogenase
Methods Enzymol.
324
218-228
2000
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
brenda
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