Information on EC 1.1.1.308 - sulfopropanediol 3-dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Cupriavidus pinatubonensis

EC NUMBER
COMMENTARY hide
1.1.1.308
-
RECOMMENDED NAME
GeneOntology No.
sulfopropanediol 3-dehydrogenase
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(R)-2,3-dihydroxypropane-1-sulfonate + 2 NAD+ + H2O = (R)-3-sulfolactate + 2 NADH + 2 H+
show the reaction diagram
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
3-sulfopropanediol degradation
-
-
SYSTEMATIC NAME
IUBMB Comments
(R)-2,3-dihydroxypropane-1-sulfonate:NAD+ 3-oxidoreductase
The enzyme is involved in degradation of (R)-2,3-dihydroxypropanesulfonate.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
JMP134, i.e. Ralstonia eutropha str. JMP134
UniProt
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-2,3-dihydroxypropane-1-sulfonate + 2 NAD+ + H2O
(R)-sulfolactate + 2 NADH + 2 H+
show the reaction diagram
degradation of (R)-2,3-dihydroxypropanesulfonate
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(R)-2,3-dihydroxypropane-1-sulfonate + 2 NAD+ + H2O
(R)-sulfolactate + 2 NADH + 2 H+
show the reaction diagram
Q46N53
degradation of (R)-2,3-dihydroxypropanesulfonate
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.46
(R)-2,3-dihydroxypropane-1-sulfonate
pH 9.0, 30°C
0.16
NAD+
pH 9.0, 30°C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
9 - 10
activity decreases rapidly with decreasing pH. At pH 6.5 the enzyme is almost inactive
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
9 - 10
pH 9-10: optimum. Activity decreases rapidly with decreasing pH. At pH 6.5 the enzyme is almost inactive
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homodimer
x * 46881, calculated from sequence; x * 47000, SDS-PAGE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE