Information on EC 1.1.1.266 - dTDP-4-dehydro-6-deoxyglucose reductase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.1.1.266
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RECOMMENDED NAME
GeneOntology No.
dTDP-4-dehydro-6-deoxyglucose reductase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dTDP-alpha-D-fucopyranose + NAD(P)+ = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NAD(P)H + H+
show the reaction diagram
The enzyme from the gram-negative bacterium Actinobacillus actinomycetemcomitans forms activated fucose for incorporation into capsular polysaccharide
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
dTDP-D-beta-fucofuranose biosynthesis
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superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis
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Polyketide sugar unit biosynthesis
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Biosynthesis of antibiotics
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SYSTEMATIC NAME
IUBMB Comments
dTDP-alpha-D-fucopyranose:NAD(P)+ oxidoreductase
The enzymes from the Gram-negative bacteria Aggregatibacter actinomycetemcomitans and Escherichia coli O52 are involved in activation of fucose for incorporation into capsular polysaccharide O-antigens [1,3]. The enzyme from the Gram-positive bacterium Anoxybacillus tepidamans (Geobacillus tepidamans) is involved in activation of fucose for incorporation into the organism's S-layer [2]. The enzyme from Escherichia coli O52 has a higher catalytic efficiency with NADH than with NADPH [3].
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain Y4, serotype b
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Manually annotated by BRENDA team
strain Y4, serotype b
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
dTDP-D-fucose + NADP+
dTDP-4-dehydro-6-deoxy-D-glucose + NADPH
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
dTDP-D-fucose + NADP+
dTDP-4-dehydro-6-deoxy-D-glucose + NADPH
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.097
dTDP-4-keto-6-deoxy-D-glucose
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sequential reaction mechnism
0.029
NADPH
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sequential reaction mechanism
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
43.5
dTDP-4-keto-6-deoxy-D-glucose
Aggregatibacter actinomycetemcomitans
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
to homogeneity, recombinant enzyme
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
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