Information on EC 1.1.1.186 - dTDP-galactose 6-dehydrogenase

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The expected taxonomic range for this enzyme is: Beta vulgaris

EC NUMBER
COMMENTARY hide
1.1.1.186
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RECOMMENDED NAME
GeneOntology No.
dTDP-galactose 6-dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dTDP-D-galactose + 2 NADP+ + H2O = dTDP-D-galacturonate + 2 NADPH + 2 H+
show the reaction diagram
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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-
-
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redox reaction
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-
-
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reduction
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-
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SYSTEMATIC NAME
IUBMB Comments
dTDP-D-galactose:NADP+ 6-oxidoreductase
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
TDP-D-glucose + 2 NADP+ + H2O
TDP-D-galacturonate + 2 NADPH + 2 H+
show the reaction diagram
-
epimerization of TDP-D-glucose to TDP-D-galactose
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
TDP-D-glucose + 2 NADP+ + H2O
TDP-D-galacturonate + 2 NADPH + 2 H+
show the reaction diagram
-
epimerization of TDP-D-glucose to TDP-D-galactose
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADP+
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cannot be replaced by NAD+
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4
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half-life: 10 h
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
freezing and thawing inactivate, incubation with 1 mM TDP-D-glucose stabilizes 2-3fold
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial, contains TDP-D-glucose 4-epimerase
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