Information on EC 1.1.1.177 - glycerol-3-phosphate 1-dehydrogenase (NADP+)

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The expected taxonomic range for this enzyme is: Archaea, Eukaryota

EC NUMBER
COMMENTARY hide
1.1.1.177
-
RECOMMENDED NAME
GeneOntology No.
glycerol-3-phosphate 1-dehydrogenase (NADP+)
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
sn-glycerol 3-phosphate + NADP+ = D-glyceraldehyde 3-phosphate + NADPH + H+
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
lipid metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
sn-glycerol-3-phosphate:NADP+ 1-oxidoreductase
-
CAS REGISTRY NUMBER
COMMENTARY hide
37213-46-0
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
recombinant enzyme
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-glyceraldehyde 3-phosphate + NADPH
L-alpha-glycerol 3-phosphate + NADP+
show the reaction diagram
-
-
-
-
r
L-alpha-glycerol 3-phosphate + NADP+
D-glyceraldehyde 3-phosphate + NADPH
show the reaction diagram
-
-
-
-
r
sn-glycerol 3-phosphate + NADP+
D-glyceraldehyde 3-phosphate + NADPH + H+
show the reaction diagram
-
involved in a shortened pentose phosphate pathway of the utilization of glucose in muscle tissue
-
r
additional information
?
-
-
no enzymic activity with dihydroxyacetone, glycerol, glycerol-2-phosphate, D-glyceraldehyde-3-phosphate, DL-glyceraldehyde, D-erythrose-4-phosphate, D-fructose-4-phosphate
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
sn-glycerol 3-phosphate + NADP+
D-glyceraldehyde 3-phosphate + NADPH + H+
show the reaction diagram
-
involved in a shortened pentose phosphate pathway of the utilization of glucose in muscle tissue
-
r
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADP+
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
D-glyceraldehyde 3-phosphate
-
-
L-alpha-glycerol 3-phosphate
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1
D-glyceraldehyde 3-phosphate
-
pH 6.6, 70C
0.1
L-alpha-glycerol 3-phosphate
-
pH 6.6, 70C
0.8
NADP+
-
pH 6.6, 70C
0.04
NADPH
-
pH 6.6, 70C
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.1
D-glyceraldehyde 3-phosphate
-
pH 6.6, 70C
17
L-alpha-glycerol 3-phosphate
-
pH 6.6, 70C
0.005
NADP+
-
pH 6.6, 70C
additional information
additional information
-
KI-value for NADPH is below 0.005 mM
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4
-
pH 6.6, 70C, substrate L-alpha-glycerol 3-phosphate
44
-
pH 6.6, 70C, substrate D-glyceraldehyde 3-phosphate
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5
-
or below, reduction reaction
9.5
-
or above, oxidation reaction
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5
-
deduced from gene sequence
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
myocardium, intermediate activity
Manually annotated by BRENDA team
-
low activity
Manually annotated by BRENDA team
-
highest activity
Manually annotated by BRENDA team
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
-
crystallization data
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
85
-
30 min, in presence of 200 mM potassium phosphate or 100 mM NaCl or 50 mM ammonium sulfate, completely stable