Information on EC 1.1.1.164 - hexadecanol dehydrogenase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY hide
1.1.1.164
-
RECOMMENDED NAME
GeneOntology No.
hexadecanol dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
hexadecanol + NAD+ = hexadecanal + NADH + H+
show the reaction diagram
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
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reduction
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
hexadecanol:NAD+ oxidoreductase
The liver enzyme acts on long-chain alcohols from C8 to C16. The Euglena enzyme also oxidizes the corresponding aldehydes to fatty acids.
CAS REGISTRY NUMBER
COMMENTARY hide
62213-59-6
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain HO1-N
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-
Manually annotated by BRENDA team
strain HO1-N
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-
Manually annotated by BRENDA team
Z
-
-
Manually annotated by BRENDA team
Z
-
-
Manually annotated by BRENDA team
strain YR-1
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-
Manually annotated by BRENDA team
strain YR-1
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
hexadecanal + NADH
hexadecanol + NAD+
show the reaction diagram
hexadecanol + NAD+
hexadecanal + NADH
show the reaction diagram
hexadecanol + NAD+
hexadecanal + NADH + H+
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
hexadecanal + NADH
hexadecanol + NAD+
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADP+
-
low activity
NADPH
-
utilized to a lesser extent than NADH
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
rifampicin
-
inhibits enzyme induction in hexadecanol-grown cells, not in cells grown on ethanol, palmitate or hexadecane
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0016 - 0.0073
hexadecanol
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0008
-
growth substrate of cells ethanol, assay substrate n-hexadecanol
0.0011
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growth substrate of cells palmitic acid, assay substrate n-hexadecanol
0.0046
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growth substrate of cells hexadecanol, assay substrate n-hexadecanol
0.0059
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growth substrate of cells hexadecane, assay substrate n-hexadecanol
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7
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aerobically grown mycelial cells
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
highly unstable, more than 50% loss of activity within 24 h
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, Tris-HCl 10 mM, pH 7.8, precipitation at 50% ammonium sulfate saturation, dissolved in 15fold reduced volume
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE