Reference on EC 1.1.1.146 - 11beta-hydroxysteroid dehydrogenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hult, M.; Nobel, C.S.I.; Abrahmsen, L.; Nicoll-Griffith, D.A.; Jrnvall, H.; Oppermann, U.C.T.
Novel enzymological profiles of human 11beta-hydroxysteroid dehydrogenase type 1
Chem. Biol. Interact.
130-132
805-8014
2001
Homo sapiens
Walker, E.A.; Clarks, A.M.; Hewison, M.; Ride, J.P.; Steward, P.M.
Functional expression, characterization, and purification of the catalytic domain of human 11-beta-hydroxysteroid dehydrogenase type 1
J. Biol. Chem.
276
21343-21350
2001
Homo sapiens
Oppermann, U.C.T.; Persson, B.; Jornvall, H.
The 11beta-hydroxysteroid dehydrogenase system, a determinant of glucocorticoid and mineralocorticoid action
Eur. J. Biochem.
249
355-360
1997
Comamonas testosteroni, Oryctolagus cuniculus, Homo sapiens, Mus musculus
-
Latif, S.A.; Sheff, M.F.; Ribeiro, C.E.; Morris, D.J.
Selective inhibition of sheep kidney 11beta-hydroxysteroid dehydrogenase isoform 2 activity by 5alpha-reduced (but not 5beta) derivates of adrenocorticosteroids
Steroids
62
230-237
1997
Rattus sp.
Ferrari, P.; Smith, R.E.; Funder, J.W.; Krozowski, Z.S.
Substrate and inhibitor specificity of the clones human 11beta-hydroxysteroid dehydrogenase type 2 isoform
Am. J. Physiol.
270
E900-904
1996
Homo sapiens
Alfaidy, N.; Blot-Chabaud, M.; Robic, D.; Kenouch, S.; Bourbouze, R.; Bonvalet, J.P.; Farman, N.
Characteristics and regulation of 11beta-hydroxysteroid dehydrogenase of proximal and distal nephron
Biochim. Biophys. Acta
1243
461-468
1995
Rattus norvegicus
Blum , S.; Buhler, H.
Characterization of human placental 11beta-hydroxysteroid dehydrogenase, a key enzyme of cortocosteroid metabolism
Cell. Physiol. Biochem.
5
167-175
1995
Homo sapiens
-
Ozols, J.
Lumenal orientation and post-translational modifications of the liver microsomal 11beta-hydroxysteroid dehydrogenase
J. Biol. Chem.
270
2305-2312
1995
Oryctolagus cuniculus
Lakshim, V.; Nath, N.; Muneyyirci-Delale, O.
Characterization of 11beta-hydroxysteroid dehydrogenase of human placenta: Evidence for the existence of two species of 11beta-hydroxysteroid dehydrogenases
J. Steroid Biochem. Mol. Biol.
45
391-397
1993
Homo sapiens
Monder, C.
The forms and functions of 11beta-hydroxysteroid dehydrogenase
J. Steroid Biochem. Mol. Biol.
45
161-165
1993
Rattus norvegicus
Hundertmark, S.; Ragosch, V.; Schein, B.; Buhler, H.; Fromm, M.; Lorenz, U.; Weitzel, H.K.
11-beta-Hydroxysteroid dehydrogenase of rat lung: Enzyme kinetic, oxidase-reductase ration, electrolyte and trace element dependence
Enzyme Protein
47
83-91
1993
Rattus norvegicus, Rattus sp.
Buhler, H.; Perschel, F.H.; Hierholzer, K.
Inhibition of rat renal 11beta-hydroxysteroid dehydrogenase by steroidal compounds and triterpenoids; structure/function relationship
Biochim. Biophys. Acta
1075
206-212
1991
Rattus sp.
Sang, G.W.; Lorenzo, B.; Reidenberg, M.M.
Inhibitory effects of gossypol on corticosteroid 11beta-hydroxysteroid dehydrogenase from guinea pig kidney: A possible mechanism for causing hypokalemia
J. Steroid Biochem. Mol. Biol.
39
169-176
1991
Cavia porcellus
Monder, C.; Lakshmi, V.; Miroff, Y.
Kinetic studies on rat liver 11beta-hydroxysteroid dehydrogenase
Biochim. Biophys. Acta
1115
23-29
1991
Rattus sp.
Agarwal, A.K.; Tusie-Luna, M.T.; Monder, C.; White, P.C.
Expression of 11beta-hydroxysteroid dehydrogenase using recombinant vaccinia virus
Mol. Endocrinol.
4
1827-1832
1990
Rattus sp.
Monder, C.; Lakshmi, V.
Evidence for kinetically distinct forms of corticosteroid 11beta-dehydrogenase in rat liver microsomes
J. Steroid Biochem.
32
77-83
1989
Rattus sp.
Monder, C.; Lakshmi, V.
Corticosteroid 11beta-hydroxysteroid dehydrogenase activities in vertebrate liver
Steroids
52
515-528
1988
aves, dogfish, Mammalia, no activity in frog, no activity in Necturus maculosus, no activity in shark, no activity in toad, Rattus sp.
Lakshmi, V.; Monder, C.
Purification and characterization of the corticosteroid 11beta-dehydrogenase component of the rat liver 11beta-hydroxysteroid dehydrogenase complex
Endocrinology
123
2390-2398
1988
Rattus sp.
Pearson Murphy, B.E.
Specificity of human 11beta-hydroxysteroid dehydrogenase
J. Steroid Biochem.
14
807-809
1981
Homo sapiens
Bush, I.E.; Hunter, S.A.; Meigs, R.A.
Metabolism of 11-oxogenated steroids. Metabolism in vitro by preparations of liver
Biochem. J.
107
239-258
1968
Bos taurus, Cavia porcellus, Oryctolagus cuniculus, Rattus norvegicus, Rattus sp.
Gomez-Sanchez, E.P.; Ganjam, V.; Chen, Y.J.; Liu, Y.; Zhou, M.Y.; Toroslu, C.; Romero, D.G.; Hughson, M.D.; de Rodriguez, A.; Gomez-Sanchez, C.E.
Regulation of 11beta-hydroxysteroid dehydrogenase enzymes in the rat kidney by estradiol
Am. J. Physiol.
285
E272-279
2003
Rattus norvegicus
Holmes, M.C.; Yau, J.L.W.; Kotelevtsev, Y.; Mullins, J.J.; Seckl, J.R.
11beta-Hydroxysteroid dehydrogenases in the brain: two enzymes two roles
Ann. N. Y. Acad. Sci.
1007
357-366
2003
Mus musculus
Maser, E.; Volker, B.; Friebertshauser, J.
11 beta-Hydroxysteroid dehydrogenase type 1 from human liver: dimerization and enzyme cooperativity support its postulated role as glucocorticoid reductase
Biochemistry
41
2459-2465
2002
Homo sapiens
Blum, A.; Raum, A.; Maser, E.
Functional characterization of the human 11 beta-hydroxysteroid dehydrogenase 1B (11 beta-HSD 1B) variant
Biochemistry
42
4108-4117
2003
Homo sapiens
Schipper, L.; Spee, B.; Rothuizen, J.; Woutersen-van Nijnanten, F.; Fink-Gremmels, J.
Characterisation of 11beta-hydroxysteroid dehydrogenases in feline kidney and liver
Biochim. Biophys. Acta
1688
68-77
2004
Felis catus
Zbankova, S.; Bryndova, J.; Kment, M.; Pacha, J.
Expression of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in colorectal cancer
Cancer Lett.
210
95-100
2004
Homo sapiens
Maser, E.; Friebertshauser, J.; Volker, B.
Purification, characterization and NNK carbonyl reductase activities of 11beta-hydroxysteroid dehydrogenase type 1 from human liver: enzyme cooperativity and significance in the detoxification of a tobacco-derived carcinogen
Chem. Biol. Interact.
143-144
435-448
2003
Homo sapiens
Wsol, V.; Szotakova, B.; Skalova, L.; Maser, E.
Stereochemical aspects of carbonyl reduction of the original anticancer drug oracin by mouse liver microsomes and purified 11beta-hydroxysteroid dehydrogenase type 1
Chem. Biol. Interact.
143-144
459-468
2003
Mus musculus
Blum, A.; Maser, E.
The critical role of the N-terminus of 11beta-hydroxysteroid dehydrogenase type 1, as being encoded by exon 1, for enzyme stabilization and activity
Chem. Biol. Interact.
143-144
469-480
2003
Homo sapiens
Wang, G.M.; Ge, R.S.; Latif, S.A.; Morris, D.J.; Hardy, M.P.
Expression of 11beta-hydroxylase in rat Leydig cells
Endocrinology
143
621-626
2002
Rattus norvegicus
Waddell, B.J.; Hisheh, S.; Krozowski, Z.S.; Burton, P.J.
Localization of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in the male reproductive tract
Endocrinology
144
3101-3106
2003
Rattus norvegicus
Shafqat, N.; Elleby, B.; Svensson, S.; Shafqat, J.; Jornvall, H.; Abrahmsen, L.; Oppermann, U.
Comparative enzymology of 11beta -hydroxysteroid dehydrogenase type 1 from glucocorticoid resistant (guinea pig) versus sensitive (human) species
J. Biol. Chem.
278
2030-2035
2003
Cavia porcellus, Homo sapiens
Schweizer, R.A.; Zurcher, M.; Balazs, Z.; Dick, B.; Odermatt, A.
Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme
J. Biol. Chem.
279
18415-18424
2004
Homo sapiens, Rattus norvegicus, Mesocricetus auratus (Q6R0J2)
Frick, C.; Atanasov, A.G.; Arnold, P.; Ozols, J.; Odermatt, A.
Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase
J. Biol. Chem.
279
31131-31138
2004
Homo sapiens
Roobol-Boza, M.; Dolby, V.; Doverskog, M.; Barrefelt, A.; Lindqvist, F.; Oppermann, U.C.; Kohler Van Alstine, K.; Tjerneld, F.
Membrane protein isolation by in situ solubilization, partitioning and affinity adsorption in aqueous two-phase systems. Purification of the human type 1 11beta-hydroxysteroid dehydrogenase
J. Chromatogr. A
1043
217-223
2004
Homo sapiens
Nobel, C.S.I.; Dunas, F.; Abrahmsen, L.B.
Purification of full-length recombinant human and rat type 1 11beta-hydroxysteroid dehydrogenases with retained oxidoreductase activities
Protein Expr. Purif.
26
349-356
2002
Homo sapiens, Rattus norvegicus
Wsol, V.; Szotakova, B.; Skalova, L.; Maser, E.
The novel anticancer drug oracin: different stereospecificity and cooperativity for carbonyl reduction by purified human liver 11beta-hydroxysteroid dehydrogenase type 1
Toxicology
197
253-261
2004
Homo sapiens
Gomez-Sanchez, E.P.; Venkataseshu, G.; Chen, Y.J.; Liu, Y.; Zhou, M.Y.; Toroslu, C.; Romero, D.G.; Hughson, M.D.; de Rodriguez, A.; Gomez-Sanchez, C.E.
Regulation of 11beta-hydroxysteroid dehydrogenase enzymes in the rat kidney by estradiol
Am. J. Physiol. Endocrinol. Metab.
285
E272-E279
2003
Rattus norvegicus
Garbrecht, M.R.; Schmidt, T.J.; Krozowski, Z.S.; Snyder, J.M.
11beta-Hydroxysteroid dehydrogenase type 2 and the regulation of surfactant protein A by dexamethasone metabolites
Am. J. Physiol. Endocrinol. Metab.
290
E653-E660
2006
Homo sapiens
Zhang, J.; Osslund, T.D.; Plant, M.H.; Clogston, C.L.; Nybo, R.E.; Xiong, F.; Delaney, J.M.; Jordan, S.R.
Crystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetes
Biochemistry
44
6948-6957
2005
Mus musculus (P50172), Mus musculus
Kim, K.W.; Wang, Z.; Busby, J.; Tsuruda, T.; Chen, M.; Hale, C.; Castro, V.M.; Svensson, S.; Nybo, R.; Xiong, F.; Wang, M.
The role of tyrosine 177 in human 11beta-hydroxysteroid dehydrogenase type 1 in substrate and inhibitor binding: an unlikely hydrogen bond donor for the substrate
Biochim. Biophys. Acta
1764
824-830
2006
Homo sapiens
Xiang, J.; Ipek, M.; Suri, V.; Massefski, W.; Pan, N.; Ge, Y.; Tam, M.; Xing, Y.; Tobin, J.F.; Xu, X.; Tam, S.
Synthesis and biological evaluation of sulfonamidooxazoles and beta-keto sulfones: selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I
Bioorg. Med. Chem. Lett.
15
2865-2869
2005
Homo sapiens
Olson, S.; Aster, S.D.; Brown, K.; Carbin, L.; Graham, D.W.; Hermanowski-Vosatka, A.; LeGrand, C.B.; Mundt, S.S.; Robbins, M.A.; Schaeffer, J.M.; Slossberg, L.H.; Szymonifka, M.J.; Thieringer, R.; Wright, S.D.; Balkovec, J.M.
Adamantyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
Bioorg. Med. Chem. Lett.
15
4359-4362
2005
Homo sapiens, Mus musculus (P50172), Mus musculus (P51661)
Cherkasova, O.P.
Activity of 11beta-hydroxysteroid dehydrogenase in tissues of hypertensive NISAG rats
Bull. Exp. Biol. Med.
141
30-32
2006
Rattus norvegicus
Mai, K.; Kullmann, V.; Bobbert, T.; Maser-Gluth, C.; Moehlig, M.; Baehr, V.; Pfeiffer, A.F.; Spranger, J.; Diederich, S.
In vivo activity of 11beta-hydroxysteroid dehydrogenase type 1 and free fatty acid-induced insulin resistance
Clin. Endocrinol. (Oxf.)
63
442-449
2005
Homo sapiens
Jang, C.; Obeyesekere, V.R.; Dilley, R.J.; Alford, F.P.; Inder, W.J.
11beta Hydroxysteroid dehydrogenase type 1 is expressed and is biologically active in human skeletal muscle
Clin. Endocrinol. (Oxf.)
65
800-805
2006
Homo sapiens
Basu, R.; Edgerton, D.S.; Singh, R.J.; Cherrington, A.; Rizza, R.A.
Splanchnic cortisol production in dogs occurs primarily in the liver: evidence for substantial hepatic specific 11beta hydroxysteroid dehydrogenase type 1 activity
Diabetes
55
3013-3019
2006
Canis lupus familiaris
Li, W.; Gao, L.; Wang, Y.; Duan, T.; Myatt, L.; Sun, K.
Enhancement of cortisol-induced 11beta-hydroxysteroid dehydrogenase type 1 expression by interleukin 1beta in cultured human chorionic trophoblast cells
Endocrinology
147
2490-2495
2006
Homo sapiens
Ohshima, M.; Ohno, S.; Nakajin, S.
Inhibitory effects of some possible endocrine-disrupting chemicals on the isozymes of human 11beta-hydroxysteroid dehydrogenase and expression of their mRNA in gonads and adrenal glands
Environ. Sci.
12
219-230
2005
Homo sapiens
Claus, R.; Wagner, A.; Lambert, T.
Characterization of 11beta-hydroxysteroid dehydrogenase activity in testicular tissue of control and GnRH-immunized boars as a possible regulator of spermatogenesis
Exp. Clin. Endocrinol. Diabetes
113
262-267
2005
Sus scrofa (Q95L61)
Atanasov, A.G.; Dzyakanchuk, A.A.; Schweizer, R.A.; Nashev, L.G.; Maurer, E.M.; Odermatt, A.
Coffee inhibits the reactivation of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1: a glucocorticoid connection in the anti-diabetic action of coffee?
FEBS Lett.
580
4081-4085
2006
Homo sapiens
Ogg, D.; Elleby, B.; Norstroem, C.; Stefansson, K.; Abrahmsen, L.; Oppermann, U.; Svensson, S.
The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions
J. Biol. Chem.
280
3789-3794
2005
Cavia porcellus (Q6QLL4), Cavia porcellus
Hosfield, D.J.; Wu, Y.; Skene, R.J.; Hilgers, M.; Jennings, A.; Snell, G.P.; Aertgeerts, K.
Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation
J. Biol. Chem.
280
4639-4648
2005
Homo sapiens
McCormick, K.L.; Wang, X.; Mick, G.J.
Evidence that the 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD1) is regulated by pentose pathway flux. Studies in rat adipocytes and microsomes
J. Biol. Chem.
281
341-347
2006
Rattus norvegicus
Miguet, L.; Zhang, Z.; Barbier, M.; Grigorov, M.G.
Comparison of a homology model and the crystallographic structure of human 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) in a structure-based identification of inhibitors
J. Comput. Aided Mol. Des.
20
67-81
2006
Homo sapiens
Gilmour, J.S.; Coutinho, A.E.; Cailhier, J.F.; Man, T.Y.; Clay, M.; Thomas, G.; Harris, H.J.; Mullins, J.J.; Seckl, J.R.; Savill, J.S.; Chapman, K.E.
Local amplification of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes
J. Immunol.
176
7605-7611
2006
Homo sapiens, Mus musculus
Mazancova, K.; Kopecky, M.; Miksik, I.; Pacha, J.
11beta-Hydroxysteroid dehydrogenase in the heart of normotensive and hypertensive rats
J. Steroid Biochem. Mol. Biol.
94
273-277
2005
Rattus norvegicus
Ayachi, S.E.; Paulmyer-Lacroix, O.; Verdier, M.; Alessi, M.C.; Dutour, A.; Grino, M.
11beta-Hydroxysteroid dehydrogenase type 1-driven cortisone reactivation regulates plasminogen activator inhibitor type 1 in adipose tissue of obese women
J. Thromb. Haemost.
4
621-627
2006
Homo sapiens
Latif, S.A.; Pardo, H.A.; Hardy, M.P.; Morris, D.J.
Endogenous selective inhibitors of 11beta-hydroxysteroid dehydrogenase isoforms 1 and 2 of adrenal origin
Mol. Cell. Endocrinol.
243
43-50
2005
Ovis aries, Homo sapiens
Odermatt, A.; Atanasov, A.G.; Balazs, Z.; Schweizer, R.A.; Nashev, L.G.; Schuster, D.; Langer, T.
Why is 11beta-hydroxysteroid dehydrogenase type 1 facing the endoplasmic reticulum lumen? Physiological relevance of the membrane topology of 11beta-HSD1
Mol. Cell. Endocrinol.
248
15-23
2006
Homo sapiens (P28845)
Su, X.; Vicker, N.; Ganeshapillai, D.; Smith, A.; Purohit, A.; Reed, M.J.; Potter, B.V.
Benzothiazole derivatives as novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1
Mol. Cell. Endocrinol.
248
214-217
2006
Homo sapiens
Czegle, I.; Piccirella, S.; Senesi, S.; Csala, M.; Mandl, J.; Banhegyi, G.; Fulceri, R.; Benedetti, A.
Cooperativity between 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum
Mol. Cell. Endocrinol.
248
24-25
2006
Rattus norvegicus
Hult, M.; Shafqat, N.; Elleby, B.; Mitschke, D.; Svensson, S.; Forsgren, M.; Barf, T.; Vallgarda, J.; Abrahmsen, L.; Oppermann, U.
Active site variability of type 1 11beta-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons
Mol. Cell. Endocrinol.
248
26-33
2006
Cavia porcellus, Mus musculus, Rattus norvegicus, Homo sapiens (P28845), Homo sapiens
Maser, E.; Wsol, V.; Martin, H.J.
11beta-Hydroxysteroid dehydrogenase type 1: purification from human liver and characterization as carbonyl reductase of xenobiotics
Mol. Cell. Endocrinol.
248
34-37
2006
Homo sapiens
Arai, N.; Masuzaki, H.; Tanaka, T.; Ishii, T.; Yasue, S.; Kobayashi, N.; Tomita, T.; Noguchi, M.; Kusakabe, T.; Fujikura, J.; Ebihara, K.; Hirata, M.; Hosoda, K.; Hayashi, T.; Sawai, H.; Minokoshi, Y.; Nakao, K.
Ceramide and adenosine 5-monophosphate-activated protein kinase are two novel regulators of 11beta-hydroxysteroid dehydrogenase type 1 expression and activity in cultured preadipocytes
Endocrinology
148
5268-5277
2007
Mus musculus
De Sousa Peixoto, R.A.; Turban, S.; Battle, J.H.; Chapman, K.E.; Seckl, J.R.; Morton, N.M.
Preadipocyte 11beta-hydroxysteroid dehydrogenase type 1 is a keto-reductase and contributes to diet-induced visceral obesity in vivo
Endocrinology
149
1861-1868
2008
Mus musculus
Gomez-Sanchez, E.P.; Romero, D.G.; de Rodriguez, A.F.; Warden, M.P.; Krozowski, Z.; Gomez-Sanchez, C.E.
Hexose-6-phosphate dehydrogenase and 11beta-hydroxysteroid dehydrogenase-1 tissue distribution in the rat
Endocrinology
149
525-533
2008
Rattus norvegicus
Balazs, Z.; Schweizer, R.A.; Frey, F.J.; Rohner-Jeanrenaud, F.; Odermatt, A.
DHEA induces 11 -HSD2 by acting on CCAAT/enhancer-binding proteins
J. Am. Soc. Nephrol.
19
92-101
2008
Rattus norvegicus
Ito-Kobayashi, M.; Aoyagi, A.; Tanaka, I.; Muramatsu, Y.; Umetani, M.; Takatsu, T.
Sterenin A, B, C and D, novel 11beta-hydroxysteroid dehydrogenase type 1 inhibitors from Stereum sp. SANK 21205
J. Antibiot.
61
128-135
2008
Homo sapiens
Jang, C.; Obeyesekere, V.R.; Dilley, R.J.; Krozowski, Z.; Inder, W.J.; Alford, F.P.
Altered activity of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in skeletal muscle confers metabolic protection in subjects with type 2 diabetes
J. Clin. Endocrinol. Metab.
92
3314-3320
2007
Homo sapiens
Sloboda, D.M.; Moss, T.J.; Li, S.; Matthews, S.G.; Challis, J.R.; Newnham, J.P.
Expression of glucocorticoid receptor, mineralocorticoid receptor, and 11beta-hydroxysteroid dehydrogenase 1 and 2 in the fetal and postnatal ovine hippocampus: ontogeny and effects of prenatal glucocorticoid exposure
J. Endocrinol.
197
213-220
2008
Ovis aries
Perrone, C.E.; Mattocks, D.A.; Hristopoulos, G.; Plummer, J.D.; Krajcik, R.A.; Orentreich, N.
Methionine restriction effects on 11 -HSD1 activity and lipogenic/lipolytic balance in F344 rat adipose tissue
J. Lipid Res.
49
12-23
2008
Rattus norvegicus
Sinclair, A.J.; Onyimba, C.U.; Khosla, P.; Vijapurapu, N.; Tomlinson, J.W.; Burdon, M.A.; Stewart, P.M.; Murray, P.I.; Walker, E.A.; Rauz, S.
Corticosteroids, 11beta-hydroxysteroid dehydrogenase isozymes and the rabbit choroid plexus
J. Neuroendocrinol.
19
614-620
2007
Oryctolagus cuniculus
Gong, R.; Morris, D.J.; Brem, A.S.
Human renal 11beta-hydroxysteroid dehydrogenase 1 functions and co-localizes with COX-2
Life Sci.
82
631-637
2008
Homo sapiens
Sun, L.; Stenken, J.A.; Yang, A.Y.; Zhao, J.J.; Musson, D.G.
An in vitro microdialysis methodology to study 11beta-hydroxysteroid dehydrogenase type 1 enzyme activity in liver microsomes
Anal. Biochem.
370
26-37
2007
Canis lupus, Homo sapiens
Bhat, B.G.; Younis, H.; Herrera, J.; Palacio, K.; Pascual, B.; Hur, G.; Jessen, B.; Ogilvie, K.M.; Rejto, P.A.
Antisense inhibition of 11betahydroxysteroid dehydrogenase type 1 improves diabetes in a novel cortisone-induced diabetic KK mouse model
Biochem. Biophys. Res. Commun.
365
740-745
2008
Mus musculus
Flyren, K.; Bergquist, L.O.; Castro, V.M.; Fotsch, C.; Johansson, L.; St Jean, D.J.; Sutin, L.; Williams, M.
Piperidine amides as 11beta-hydroxysteroid dehydrogenase type 1 inhibitors
Bioorg. Med. Chem. Lett.
17
3421-3425
2007
Homo sapiens
Yang, H.; Dou, W.; Lou, J.; Leng, Y.; Shen, J.
Discovery of novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling
Bioorg. Med. Chem. Lett.
18
1340-1345
2008
Homo sapiens, Mus musculus
Aster, S.D.; Graham, D.W.; Kharbanda, D.; Patel, G.; Ponpipom, M.; Santorelli, G.M.; Szymonifka, M.J.; Mundt, S.S.; Shah, K.; Springer, M.S.; Thieringer, R.; Hermanowski-Vosatka, A.; Wright, S.D.; Xiao, J.; Zokian, H.; Balkovec, J.M.
Bis-aryl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
Bioorg. Med. Chem. Lett.
18
2799-2804
2008
Homo sapiens, Mus musculus
Wang, H.; Ruan, Z.; Li, J.J.; Simpkins, L.M.; Smirk, R.A.; Wu, S.C.; Hutchins, R.D.; Nirschl, D.S.; Van Kirk, K.; Cooper, C.B.; Sutton, J.C.; Ma, Z.; Golla, R.; Seethala, R.; Salyan, M.E.; Nayeem, A.; Krystek, S.R.; Sheriff, S.; Camac, D.M.; Morin, P.E.; Carpenter, B.; Robl, J.A.; Zahler, R.; Gordon, D.A.; Hamann, L.G.
Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
Bioorg. Med. Chem. Lett.
18
3168-3172
2008
Homo sapiens
Zhu, Y.; Olson, S.H.; Hermanowski-Vosatka, A.; Mundt, S.; Shah, K.; Springer, M.; Thieringer, R.; Wright, S.; Xiao, J.; Zokian, H.; Balkovec, J.M.
4-Methyl-5-phenyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I
Bioorg. Med. Chem. Lett.
18
3405-3411
2008
Homo sapiens, Mus musculus
Zhu, Y.; Olson, S.H.; Graham, D.; Patel, G.; Hermanowski-Vosatka, A.; Mundt, S.; Shah, K.; Springer, M.; Thieringer, R.; Wright, S.; Xiao, J.; Zokian, H.; Dragovic, J.; Balkovec, J.M.
Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I
Bioorg. Med. Chem. Lett.
18
3412-3416
2008
Homo sapiens, Mus musculus
Sun, D.; Wang, Z.; Di, Y.; Jaen, J.C.; Labelle, M.; Ma, J.; Miao, S.; Sudom, A.; Tang, L.; Tomooka, C.S.; Tu, H.; Ursu, S.; Walker, N.; Yan, X.; Ye, Q.; Powers, J.P.
Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)
Bioorg. Med. Chem. Lett.
18
3513-3516
2008
Homo sapiens, Mus musculus
Ahmed, A.; Saksena, S.; Sherlock, M.; Olliff, S.P.; Elias, E.; Stewart, P.M.
Induction of hepatic 11beta-hydroxysteroid dehydrogenase type 1 in patients with alcoholic liver disease
Clin. Endocrinol. (Oxf.)
68
898-903
2008
Homo sapiens
Marcolongo, P.; Piccirella, S.; Senesi, S.; Wunderlich, L.; Gerin, I.; Mandl, J.; Fulceri, R.; Banhegyi, G.; Benedetti, A.
The glucose-6-phosphate transporter-hexose-6-phosphate dehydrogenase-11beta-hydroxysteroid dehydrogenase type 1 system of the adipose tissue
Endocrinology
148
2487-2495
2007
Rattus norvegicus
Kim, K.W.; Wang, Z.; Busby, J.; Tsuruda, T.; Chen, M.; Hale, C.; Castro, V.M.; Svensson, S.; Nybo, R.; Xiong, F.; Wang, M.
The selectivity of tyrosine 280 of human 11beta-hydroxysteroid dehydrogenase type 1 in inhibitor binding
FEBS Lett.
581
995-999
2007
Homo sapiens (P28845), Homo sapiens
Kim, J.; Temple, K.A.; Jones, S.A.; Meredith, K.N.; Basko, J.L.; Brady, M.J.
Differential modulation of 3T3-L1 adipogenesis mediated by 11beta-hydroxysteroid dehydrogenase-1 levels
J. Biol. Chem.
282
11038-11046
2007
Mus musculus
Walker, E.A.; Ahmed, A.; Lavery, G.G.; Tomlinson, J.W.; Kim, S.Y.; Cooper, M.S.; Ride, J.P.; Hughes, B.A.; Shackleton, C.H.; McKiernan, P.; Elias, E.; Chou, J.Y.; Stewart, P.M.
11beta-Hydroxysteroid dehydrogenase type 1 regulation by intracellular glucose 6-phosphate provides evidence for a novel link between glucose metabolism and hypothalamo-pituitary-adrenal axis function
J. Biol. Chem.
282
27030-27036
2007
Homo sapiens, Mus musculus
Bujalska, I.J.; Durrani, O.M.; Abbott, J.; Onyimba, C.U.; Khosla, P.; Moosavi, A.H.; Reuser, T.T.; Stewart, P.M.; Tomlinson, J.W.; Walker, E.A.; Rauz, S.
Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat
J. Endocrinol.
192
279-288
2007
Homo sapiens
Johansson, L.; Fotsch, C.; Bartberger, M.D.; Castro, V.M.; Chen, M.; Emery, M.; Gustafsson, S.; Hale, C.; Hickman, D.; Homan, E.; Jordan, S.R.; Komorowski, R.; Li, A.; McRae, K.; Moniz, G.; Matsumoto, G.; Orihuela, C.; Palm, G.; Veniant, M.; Wang, M.; Williams, M.; Zhang, J.
2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice
J. Med. Chem.
51
2933-2943
2008
Homo sapiens (P28845), Homo sapiens
Julian, L.D.; Wang, Z.; Bostick, T.; Caille, S.; Choi, R.; Degraffenreid, M.; Di, Y.; He, X.; Hungate, R.W.; Jaen, J.C.; Liu, J.; Monshouwer, M.; McMinn, D.; Rew, Y.; Sudom, A.; Sun, D.; Tu, H.; Ursu, S.; Walker, N.; Yan, X.; Ye, Q.; Powers, J.P.
Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model
J. Med. Chem.
51
3953-3960
2008
Macaca fascicularis, Homo sapiens, Homo sapiens (P28845)
London, E.; Lala, G.; Berger, R.; Panzenbeck, A.; Kohli, A.A.; Renner, M.; Jackson, A.; Raynor, T.; Loya, K.; Castonguay, T.W.
Sucrose access differentially modifies 11beta-hydroxysteroid dehydrogenase-1 and hexose-6-phosphate dehydrogenase message in liver and adipose tissue in rats
J. Nutr.
137
2616-2621
2007
Rattus norvegicus
Klusonova, P.; Kucka, M.; Ergang, P.; Miksik, I.; Bryndova, J.; Pacha, J.
Cloning of chicken 11beta-hydroxysteroid dehydrogenase type 1 and its tissue distribution
J. Steroid Biochem. Mol. Biol.
111
217-224
2008
Gallus gallus
Sakumoto, R.; Ito, S.; Okuda, K.
Changes in expression of 11beta-hydroxysteroid dehydrogenase type-1, type-2 and glucocorticoid receptor mRNAs in porcine corpus luteum during the estrous cycle
Mol. Reprod. Dev.
75
925-930
2008
Sus scrofa
Munoz, R.; Carvajal, C.; Escalona, A.; Boza, C.; Perez, G.; Ibanez, L.; Fardella, C.
11beta-Hydroxysteroid dehydrogenase type 1 is overexpressed in subcutaneous adipose tissue of morbidly obese patients
Obes. Surg.
19
764-770
2008
Homo sapiens
Nashev, L.G.; Chandsawangbhuwana, C.; Balazs, Z.; Atanasov, A.G.; Dick, B.; Frey, F.J.; Baker, M.E.; Odermatt, A.
Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids
PLoS ONE
2
e561
2007
Homo sapiens
Sunak, N.; Green, D.F.; Abeydeera, L.R.; Thurston, L.M.; Michael, A.E.
Implication of cortisol and 11beta -hydroxysteroid dehydrogenase enzymes in the development of porcine (Sus scrofa domestica) ovarian follicles and cysts
Reproduction
133
1149-1158
2007
Rattus norvegicus, Sus scrofa
Sharp, V.; Thurston, L.M.; Fowkes, R.C.; Michael, A.E.
11Beta-hydroxysteroid dehydrogenase enzymes in the testis and male reproductive tract of the boar (Sus scrofa domestica) indicate local roles for glucocorticoids in male reproductive physiology
Reproduction
134
473-482
2007
Sus scrofa
Hennebert, O.; Le Mee, S.; Pernelle, C.; Morfin, R.
5Alpha-androstane-3beta,7alpha,17beta-triol and 5alpha-androstane-3beta,7beta,17beta-triol as substrates for the human 11beta-hydroxysteroid dehydrogenase type 1
Steroids
72
855-864
2007
Homo sapiens
Czegle, I.; Margittai, E.; Senesi, S.; Benedetti, A.; Banhegyi, G.
Different expression and distribution of 11beta-hydroxysteroid dehydrogenase type 1 in obese and lean animal models of type 2 diabetes
Acta Physiol. Hung.
95
419-424
2008
Rattus norvegicus
Hong, D.; Li, X.W.; Lian, Q.Q.; Lamba, P.; Bernard, D.J.; Hardy, D.O.; Chen, H.X.; Ge, R.S.
Mono-(2-ethylhexyl) phthalate (MEHP) regulates glucocorticoid metabolism through 11beta-hydroxysteroid dehydrogenase 2 in murine gonadotrope cells
Biochem. Biophys. Res. Commun.
389
305-309
2009
Mus musculus
Lee, H.Y.; Acosta, T.J.; Skarzynski, D.J.; Okuda, K.
Prostaglandin F2alpha stimulates 11beta-hydroxysteroid dehydrogenase 1 enzyme bioactivity and protein expression in bovine endometrial stromal cells
Biol. Reprod.
80
657-664
2009
Bos taurus
Rew, Y.; McMinn, D.L.; Wang, Z.; He, X.; Hungate, R.W.; Jaen, J.C.; Sudom, A.; Sun, D.; Tu, H.; Ursu, S.; Villemure, E.; Walker, N.P.; Yan, X.; Ye, Q.; Powers, J.P.
Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors
Bioorg. Med. Chem. Lett.
19
1797-1801
2009
Homo sapiens (P28845)
Roche, D.; Carniato, D.; Leriche, C.; Lepifre, F.; Christmann-Franck, S.; Graedler, U.; Charon, C.; Bozec, S.; Doare, L.; Schmidlin, F.; Lecomte, M.; Valeur, E.
Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I
Bioorg. Med. Chem. Lett.
19
2674-2678
2009
Homo sapiens (P28845), Homo sapiens
Lepifre, F.; Christmann-Franck, S.; Roche, D.; Leriche, C.; Carniato, D.; Charon, C.; Bozec, S.; Doare, L.; Schmidlin, F.; Lecomte, M.; Valeur, E.
Discovery and structure-guided drug design of inhibitors of 11beta-hydroxysteroid-dehydrogenase type I based on a spiro-carboxamide scaffold
Bioorg. Med. Chem. Lett.
19
3682-3685
2009
Homo sapiens (P28845), Homo sapiens
Tu, H.; Powers, J.P.; Liu, J.; Ursu, S.; Sudom, A.; Yan, X.; Xu, H.; Meininger, D.; Degraffenreid, M.; He, X.; Jaen, J.C.; Sun, D.; Labelle, M.; Yamamoto, H.; Shan, B.; Walker, N.P.; Wang, Z.
Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1
Bioorg. Med. Chem.
16
8922-8931
2008
Homo sapiens (P28845), Homo sapiens
Saiah, E.
The role of 11beta-hydroxysteroid dehydrogenase in metabolic disease and therapeutic potential of 11beta-HSD1 inhibitors
Curr. Med. Chem.
15
642-649
2008
Homo sapiens, Mus musculus
Swali, A.; Walker, E.A.; Lavery, G.G.; Tomlinson, J.W.; Stewart, P.M.
11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets
Diabetologia
51
2003-2011
2008
Homo sapiens, Mus musculus
Balachandran, A.; Guan, H.; Sellan, M.; van Uum, S.; Yang, K.
Insulin and dexamethasone dynamically regulate adipocyte 11beta-hydroxysteroid dehydrogenase type 1
Endocrinology
149
4069-4079
2008
Mus musculus, Rattus norvegicus
Mericq, V.; Medina, P.; Kakarieka, E.; Marquez, L.; Johnson, M.C.; Iniguez, G.
Differences in expression and activity of 11beta-hydroxysteroid dehydrogenase type 1 and 2 in human placentas of term pregnancies according to birth weight and gender
Eur. J. Endocrinol.
161
419-425
2009
Homo sapiens
Yang, H.; Shen, Y.; Chen, J.; Jiang, Q.; Leng, Y.; Shen, J.
Structure-based virtual screening for identification of novel 11beta-HSD1 inhibitors
Eur. J. Med. Chem.
44
1167-1171
2009
Mus musculus, Homo sapiens (P28845)
Gumy, C.; Thurnbichler, C.; Aubry, E.M.; Balazs, Z.; Pfisterer, P.; Baumgartner, L.; Stuppner, H.; Odermatt, A.; Rollinger, J.M.
Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 by plant extracts used as traditional antidiabetic medicines
Fitoterapia
80
200-205
2009
Homo sapiens
Mericq, V.; Medina, P.; Bouwman, C.; Johnson, M.C.; Godoy, J.; Lopez, T.; Iniguez, G.
Expression and activity of 11beta-hydroxysteroid dehydrogenase type 1 enzyme in subcutaneous and visceral adipose tissue of prepubertal children
Horm. Res.
71
89-93
2009
Homo sapiens
Cooper, M.S.
11beta-Hydroxysteroid dehydrogenase: a regulator of glucocorticoid response in osteoporosis
J. Endocrinol. Invest.
31 (7 Suppl)
16-21
2008
Homo sapiens
Wan, Z.K.; Chenail, E.; Xiang, J.; Li, H.Q.; Ipek, M.; Bard, J.; Svenson, K.; Mansour, T.S.; Xu, X.; Tian, X.; Suri, V.; Hahm, S.; Xing, Y.; Johnson, C.E.; Li, X.; Qadri, A.; Panza, D.; Perreault, M.; Tobin, J.F.; Saiah, E.
Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model
J. Med. Chem.
52
5449-5461
2009
Mus musculus, Homo sapiens (P28845), Homo sapiens
Anderson, S.; Carreiro, S.; Quenzer, T.; Gale, D.; Xiang, C.; Gukasyan, H.; Lafontaine, J.; Cheng, H.; Krauss, A.; Prasanna, G.
In vivo evaluation of 11beta-hydroxysteroid dehydrogenase activity in the rabbit eye
J. Ocul. Pharmacol. Ther.
25
215-222
2009
Oryctolagus cuniculus
Chen, B.B.; Lin, H.; Hu, G.X.; Su, Y.; Zhou, H.Y.; Lian, Q.Q.; Cai, H.; Hardy, D.O.; Gu, D.Y.; Ge, R.S.
The (+)- and (-)-gossypols potently inhibit human and rat 11beta-hydroxysteroid dehydrogenase type 2
J. Steroid Biochem. Mol. Biol.
113
177-181
2009
Homo sapiens, Rattus norvegicus
Classen-Houben, D.; Schuster, D.; Da Cunha, T.; Odermatt, A.; Wolber, G.; Jordis, U.; Kueenburg, B.
Selective inhibition of 11beta-hydroxysteroid dehydrogenase 1 by 18alpha-glycyrrhetinic acid but not 18beta-glycyrrhetinic acid
J. Steroid Biochem. Mol. Biol.
113
248-252
2009
Homo sapiens (P28845), Homo sapiens
Sharp, V.; Thurston, L.M.; Fowkes, R.C.; Michael, A.E.
Expression and activities of 11betaHSD enzymes in the testes and reproductive tracts of sexually immature male pigs
J. Steroid Biochem. Mol. Biol.
115
98-106
2009
Sus scrofa
Wang, D.Y.; Lu, Q.; Walsh, S.L.; Payne, L.; Modha, S.S.; Scott, M.J.; Sweitzer, T.D.; Ames, R.S.; Krosky, D.J.; Li, H.
Development of a high-throughput cell-based assay for 11beta-hydroxysteroid dehydrogenase type 1 using BacMam technology
Mol. Biotechnol.
39
127-134
2008
Homo sapiens, Mus musculus
Chapman, K.E.; Coutinho, A.E.; Gray, M.; Gilmour, J.S.; Savill, J.S.; Seckl, J.R.
The role and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in the inflammatory response
Mol. Cell. Endocrinol.
301
123-131
2009
Homo sapiens, Mus musculus
Blum, A.; Favia, A.D.; Maser, E.
11beta-Hydroxysteroid dehydrogenase type 1 inhibitors with oleanan and ursan scaffolds
Mol. Cell. Endocrinol.
301
132-136
2009
Homo sapiens (P28845), Homo sapiens
Dzyakanchuk, A.A.; Balazs, Z.; Nashev, L.G.; Amrein, K.E.; Odermatt, A.
11beta-Hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP(+) and is stimulated by extracellular glucose
Mol. Cell. Endocrinol.
301
137-141
2009
Homo sapiens, Mus musculus
Su, X.; Vicker, N.; Trusselle, M.; Halem, H.; Culler, M.D.; Potter, B.V.
Discovery of novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1
Mol. Cell. Endocrinol.
301
169-173
2009
Homo sapiens
Abbott, A.N.; Guidry, T.V.; Welsh, K.J.; Thomas, A.M.; Kling, M.A.; Hunter, R.L.; Actor, J.K.
11beta-hydroxysteroid dehydrogenases are regulated during the pulmonary granulomatous response to the mycobacterial glycolipid trehalose-6,6-dimycolate
Neuroimmunomodulation
16
147-154
2009
Mus musculus
Gong, R.; Morris, D.J.; Brem, A.S.
Variable expression of 11beta Hydroxysteroid dehydrogenase (11beta-HSD) isoforms in vascular endothelial cells
Steroids
73
1187-1196
2008
Homo sapiens, Homo sapiens (P80365), Rattus norvegicus
Mondok, A.; Varga, I.; Glaz, E.; Szucs, N.; Toth, M.; Patocs, A.; Beko, G.; Racz, K.
11beta-hydroxysteroid dehydrogenase activity in acromegalic patients with normal or impaired carbohydrate metabolism
Steroids
74
725-729
2009
Homo sapiens
Skarydova, L.; Skarka, A.; Novotna, R.; Zivna, L.; Martin, H.J.; Wsol, V.; Maser, E.
Partial purification and characterization of a new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin
Toxicology
264
52-60
2009
Homo sapiens
Zhang, X.; Zhou, Y.; Shen, Y.; Du, L.L.; Chen, J.H.; Leng, Y.; Shen, J.H.
Derivatives of (phenylsulfonamido-methyl)nicotine and (phenylsulfonamido-methyl)thiazole as novel 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: synthesis and biological activities in vitro
Acta Pharmacol. Sin.
30
1344-1350
2009
Homo sapiens (P28845), Homo sapiens, Mus musculus (P50172), Mus musculus
Cho, Y.S.; Kim, C.H.; Cheon, H.G.
Cell-based assay for screening 11beta-hydroxysteroid dehydrogenase 1 inhibitors
Anal. Biochem.
392
110-116
2009
Mus musculus
Sun, D.; Wang, Z.; Cardozo, M.; Choi, R.; Degraffenreid, M.; Di, Y.; He, X.; Jaen, J.C.; Labelle, M.; Liu, J.; Ma, J.; Miao, S.; Sudom, A.; Tang, L.; Tu, H.; Ursu, S.; Walker, N.; Yan, X.; Ye, Q.; Powers, J.P.
Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1)
Bioorg. Med. Chem. Lett.
19
1522-1527
2009
Homo sapiens
Siu, M.; Johnson, T.O.; Wang, Y.; Nair, S.K.; Taylor, W.D.; Cripps, S.J.; Matthews, J.J.; Edwards, M.P.; Pauly, T.A.; Ermolieff, J.; Castro, A.; Hosea, N.A.; LaPaglia, A.; Fanjul, A.N.; Vogel, J.E.
N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275
Bioorg. Med. Chem. Lett.
19
3493-3497
2009
Homo sapiens
Zhang, X.; Zhou, Z.; Yang, H.; Chen, J.; Feng, Y.; Du, L.; Leng, Y.; Shen, J.
4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice
Bioorg. Med. Chem. Lett.
19
4455-4458
2009
Homo sapiens, Mus musculus
Kim, S.H.; Ramu, R.; Kwon, S.W.; Lee, S.H.; Kim, C.H.; Kang, S.K.; Rhee, S.D.; Bae, M.A.; Ahn, S.H.; Ha, D.C.; Cheon, H.G.; Kim, K.Y.; Ahn, J.H.
Discovery of cyclicsulfonamide derivatives as 11beta-hydroxysteroid dehydrogenase 1 inhibitors
Bioorg. Med. Chem. Lett.
20
1065-1069
2010
Homo sapiens, Mus musculus
Stanetty, C.; Czollner, L.; Koller, I.; Shah, P.; Gaware, R.; Cunha, T.D.; Odermatt, A.; Jordis, U.; Kosma, P.; Classen-Houben, D.
Synthesis of novel 3-amino and 29-hydroxamic acid derivatives of glycyrrhetinic acid as selective 11beta-hydroxysteroid dehydrogenase 2 inhibitors
Bioorg. Med. Chem.
18
7522-7541
2010
Homo sapiens (P28845)
Feng, Y.; Huang, S.L.; Dou, W.; Zhang, S.; Chen, J.H.; Shen, Y.; Shen, J.H.; Leng, Y.
Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice
Br. J. Pharmacol.
161
113-126
2010
Mus musculus, Homo sapiens (P28845), Homo sapiens
Xu, D.; Sheng, Y.; Zhou, Z.Y.; Liu, R.; Leng, Y.; Liu, J.K.
Sesquiterpenes from cultures of the basidiomycete Clitocybe conglobata and their 11 beta-hydroxysteroid dehydrogenase inhibitory activity
Chem. Pharm. Bull.
57
433-435
2009
Homo sapiens, Mus musculus
Su, X.; Pradaux-Caggiano, F.; Thomas, M.P.; Szeto, M.W.; Halem, H.A.; Culler, M.D.; Vicker, N.; Potter, B.V.
Discovery of adamantyl ethanone derivatives as potent 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors
ChemMedChem
5
1026-1044
2010
Homo sapiens (P28845), Homo sapiens
Ge, R.; Huang, Y.; Liang, G.; Li, X.
11beta-hydroxysteroid dehydrogenase type 1 inhibitors as promising therapeutic drugs for diabetes: status and development
Curr. Med. Chem.
17
412-422
2010
Homo sapiens, Mus musculus
Torres-Piedra, M.; Ortiz-Andrade, R.; Villalobos-Molina, R.; Singh, N.; Medina-Franco, J.L.; Webster, S.P.; Binnie, M.; Navarrete-Vazquez, G.; Estrada-Soto, S.
A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition
Eur. J. Med. Chem.
45
2606-2612
2010
Homo sapiens (P28845)
Odermatt, A.
Diazepane-acetamide derivatives as selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors
Expert Opin. Ther. Pat.
19
1477-1483
2009
Homo sapiens
Zhang, L.; Shen, Y.; Zhu, H.J.; Wang, F.; Leng, Y.; Liu, J.K.
Pentanol derivatives from basidiomycete Catathelasma imperiale and their 11beta-hydroxysteroid dehydrogenases inhibitory activity
J. Antibiot.
62
239-242
2009
Homo sapiens, Mus musculus
Tagawa, N.; Yuda, R.; Kubota, S.; Wakabayashi, M.; Yamaguchi, Y.; Kiyonaga, D.; Mori, N.; Minamitani, E.; Masuzaki, H.; Kobayashi, Y.
17Beta-estradiol inhibits 11beta-hydroxysteroid dehydrogenase type 1 activity in rodent adipocytes
J. Endocrinol.
202
131-139
2009
Mus musculus, Rattus norvegicus
Veniant, M.M.; Hale, C.; Hungate, R.W.; Gahm, K.; Emery, M.G.; Jona, J.; Joseph, S.; Adams, J.; Hague, A.; Moniz, G.; Zhang, J.; Bartberger, M.D.; Li, V.; Syed, R.; Jordan, S.; Komorowski, R.; Chen, M.M.; Cupples, R.; Kim, K.W.; St Jean, D.J.; Johansson, L.; Henriksson, M.A.; Williams, M.; Vallgarda, J.; Fots, F.o.t.s.c.
Discovery of a potent, orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: identification of (S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221)
J. Med. Chem.
53
4481-4487
2010
Homo sapiens (P28845)
Kim, C.H.; Ramu, R.; Ahn, J.H.; Bae, M.A.; Cho, Y.S.
Fenofibrate but not fenofibric acid inhibits 11beta-hydroxysteroid dehydrogenase 1 in C2C12 myotubes
Mol. Cell. Biochem.
344
91-98
2010
Mus musculus
Zhang, L.; Shen, Y.; Wang, F.; Leng, Y.; Liu, J.K.
Rare merosesquiterpenoids from basidiomycete Craterellus odoratus and their inhibition of 11beta-hydroxysteroid dehydrogenases
Phytochemistry
71
100-103
2010
Homo sapiens, Mus musculus
Webster, S.P.; Binnie, M.; McConnell, K.M.; Sooy, K.; Ward, P.; Greaney, M.F.; Vinter, A.; Pallin, T.D.; Dyke, H.J.; Gill, M.I.; Warner, I.; Seckl, J.R.; Walker, B.R.
Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles
Bioorg. Med. Chem. Lett.
20
3265-3271
2010
Homo sapiens (P28845), Homo sapiens, Mus musculus (P50172), Mus musculus
Venier, O.; Pascal, C.; Braun, A.; Namane, C.; Mougenot, P.; Crespin, O.; Pacquet, F.; Mougenot, C.; Monseau, C.; Onofri, B.; Dadji-Faihun, R.; Leger, C.; Ben-Hassine, M.; Van-Pham, T.; Ragot, J.L.; Philippo, C.; Guessregen, S.; Engel, C.; Farjot, G.; Noah, L.; Maniani, K.; Nicolai, E.
Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11beta-hydroxysteroid-dehydrogenase type 1
Bioorg. Med. Chem. Lett.
21
2244-2251
2011
Homo sapiens (P28845), Mus musculus (P50172)
Wang, H.; Robl, J.A.; Hamann, L.G.; Simpkins, L.; Golla, R.; Li, Y.X.; Seethala, R.; Zvyaga, T.; Gordon, D.A.; Li, J.J.
Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1)
Bioorg. Med. Chem. Lett.
21
4146-4149
2011
Homo sapiens (P28845), Mus musculus (P50172)
Wu, S.C.; Yoon, D.; Chin, J.; van Kirk, K.; Seethala, R.; Golla, R.; He, B.; Harrity, T.; Kunselman, L.K.; Morgan, N.N.; Ponticiello, R.P.; Taylor, J.R.; Zebo, R.; Harper, T.W.; Li, W.; Wang, M.; Zhang, L.; Sleczka, B.G.; Nayeem, A.; Sheriff, S.; Camac, D.M.; Morin, P.E.; Everlof, J.G.; Li, Y.X.; Ferraro, C.A.; et al.
Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11beta-hydroxydehydrogenase 1 (11beta-HSD1)
Bioorg. Med. Chem. Lett.
21
6693-6698
2011
Homo sapiens (P28845), Mus musculus (P50172)
Ye, X.Y.; Chen, S.Y.; Nayeem, A.; Golla, R.; Seethala, R.; Wang, M.; Harper, T.; Sleczka, B.G.; Li, Y.X.; He, B.; Kirby, M.; Gordon, D.A.; Robl, J.A.
Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1)
Bioorg. Med. Chem. Lett.
21
6699-6704
2011
Homo sapiens (P28845), Mus musculus (P50172)
Udagawa, S.; Sakami, S.; Takemura, T.; Sato, M.; Arai, T.; Nitta, A.; Aoki, T.; Kawai, K.; Iwamura, T.; Okazaki, S.; Takahashi, T.; Kaino, M.
Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1
Bioorg. Med. Chem. Lett.
23
1617-1621
2013
Homo sapiens (P28845), Mus musculus (P50172)
Su, X.; Vicker, N.; Thomas, M.P.; Pradaux-Caggiano, F.; Halem, H.; Culler, M.D.; Potter, B.V.
Discovery of adamantyl heterocyclic ketones as potent 11beta-hydroxysteroid dehydrogenase type 1 inhibitors
ChemMedChem
6
1439-1451
2011
Homo sapiens (P28845)
Xia, G.; Liu, L.; Liu, H.; Yu, J.; Xu, Z.; Chen, Q.; Ma, C.; Li, P.; Xiong, B.; Liu, X.; Shen, J.
Design and synthesis of (R)-1-arylsulfonylpiperidine-2-carboxamides as 11beta-hydroxysteroid dehydrogenase type 1 inhibitors
ChemMedChem
8
577-581
2013
Homo sapiens (P28845), Mus musculus (P50172)
Fernandino, J.I.; Hattori, R.S.; Kishii, A.; Struessmann, C.A.; Somoza, G.M.
The cortisol and androgen pathways cross talk in high temperature-induced masculinization: the 11beta-hydroxysteroid dehydrogenase as a key enzyme
Endocrinology
153
6003-6011
2012
Odontesthes bonariensis
Xu, Z.; Tice, C.M.; Zhao, W.; Cacatian, S.; Ye, Y.J.; Singh, S.B.; Lindblom, P.; McKeever, B.M.; Krosky, P.M.; Kruk, B.A.; Berbaum, J.; Harrison, R.K.; Johnson, J.A.; Bukhtiyarov, Y.; Panemangalore, R.; Scott, B.B.; Zhao, Y.; Bruno, J.G.; Togias, J.; Guo, J.; Guo, R.; Carroll, P.J.; McGeehan, G.M.; Zhuang, L. et al.
Structure-based design and synthesis of 1,3-oxazinan-2-one inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
J. Med. Chem.
54
6050-6062
2011
Homo sapiens (P28845)
Rasheeda, M.K.; Kagawa, H.; Kirubagaran, R.; Dutta-Gupta, A.; Senthilkumaran, B.
Cloning, expression and enzyme activity analysis of testicular 11beta-hydroxysteroid dehydrogenase during seasonal cycle and after hCG induction in air-breathing catfish Clarias gariepinus
J. Steroid Biochem. Mol. Biol.
120
1-10
2010
Clarias gariepinus
Kratschmar, D.V.; Vuorinen, A.; Da Cunha, T.; Wolber, G.; Classen-Houben, D.; Doblhoff, O.; Schuster, D.; Odermatt, A.
Characterization of activity and binding mode of glycyrrhetinic acid derivatives inhibiting 11beta-hydroxysteroid dehydrogenase type 2
J. Steroid Biochem. Mol. Biol.
125
129-142
2011
Homo sapiens (P28845)
Xia, G.; Liu, L.; Xue, M.; Liu, H.; Yu, J.; Li, P.; Chen, Q.; Xiong, B.; Liu, X.; Shen, J.
Discovery of novel sulfonamides as potent and selective inhibitors against human and mouse 11beta-hydroxysteroid dehydrogenase type 1
Mol. Cell. Endocrinol.
358
46-52
2012
Homo sapiens (P28845), Mus musculus (P50172)
Favia, A.; Masetti, M.; Recanatini, M.; Cavalli, A.
Substrate binding process and mechanistic functioning of type 1 11beta-hydroxysteroid dehydrogenase from enhanced sampling methods
PLoS ONE
6
e25375
2011
Homo sapiens (P28845)
Hu, G.; Lin, H.; Lian, Q.; Zhou, S.; Guo, J.; Zhou, H.; Chu, Y.; Ge, R.
Curcumin as a potent and selective inhibitor of 11beta-hydroxysteroid dehydrogenase 1: improving lipid profiles in high-fat-diet-treated rats
PLoS ONE
8
e49976
2013
Rattus norvegicus (P16232), Homo sapiens (P28845)
Latif, S.A.; Shen, M.; Ge, R.S.; Sottas, C.M.; Hardy, M.P.; Morris, D.J.
Role of 11beta-OH-C(19) and C(21) steroids in the coupling of 11beta-HSD1 and 17beta-HSD3 in regulation of testosterone biosynthesis in rat Leydig cells
Steroids
76
682-689
2011
Rattus norvegicus (P16232)
Guo, J.; Deng, H.; Li, H.; Zhu, Q.; Zhao, B.; Chen, B.; Chu, Y.; Ge, R.S.
Effects of methoxychlor and its metabolite 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 11beta-hydroxysteroid dehydrogenase activities in vitro
Toxicol. Lett.
218
18-23
2013
Homo sapiens (P28845), Rattus norvegicus (P16232)
Itoi, S.; Terao, M.; Murota, H.; Katayama, I.
11beta-Hydroxysteroid dehydrogenase 1 contributes to the pro-inflammatory response of keratinocytes
Biochem. Biophys. Res. Commun.
440
265-270
2013
Homo sapiens
Mitic, T.; Shave, S.; Semjonous, N.; McNae, I.; Cobice, D.F.; Lavery, G.G.; Webster, S.P.; Hadoke, P.W.; Walker, B.R.; Andrew, R.
11beta-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo
Biochem. Pharmacol.
86
146-153
2013
Mus musculus
Brooks, K.; Burns, G.; Spencer, T.E.
Biological roles of hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), HSD11B2, and glucocorticoid receptor (NR3C1) in sheep conceptus elongation
Biol. Reprod.
93
38
2015
Ovis aries (P50168), Ovis aries (P51975), Ovis aries
Hofer, S.; Kratschmar, D.V.; Schernthanner, B.; Vuorinen, A.; Schuster, D.; Odermatt, A.; Easmon, J.
Synthesis and biological analysis of benzazol-2-yl piperazine sulfonamides as 11beta-hydroxysteroid dehydrogenase 1 inhibitors
Bioorg. Med. Chem. Lett.
23
5397-5400
2013
Homo sapiens (P28845)
Lee, Y.; Shin, Y.J.; Ahn, S.K.
3-Amino-N-adamantyl-3-methylbutanamide derivatives as 11beta-hydroxysteroid dehydrogenase 1 inhibitor
Bioorg. Med. Chem. Lett.
24
1421-1425
2014
Mus musculus, Homo sapiens (P28845)
Gillespie, P.; Pietranico-Cole, S.; Myers, M.; Bilotta, J.A.; Conde-Knape, K.; Fotouhi, N.; Goodnow, R.A.; Guertin, K.R.; Hamilton, M.M.; Haynes, N.E.; Liu, B.; Qi, L.; Ren, Y.; Scott, N.R.; So, S.S.; Spence, C.; Taub, R.; Thakkar, K.; Tilley, J.W.; Zwingelstein, C.
Discovery of camphor-derived pyrazolones as 11beta-hydroxysteroid dehydrogenase type 1 inhibitors
Bioorg. Med. Chem. Lett.
24
2707-2711
2014
Rattus norvegicus
Ye, X.Y.; Yoon, D.; Chen, S.Y.; Nayeem, A.; Golla, R.; Seethala, R.; Wang, M.; Harper, T.; Sleczka, B.G.; Apedo, A.; Li, Y.X.; He, B.; Kirby, M.; Gordon, D.A.; Robl, J.A.
Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)
Bioorg. Med. Chem. Lett.
24
654-660
2014
Homo sapiens (P28845)
Hong, S.P.; Nam, K.Y.; Shin, Y.J.; Kim, K.W.; Ahn, S.K.
Discovery of 11beta-hydroxysteroid dehydrogenase type 1 inhibitor
Bioorg. Med. Chem. Lett.
25
3501-3506
2015
Homo sapiens, Mus musculus
Ryu, J.H.; Kim, S.; Han, H.Y.; Son, H.J.; Lee, H.J.; Shin, Y.A.; Kim, J.S.; Park, H.G.
Synthesis and biological evaluation of picolinamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)
Bioorg. Med. Chem. Lett.
25
695-700
2015
Homo sapiens (P28845)
Cherkasova, O.P.; Selyatitskaya, V.G.; Palchikova, N.A.; Kuznetsova, N.V.
Activity of 11beta-hydroxysteroid dehydrogenase in the adrenal glands, liver, and kidneys of rats with experimental diabetes
Bull. Exp. Biol. Med.
158
185-187
2014
Rattus norvegicus
Morelli, V.; Polledri, E.; Mercadante, R.; Zhukouskaya, V.; Palmieri, S.; Beck-Peccoz, P.; Spada, A.; Fustinoni, S.; Chiodini, I.
The activity of 11beta-hydroxysteroid dehydrogenase type 2 enzyme and cortisol secretion in patients with adrenal incidentalomas
Endocrine
53
809-815
2016
Homo sapiens
Coutinho, A.E.; Kipari, T.M.; Zhang, Z.; Esteves, C.L.; Lucas, C.D.; Gilmour, J.S.; Webster, S.P.; Walker, B.R.; Hughes, J.; Savill, J.S.; Seckl, J.R.; Rossi, A.G.; Chapman, K.E.
11beta-Hydroxysteroid dehydrogenase type 1 is expressed in neutrophils and restrains an inflammatory response in male mice
Endocrinology
157
2928-2936
2016
Mus musculus
Dube, S.; Norby, B.J.; Pattan, V.; Carter, R.E.; Basu, A.; Basu, R.
11beta-hydroxysteroid dehydrogenase types 1 and 2 activity in subcutaneous adipose tissue in humans: implications in obesity and diabetes
J. Clin. Endocrinol. Metab.
100
E70-E76
2015
Homo sapiens
Tagawa, N.; Kubota, S.; Kato, I.; Kobayashi, Y.
Resveratrol inhibits 11beta-hydroxysteroid dehydrogenase type 1 activity in rat adipose microsomes
J. Endocrinol.
218
311-320
2013
Rattus norvegicus
Scott, J.S.; Goldberg, F.W.; Turnbull, A.V.
Medicinal chemistry of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)
J. Med. Chem.
57
4466-4486
2014
Homo sapiens (P28845)
Odermatt, A.; Klusonova, P.
11beta-Hydroxysteroid dehydrogenase 1: Regeneration of active glucocorticoids is only part of the story
J. Steroid Biochem. Mol. Biol.
151
85-92
2015
Mus musculus
Vitku, J.; Starka, L.; Bicikova, M.; Hill, M.; Heracek, J.; Sosvorova, L.; Hampl, R.
Endocrine disruptors and other inhibitors of 11beta-hydroxysteroid dehydrogenase 1 and 2: Tissue-specific consequences of enzyme inhibition
J. Steroid Biochem. Mol. Biol.
155
207-216
2016
Homo sapiens
Penno, C.A.; Morgan, S.A.; Rose, A.J.; Herzig, S.; Lavery, G.G.; Odermatt, A.
11beta-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice
Mol. Metab.
3
554-564
2014
Mus musculus
Schmidt, M.; Straub, R.H.
11beta-Hydroxysteroid dehydrogenase enzymes modulate effects of glucocorticoids in rheumatoid arthritis synovial cells
Neuroimmunomodulation
22
40-45
2015
Homo sapiens
Chen, X.; Dong, Y.; Cao, S.; Li, X.; Wang, Z.; Chen, R.; Ge, R.S.
Effects of polybrominated diphenyl ethers on rat and human 11beta-hydroxysteroid dehydrogenase 1 and 2 activities
Pharmacology
98
115-123
2016
Homo sapiens, Rattus norvegicus
Ergang, P.; Kuzelova, A.; Sotak, M.; Klusonova, P.; Makal, J.; Pacha, J.
Distinct effect of stress on 11beta-hydroxysteroid dehydrogenase type 1 and corticosteroid receptors in dorsal and ventral hippocampus
Physiol. Res.
63
255-261
2014
Rattus norvegicus
Li, X.; Hu, G.; Li, X.; Wang, Y.Y.; Hu, Y.Y.; Zhou, H.; Latif, S.A.; Morris, D.J.; Chu, Y.; Zheng, Z.; Ge, R.S.
Metabolic coupling determines the activity: comparison of 11beta-hydroxysteroid dehydrogenase 1 and its coupling between liver parenchymal cells and testicular Leydig cells
PLoS ONE
10
e0141767
2015
Rattus norvegicus, Homo sapiens (P28845), Homo sapiens
Hintzpeter, J.; Stapelfeld, C.; Loerz, C.; Martin, H.J.; Maser, E.
Green tea and one of its constituents, epigallocatechine-3-gallate, are potent inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1
PLoS ONE
9
e84468
2014
Homo sapiens (P28845)
Almanzar, G.; Mayerl, C.; Seitz, J.C.; Hoefner, K.; Brunner, A.; Wild, V.; Jahn, D.; Geier, A.; Fassnacht, M.; Prelog, M.
Expression of 11beta-hydroxysteroid-dehydrogenase type 2 in human thymus
Steroids
110
35-40
2016
Homo sapiens
Voisin, M.; de Medina, P.; Mallinger, A.; Dalenc, F.; Huc-Claustre, E.; et, al.
Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor
Proc. Natl. Acad. Sci. USA
114
E9346-E9355
2017
Homo sapiens (P80365)
Huebner, H.; Heussner, K.; Ruebner, M.; Schmid, M.; Nadal, J.; Woelfle, J.; Hartner, A.; Menendez-Castro, C.; Rauh, M.; Beckmann, M.W.; Kehl, S.; Fahlbusch, F.B.
Influence of labor on direct and indirect determinants of placental 11beta-hydroxysteroid dehydrogenase activity
Arch. Gynecol. Obstet.
303
401-408
2021
Homo sapiens (P80365), Homo sapiens
Studzinska, R.; Kolodziejska, R.; Kupczyk, D.; Plazinski, W.; Kosmalski, T.
A novel derivatives of thiazol-4(5H)-one and their activity in the inhibition of 11beta-hydroxysteroid dehydrogenase type 1
Bioorg. Chem.
79
115-121
2018
Homo sapiens (P28845)
Studzinska, R.; Kupczyk, D.; Plazinska, A.; Kolodziejska, R.; Kosmalski, T.; Modzelewska-Banachiewicz, B.
Thiazolo[3,2-a]pyrimidin-5-one derivatives as a novel class of 11beta-hydroxysteroid dehydrogenase inhibitors
Bioorg. Chem.
81
21-26
2018
Homo sapiens (P28845)
Boudon, S.; Heidl, M.; Vuorinen, A.; Wandeler, E.; Campiche, R.; Odermatt, A.; Jackson, E.
Design, synthesis, and biological evaluation of novel selective peptide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
Bioorg. Med. Chem.
26
5128-5139
2018
Homo sapiens (P28845)
Cirillo, N.; Morgan, D.J.; Pedicillo, M.C.; Celentano, A.; Lo Muzio, L.; McCullough, M.J.; Prime, S.S.
Characterisation of the cancer-associated glucocorticoid system key role of 11beta-hydroxysteroid dehydrogenase type 2
Br. J. Cancer
117
984-993
2017
Homo sapiens (P80365)
Dammann, C.; Stapelfeld, C.; Maser, E.
Expression and activity of the cortisol-activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 is tissue and species-specific
Chem. Biol. Interact.
303
57-61
2019
Homo sapiens (P28845)
Koike, T.; Shiraki, R.; Sasuga, D.; Hosaka, M.; Kawano, T.; Fukudome, H.; Kurosawa, K.; Moritomo, A.; Mimasu, S.; Ishii, H.; Yoshimura, S.
Discovery and biological evaluation of potent and orally active human 11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes mellitus
Chem. Pharm. Bull.
67
824-838
2019
Homo sapiens (P28845)
Han, J.; Sun, W.; Gao, F.
Role of 11beta-hydroxysteroid dehydrogenase in bone metabolism
Chinese J. Tissue Eng. Res.
21
5203-5208
2017
Homo sapiens
-
Hussey, M.; Holleran, G.; Smith, S.; Sherlock, M.; McNamara, D.
The role and regulation of the 11 beta-hydroxysteroid dehydrogenase enzyme system in patients with inflammatory bowel disease
Digest. Dis. Sci.
62
3385-3390
2017
Homo sapiens (P28845), Homo sapiens (P80365)
Zhou, C.; Ye, F.; Wu, H.; Ye, H.; Chen, Q.
Recent advances in the study of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) inhibitors
Environ. Toxicol. Pharmacol.
52
47-53
2017
Rattus norvegicus (A0A1B0GWP2), Homo sapiens (P80365)
Hardy, R.S.; Fenton, C.; Croft, A.P.; Naylor, A.J.; Begum, R.; Desanti, G.; Buckley, C.D.; Lavery, G.; Cooper, M.S.; Raza, K.
11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis
J. Autoimmun.
92
104-113
2018
Mus musculus (P50172)
Ganjoo, A.; Tripathi, A.; Chetti, P.
Structural assessment and identification of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors
J. Biomol. Struct. Dyn.
38
4928-4937
2020
Homo sapiens (P28845)
Beck, K.R.; Inderbinen, S.G.; Kanagaratnam, S.; Kratschmar, D.V.; Jetten, A.M.; Yamaguchi, H.; Odermatt, A.
11beta-Hydroxysteroid dehydrogenases control access of 7beta,27-dihydroxycholesterol to retinoid-related orphan receptor gamma
J. Lipid Res.
60
1535-1546
2019
Homo sapiens (P28845), Homo sapiens (R4GN04)
Loerz, C.; Maser, E.
The cortisol-activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 in skeletal muscle in the pathogenesis of the metabolic syndrome
J. Steroid Biochem. Mol. Biol.
174
65-71
2017
Homo sapiens (P28845)
Gent, R.; du Toit, T.; Bloem, L.M.; Swart, A.C.
The 11beta-hydroxysteroid dehydrogenase isoforms pivotal catalytic activities yield potent C11-oxy C19 steroids with 11betaHSD2 favouring 11-ketotestosterone, 11-ketoandrostenedione and 11-ketoprogesterone biosynthesis
J. Steroid Biochem. Mol. Biol.
189
116-126
2019
Homo sapiens (P80365)
Beck, K.R.; Kanagaratnam, S.; Kratschmar, D.V.; Birk, J.; Yamaguchi, H.; Sailer, A.W.; Seuwen, K.; Odermatt, A.
Enzymatic interconversion of the oxysterols 7beta,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11beta-hydroxysteroid dehydrogenase type 1 and 2
J. Steroid Biochem. Mol. Biol.
190
19-28
2019
Homo sapiens (P28845), Homo sapiens (P80365), Mus musculus (P50172), Mus musculus (P51661)
Cabrera Perez, L.C.; Padilla-Martinez, I.I.; Cruz, A.; Correa Basurto, J.; Miliar Garcia, A.; Hernandez Zavala, A.A.; Gomez Lopez, M.; Rosales Hernandez, M.C.
Design, synthesis, molecular docking and in vitro evaluation of benzothiazole derivatives as 11beta-hydroxysteroid dehydrogenase type 1 inhibitors
Mol. Divers.
24
971-984
2020
Rattus norvegicus (P16232)
Shearer, F.J.G.; Wyrwoll, C.S.; Holmes, M.C.
The role of 11beta-hydroxy steroid dehydrogenase type 2 in glucocorticoid programming of affective and cognitive behaviours
Neuroendocrinology
109
257-265
2019
Mus musculus (P51661)
Lee, N.R.; Kim, B.J.; Lee, C.H.; Lee, Y.B.; Lee, S.; Hwang, H.J.; Kim, E.; Kim, S.H.; Lee, M.G.; Lee, S.E.; Lavery, G.G.; Choi, E.H.
Role of 11beta-hydroxysteroid dehydrogenase type 1 in the development of atopic dermatitis
Sci. Rep.
10
20237
2020
Homo sapiens (P28845), Mus musculus (P50172)
Inderbinen, S.G.; Zogg, M.; Kley, M.; Smiesko, M.; Odermatt, A.
Species-specific differences in the inhibition of 11beta-hydroxysteroid dehydrogenase 2 by itraconazole and posaconazole
Toxicol. Appl. Pharmacol.
412
115387
2021
Rattus norvegicus (P50233), Mus musculus (P51661), Homo sapiens (P80365), Danio rerio (Q6P0H9)
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