Information on EC 1.1.1.142 - D-pinitol dehydrogenase

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The expected taxonomic range for this enzyme is: Trifolium incarnatum

EC NUMBER
COMMENTARY hide
1.1.1.142
-
RECOMMENDED NAME
GeneOntology No.
D-pinitol dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
1D-3-O-methyl-chiro-inositol + NADP+ = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADPH + H+
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
pinitol biosynthesis II
-
-
SYSTEMATIC NAME
IUBMB Comments
1D-3-O-methyl-chiro-inositol:NADP+ oxidoreductase
-
CAS REGISTRY NUMBER
COMMENTARY hide
37250-71-8
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,4,6/3,5-pentahydroxycyclohexanone + NADPH
? + NADP+
show the reaction diagram
-
-
-
?
5D-5-O-methyl-chiro-inositol + NADP+
5D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADPH + H+
show the reaction diagram
-
A-site specificity
-
r
D-2,3,5/4,6-pentahydroxycyclohexanone + NADPH
? + NADP+
show the reaction diagram
-
-
-
?
dihydroxyacetone + NADPH
propanetriol + NADP+
show the reaction diagram
-
low activity
-
?
DL-2,3,4,6/5-pentahydroxycyclohexanone + NADPH
? + NADP+
show the reaction diagram
-
low activity
-
?
L-2,3,5/4,6-pentahydroxycyclohexanone + NADPH
? + NADP+
show the reaction diagram
-
low activity
-
?
L-3-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADPH
? + NADP+
show the reaction diagram
-
low activity
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
5D-5-O-methyl-chiro-inositol + NADP+
5D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADPH + H+
show the reaction diagram
-
A-site specificity
-
r
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Cu2+
-
21% inhibition at 0.1 mM
Fe2+
-
25% inhibition at 0.1 mM
p-chloromercuribenzoate
-
25% inhibition at 1 mM
Phenylmercurinitrate
-
15% inhibition at 0.1 mM
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
prior to formation of flowers
Manually annotated by BRENDA team
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
34000
-
gel filtration
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
2°C, 0.01 M phosphate buffer, pH 7.2, little loss of activity within 3 weeks
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE