Information on EC 1.1.1.137 - ribitol-5-phosphate 2-dehydrogenase

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The expected taxonomic range for this enzyme is: Lactobacillus

EC NUMBER
COMMENTARY hide
1.1.1.137
-
RECOMMENDED NAME
GeneOntology No.
ribitol-5-phosphate 2-dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+
show the reaction diagram
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Metabolic pathways
-
-
Pentose and glucuronate interconversions
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SYSTEMATIC NAME
IUBMB Comments
D-ribitol-5-phosphate:NAD(P)+ 2-oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY hide
37250-67-2
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
no activity in Bacillus subtilis
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-ribitol 5-phosphate + NAD+
D-ribulose 5-phosphate + NADH
show the reaction diagram
-
-
-
r
D-ribulose 5-phosphate + NADH + H+
D-ribitol 5-phosphate + NAD+
show the reaction diagram
D-ribulose 5-phosphate + NADPH + H+
D-ribitol 5-phosphate + NADP+
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADH
-
cofactor
NADP+
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.66
D-ribitol 5-phosphate
-
-
0.15
D-ribulose 5-phosphate
-
-
0.025
NAD+
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-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.5 - 6.5
-
D-ribitol 5-phosphate + NAD+
8 - 9
-
D-ribulose 5-phosphate + NADH
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
49000
-
2 * 49000, denaturing PAGE
115000
-
gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
-
2 * 49000, denaturing PAGE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, lyophilized powder, stable for 3 weeks
-
frozen, stable for at least a week
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE