Information on EC 1.1.1.115 - ribose 1-dehydrogenase (NADP+)

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The expected taxonomic range for this enzyme is: Sus scrofa

EC NUMBER
COMMENTARY hide
1.1.1.115
-
RECOMMENDED NAME
GeneOntology No.
ribose 1-dehydrogenase (NADP+)
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-ribose + NADP+ + H2O = D-ribonate + NADPH + H+
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
D-ribose:NADP+ 1-oxidoreductase
Also acts, more slowly, on D-xylose and other pentoses.
CAS REGISTRY NUMBER
COMMENTARY hide
37250-46-7
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-arabinose + NADP+ + H2O
?
show the reaction diagram
-
-
-
-
?
D-ribose + NADP+ + H2O
D-ribonate + NADPH
show the reaction diagram
-
-
-
-
?
D-xylose + NADP+ + H2O
?
show the reaction diagram
-
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADP+
-
cofactor
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
HgCl2
-
2.5 mM, 94% inhibition
iodoacetamide
-
200 mM, 90% inhibition
NEM
-
10 mM, 81% inhibition
p-chloromercuribenzoate
-
0.2 mM, 92% inhibition
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
7.7
D-arabinose
-
-
8
D-ribose
-
-
1.4
D-xylose
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
9.7
-
-
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
9 - 10.3
-
about 55% of maximal activity at pH 9.0 and at pH 10.3
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team