2.7.7.B4: adenylyltransferase UBA4

This is an abbreviated version!
For detailed information about adenylyltransferase UBA4, go to the full flat file.

Reaction

Synonyms

N-terminal domain of Uba4, nucleotide-binding domain of Uba4p, Uba4, Uba4p

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.7 Nucleotidyltransferases

2.7.7.B4 adenylyltransferase UBA4

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Results	in table
1	AA Sequence
2	Cloned(Commentary)
3	Natural Substrates/ Products (Substrates)
3	Organism
1	Purification (Commentary)
1	Reaction
3	Reference
6	Substrates and Products (Substrate)
1	Subunits
5	Synonyms
1	Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.7.7.B4 - adenylyltransferase UBA4

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ATP + Urm1p-terminal-Gly

diphosphate + Urm1p-terminal-Gly-AMP

2 entries

Urm1p-terminal-Gly-AMP + Uba4-SSH

Urm1p-terminal-Gly-COSH + human MOCS2A-SH + AMP

Saccharomyces cerevisiae

P38820

the N-terminal domain of Uba4 catalyzes the activation of Urm1 by formation of an acyl-adenylate bond. After adenylation, persulfurated Uba4 is able to form a thiocarboxylate group at the C-terminal glycine of Urm1. The formation of a thioester intermediate between Uba4 and Urm1 is not observed. The functional similarities between Uba4 and MOCS3 (protein essential for the biosynthesis of the molybdenum cofactor in human) further demonstrate the evolutionary link between ATP-dependent protein conjugation and ATP-dependent cofactor sulfuration

690968