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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
additional information
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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
African swine fever virus Badajoz 1971 Vero-adapted
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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
DNA replication can be accomplished using dNDPs as substrates. In thermophiles, genome replication may be less sensitive to the energy charge of the cell than in mesophiles because thermostable polymerases can accept the diphosphorylated as well as the triphosphorylated substrates. DNA replication is thus less affected by the intracellular ATP/ADP ratio, and the relatively high efficiency with which DNA is synthesized at elevated temperatures suggests that thermophiles may be able to dispense with the triphosphorylated substrates entirely
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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
the template-dependent polymerase that can repair non-complementary DNA double strand breaks with unpaired 3' primer termini by nonhomologous end joining. Its role is to fill short gaps arising as intermediates in the process of V(D)J recombination and during processing of accidental double strand breaks
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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
DNA replication can be accomplished using dNDPs as substrates. In thermophiles, genome replication may be less sensitive to the energy charge of the cell than in mesophiles because thermostable polymerases can accept the diphosphorylated as well as the triphosphorylated substrates. DNA replication is thus less affected by the intracellular ATP/ADP ratio, and the relatively high efficiency with which DNA is synthesized at elevated temperatures suggests that thermophiles may be able to dispense with the triphosphorylated substrates entirely
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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
the catalytic core of yeast DNA polymerase eta prefers to incorporate dCTP opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine (damage produced by reactive oxygen species in DNA). dCTP incorporation is slower than the dissociation of the polymerase from DNA. 57% of the extension products beyond the 7,8-dihydro-8-oxo-2'-deoxyguanosine are the products corresponding to the correct incorporation (C) and 43% corresponding to dATP misincorporation
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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
the catalytic core of yeast DNA polymerase eta prefers to incorporate dCTP opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine (damage produced by reactive oxygen species in DNA). dCTP incorporation is slower than the dissociation of the polymerase from DNA. 57% of the extension products beyond the 7,8-dihydro-8-oxo-2'-deoxyguanosine are the products corresponding to the correct incorporation (C) and 43% corresponding to dATP misincorporation
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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
DNA replication can be accomplished using dNDPs as substrates. In thermophiles, genome replication may be less sensitive to the energy charge of the cell than in mesophiles because thermostable polymerases can accept the diphosphorylated as well as the triphosphorylated substrates. DNA replication is thus less affected by the intracellular ATP/ADP ratio, and the relatively high efficiency with which DNA is synthesized at elevated temperatures suggests that thermophiles may be able to dispense with the triphosphorylated substrates entirely
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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
DNA replication can be accomplished using dNDPs as substrates. In thermophiles, genome replication may be less sensitive to the energy charge of the cell than in mesophiles because thermostable polymerases can accept the diphosphorylated as well as the triphosphorylated substrates. DNA replication is thus less affected by the intracellular ATP/ADP ratio, and the relatively high efficiency with which DNA is synthesized at elevated temperatures suggests that thermophiles may be able to dispense with the triphosphorylated substrates entirely
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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natural substrate is gapped DNA
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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polymerase I plays a role in repair of chromosomal damage
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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physiological role of pol I and pol III
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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polymerase III is necessary for DNA replication
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
Betapolyomavirus macacae
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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643602, 643607, 643608, 643609, 643618, 643619, 643620, 643622, 643649, 643650, 643655, 643668 -
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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polymerase alpha: role in DNA replication
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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overview: physiological roles in replication and in DNA repair synthesis
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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enzyme is active only in cells at meiotic prophase, in somatic cells it is in an inactive state
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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DNA polymerase delta: with its auxiliary factor i.e. proliferating cell nuclear antigen, largely responsible for leading-strand synthesis
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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overview: physiological roles in replication and in DNA repair synthesis
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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DNA polymerase alpha: with its associated primase largely responsible for lagging-strand synthesis
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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643595, 643597, 643606, 643622, 643623, 643624, 643626, 643657, 643658, 704278, 722100 -
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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physiological role of pol I
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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physiological role of pol I, II and pol III
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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pol III can repair short gaps created by nuclease in duplex DNA, for efficient replication of the long, single-stranded templates pol III requires auxiliary subunits
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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polymerase III: role in replication of chromosomal DNA
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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polymerase II: role in DNA repair
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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DNA polymerase V is involved in translesion synthesis and mutagenesis
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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gamma-phosphates of the incoming dNTP, contributing to charge neutralization and alignment of the alpha-phosphate for reaction
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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overview: physiological roles in replication and in DNA repair synthesis
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
Herpes simplex virus
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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643424, 643603, 643607, 643608, 643623, 643647, 643649, 643650, 643668, 702071, 702087, 721129, 721707, 722686, 723570, 723694 -
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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overview: functional role of mammalian DNA polymerases
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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polymerase alpha: role in DNA replication
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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polymerase beta: role in DNA repair
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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DNA polymerase delta: with its auxiliary factor i.e. proliferating cell nuclear antigen, largely responsible for leading-strand synthesis
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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overview: physiological roles in replication and in DNA repair synthesis
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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DNA polymerase alpha: with its associated primase largely responsible for lagging-strand synthesis
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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Pol lambda plays a role in the short-patch base excision repair rather than contributes to the long-patch base excision repair pathway
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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DNA polymerase iota may play a limited and error-prone role in translesion synthesis across the N2-guanine adducts (possibly medium sized adducts up to N2-benzylguanine) due to the low polymerization rates and high error rates
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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role in DNA gap repair
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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overview: functional role of mammalian DNA polymerases
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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overview: physiological roles in replication and in DNA repair synthesis
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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OsPOLP1 might be involved in a repair pathway similar to long-patch base excision repair. Possible role of POLPs in plastidial DNA replication and repair
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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PabPolD might play an important role in DNA replication likely together with PabpolB, suggesting that archaea require two DNA polymerases at the replication fork
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
the enzyme has a template-primer preference which is characteristic of a replicative DNA polymerase
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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the enzyme plays an essential role in DNA replication, repair, and recombination
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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polymerase alpha: role in DNA replication
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
Ruellia sp.
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
two representative types of lesions: (i) 7,8-dihydro-8-oxoguanine, a small, highly prevalent lesion caused by oxidative damage; and (ii) bulky lesions derived from the environmental pre-carcinogen benzo[a]pyrene. The diol epoxide (+)-(7R,8S,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[ a]pyrene reacts largely, but not exclusively, with the exocyclic amino group of guanine to produce the major 10S (+) trans-anti-BP-N2-dG adduct, that is bypassed by Dpo4
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deamination of cytosine to uracil is a hydrolytic reaction that is greatly accelerated at high temperatures. The resulting uracil pairs with adenine during DNA replication, thereby inducing G:C to A:T transitions in the progeny. B-family DNA polymerases from hyperthermophilic archaea recognize the presence of uracil in DNA and stall DNA synthesis. Although PolB1 per se specifically binds to uracil-containing single-stranded DNA, the binding efficiency is substantially enhanced by the initiation of DNA synthesis. The generation of ds DNA is significantly inhibited, however, by the presence of template uracil. Pol B1 more efficiently recognizes uracil in DNA during DNA synthesis rather than during random diffusion in solution. Single molecules of Pol B1 bind to template uracil and stall DNA synthesis
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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the enzyme bypasses DNA adducts pyrrolo-deoxycytosine, dP, N6-furfuryl-deoxyadenosine, and 1,N6-ethenodeoxyadenosine in a process known as translesion synthesis
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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the Y-family DNA polymerases promote mutagenesis through the erroneous incorporation of oxidized dNTPs during DNA synthesis 2-OH-dATP is predominantly incorporated opposite guanine and thymine
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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the Y-family DNA polymerases promote mutagenesis through the erroneous incorporation of oxidized dNTPs during DNA synthesis. 2-OH-dATP is predominantly incorporated opposite guanine and thymine
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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the Y-family DNA polymerases promote mutagenesis through the erroneous incorporation of oxidized dNTPs during DNA synthesis 2-OH-dATP is predominantly incorporated opposite guanine and thymine
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
the Y-family DNA polymerases promote mutagenesis through the erroneous incorporation of oxidized dNTPs during DNA synthesis. 2-OH-dATP is predominantly incorporated opposite guanine and thymine
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
the Y-family DNA polymerases promote mutagenesis through the erroneous incorporation of oxidized dNTPs during DNA synthesis 2-OH-dATP is predominantly incorporated opposite guanine and thymine
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
the Y-family DNA polymerases promote mutagenesis through the erroneous incorporation of oxidized dNTPs during DNA synthesis. 2-OH-dATP is predominantly incorporated opposite guanine and thymine
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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role in non-homologous end joining of double strand breaks, perhaps including those with damaged ends, possible role for pol IV in base excision repair
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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double-stranded DNA property of DNA polymerase epsilon is required for epigenetic silencing at telomeres
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
Salasvirus phi29
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
Tequatrovirus T4
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
Tequatrovirus T4
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exonuclease activity contributes to the avoidance of alkylation mutations
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
Tequatrovirus T4
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phage T4 DNA polymerase is essential for initiation and maintenance of viral DNA replication
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
Tequintavirus T5
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
Testudines agrionemys
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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overview: physiological roles in replication and in DNA repair synthesis
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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additional information
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the R2 polymerase can utilize both RNA and DNA templates, but the processivity of the enzyme on single stranded DNA templates is higher than its processivity on RNA templates, R2-RT is also capable of synthesizing the second DNA strand during retrotransposition
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additional information
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PolH can be up-regulated by DNA breaks induced by ionizing radiation or chemotherapeutic agents, and knockdown of PolH gives cells resistance to apoptosis induced by DNA breaks in multiple cell lines and cell types in a p53-dependent manner. PolH has a role in the DNA damage checkpoint. POlH is target of p53
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additional information
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all pols exclusively promote misincorporation of dCMP opposite a 2'-deoxyinosine lesion during translesion synthesis, isozymes pol alpha, pol eta, and pol kappaDELTAC promote preferential incorporation of 2'-deoxycytidine monophosphate , the wrong base, opposite a 2'-deoxyinosine lesion, no incorporation of 2'-deoxythymidine monophosphate, the correct base, is observed opposite the lesion
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additional information
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comparing RNA primer-templates and DNA primer templates of identical sequence show that herpes polymerase greatly prefers to elongate the DNA primer by 650-26000fold, thus accounting for the extremely low efficiency with which herpes polymerase elongates primase-synthesized primers
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additional information
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Neq L and Neq S are needed to form the active DNA polymerase that possesses higher proofreading activity. The genetically protein splicing-processed Neq P shows the same properties as the protein trans-spliced Neq C
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additional information
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the enzyme is responsible for mutagenesis, e.g. UV-induced, in human host cells of lungs of cystic fibrosis patients contributing to morbidity and mortality of these people, with a striking correlation between mutagenesis and the persistence of Pseudomonas aeruginosa, mechanisms of mutagenesis, enzyme regulation, overview, the enzyme is responsible for resistance to to nitrofurazone and 4-nitroquinoline-1-oxide toxification
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additional information
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replication cycle of Dpo4, and induced fit and translocation mechanisms, overview
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additional information
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replication cycle of Dpo4, and induced fit and translocation mechanisms, overview
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additional information
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the widely used anticancer drug, cis-diamminedichloroplatinum(II), i.e. cisplatin, reacts with adjacent purine bases in DNA to form predominantly cis-[Pt(NH3)2(d(GpG)-N7(1),-N7(2))] intrastrand cross-links, DNA polymerase IV is able to perform translesion synthesis in the presence of DNA-distorting damage such as cisplatin-DNA adducts, overview
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additional information
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the DNA polymerase gene of Thermococcus marinus contains an intein inserted at the pol-b site
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additional information
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DNA-dependent DNA polymerase commonly accepts DNA and dNTP and excludes RNA and rNTP, but some enzyme mutants also show RNA-dependent DNA polymerase activity as reverse transcriptases, overview. Reverse transcriptase is the enzyme that catalyzes DNA polymerization using RNA as a template, i.e. RNA-dependent DNA polymerase, see for EC 2.7.7.49
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additional information
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only the enzyme mutant T326A/L324A/Q384A/F388A/m4008A/Y438A shows RNA-dependent DNA polymerase activity, EC 2.7..7.49
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additional information
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only the enzyme mutant T326A/L324A/Q384A/F388A/m4008A/Y438A shows RNA-dependent DNA polymerase activity, EC 2.7..7.49
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additional information
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DNA-dependent DNA polymerase commonly accepts DNA and dNTP and excludes RNA and rNTP, but some enzyme mutants also show RNA-dependent DNA polymerase activity as reverse transcriptases, overview. Reverse transcriptase is the enzyme that catalyzes DNA polymerization using RNA as a template, i.e. RNA-dependent DNA polymerase, see for EC 2.7.7.49
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additional information
?
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DNA-dependent DNA polymerase commonly accepts DNA and dNTP and excludes RNA and rNTP, but some enzyme mutants also show RNA-dependent DNA polymerase activity as reverse transcriptases, overview. Reverse transcriptase is the enzyme that catalyzes DNA polymerization using RNA as a template, i.e. RNA-dependent DNA polymerase, see for EC 2.7.7.49
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additional information
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the catalytic efficiency of PolX is almost the same with and without dNTPs, whereas that of the domain mixture increases on the addition of dNTPs
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additional information
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the catalytic efficiency of PolX is almost the same with and without dNTPs, whereas that of the domain mixture increases on the addition of dNTPs
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