2.7.7.6: DNA-directed RNA polymerase

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For detailed information about DNA-directed RNA polymerase, go to the full flat file.

Reaction

Synonyms

C RNA formation factors, chloroplast soluble RNA polymerase, deoxyribonucleic acid-dependent ribonucleic acid polymerase, DNA-dependent ribonucleate nucleotidyltransferase, DNA-dependent RNA nucleotidyltransferase, DNA-dependent RNA polymerase, DNA-dependent RNA polymerase I, DNA-dependent RNA polymerase III, DNA-dependent RNAP, h-mtRNAP, K1E RNAP, mitochondrial RNA polymerase, mitoRNAP, More, mtRNAP, multi-subunit RNA polymerase, nucleotidyltransferase, ribonucleate, plastid RNA polymerase, plastid-encoded polymerase, plastid-encoded RNA polymerase, Pol I, Pol II, pol III, Pol IIIalpha, Pol IIIbeta, Pol IV, Pol V, polI, PolIII, POLRMT, ribonucleate nucleotidyltransferase, ribonucleate polymerase, ribonucleic acid formation factors, C, ribonucleic acid nucleotidyltransferase, ribonucleic acid polymerase, ribonucleic acid transcriptase, ribonucleic polymerase, ribonucleic transcriptase, rifampicin-resistant RNA polymerase, RNA formation factors, C, RNA nucleotidyltransferase, RNA nucleotidyltransferase (DNA-directed), RNA pol III, RNA polymerase, RNA polymerase core enzyme, RNA polymerase I, RNA polymerase II, RNA polymerase II complex, RNA polymerase III, RNA polymerase III complex, RNA transcriptase, RNAP, RNAP core enzyme, RNAP I, RNAP II, RNAP III, RNAP sigma70, RNAP-II, RNAP2, RNAPII, RPO, rpo1N, Rpo41, RpoA, RpoD, RpoS, RpoT, Saci_0834, sigma38 RNA polymerase, sigmaS-containing RNA polymerase, T7 RNA polymerase, T7 RNAP, T7-like RNA polymerase, Taq polymerase, transcriptase, YonO

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.7 Nucleotidyltransferases

                2.7.7.6 DNA-directed RNA polymerase

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Results	in table
56	Activating Compound
385907	AA Sequence
15	Application
1	CAS Registry Number
77	Cloned(Commentary)
1	Cofactor
34	Crystallization (Commentary)
4851	Disease/ Diagnostics
5	Expression
117	General Information
5	General Stability
8	IC50 Value
164	Inhibitors
44	KM Value [mM]
52	Localization
67	Metals/Ions
122	Molecular Weight [Da]
84	Natural Substrates/ Products (Substrates)
551	Organism
1	Oxidation Stability
4123	PDB ID
29	pH Optimum
3	pH Range
20	Posttranslational Modification
77	Protein Variants
50	Purification (Commentary)
3	Reaction
3	Reaction Type
312	Reference
2	Renatured (Commentary)
67	Source Tissue
26	Specific Activity [micromol/min/mg]
3	Storage Stability
245	Substrates and Products (Substrate)
100	Subunits
403	Synonyms
1	Systematic Name
26	Temperature Optimum [°C]
4	Temperature Range [°C]
8	Temperature Stability [°C]
22	Turnover Number [1/s]

General Stability

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General Stability on EC 2.7.7.6 - DNA-directed RNA polymerase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

40% glycerol is absolutely required for stability

Clostridium acetobutylicum

-

643558

each freeze-thaw cycle results in significant loss of activity

Pseudomonas aeruginosa

-

660929

enzyme shows an extreme instability in the presence of salts

Microchaete diplosiphon

-

643552

nucleolar enzyme appears to be less stable than the nucleoplasmic enzyme, particularly in the presence of salt

Rattus norvegicus

-

643550

the two largest Pol I subunits do not dissociate from one another between rounds of transcription. Pol I is relatively stable through multiple rounds of transcription

Saccharomyces cerevisiae

-

663216