2.7.7.53: ATP adenylyltransferase
This is an abbreviated version!
For detailed information about ATP adenylyltransferase, go to the full flat file.
Word Map on EC 2.7.7.53
-
2.7.7.53
-
phosphorolysis
-
tuberculosis
-
polyphosphate
-
blanquet
-
3.6.1.41
-
lupin
-
5',5'-p1,p4-tetraphosphate
-
phosphorylases
-
5'-phosphosulfate
-
ap4g
-
synthetases
- 2.7.7.53
-
phosphorolysis
- tuberculosis
- polyphosphate
-
blanquet
-
3.6.1.41
-
lupin
- 5',5'-p1,p4-tetraphosphate
- phosphorylases
- 5'-phosphosulfate
- ap4g
- synthetases
Reaction
Synonyms
5',5'''-P1,P4-tetraphosphate phosphorylase, adenine triphosphate adenylyltransferase, adenylyltransferase, adenine triphosphate, AP-4-A phosphorylase, Ap3A/Ap4A phosphorylase, Ap4A phosphorylase, bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming), diadenosine 5',5'''-P1,P4-tetraphosphate alpha,beta-phosphorylase, diadenosine 5',5'''-P1,P4-tetraphosphate alpha,beta-phosphorylase (ADP-forming), diadenosine 5',5'''-P1,P4-tetraphosphate alphabeta-phosphorylase (ADP-forming), diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase, diadenosinetetraphosphate alpha,beta-phosphorylase, diadenosinetetraphosphate alphabeta-phosphorylase, dinucleoside oligophosphate alphabeta-phosphorylase, MAV_3489, MEG_2932, Rv2613c
ECTree
2.7.7.53 ATP adenylyltransferaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.7.7.53 - ATP adenylyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
NDP + polyphosphate
polyphosphate + NDP
-
exchange reaction
-
r
P1(5'-adenosyl)-P4(5'-cytosyl) tetraphosphate + phosphate
CDP + ATP
-
-
not CTP + ADP
?
P1(5'-adenosyl)-P4(5'-guanosyl) tetraphosphate + phosphate
GDP + ATP
-
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
?
-
involved in catabolism of dinucleoside polyphosphates
-
-
?
P1,P5-bis(5'-guanosyl) pentaphosphate + phosphate
guanosine tetraphosphate + GDP
106% activity compared to P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P5-bis(5'-guanosyl)pentaphosphate + phosphate
?
wild-type, 106% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 95%, respectively
-
-
?
P1,P6-bis(5'-adenosyl) hexaphosphate + phosphate
adenosine pentaphosphate + ADP
25% activity compared to P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1-(5'-adenosyl)-P4-(5'-deoxythymidyl) tetraphosphate + phosphate
ATP + dTDP
68% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
or ADP + dTTP, major products
-
?
P1-(5'-adenosyl)-P5-(5'-deoxythymidyl) pentaphosphate + phosphate
p4A + dTDP
30% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
or ADP + p4dT, major products
-
?
P1-(5'-adenosyl)-P5-(5'-guanosyl) pentaphosphate + phosphate
p4A + GDP
49% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major products
-
?
P1-(5'-adenosyl)P4-(5'-deoxythymidyl) pentaphosphate + phosphate
p4A + dTDP
31% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
or ADP + p4dT, major products
-
?
P1-(5'-adenosyl)P4-(5'-deoxythymidyl) tetraphosphate + phosphate
ATP + dTDP
85% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
or ADP + dTTP, major products
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) pentaphosphate + phosphate
p4A + GDP
30% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major products
-
?
P1-(5'-adenosyl)P5-(5'-guanosyl) pentaphosphate + phosphate
adenosine tetraphosphate + GDP
76% activity compared to P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
ADP + ATP
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
-
-
-
r
ADP + ATP
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
-
-
-
-
r
ADP + ATP
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
-
-
-
-
r
ADP + ATP
phosphate + P1,P4-bis(5'-adenosyl)tetraphosphate
-
-
-
?
ADP + ATP
phosphate + P1,P4-bis(5'-adenosyl)tetraphosphate
-
-
-
?
ADP + ATP
phosphate + P1,P4-bis(5'-adenosyl)tetraphosphate
-
-
-
?
ADP + phosphate
phosphate + ADP
-
90% activity due to isoform I
-
r
ADP + phosphate
phosphate + ADP
-
ADP/phosphate exchange reaction
-
r
ADP + phosphate
phosphate + ADP
-
ADP/phosphate exchange reaction
-
r
NDP + phosphate
phosphate + NDP
-
exchange reaction between beta-phosphate of NDP and phosphate from the medium
-
r
NDP + phosphate
phosphate + NDP
-
enzyme performs the exchange reaction also with polyphosphates
-
r
NDP + phosphate
phosphate + NDP
-
90% activity due to isoform I
-
r
NTP + N'DP
P1,P4-bis(5'-nucleosyl) tetraphosphate' + phosphate
-
asymmetric catalytic site: synthesis of Ap4G or Ap4C is much faster from ATP plus CDP or GDP than from CTP or GTP plus ADP
N is A or G, N' is A, C, G, U or dA
?
NTP + N'DP
P1,P4-bis(5'-nucleosyl) tetraphosphate' + phosphate
-
N is A or G, not C, U or dA, and N' is A, C, G, U or dA
N is A or G, N' is A, C, G, U or dA
?
P1,P2-bis(5'-adenosyl) diphosphate + phosphate
?
-
no activity
-
-
?
P1,P2-bis(5'-adenosyl) diphosphate + phosphate
?
-
i.e. AP2A
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
2 ADP
14% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major product
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
2 ADP
14% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major product
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
2 ADP
wild-type, 19% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 29%, respectively
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
2 ADP
26% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major product
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
2 ADP
26% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major product
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
ADP
-
preferred substrate
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
ADP
-
i.e. AP3A
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
ADP
19% activity compared to P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
ADP
19% activity compared to P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
ADP
-
i.e. AP3A
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
ADP
-
no activity with
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
ADP
-
i.e. AP3A
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
ADP
-
no activity with
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate with CF2-bridge between P1 and P2 + phosphate
?
-
low activity
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate with CF2-bridge between P1 and P2 + phosphate
?
-
ApCF2ppA, difluoromethylene group substituting the oxygen
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate with CH2-bridge between P1 and P2 + phosphate
?
-
poor substrate
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate with CH2-bridge between P1 and P2 + phosphate
?
-
i.e. ApCH2ppA, methylene group substituting the oxygen
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate with CHF-bridge between P1 and P2 + phosphate
?
-
low activity
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate with CHF-bridge between P1 and P2 + phosphate
?
-
i.e. ApCHFppA, fluoromethylene group substituting the oxygen
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + arsenate
?
-
182% activity compared to phosphate
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + arsenate
?
-
arsenolysis, at about 80% the rate of phosphorolysis
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + arsenate
?
-
irreversible formation of reaction intermediate AMP-enzyme, unstable
-
-
ir
P1,P4-bis(5'-adenosyl) tetraphosphate + chromate
?
-
poor substrate
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + molybdate
?
-
poor substrate
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
i.e. Ap4A or AppppA, substrate specificity
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
i.e. Ap4A or AppppA, substrate specificity
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
no formation of AMP observed
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
no formation of AMP observed
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
no formation of AMP observed
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
no formation of AMP observed
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
i.e. Ap4A or AppppA, substrate specificity
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
AMP-enzyme intermediate
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ATP + ADP
100% activity
-
-
ir
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ATP + ADP
100% activity
-
-
ir
P1,P4-bis(5'-adenosyl) tetraphosphate + tungstate
?
-
no activity
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + vanadate
?
-
225% activity compared to phosphate
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate with CH2-bridge between P3 and P4 + phosphate
?
-
i.e. ApppCH2pA, methylene group substituting the oxygen
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate with CH2-bridge between P3 and P4 + phosphate
?
-
i.e. ApppCH2pA, methylene group substituting the oxygen
-
-
?
P1,P4-bis(5'-adenosyl)tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl)tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GDP + GTP
-
i.e. GP4G
-
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GDP + GTP
53% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major products
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GDP + GTP
53% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major products
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GDP + GTP
56% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major products
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GDP + GTP
56% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major products
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GDP + GTP
-
arsenate can replace phosphate
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GDP + GTP
-
i.e. GP4G
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GTP + GDP
107% activity compared to P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GTP + GDP
wild-type, 107% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 53%, respectively
-
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GTP + GDP
wild-type, 107% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 53%, respectively
-
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GTP + GDP
107% activity compared to P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
?
47% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
?
47% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
?
44% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
?
44% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
adenosine tetraphosphate + ADP
106% activity compared to P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
adenosine tetraphosphate + ADP
106% activity compared to P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
ADP + p4A
-
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
ADP + p4A
-
arsenate can replace phosphate
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
ADP + p4A
-
i.e. AP5A
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
ADP + p4A
-
arsenate can replace phosphate
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
ADP + p4A
-
i.e. AP5A
-
?
P1,P5-bis(5'-adenosyl)pentaphosphate + phosphate
?
wild-type, 106% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 290%, respectively
-
-
?
P1,P5-bis(5'-adenosyl)pentaphosphate + phosphate
?
wild-type, 106% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 290%, respectively
-
-
?
P1,P5-bis(5'-guanosyl) pentaphosphate + phosphate
p4G + GDP
55% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major products
-
?
P1,P5-bis(5'-guanosyl) pentaphosphate + phosphate
p4G + GDP
49% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major products
-
?
P1,P6-bis(5'-adenosyl)hexaphosphate + phosphate
?
wild-type, 25% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, very poor substrate for mutant A149Del, respectively
-
-
?
P1,P6-bis(5'-adenosyl)hexaphosphate + phosphate
?
wild-type, 25% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, very poor substrate for mutant A149Del, respectively
-
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
ATP + GDP
93% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
or ADP plus GTP, major products
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
ATP + GDP
93% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
or ADP plus GTP, major products
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
ATP + GDP
100% activity compared to P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
ATP + GDP
wild-type, 100% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 67%, respectively
-
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
ATP + GDP
wild-type, 100% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 67%, respectively
-
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
ATP + GDP
80% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
or ADP plus GTP, major products
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
ATP + GDP
80% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
or ADP plus GTP, major products
-
?
additional information
?
-
-
enzyme splits the anhydride bond between the alpha and beta phosphates by phosphorolysis
-
-
?
additional information
?
-
-
no activity with P1,P3-bis(5'-adenosyl) triphosphate with CH2-bridge between P1and P2 and between P3 and P4, i.e. ApCH2pCH2pA
-
-
?
additional information
?
-
-
P1,P6-bis(5'-adenosyl) hexaphosphate is a very poor substrate
-
-
?
additional information
?
-
the enzyme shows no hydrolysis of AMP-NH2, and almost no activity with adenosine tetraphosphate, ATP, ADP-ribose, ADP-glucose, guanosine tetraphosphate, guanosine 5'-triphosphate, GDP-glucose, GDP-mannose, adenylyl imidodiphosphate, and guanylyl imidodiphosphate
-
-
?
additional information
?
-
the enzyme shows no hydrolysis of AMP-NH2, and almost no activity with adenosine tetraphosphate, ATP, ADP-ribose, ADP-glucose, guanosine tetraphosphate, guanosine 5'-triphosphate, GDP-glucose, GDP-mannose, adenylyl imidodiphosphate, and guanylyl imidodiphosphate
-
-
?
additional information
?
-
-
the enzyme shows no hydrolysis of AMP-NH2, and almost no activity with adenosine tetraphosphate, ATP, ADP-ribose, ADP-glucose, guanosine tetraphosphate, guanosine 5'-triphosphate, GDP-glucose, GDP-mannose, adenylyl imidodiphosphate, and guanylyl imidodiphosphate
-
-
?
additional information
?
-
-
no substrates are phosphonate analogs of Ap4A
-
-
?
additional information
?
-
-
no substrates are 3'-adenosyltetraphosphate, poly(A), 3',5'-cAMP, NADP+, P1-bis(5'-adenosyl) monophosphate Ap2A, thymidine 5'-monophosphate-p-nitrophenylester
-
-
?
additional information
?
-
-
no substrates are AMP, p-nitrophenylthymidine 5'-triphosphate, bis-p-nitrophenyl phosphate
-
-
?
