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2.7.7.48: RNA-directed RNA polymerase

This is an abbreviated version!
For detailed information about RNA-directed RNA polymerase, go to the full flat file.

Word Map on EC 2.7.7.48

Reaction

nucleoside triphosphate
+
RNAn
=
diphosphate
 +
RNAn+1

Synonyms

111 kDa protein, 180 kDa protein, 182 kDa protein, 183 kDa protein, 186 kDa protein, 216.5 kDa protein, 2A protein, 3CD protein, 3D pol, 3D polymerase, 3Dpol, 3Dpol-like protein, 3P complex, 69.6 kDa protein, core protein, core protein VP1, CVB3 RdRp, D-elp1, DENV 3 polymerase, DENV 3 RdRp, DENV RdRp, ego-1, ego-11, FluPol, FMDV 3D, GhRdRP, HC-J4 NS5BDELTA21, HCN NS5B protein, HCV NS5B, HCV NS5B polymerase, HCV RdRp, hepatitis C virus polymerase, HRV16 3Dpol, influenza polymerase PA, inner layer protein VP1, JEV NS5, JEV NS5 protein, JEV RdRp, jRdRp, L protein, L/P RdRP, large structural protein, M1 phosphoprotein, MOP1, More, NgRDR1, NIB, nonstructural phosphoprotein, nonstructural protein, nonstructural protein 12, nonstructural protein 5B, NS5, NS5 polymerase, NS5 protein, NS5 RdRp, NS5B, NS5B enzyme, NS5B polymerase, NS5B protein, NS5B RdRp, NS5B RNA-dependent RNA polymerase, NS5b-directed RNA polymerase, NS7, nsp12, nsp4, nucleocapsid phosphoprotein, nucleotidyltransferase, ribonucleate, RNA-dependent, ORF1, ORF1A, ORF1B, OsRDR6, P protein, P180, P3D, P66, P70, P88 protein, p92, PB1, PB1 proteins, PB2, PB2 proteins, Phage f2 replicase, phi6, phi6 polymerase, picornaviral 3D polymerase, plant-encoded RNA-dependent RNA polymerase 1, Pol, Pol IV, polymerase 3Dpol, polymerase acidic protein, polymerase basic 1 protein, polymerase L, protein 3Dpol, proteins PB1, proteins, PB 2, proteins, specific or class, lambda3, of reovirus, proteins, specific or class, PB 1, proteins, specific or class, PB 2, Q-beta replicase, Qbeta replicase, Qbeta-replicase, RDR, RDR1, RDR1a, RDR1b, RDR1c, RDR1c2, RDR2, RDR6, RDRP, replicase, phage f2, replicase, Qbeta, ribonucleic acid replicase, ribonucleic acid-dependent ribonucleate nucleotidyltransferase, ribonucleic acid-dependent ribonucleic acid polymerase, ribonucleic replicase, ribonucleic synthetase, RNA dependent RNA polymerase, RNA nucleotidyltransferase (RNA-directed), RNA polymerase, RNA polymerase IV, RNA replicase, RNA synthetase, RNA transcriptase, RNA-binding protein, RNA-dependent ribonucleate nucleotidyltransferase, RNA-dependent RNA polymerase, RNA-dependent RNA polymerase 1, RNA-Dependent RNA Polymerase 2, RNA-dependent RNA polymerase 6, RNA-dependent RNA polymerase NIb, RNA-dependent RNA polymerase NS5B, RNA-dependent RNA polymerases, RNA-dependent RNA replicase, RNA-dependent RNA-polymerase, RNA-directed RNA polymerase, RNA-directed RNA polymerase L, RNAdependent RNA polymerase, rrf-1, RRF-3, RrpC, RSV RdRp, SARS-CoV-2 RdRp, SARS-CoV-2 RNA polymerase, SARSCoV-2 polymerase, SARSCoV-2-core polymerase complex, self-priming RdRp, sigma NS protein, transcriptase, VP1, VP1 protein, WNV NS5

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.48 RNA-directed RNA polymerase

Expression

Expression on EC 2.7.7.48 - RNA-directed RNA polymerase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
ectopic application of salicylic acid induces the expression of cucumber RDR1b gene
ectopic application of salicylic acid induces the expression of cucumber RDRc1/c2 genes
ectopic application of salicylic acid induces the expression of RDR1a
large-scale mutagenesis of the RdRp domain of Lassa virus L protein, overview. Mutation of two adjacent residues in the putative palm-thumb subdomain junction, G1394 and D1395, by PCR-based mutagenesis in strain AV, lead to a defect in mRNA synthesis but do not affect antigenomic RNA synthesis. Clear dominant-negative effects are only seen with mutants affecting residues in motifs pre-A with K1127, R1134, E1135, L1136, D1140, and K1144, A with D1193, B with G1298, C with S1333, D1334, and D1335, and D with K1376, overview
-
RDR1 expression is elevated following plant treatment with defensive phytohormones, StRDR1 is salicylic acid-responsive
the expression of all CsRDR1 genes is induced by virus infection
the expression of all CsRDR1 genes is induced by virus infection, after which the expression level of CsRDR1b increases 10-20fold in several virus-resistant cucumber cultivars
the expression of all CsRDR1 genes is induced by virus infection. CsRDR1c1/c2 genes are highly induced (25-1300fold) in susceptible cucumber cultivars infected with RNA or DNA viruses
the isoform RDR1 promoter has a broad-spectrum response to various stresses and is sensitive to 1-naphthaleneacetic acid, abscisic acid, and salicylic acid
tobacco mosaic virus inoculation onto Solanum lycopersicum leaves induces an increase in SlRDR1 gene expression in the upper uninoculated leaves. Expression of alternative oxidase SlAOX1a is more rapidly induced. Application of an exogenous AOX activator on empty vector-silenced control plants greatly induces the accumulation of SlRDR1 and SlAOX1a transcript and reduces tobacco mosaic virus viral RNA accumulation, but failed to have such effects on SlRDR1-silenced plants
transcripts of NgRDR1 can be induced by biotic stresses, such as exogenous signaling molecules including salicylic acid and analogues, hydrogen peroxide, and methyl jasmonate. NgRDR1 expression can be up-regulated by potato virus Y, tobacco mosaic virus, and cucumber mosaic virus, but not by potato virus X. Besides, different kinds of fungi can also induce NgRDR1 expression, expression profiles of NgRDR1 under abiotic stresses, overview