2.7.7.46: gentamicin 2''-nucleotidyltransferase

This is an abbreviated version!
For detailed information about gentamicin 2''-nucleotidyltransferase, go to the full flat file.

Reaction

Synonyms

AAD 2'', aadB, aadB(ant2')Ia, aminoglycoside adenyltransferase 2''-Ia, aminoglycoside adenylyltransferase, aminoglycoside nucleotidyltransferase 2''-I, ANT(2'')-I, ANT(2'')-Ia, ANT2'', gentamicin 2''-adenylyltransferase, gentamicin nucleotidyltransferase

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.7 Nucleotidyltransferases

                2.7.7.46 gentamicin 2''-nucleotidyltransferase

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Results	in table
11	AA Sequence
4	Application
1	CAS Registry Number
2	Cloned(Commentary)
2	Expression
1	General Stability
14	Inhibitors
10	Ki Value [mM]
13	KM Value [mM]
2	Localization
6	Metals/Ions
2	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
16	Organism
3	PDB ID
2	pH Optimum
2	pH Range
2	pI Value
3	Protein Variants
4	Purification (Commentary)
2	Reaction
1	Reaction Type
14	Reference
2	Specific Activity [micromol/min/mg]
1	Storage Stability
45	Substrates and Products (Substrate)
2	Subunits
18	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 2.7.7.46 - gentamicin 2''-nucleotidyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

adenosine 5'-mono-O-phosphorothiolate + tobramycin

diphosphate + 2''-(adenosine-5'-thiophosphoryl)-tobramycin

Escherichia coli

-

-

645291

-

-

r

ATP + dibekacin

diphosphate + 2''-adenylyldibekacin

Pseudomonas aeruginosa

-

-

637300

-

-

r

ATP + dideoxykanamycin B

diphosphate + 3',4'-dideoxykanamycin B-2''-adenylate

4 entries

ATP + gentamicin

diphosphate + 2''-adenylylgentamicin

3 entries

ATP + gentamicin A

diphosphate + 2''-adenylylgentamicin A

3 entries

ATP + gentamicin C1

diphosphate + 2''-adenylylgentamicin C1

3 entries

ATP + gentamicin C1a

diphosphate + 2''-adenylylgentamicin C1a

2 entries

ATP + gentamicin C2

diphosphate + 2''-adenylylgentamicin C2

Pseudomonas aeruginosa

-

gentamicin A, C1, C1a, or C2 can act as acceptors, dATP, CTP, ITP or GTP can act as donors

637300

-

-

?

ATP + kanamycin A

diphosphate + 2''-adenylylkanamycin A

3 entries

ATP + kanamycin B

diphosphate + 2''-adenylylkanamycin B

Klebsiella pneumoniae

P0AE05

-

762337

-

-

?

ATP + neomycin C

diphosphate + 2''-adenylylneomycin C

2 entries

ATP + netilmicin C

diphosphate + 2''-adenylylnetilmicin C

Escherichia coli

-

-

645290

-

-

r

ATP + sisomicin

diphosphate + 2''-adenylylsisomicin

3 entries

ATP + tobramycin

diphosphate + 2''-(adenosine-5'-phosphoryl)-tobramycin

Escherichia coli

-

-

645291

-

-

r

ATP + tobramycin

diphosphate + 2''-adenylyltobramycin

3 entries

ATP + tobramycin A

diphosphate + 2''-adenylyltobramycin

Klebsiella pneumoniae

P0AE05

-

762337

-

-

?

CTP + tobramycin

diphosphate + 2''-cytosylyltobramycin

Escherichia coli

-

-

645286

-

-

r

dATP + tobramycin

diphosphate + 2''-deoxyadenylyltobramycin

Escherichia coli

-

-

645286

-

-

r

dCTP + tobramycin

diphosphate + 2''-deoxycytosylyltobramycin

Escherichia coli

-

-

645286

-

-

r

dGTP + tobramycin

diphosphate + 2''-deoxyguanosylyltobramycin

Escherichia coli

-

-

645286

-

-

r

dTTP + tobramycin

diphosphate + 2''-deoxythymidylyltobramycin

Escherichia coli

-

-

645286

-

-

r

GTP + tobramycin

diphosphate + 2''-guanosylyltobramycin

Escherichia coli

-

-

645286

-

-

r

nucleoside triphosphate + gentamicin

diphosphate + 2''-nucleotidylgentamicin

2 entries

additional information

?

-

Pseudomonas aeruginosa

-

amikacin, neomycin, lividomycin and butirosin A and B are no substrates

637300

-

-

?

ATP + dideoxykanamycin B

diphosphate + 3',4'-dideoxykanamycin B-2''-adenylate

Escherichia coli

-

adenylates the 2-hydroxyl group of the 3-amino-3-deoxy-D-glucose moiety

645287

3',4'-dideoxykanamycin B-2''-adenylate

645287

r

ATP + dideoxykanamycin B

diphosphate + 3',4'-dideoxykanamycin B-2''-adenylate

Escherichia coli

-

adenylates the 2-hydroxyl group of the 3-amino-3-deoxy-D-glucose moiety

645288

3',4'-dideoxykanamycin B-2''-adenylate

645288

r

ATP + dideoxykanamycin B

diphosphate + 3',4'-dideoxykanamycin B-2''-adenylate

Escherichia coli JR66/W677

-

adenylates the 2-hydroxyl group of the 3-amino-3-deoxy-D-glucose moiety

645287

3',4'-dideoxykanamycin B-2''-adenylate

645287

r

ATP + dideoxykanamycin B

diphosphate + 3',4'-dideoxykanamycin B-2''-adenylate

Escherichia coli JR66/W677

-

adenylates the 2-hydroxyl group of the 3-amino-3-deoxy-D-glucose moiety

645288

3',4'-dideoxykanamycin B-2''-adenylate

645288

r

ATP + gentamicin

diphosphate + 2''-adenylylgentamicin

Acinetobacter baumannii

B0VCJ4

-

761963

-

-

?

ATP + gentamicin

diphosphate + 2''-adenylylgentamicin

Acinetobacter baumannii AB5075

B0VCJ4

-

761963

-

-

?

ATP + gentamicin

diphosphate + 2''-adenylylgentamicin

Klebsiella pneumoniae

P0AE05

-

762337

-

-

?

ATP + gentamicin A

diphosphate + 2''-adenylylgentamicin A

Escherichia coli

-

gentamicin A, C1 and C1a, MgATP2-, MgdATP2- and MgdGTP2- can act as donors

645289

-

-

r

ATP + gentamicin A

diphosphate + 2''-adenylylgentamicin A

Escherichia coli W677/pMY10

-

gentamicin A, C1 and C1a, MgATP2-, MgdATP2- and MgdGTP2- can act as donors

645289

-

-

r

ATP + gentamicin A

diphosphate + 2''-adenylylgentamicin A

Pseudomonas aeruginosa

-

gentamicin A, C1, C1a, or C2 can act as acceptors, dATP, CTP, ITP or GTP can act as donors

637300

-

637300

r

ATP + gentamicin C1

diphosphate + 2''-adenylylgentamicin C1

Escherichia coli

-

gentamicin A, C1 and C1a, MgATP2-, MgdATP2- and MgdGTP2- can act as donors

645289

-

-

?

ATP + gentamicin C1

diphosphate + 2''-adenylylgentamicin C1

Escherichia coli W677/pMY10

-

gentamicin A, C1 and C1a, MgATP2-, MgdATP2- and MgdGTP2- can act as donors

645289

-

-

?

ATP + gentamicin C1

diphosphate + 2''-adenylylgentamicin C1

Pseudomonas aeruginosa

-

gentamicin A, C1, C1a, or C2 can act as acceptors, dATP, CTP, ITP or GTP can act as donors

637300

-

-

?

ATP + gentamicin C1a

diphosphate + 2''-adenylylgentamicin C1a

Escherichia coli

-

gentamicin A, C1 and C1a, MgATP2-, MgdATP2- and MgdGTP2- can act as donors

645289

-

-

?

ATP + gentamicin C1a

diphosphate + 2''-adenylylgentamicin C1a

Pseudomonas aeruginosa

-

gentamicin A, C1, C1a, or C2 can act as acceptors, dATP, CTP, ITP or GTP can act as donors

637300

-

-

?

ATP + kanamycin A

diphosphate + 2''-adenylylkanamycin A

Escherichia coli

-

-

645291

-

-

r

ATP + kanamycin A

diphosphate + 2''-adenylylkanamycin A

Klebsiella pneumoniae

P0AE05

-

762337

-

-

?

ATP + kanamycin A

diphosphate + 2''-adenylylkanamycin A

Pseudomonas aeruginosa

-

poor substrate

637300

-

-

r

ATP + neomycin C

diphosphate + 2''-adenylylneomycin C

Escherichia coli

-

-

645289

-

-

r

ATP + neomycin C

diphosphate + 2''-adenylylneomycin C

Escherichia coli W677/pMY10

-

-

645289

-

-

r

ATP + sisomicin

diphosphate + 2''-adenylylsisomicin

Escherichia coli

-

-

645289, 645290

-

-

r

ATP + sisomicin

diphosphate + 2''-adenylylsisomicin

Escherichia coli W677/pMY10

-

-

645289

-

-

r

ATP + sisomicin

diphosphate + 2''-adenylylsisomicin

Pseudomonas aeruginosa

-

-

637300

-

-

r

ATP + tobramycin

diphosphate + 2''-adenylyltobramycin

Escherichia coli

-

-

645286, 645289, 645291

-

-

r

ATP + tobramycin

diphosphate + 2''-adenylyltobramycin

Escherichia coli W677/pMY10

-

-

645289

-

-

r

ATP + tobramycin

diphosphate + 2''-adenylyltobramycin

Pseudomonas aeruginosa

-

poor substrate

637300

-

-

r

nucleoside triphosphate + gentamicin

diphosphate + 2''-nucleotidylgentamicin

Acinetobacter baumannii

B0VCJ4

-

761963

-

-

?

nucleoside triphosphate + gentamicin

diphosphate + 2''-nucleotidylgentamicin

Acinetobacter baumannii AB5075

B0VCJ4

-

761963

-

-

?