2.7.7.45: guanosine-triphosphate guanylyltransferase
This is an abbreviated version!
For detailed information about guanosine-triphosphate guanylyltransferase, go to the full flat file.
Reaction
Synonyms
diguanosine tetraphosphate synthetase, Gp4G synthetase, GTP-GTP guanylyltransferase, guanosine triphosphate-guanose triphosphate guanylyltransferase, guanylyltransferase, guanosine triphosphate, More, synthetase, diguanosine tetraphosphate
ECTree
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Reaction
Reaction on EC 2.7.7.45 - guanosine-triphosphate guanylyltransferase
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2 GTP = diphosphate + P1,P4-bis(5'-guanosyl) tetraphosphate
ping-pong kinetics with a covalent enzyme-guanylate intermediate containing a phosphoramidate linkage, probably phospholysine
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2 GTP = diphosphate + P1,P4-bis(5'-guanosyl) tetraphosphate
the alpha-phosphorus group of the GMP of the covalent reaction intermediate is linked via the Nepsilon2 ring nitrogen of a histidine residue of the enzyme
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