2.7.7.41: phosphatidate cytidylyltransferase
This is an abbreviated version!
For detailed information about phosphatidate cytidylyltransferase, go to the full flat file.
Word Map on EC 2.7.7.41
-
2.7.7.41
-
phospholipid
-
phosphatidylinositol
-
phosphatidylglycerol
-
cardiolipin
-
cds1
-
liponucleotide
-
raetz
-
phosphatidyltransferase
-
diphosphate-diacylglycerol
- 2.7.7.41
- phospholipid
- phosphatidylinositol
- phosphatidylglycerol
- cardiolipin
- cds1
- liponucleotide
-
raetz
-
phosphatidyltransferase
-
diphosphate-diacylglycerol
Reaction
Synonyms
CarS, CDP diacylglycerol synthase, CDP-DAG synthase, CDP-DG, CDP-DG synthase, CDP-DG synthetase, CDP-diacylglyceride synthetase, CDP-diacylglycerol synthase, CDP-diacylglycerol synthetase, CDP-diglyceride pyrophosphorylase, CDP-diglyceride synthetase, CDPdiglyceride pyrophosphorylase, CDS, CDS1, CDS2, CDS3, Cds4, Cds5, CdsA, CTP-diacylglycerol synthetase, CTP:1,2-diacylglycerophosphate-cytidyl transferase, CTP:phosphatidate cytidylyltransferase, cytidine 5'-diphosphate diacylglycerol synthase, cytidine diphosphoglyceride pyrophosphorylase, cytidinediphosphate diacylglycerol synthase, cytidylyltransferase, phosphatidate, DAG synthetase, More, phosphatidate cytidyltransferase, phosphatidate cytidyltransferase 2, phosphatidic acid cytidylyltransferase, SJAG_00426, Tam41, TAMM41, Tb927.7.220, TbCDS, YnbD
ECTree
2.7.7.41 phosphatidate cytidylyltransferaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.7.7.41 - phosphatidate cytidylyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CTP + 1,2-diarachidonoyl phosphatidic acid
diphosphate + CDP-1,2-diarachidonoylglycerol
-
-
-
-
?
CTP + 1,2-diarachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-diarachidonoylglycerol
CTP + 1,2-dicaproyl phosphatidic acid
diphosphate + CDP-1,2-dicaproylglycerol
-
-
-
-
?
CTP + 1,2-dioleoyl-sn-glycerol 3-phosphate
diphosphate + CDP-1,2-dioleoylglycerol
-
-
-
?
CTP + 1,2-diolinoleoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-diolinoleoylglycerol
-
-
-
?
CTP + 1,2-distearoyl phosphatidic acid
diphosphate + CDP-1,2-distearoylglycerol
-
-
-
-
?
CTP + 1-arachidonoyl-2-stearoyl phosphatidic acid
diphosphate + CDP-1-arachidonoyl-2-stearoylglycerol
-
-
-
-
?
CTP + 1-oleoyl-2-palmitoyl phosphatidic acid
diphosphate + CDP-1-oleoyl-2-palmitoylglycerol
-
reaction with 1-oleoyl-2-palmitoyl phosphatidic acid at 83.4% of the activity with phosphatidic acid from egg phosphatidylcholine
-
-
?
CTP + 1-oleoyl-2-stearoyl phosphatidic acid
diphosphate + CDP-1-oleoyl-2-stearoylglycerol
-
-
-
-
?
CTP + 1-palmitoyl-2-arachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1-palmitoyl-2-arachidonoylglycerol
CTP + 1-palmitoyl-2-oleoyl phosphatidic acid
diphosphate + CDP-1-palmitoyl-2-oleoylglycerol
CTP + 1-palmitoyl-2-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sn-glycero-3-phosphate
diphosphate + CDP-1-palmitoyl-2-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]glycerol
i.e. commercial substrate NBD-PA
-
-
?
CTP + 1-stearoyl-2-arachidonoyl phosphatidic acid
diphosphate + CDP-1-stearoyl-2-arachidonoylglycerol
CTP + 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-arachidonoyl-glycerol
-
-
-
?
CTP + 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-arachidonoylglycerol
-
-
-
?
CTP + 1-stearoyl-2-docosahexaenoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-docosahexaenoylglycerol
-
-
-
?
CTP + 1-stearoyl-2-linoleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-linoleoyl-glycerol
-
-
-
?
CTP + 1-stearoyl-2-linoleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-linoleoylglycerol
CTP + 1-stearoyl-2-oleoyl phosphatidic acid
diphosphate + CDP-1-stearoyl-2-oleoylglycerol
-
-
-
-
?
CTP + 1-stearoyl-2-oleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-oleoylglycerol
CTP + 1,2-diarachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-diarachidonoylglycerol
-
-
-
?
CTP + 1,2-diarachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-diarachidonoylglycerol
50% of the activity with 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
CTP + 1,2-dilinoleoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-dilinoleoylglycerol
-
-
-
?
CTP + 1,2-dilinoleoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-dilinoleoylglycerol
20% of the activity with 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
CTP + 1,2-dioleoyl phosphatidic acid
diphosphate + CDP-dioleoylglycerol
-
-
-
?
CTP + 1,2-dioleoyl phosphatidic acid
diphosphate + CDP-dioleoylglycerol
-
reaction with 1-oleoyl-2-palmitoyl-phosphatidic acid at 87.5% of the activity with phosphatidic acid from egg phosphatidylcholine
-
-
?
CTP + 1,2-dioleoyl phosphatidic acid
diphosphate + CDP-dioleoylglycerol
-
-
-
-
?
CTP + 1,2-dioleoyl-sn-glycero-3-phosphate
diphosphate + CDP-1,2-dioleoylglycerol
-
-
-
?
CTP + 1,2-dioleoyl-sn-glycero-3-phosphate
diphosphate + CDP-1,2-dioleoylglycerol
-
-
-
?
CTP + 1,2-dioleoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-dioleoylglycerol
-
-
-
?
CTP + 1,2-dioleoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-dioleoylglycerol
less than 5% of the activity with 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
CTP + 1,2-dipalmitoyl phosphatidic acid
diphosphate + CDP-dipalmitoylglycerol
best substrate
-
-
?
CTP + 1,2-dipalmitoyl phosphatidic acid
diphosphate + CDP-dipalmitoylglycerol
-
-
-
-
?
CTP + 1,2-dipalmitoyl phosphatidic acid
diphosphate + CDP-dipalmitoylglycerol
-
reaction with 1-oleoyl-2-palmitoyl phosphatidic acid at 4.6% of the activity with phosphatidic acid from egg phosphatidylcholine
-
-
?
CTP + 1,2-dipalmitoyl phosphatidic acid
diphosphate + CDP-dipalmitoylglycerol
-
-
-
-
?
CTP + 1-palmitoyl-2-arachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1-palmitoyl-2-arachidonoylglycerol
-
-
-
?
CTP + 1-palmitoyl-2-arachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1-palmitoyl-2-arachidonoylglycerol
65% of the activity with 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
CTP + 1-palmitoyl-2-oleoyl phosphatidic acid
diphosphate + CDP-1-palmitoyl-2-oleoylglycerol
best substrate
-
-
?
CTP + 1-palmitoyl-2-oleoyl phosphatidic acid
diphosphate + CDP-1-palmitoyl-2-oleoylglycerol
-
reaction with 1-oleoyl-2-palmitoyl phosphatidic acid at 99.7% of the activity with phosphatidic acid from egg phosphatidylcholine
-
-
?
CTP + 1-palmitoyl-2-oleoyl phosphatidic acid
diphosphate + CDP-1-palmitoyl-2-oleoylglycerol
-
-
-
-
?
CTP + 1-stearoyl-2-arachidonoyl phosphatidic acid
diphosphate + CDP-1-stearoyl-2-arachidonoylglycerol
-
-
-
-
?
CTP + 1-stearoyl-2-arachidonoyl phosphatidic acid
diphosphate + CDP-1-stearoyl-2-arachidonoylglycerol
-
-
-
?
CTP + 1-stearoyl-2-linoleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-linoleoylglycerol
-
-
-
?
CTP + 1-stearoyl-2-linoleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-linoleoylglycerol
20% of the activity with 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
CTP + 1-stearoyl-2-oleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-oleoylglycerol
-
-
-
?
CTP + 1-stearoyl-2-oleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-oleoylglycerol
20% of the activity with 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
involved in phospholipid synthesis
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
Bacillus subtilis Marburg / DSM 10 / ATCC 6051
-
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
Bacillus subtilis Marburg / DSM 10 / ATCC 6051
-
involved in phospholipid synthesis
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
isozyme CDS1 shows no particular substrate specificity, displaying similar activities for almost all substrates tested
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
isozyme CDS2 is selective for the acyl chains at the sn-1 and sn-2 positions, the most preferred species being 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
involved in the de novo biosynthesis of cardiolipin
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
involved in the synthesis of phospholipids and of phosphatidylinositol 4,5-diphosphate, which plays an important role in phosphoinositide-mediated signallng pathways
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
involved in the de novo biosynthesis of cardiolipin
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
NBD-phosphatidate
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
r
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
r
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927
-
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
phosphatidic acid from egg lecithin and 1-stearoyl 2-arachidonoyl phosphatidic acid are preferred substrates for the microsomal enzyme
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
Drosophila sp. (in: flies)
-
-
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
Drosophila sp. (in: flies)
-
the enzyme is required for the regeneration of the signalling molecule phosphatidylinositol-4,5-diphosphate from phosphatidic acid. A photoreceptor cell-specific isoform is a key regulator of phototransduction, a G-protein-coupled signalling cascade mediated by phospholipase C
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
Drosophila sp. (in: flies)
-
the enzyme plays a regulatory role in phototransduction by ensuring an adequate supply of phosphatidylinositol-4,5-diphosphate
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
the enzyme is specific for long-chain phosphatidic acid. 1-Acyl-sn-glycero-3-phosphate is not a substrate and phosphatidic acids with acyl chains shorter than 16 carbons are poor substrates
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
high activity with phosphatidic acid from egg phosphatidylcholine
-
-
r
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
strong preference for phosphatidic acid with 16-carbon and 18-carbon length fatty acids and at least one unsaturated fatty acid
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
equilibrium constant is 0.22
-
-
r
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
the enzyme is involved in the regulation of phospholipid metabolism
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
the activity is essential for all phospholipid biosynthesis in Escherichia coli
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
the enzyme produces key intermediates in phospholipid biosynthesis
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
didecanoyl phosphatidic acid is the most active of the synthetic phosphatidic acids tested, lysophosphatidic acid is a poor substrate
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
the level of CDP-diacylglycerol synthetase 1 is not a critical determinant of cellular phosphatidylinositol content. This argues against a determining role of the activity in the regulation of phosphatidylinositol biosynthesis
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
Micrococcus cerificans
-
highly specific for CTP
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
Micrococcus cerificans
-
enzyme is involved in synthesis of CDP-diglyceride, which plays a primary role in bacterial biosyntheses of essential phosphoglycerides
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
the enzyme catalyzes the synthesis of CDPdiacylglycerol, an obligatory intermediate compound in the biosynthesis of the major anionic and zwitterionic phospholipids
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
-
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
reaction with 1,2-dioleoylphosphatidic acid. Varying the fatty acid composition in the phosphatidic acids added exogenously gives the following order of decreasing activity: 1-stearoyl-2-oleoylphosphatidic acid, 1-oleoyl-2-stearoylphosphatidic acid, 1,2-dioleoylphosphatidic acid, 1-palmitoyl-2-oleoylphosphatidic acid, 1-stearoyl-2-arachidonoylphosphatidic acid, 1-arachidonoyl-2-stearoylphosphatidic acid, 1,2-diarachidonoylphosphatidic acid, 1,2-dicaproylphosphatidic acid, 1,2-dipalmitoylphosphatidic acid, 1,2-distearoylphosphatidic acid
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
the enzyme prefers 1-stearoyl-2-arachidonoyl phosphatidic acid as substrate. Little or no activity is detected towards phosphatidic acids containing saturated fatty acyl groups in both the sn-1 and sn-2 positions
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
the enzyme shows a linear increase in activity with membrane-bound phosphatidate concentrations up to at least 100 nmol phosphatidate per mg of microsomal protein. The enzyme has a large reserve capacity and suggests that the enzyme is operating intracellularly, i.e. at phosphatidate concentrations of 5-10 mM/mg endoplasmic reticulum protein, far below the maximal capacity. The ratio of phosphatidate conversion into CDP diglyceride and 1,2-diglyceride seems to be constant for a large range of membrane-bounmd phosphatidate concentrations. The membrane-bound enzyme cannot utilize phosphatidate substrate present in heat denatured membranes, but is active on phosphatidate incorporated into membranes of phospholipid vesicles
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
enzyme plays a central role in phospholipid biosynthesis
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
-
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
equilibrium constant is 0.001. Reverse reaction is favored in vitro
-
-
r
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
the enzyme is involved in the regulation of phospholipid metabolism
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
regulation of phospholipid biosynthetic enzymes by the level of CDP-diacylglycerol synthase activity
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
activity with phosphatidate obtained from egg lecithin which has a variety of mixed fatty acid in ester linkage. The phosphatidate has two oleoyl fatty acids is only 20% as effective as the phospatidate prepared from egg lecithin
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
-
-
?
dCTP + phosphatidate
diphosphate + dCDPdiacylglycerol
-
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
-
-
?
dCTP + phosphatidate
diphosphate + dCDPdiacylglycerol
-
reaction at the same rate as CTP
-
-
?
dCTP + phosphatidate
diphosphate + dCDPdiacylglycerol
-
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
-
-
?
dCTP + phosphatidate
diphosphate + dCDPdiacylglycerol
-
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
-
-
?
dCTP + phosphatidate
diphosphate + dCDPdiacylglycerol
Micrococcus cerificans
-
50% of the activity with CTP
-
-
?
dCTP + phosphatidate
diphosphate + dCDPdiacylglycerol
-
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
-
-
?
dCTP + phosphatidate
diphosphate + dCDPdiacylglycerol
-
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
-
-
?
diphosphate + CDP-diacylglycerol
CTP + phosphatidate
-
-
-
r
diphosphate + CDP-diacylglycerol
CTP + phosphatidate
-
-
-
r
additional information
?
-
decreasing activity in the order 1,2-dioleoyl phosphatidic acid, 1-palmitoyl-2-oleoyl phosphatidic acid, 1,2-dipalmitoyl phosphatidic acid
-
-
?
additional information
?
-
decreasing activity in the order 1,2-dioleoyl phosphatidic acid, 1-palmitoyl-2-oleoyl phosphatidic acid, 1,2-dipalmitoyl phosphatidic acid
-
-
?
additional information
?
-
decreasing activity in the order 1,2-dioleoyl phosphatidic acid, 1-palmitoyl-2-oleoyl phosphatidic acid, 1,2-dipalmitoyl phosphatidic acid
-
-
?
additional information
?
-
-
decreasing activity in the order 1,2-dioleoyl phosphatidic acid, 1-palmitoyl-2-oleoyl phosphatidic acid, 1,2-dipalmitoyl phosphatidic acid
-
-
?
additional information
?
-
the extraplastidial isoforms are most active with the 18:1/18:1 species of phosphatidates and their activities decreases in the order of 16:0/18:1 phosphatidate to 16:0/16:0 phosphatidate
-
-
?
additional information
?
-
the extraplastidial isoforms are most active with the 18:1/18:1 species of phosphatidates and their activities decreases in the order of 16:0/18:1 phosphatidate to 16:0/16:0 phosphatidate
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additional information
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the extraplastidial isoforms are most active with the 18:1/18:1 species of phosphatidates and their activities decreases in the order of 16:0/18:1 phosphatidate to 16:0/16:0 phosphatidate
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?
additional information
?
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the extraplastidial isoforms are most active with the 18:1/18:1 species of phosphatidates and their activities decreases in the order of 16:0/18:1 phosphatidate to 16:0/16:0 phosphatidate
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?
additional information
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CDS2 shows substrate specificity at both the sn-1 and sn-2 acyl chain positions. The most preferred substrate is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
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additional information
?
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CDS2 shows substrate specificity at both the sn-1 and sn-2 acyl chain positions. The most preferred substrate is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
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?
additional information
?
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CDS2 shows substrate specificity at both the sn-1 and sn-2 acyl chain positions. The most preferred substrate is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
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?
additional information
?
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isoform CDS1 appears to have no substrate preference for 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid, with variations of the sn-1 and sn-2 acyl chains resulting in no significant changes in preference
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?
additional information
?
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isoform CDS1 appears to have no substrate preference for 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid, with variations of the sn-1 and sn-2 acyl chains resulting in no significant changes in preference
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?
additional information
?
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isoform CDS1 appears to have no substrate preference for 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid, with variations of the sn-1 and sn-2 acyl chains resulting in no significant changes in preference
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?
additional information
?
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mixed micelle-based enzymatic activity with recombinant enzyme. Substrate specificity of CDS1, overview
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?
additional information
?
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mixed micelle-based enzymatic activity with recombinant enzyme. Substrate specificity of CDS1, overview
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?
additional information
?
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mixed micelle-based enzymatic activity with recombinant enzyme. Substrate specificity of CDS1, overview
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?
additional information
?
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mixed micelle-based enzymatic activity with recombinant enzyme. Substrate specificity of CDS2, overview
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?
additional information
?
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mixed micelle-based enzymatic activity with recombinant enzyme. Substrate specificity of CDS2, overview
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?
additional information
?
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mixed micelle-based enzymatic activity with recombinant enzyme. Substrate specificity of CDS2, overview
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?
additional information
?
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the enzyme does not bind phosphatidylserine, phosphatidylethanolamine, or phosphatidylcholine
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additional information
?
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the enzyme does not bind phosphatidylserine, phosphatidylethanolamine, or phosphatidylcholine
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additional information
?
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the enzyme does not bind phosphatidylserine, phosphatidylethanolamine, or phosphatidylcholine
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