2.7.7.41: phosphatidate cytidylyltransferase
This is an abbreviated version!
For detailed information about phosphatidate cytidylyltransferase, go to the full flat file.
Word Map on EC 2.7.7.41
-
2.7.7.41
-
phospholipid
-
phosphatidylinositol
-
phosphatidylglycerol
-
cardiolipin
-
cds1
-
liponucleotide
-
raetz
-
phosphatidyltransferase
-
diphosphate-diacylglycerol
- 2.7.7.41
- phospholipid
- phosphatidylinositol
- phosphatidylglycerol
- cardiolipin
- cds1
- liponucleotide
-
raetz
-
phosphatidyltransferase
-
diphosphate-diacylglycerol
Reaction
Synonyms
CarS, CDP diacylglycerol synthase, CDP-DAG synthase, CDP-DG, CDP-DG synthase, CDP-DG synthetase, CDP-diacylglyceride synthetase, CDP-diacylglycerol synthase, CDP-diacylglycerol synthetase, CDP-diglyceride pyrophosphorylase, CDP-diglyceride synthetase, CDPdiglyceride pyrophosphorylase, CDS, CDS1, CDS2, CDS3, Cds4, Cds5, CdsA, CTP-diacylglycerol synthetase, CTP:1,2-diacylglycerophosphate-cytidyl transferase, CTP:phosphatidate cytidylyltransferase, cytidine 5'-diphosphate diacylglycerol synthase, cytidine diphosphoglyceride pyrophosphorylase, cytidinediphosphate diacylglycerol synthase, cytidylyltransferase, phosphatidate, DAG synthetase, More, phosphatidate cytidyltransferase, phosphatidate cytidyltransferase 2, phosphatidic acid cytidylyltransferase, SJAG_00426, Tam41, TAMM41, Tb927.7.220, TbCDS, YnbD
ECTree
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Reference on EC 2.7.7.41 - phosphatidate cytidylyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
McCaman, R.E.; Finnerty, W.R.
Biosynthesis of cytidine diphosphate-diglyceride by a particulate fraction from Micrococcus cerificans
J. Biol. Chem.
243
5074-5080
1968
Micrococcus cerificans
Lin, C.H.; Lin, J.; Strickland, K.P.
Bovine brain microsomal CDP-diacylglycerol synthetase: solubilization and properties
Biochem. Int.
25
299-306
1991
Bos taurus
Petzold, G.L.; Agranoff, B.W.
The biosynthesis of cytidine diphosphate diglyceride by embryonic chick brain
J. Biol. Chem.
242
1187-1191
1967
Gallus gallus
Sparrow, C.P.
Purification of CDPdiacylglycerol synthase from Escherichia coli
Methods Enzymol.
209
237-242
1992
Escherichia coli
Carman, G.M.; Kelley, M.J.
CDPdiacylglycerol synthase from yeast
Methods Enzymol.
209
242-247
1992
Saccharomyces cerevisiae
Mok, A.Y.P.; McDougall, G.E.; McMurray, W.C.
CDP-diacylglycerol synthesis in rat liver mitochondria
FEBS Lett.
312
236-240
1992
Rattus norvegicus
Carman, G.M.; Zaniewski, R.L.; Cousminer, J.J.
CDP-diacylglycerol synthase activity in Clostridium perfringens
Appl. Environ. Microbiol.
43
81-85
1982
Clostridium perfringens
Liteplo, R.G.; Sribney, M.
The stimulation of rat liver microsomal CTP: phosphatidate cytidylyltransferase activity by guanosine triphosphate
Biochim. Biophys. Acta
619
660-668
1980
Rattus norvegicus
Sribney, M.; Dove, J.L.; Lyman, E.M.
Studies on the synthesis of CDP-diacylglycerol: stimulation by GTP and inhibition by ATP and fluoride
Biochim. Biophys. Acta
79
749-755
1977
Rattus norvegicus
Gaillard, J.L.; Lubochinsky, B.; Rigomier, D.
Specific inhibition of phosphatidate cytidylyltransferase from Bacillus subtilis membranes by cytidine monophosphate
Biochim. Biophys. Acta
753
372-380
1983
Bacillus subtilis
Hanenberg, A.; Heim, S.; Wissing, J.B.; Wagner, K.G.
Characterization of cytidine triphosphate:phosphatidate cytidyltransferase from suspension cultured Catharanthus roseus cells
Plant Sci.
88
13-18
1993
Catharanthus roseus
-
Sparrow, C.P.; Raetz, C.R.H.
Purification and properties of the membrane-bound CDP-diglyceride synthetase from Escherichia coli
J. Biol. Chem.
260
12084-12091
1985
Escherichia coli
Kelley, M.J.; Carman, G.M.
Purification and characterization of CDP-diacylglycerol synthase from Saccharomyces cerevisiae
J. Biol. Chem.
262
14563-14570
1987
Saccharomyces cerevisiae
Belendiuk, G.; Mangnall, D.; Tung, B.; Westley, J.; Getz, G.S.
CTP-phosphatidic acid cytidyltransferase from Saccharomyces cerevisiae. Partial purification, characterization, and kinetic behavior
J. Biol. Chem.
253
4555-4565
1978
Saccharomyces cerevisiae
Sribney, M.; Hegadorn, C.A.
Biosynthesis of CDP-diacylglycerol in hog mesenteric lymph node lymphocytes
J. Biochem.
60
668-674
1982
Sus scrofa
Bishop, H.H.; Strickland, K.P.
Studies on the formation by rat brain preparations of CDP-diglyceride from CTP and phosphatidic acids of varying fatty acid compositions
Can. J. Biochem.
54
249-260
1976
Rattus norvegicus
Sturton, R.G.; Brindley, D.N.
Factors controlling the activities of phosphatidate phosphohydrolase and phosphatidate cytidylyltransferase. The effects of chlorpromazine, demethylimipramine, cinchocaine, norfenfluramine, mepyramine and magnesium ions
Biochem. J.
162
25-32
1977
Rattus norvegicus
Langley, K.E.; Kennedy, E.P.
Partial purification and properties of CTP:phosphatidic acid cytidylyltransferase from membranes of Escherichia coli
J. Bacteriol.
136
85-95
1978
Escherichia coli
Van Heusden, G.P.H.; Van den Bosch, H.
The influence of exogenous and of membrane-bound phosphatidate concentration on the activity of CTP: phosphatidate cytidylyltransferase and phosphatidate phosphohydrolase
Eur. J. Biochem.
84
405-412
1978
Rattus norvegicus
Wu, L.; Niemeyer, B.; Colley, N.; Socolich, M.; Zuker, C.S.
Regulation of PLC-mediated signaling in vivo by CDP-diacylglycerol synthase
Nature
373
216-222
1995
Drosophila sp. (in: flies)
Weber, C.H.; Park, Y.S.; Sanker, S.; Kent, C.; Ludwig, M.L.
A prototypical cytidylyltransferase: CTP:glycerol-3-phosphate cytidylyltransferase from Bacillus subtilis
Structure Fold. Des.
7
1113-1124
1999
Bacillus subtilis
Weeks, R.; Dowhan, W.; Shen, H.; Balantac, N.; Meengs, B.; Nudelman, E.; Leung, D.W.
Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA
DNA Cell Biol.
16
281-289
1997
Homo sapiens
Heacock, A.M.; Agranoff, B.W.
CDP-diacylglycerol synthase from mammalian tissues
Biochim. Biophys. Acta
1348
166-172
1997
Cavia porcellus, Drosophila sp. (in: flies), Escherichia coli, Homo sapiens, Rattus norvegicus, Sus scrofa
Martin, D.; Gannoun-Zaki, L.; Bonnefoy, S.; Eldin, P.; Wengelnik, K.; Vial, H.
Characterization of Plasmodium falciparum CDP-diacylglycerol synthase, a proteolytically cleaved enzyme
Mol. Biochem. Parasitol.
110
93-105
2000
Plasmodium falciparum (Q9NIH5), Plasmodium falciparum
Dowhan, W.
CDP-diacylglycerol synthase of microorganisms
Biochim. Biophys. Acta
1348
157-165
1997
Saccharomyces cerevisiae, Escherichia coli
Monaco, M.E.; Feldman, M.
Extraction and stabilization of mammalian CDP-diacylglycerol synthase activity
Biochem. Biophys. Res. Commun.
239
166-170
1997
Rattus norvegicus
Lykidis, A.; Jackson, P.; Rock, C.O.; Jackowski, S.
The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content
J. Biol. Chem.
272
33402-33409
1997
Homo sapiens (Q92903), Homo sapiens
Kopka, J.; Ludewig, M.; Mueller-Roeber, B.
Complementary DNAs encoding eukaryotic-type cytidine-5'-diphosphate-diacylglycerol synthases of two plant species
Plant Physiol.
113
997-1002
1997
Arabidopsis thaliana, Solanum tuberosum
Saito, S.; Goto, K.; Tonosaki, A.; Kondo, H.
Gene cloning and characterization of CDP-diacylglycerol synthase from rat brain
J. Biol. Chem.
272
9503-9509
1997
Rattus norvegicus (O35052)
Shen, H.; Heacock, P.N.; Clancey, C.J.; Dowhan, W.
The CDS1 gene encoding CDP-diacylglycerol synthase in Saccharomyces cerevisiae is essential for cell growth
J. Biol. Chem.
271
789-795
1996
Saccharomyces cerevisiae (P38221), Saccharomyces cerevisiae
Shen, H.; Dowhan, W.
Regulation of phospholipid biosynthetic enzymes by the level of CDP-diacylglycerol synthase activity
J. Biol. Chem.
272
11215-11220
1997
Saccharomyces cerevisiae
Nishibori, A.; Kusaka, J.; Hara, H.; Umeda, M.; Matsumoto, K.
Phosphatidylethanolamine domains and localization of phospholipid synthases in Bacillus subtilis membranes
J. Bacteriol.
187
2163-2174
2005
Bacillus subtilis, Bacillus subtilis Marburg / DSM 10 / ATCC 6051
Inglis-Broadgate, S.L.; Ocaka, L.; Banerjee, R.; Gaasenbeek, M.; Chapple, J.P.; Cheetham, M.E.; Clark, B.J.; Hunt, D.M.; Halford, S.
Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2
Gene
356
19-31
2005
Mus musculus (P98191), Mus musculus (Q99L43), Mus musculus
Jiang, Y.J.; Lu, B.; Xu, F.Y.; Gartshore, J.; Taylor, W.A.; Halayko, A.J.; Gonzalez, F.J.; Takasaki, J.; Choy, P.C.; Hatch, G.M.
Stimulation of cardiac cardiolipin biosynthesis by PPARalpha activation
J. Lipid Res.
45
244-252
2004
Mus musculus, Rattus norvegicus
Mercade, A.; Sanchez, A.; Folch, J.M.
Characterization and physical mapping of the porcine CDS1 and CDS2 genes
Anim. Biotechnol.
18
23-35
2007
Sus scrofa
Laczko-Dobos, H.; Ughy, B.; Toth, S.Z.; Komenda, J.; Zsiros, O.; Domonkos, I.; Parducz, A.; Bogos, B.; Komura, M.; Itoh, S.; Gombos, Z.
Role of phosphatidylglycerol in the function and assembly of Photosystem II reaction center, studied in a cdsA-inactivated PAL mutant strain of Synechocystis sp. PCC6803 that lacks phycobilisomes
Biochim. Biophys. Acta
1777
1184-1194
2008
Synechocystis sp.
Shastri, S.; Zeeman, A.M.; Berry, L.; Verburgh, R.J.; Braun-Breton, C.; Thomas, A.W.; Gannoun-Zaki, L.; Kocken, C.H.; Vial, H.J.
Plasmodium CDP-DAG synthase: an atypical gene with an essential N-terminal extension
Int. J. Parasitol.
40
1257-1268
2010
Plasmodium falciparum (Q8ILZ6), Plasmodium falciparum
Waugh, M.G.; Minogue, S.; Clayton, E.L.; Hsuan, J.J.
CDP-diacylglycerol phospholipid synthesis in detergent-soluble, non-raft, membrane microdomains of the endoplasmic reticulum
J. Lipid Res.
52
2148-2158
2011
Homo sapiens
Serricchio, M.; Buetikofer, P.
Phosphatidylglycerophosphate synthase associates with a mitochondrial inner membrane complex and is essential for growth of Trypanosoma brucei
Mol. Microbiol.
87
569-579
2013
Trypanosoma brucei brucei (Q57U32), Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927 (Q57U32)
DSouza, K.; Kim, Y.J.; Balla, T.; Epand, R.M.
Distinct properties of the two isoforms of CDP-diacylglycerol synthase
Biochemistry
53
7358-7367
2014
Homo sapiens (O95674), Homo sapiens (Q92903), Homo sapiens
Tamura, Y.; Harada, Y.; Nishikawa, S.; Yamano, K.; Kamiya, M.; Shiota, T.; Kuroda, T.; Kuge, O.; Sesaki, H.; Imai, K.; Tomii, K.; Endo, T.
Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria
Cell Metab.
17
709-718
2013
Saccharomyces cerevisiae (P38221), Saccharomyces cerevisiae (P53230), Saccharomyces cerevisiae
Qi, Y.; Kapterian, T.S.; Du, X.; Ma, Q.; Fei, W.; Zhang, Y.; Huang, X.; Dawes, I.W.; Yang, H.
CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development
J. Lipid Res.
57
767-780
2016
Homo sapiens (O95674), Homo sapiens (Q92903), Mus musculus (P98191), Mus musculus (Q99L43)
He, Y.; Yam, C.; Pomraning, K.; Chin, J.S.; Yew, J.Y.; Freitag, M.; Oliferenko, S.
Increase in cellular triacylglycerol content and emergence of large ER-associated lipid droplets in the absence of CDP-DG synthase function
Mol. Biol. Cell
25
4083-4095
2014
Schizosaccharomyces japonicus, Schizosaccharomyces japonicus (B6JVL2), Schizosaccharomyces pombe (Q9P381), Schizosaccharomyces pombe, Schizosaccharomyces pombe 972 (Q9P381), Schizosaccharomyces japonicus yFS275 (B6JVL2)
Zhou, Y.; Peisker, H.; Weth, A.; Baumgartner, W.; Doermann, P.; Frentzen, M.
Extraplastidial cytidinediphosphate diacylglycerol synthase activity is required for vegetative development in Arabidopsis thaliana
Plant J.
75
867-879
2013
Arabidopsis thaliana (O04928), Arabidopsis thaliana (O49639), Arabidopsis thaliana (Q1PE48), Arabidopsis thaliana
Liu, Y.; Wang, W.; Shui, G.; Huang, X.
CDP-diacylglycerol synthetase coordinates cell growth and fat storage through phosphatidylinositol metabolism and the insulin pathway
PLoS Genet.
10
e1004172
2014
Drosophila melanogaster, Drosophila melanogaster (P56079)
Lilley, A.C.; Major, L.; Young, S.; Stark, M.J.; Smith, T.K.
The essential roles of cytidine diphosphate-diacylglycerol synthase in bloodstream form Trypanosoma brucei
Mol. Microbiol.
92
453-470
2014
Trypanosoma brucei brucei (Q57U32), Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927 (Q57U32)
Blunsom, N.J.; Gomez-Espinosa, E.; Ashlin, T.G.; Cockcroft, S.
Mitochondrial CDP-diacylglycerol synthase activity is due to the peripheral protein, TAMM41 and not due to the integral membrane protein, CDP-diacylglycerol synthase 1
Biochim. Biophys. Acta Mol. Cell Biol. Lipids
1863
284-298
2018
Rattus norvegicus (D3ZKT0)
Blunsom, N.J.; Cockcroft, S.
CDP-diacylglycerol synthases (CDS) gateway to phosphatidylinositol and cardiolipin synthesis
Front. Cell Dev. Biol.
8
63
2020
Aeropyrum pernix, Saccharomyces cerevisiae, Drosophila melanogaster, Schizosaccharomyces pombe, Streptococcus mitis, Streptococcus oralis, Thermotoga maritima, Toxoplasma gondii, Trypanosoma brucei brucei, Eimeria falciformis, Arabidopsis thaliana (O04928), Arabidopsis thaliana (O49639), Arabidopsis thaliana (Q1PE48), Arabidopsis thaliana (Q94A03), Arabidopsis thaliana (Q9M001), Escherichia coli (P0ABG1), Danio rerio (Q3B7H2), Homo sapiens (Q92903), Homo sapiens (Q95674)
Kong, P.; Ufermann, C.M.; Zimmermann, D.L.M.; Yin, Q.; Suo, X.; Helms, J.B.; Brouwers, J.F.; Gupta, N.
Two phylogenetically and compartmentally distinct CDP-diacylglycerol synthases cooperate for lipid biogenesis in Toxoplasma gondii
J. Biol. Chem.
292
7145-7159
2017
Toxoplasma gondii (A0A191SG65), Toxoplasma gondii (A0A192XRE2), Toxoplasma gondii
Xu, Y.; Mak, H.Y.; Lukmantara, I.; Li, Y.E.; Hoehn, K.L.; Huang, X.; Du, X.; Yang, H.
CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms
J. Biol. Chem.
294
16740-16755
2019
Homo sapiens (O95674), Homo sapiens (Q92903)
Laurinyecz, B.; Peter, M.; Vedelek, V.; Kovacs, A.L.; Juhasz, G.; Maroy, P.; Vigh, L.; Balogh, G.; Sinka, R.
Reduced expression of CDP-DAG synthase changes lipid composition and leads to male sterility in Drosophila
Open Biology
6
50169
2016
Drosophila melanogaster (P56079)
Jiao, H.; Yin, Y.; Liu, Z.
Structures of the mitochondrial CDP-DAG synthase Tam41 suggest a potential lipid substrate pathway from membrane to the active site
Structure
27
1258-1269
2019
Schizosaccharomyces pombe (O74339), Schizosaccharomyces pombe, Schizosaccharomyces pombe 972 (O74339)
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