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5,5'-dithiobis(2-nitrobenzoic acid)
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-
Ca2+
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2 mM, 45% inhibition, even in presence of optimal Mg2+ concentrations
CDP-dipalmitin
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inhibits diphosphorolysis of CDP-dipalmitin
Co2+
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2 mM, 58% inhibition, even in presence of optimal Mg2+ concentrations
deoxycholate
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partial inhibition
FeSO4
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2 mM, 97% inhibition, even in presence of optimal Mg2+ concentrations
hydrazine
Micrococcus cerificans
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-
L-alpha-phosphatidylinositol 4,5-bisphosphate
1 mol%, 80% inhibition; strongest inhibitor among the phosphatidylinositols tested
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L-alpha-phosphatidylinositol 4-phosphate
1 mol%, 50% inhibition
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lysolecithin
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1 mM, 89% inhibition
lysophosphatidylcholine
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the solubilized but not the microsomal enzyme is strongly inhibited
oleic acid
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2 mM, 84% inhibition
palmitic acid
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2 mM, 76% inhibition
phosphatidylethanolamine
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2 mM, 16% inhibition
phosphatidylinositol 4,5-bisphosphate
strong
phosphatidylinositol 4-phosphate
55% inhibition at 1 mol%
phosphatidylinositol-(4,5)-bisphosphate
80% inhibition at 1 mol%, CDS2 is inhibited by its anionic phospholipid end products, with phosphatidylinositol-(4,5)-bisphosphate showing the strongest inhibition; CDS1 is inhibited by their anionic phospholipid end products, with phosphatidylinositol-(4,5)-bisphosphate showing the strongest inhibition
phosphatidylserine
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2 mM, 46% inhibition
sodium lauryl sulfate
Micrococcus cerificans
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-
Thiophosphatidate
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competitive
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ZWT-12
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2 mM, 86% inhibition
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ZWT-14
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2 mM, 92% inhibition
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ATP
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slight inhibition below 0.175 mM
ATP
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3 mM 50% inhibition. 5 mM, complete inhibition
cardiolipin
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the solubilized but not the microsomal enzyme is strongly inhibited
cardiolipin
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2 mM, 27% inhibition
CTP
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-
CTP
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competitive with dCTP
dCTP
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competitive with respect to CTP
dCTP
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competitive with respect to CTP
dCTP
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2.5 mM, 54% inhibition of purified enzyme; competitive with respect to CTP
diphosphate
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-
diphosphate
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2.5 mM, 80% inhibition of purified enzyme, noncompetitive with respect to CTP and phosphatidic acid
EDTA
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-
EDTA
the enzyme activity is almost completely inhibited when EDTA is added to the reaction
F-
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20 mM, completely abolishes the stimulatory effect of GTP
F-
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20 mM NaF, 70% inhibition
Hg2+
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0.1 mM, 90% inhibition
Hg2+
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5 mM HgCl2, 78% inhibition
Mg2+
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33% inhibition at 25 mM Mg2+
Mg2+
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in presence of Mn2+
palmitoyl-CoA
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inhibits incorporation of CTP into CDP-diglyceride in presence or absence of added phosphatidic acid
palmitoyl-CoA
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0.5 mM, 70% inhibition
PCMB
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0.03 mM, 90% inhibition
PCMB
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5 mM, 88% inhibition
phosphatidylinositol
15-20% inhibition by soybean and liver phosphatidylinositol, inhibition of CDS2 by phosphatidylinositol is acyl chain-dependent, with the strongest inhibition seen with the 1-stearoyl-2-arachidonoyl species; CDS1 shows no acyl chain-dependent inhibition; significant inhibition of isoform CDS2 by both soybean and liver PI, with 15?20% residual activity
phosphatidylinositol
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2 mM, 23% inhibition
SDS
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0.1% w/v
sodium deoxycholate
Micrococcus cerificans
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-
Triton X-100
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above 20 mM
Tween 20
Micrococcus cerificans
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-
additional information
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no inhibition by 1.65 mM ADP
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additional information
no significant inhibition in activity when either soybean or liver phosphatidylinositol is used at equimolar concentrations with respect to substrate. Neither soy nor egg phosphatidylglycerol has any significant inhibitory effect when used at equimolar concentrations with respect to substrate. Isoform CDS1 shows no acyl chain-dependent inhibition for 1-stearoyl-2-arachidonoyl-snphosphatidylinositol, 1-stearoyl-2-linoleoyl-sn-phosphatidylinositol, or 1,2-diolinoleoyl-sn-phosphatidylinositol
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additional information
no significant inhibition in activity when either soybean or liver phosphatidylinositol is used at equimolar concentrations with respect to substrate. Neither soy nor egg phosphatidylglycerol has any significant inhibitory effect when used at equimolar concentrations with respect to substrate. Isoform CDS1 shows no acyl chain-dependent inhibition for 1-stearoyl-2-arachidonoyl-snphosphatidylinositol, 1-stearoyl-2-linoleoyl-sn-phosphatidylinositol, or 1,2-diolinoleoyl-sn-phosphatidylinositol
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additional information
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no significant inhibition in activity when either soybean or liver phosphatidylinositol is used at equimolar concentrations with respect to substrate. Neither soy nor egg phosphatidylglycerol has any significant inhibitory effect when used at equimolar concentrations with respect to substrate. Isoform CDS1 shows no acyl chain-dependent inhibition for 1-stearoyl-2-arachidonoyl-snphosphatidylinositol, 1-stearoyl-2-linoleoyl-sn-phosphatidylinositol, or 1,2-diolinoleoyl-sn-phosphatidylinositol
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