2.7.7.40: D-ribitol-5-phosphate cytidylyltransferase
This is an abbreviated version!
For detailed information about D-ribitol-5-phosphate cytidylyltransferase, go to the full flat file.
Word Map on EC 2.7.7.40
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2.7.7.40
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dystrophy
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muscular
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polysaccharide
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fukutin
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teichoic
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fukutin-related
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dystroglycanopathy
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glycan
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influenzae
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haemophilus
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walker-warburg
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dispensability
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malformation
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alpha-dystroglycan
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capsular
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hydrocephalus
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polyribitol
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lissencephaly
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o-mannose
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virulence-associated
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hypoplasia
- 2.7.7.40
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dystrophy
-
muscular
- polysaccharide
-
fukutin
-
teichoic
-
fukutin-related
-
dystroglycanopathy
- glycan
- influenzae
-
haemophilus
-
walker-warburg
-
dispensability
-
malformation
- alpha-dystroglycan
- capsular
-
hydrocephalus
-
polyribitol
-
lissencephaly
-
o-mannose
-
virulence-associated
-
hypoplasia
Reaction
Synonyms
Bcs1, CDP-L-ribitol pyrophosphorylase A, CDP-ribitol (ribose) pyrophosphorylase, CDP-ribitol pyrophosphorylase, CDP-ribitol synthase, CDPribitol pyrophosphorylase, CRPPA, cytidine diphosphate ribitol pyrophosphorylase, cytidine diphosphate-l-ribitol pyrophosphorylase A, Cytidine diphosphoribitol pyrophosphorylase, cytidylyltransferase, cytidylyltransferase, ribitol 5-phosphate, isoprenoid synthase domain-containing protein, IspD, ribitol 5-phosphate cytidylyltransferase, TarI, TarIJ
ECTree
2.7.7.40 D-ribitol-5-phosphate cytidylyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.7.7.40 - D-ribitol-5-phosphate cytidylyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CTP + D-arabitol 5-phosphate
diphosphate + CDP-arabitol
up to 10% activity compared to D-ribitol 5-phosphate
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-
?
CTP + D-xylitol 5-phosphate
diphosphate + CDP-xylitol
up to 10% activity compared to D-ribitol 5-phosphate
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-
?
CTP + D-ribitol 5-phosphate
diphosphate + CDP-ribitol
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ordered bi-bi mechanism
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?
CTP + D-ribitol 5-phosphate
diphosphate + CDP-ribitol
highest activity
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-
r
CTP + D-ribitol 5-phosphate
diphosphate + CDP-ribitol
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tarI encodes an orthologue of the cytidylyltransferase domain of Bcs1 from Haemophilus influenzae and tarJ encodes an analogue of the reductase domain of Bcs1, TarI and TyrJ form a functional CDP-ribitol synthase complex. Release and free diffusion of the intermediate ribitol 5-phosphate without channelling between active sites, ordered bi-bi mechanism
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?
CTP + D-ribitol 5-phosphate
diphosphate + CDPribitol
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-
-
?
CTP + D-ribitol 5-phosphate
diphosphate + CDPribitol
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-
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?
additional information
?
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enzyme functions possibly in synthesis of teichoic acids, repression of enzyme synthesis occurs at the onset of phosphate starvation
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?
additional information
?
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enzyme functions possibly in synthesis of teichoic acids, repression of enzyme synthesis occurs at the onset of phosphate starvation
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?
additional information
?
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enzyme has also ribitol 5-phosphate dehydrogenase activity
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-
?
additional information
?
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enzyme has also ribitol 5-phosphate dehydrogenase activity
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?
additional information
?
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no activity with erythritol 4-phosphate, sorbitol 6-phosphate and UTP
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-
?
additional information
?
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no activity with ATP, GTP, UTP, ADP or CDP
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-
?
additional information
?
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the enzyme is capable of generating CDP-ribitol or CDP-ribose using CTP and ribitol-5-phosphate or ribose-5-phosphate, respectively, but is not able to generate the sugar (alcohol) nucleotides with ribitol or ribose
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?
additional information
?
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the enzyme is capable of generating CDP-ribitol or CDP-ribose using CTP and ribitol-5-phosphate or ribose-5-phosphate, respectively, but is not able to generate the sugar (alcohol) nucleotides with ribitol or ribose
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-
?
additional information
?
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the enzyme has no activity with UTP, or in the presence of CTP and 2-C-methyl-D-erythritol 4-phosphate
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