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2.7.7.38: 3-deoxy-manno-octulosonate cytidylyltransferase

This is an abbreviated version!
For detailed information about 3-deoxy-manno-octulosonate cytidylyltransferase, go to the full flat file.

Word Map on EC 2.7.7.38

Reaction

CTP
+
3-deoxy-D-manno-octulosonate
=
diphosphate
+
CMP-3-deoxy-D-manno-octulosonate

Synonyms

2-keto-3-deoxy-D-manno-octulosonate cytidylyltransferase, 2-keto-3-deoxyoctonate cytidylyltransferase, 3-deoxy-D-manno-octulosonate cytidylyltransferase, 3-deoxy-manno-octulosonate cytidylyltransferase, arabinose-5-phosphate isomerase, At1g53000, CKS, CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase, CMP-3-deoxy-D-manno-octulosonate synthetase, CMP-KDO synthetase, CMP/KDO synthase, CMP:KDO synthase, CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase, cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase, cytidine monophospho-3-deoxy-D-manno-octulosonate synthetase, K-CKS, K-KDO-CT, Kdo cytidylyltransferase, KDO-CT, KdsB, KpsF, L-CKS, L-KDO-CT

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.38 3-deoxy-manno-octulosonate cytidylyltransferase

Crystallization

Crystallization on EC 2.7.7.38 - 3-deoxy-manno-octulosonate cytidylyltransferase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
to 2.1 A resolution. Two Mg2+ ions are part of the active site of the enzyme
crystallized in space group P2(1), cell dimensions a = 46.1, b = 133.8, c = 48.5, beta 102.6°
KDO-CT crystallized in presence of CMP-NeuAc, crystallizes as a dimer composed of 27kDa monomers
native crystals are orthorhombic, belonging to space group P2(1)2(1)2(1) with unit-cell parameters a = 48.6, b = 83.1, c = 117.3 A
-
the structure of 3-deoxy-manno-octulosonate cytidylyltransferase from Haemophilus influenzae complexed with the substrate 3-deoxy-manno-octulosonate is determined at 2.30 A resolution