2.7.7.33: glucose-1-phosphate cytidylyltransferase
This is an abbreviated version!
For detailed information about glucose-1-phosphate cytidylyltransferase, go to the full flat file.
Word Map on EC 2.7.7.33
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2.7.7.33
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pyrophosphate
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ping-pong
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nucleotidylyltransferases
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hexamer
-
typhi
-
pseudotuberculosis
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thymidylyltransferase
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enterica
-
medicine
- 2.7.7.33
- pyrophosphate
-
ping-pong
-
nucleotidylyltransferases
-
hexamer
- typhi
- pseudotuberculosis
-
thymidylyltransferase
- enterica
- medicine
Reaction
Synonyms
alpha-D-glucose-1-phosphate cytidylyltransferase, CDP-D-glucose synthase, CDP-glucose pyrophosphorylase, CDPglucose pyrophosphorylase, cytidine diphosphate glucose pyrophosphorylase, cytidine diphosphate-D-glucose pyrophosphorylase, cytidine diphosphoglucose pyrophosphorylase, cytidylyltransferase, glucose 1-phosphate
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Substrates Products
Substrates Products on EC 2.7.7.33 - glucose-1-phosphate cytidylyltransferase
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REACTION DIAGRAM
CTP + alpha-D-xylose 1-phosphate
diphosphate + CDPxylose
-
poor substrate
-
?
diphosphate + CDP-glucose
-
the structure of the enzyme with bound MgCTP reveals that the binding pocket for the nucleotide is contained within one subunit rather than shared between two. Key side chains involved in nucleotide binding include Thr14, Arg15, Lys25, and Arg111
-
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDP-glucose
-
-
-
?
diphosphate + CDPglucose
-
highly specific
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrates in the reverse reaction: ADPglucose, dTDPglucose, UDPglucose
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: alpha-D-mannose 1-phosphate, N-acetyl-alpha-D-glucosamine 1-phosphate
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: dTTP, alpha-D-galactose 1-phosphate
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: ATP, GTP
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: dATP, dGTP, dCTP, D-ribitol 5-phosphate, L-glycerol 3-phosphate
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrates in the reverse reaction: GDPglucose
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
highly specific
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrates in the reverse reaction: ADPglucose, dTDPglucose, UDPglucose
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: alpha-D-mannose 1-phosphate, N-acetyl-alpha-D-glucosamine 1-phosphate
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: dTTP, alpha-D-galactose 1-phosphate
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: ATP, GTP
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
best substrates
-
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrates in the reverse reaction: ADPglucose, dTDPglucose, UDPglucose
-
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: alpha-D-mannose 1-phosphate, N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: dTTP, alpha-D-galactose 1-phosphate
-
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: ATP, GTP
-
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
catalyzes bimolecular group transfer reaction
-
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrates in the reverse reaction: UDPgalactose, UDP-D-mannose, UDP-N-acetyl-D-glucosamine, dTDP-L-rhamnose
-
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: D-ribose 1-phosphate
-
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrates in the reverse reaction: ADPglucose, dTDPglucose, UDPglucose
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the reverse reaction: CDPparatose
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: alpha-D-mannose 1-phosphate, N-acetyl-alpha-D-glucosamine 1-phosphate
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
specific for base and sugar
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: GTP and D-mannose 1-phosphate
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrates in the reverse reaction: GDPglucose
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
specific for CTP and alpha-D-glucose 1-phosphate
-
-
?
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
specific for CTP and alpha-D-glucose 1-phosphate
-
-
?
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
-
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: ATP, GTP
-
-
?
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: TTP
-
-
?
diphosphate + CDPglucosamine
-
reaction at about 25% the rate with glucose 1-phosphate
-
-
?
CTP + D-glucosamine 1-phosphate
diphosphate + CDPglucosamine
-
reaction at about 15% the rate with glucose 1-phosphate
-
?
?
-
first of five enzymes committed to CDP-D-abequose biosynthesis
-
-
r
CTP + D-glucose 1-phosphate
?
-
branch-point in glucose 1-phosphate anabolism
-
-
r
CTP + D-glucose 1-phosphate
?
first step in biosynthesis of CDP-ascarylose
-
-
r
diphosphate + CDP-glucose
CTP + alpha-D-glucose 1-phosphate
-
-
-
-
?
diphosphate + UDP-glucose
-
poor substrate
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
-
?