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2.7.7.3: pantetheine-phosphate adenylyltransferase

This is an abbreviated version!
For detailed information about pantetheine-phosphate adenylyltransferase, go to the full flat file.

Word Map on EC 2.7.7.3

Reaction

ATP
+
pantetheine 4'-phosphate
=
diphosphate
 +
3'-dephospho-CoA

Synonyms

3'-dephospho-CoA pyrophosphorylase, 4'-phosphopantetheine adenylyltransferase, 4-phosphopantetheine adenylyltransferase, CoaD, dephospho-CoA pyrophosphorylase, dephospho-coenzyme A pyrophosphorylase, Enterococcus faecalis PPAT, More, pantetheine phosphate adenylyltransferase, phosphopantetheine adenylyltransferase, PPAT

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.3 pantetheine-phosphate adenylyltransferase

IC50 Value

IC50 Value on EC 2.7.7.3 - pantetheine-phosphate adenylyltransferase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00033 - 0.005
(1S,2S)-N-(3,4-dichlorobenzyl)-2-(4,6-dimethoxypyrimidin-2-yl)cyclohexanecarboxamide
0.000098 - 0.0088
(1S,2S)-N-(3-chlorobenzyl)-2-(4,6-dimethoxypyrimidin-2-yl)cyclohexanecarboxamide
0.00025
(2S)-2-(3-chlorophenyl)-2-[(5-methyl-7-oxo-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)amino]ethyl carbamate
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.000056 - 0.000064
(3R)-3-(3-chlorophenyl)-3-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]propanenitrile
0.000056 - 0.000064
(3R)-3-(3-chlorophenyl)-3-[(5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)amino]propanenitrile
0.000037 - 0.000049
(3R)-3-(3-chlorophenyl)-3-[(5-methyl-7-oxo-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)amino]propanenitrile
0.0000011 - 0.0000054
(3R)-3-(3-chlorophenyl)-3-[(7-[[2-(3,5-dimethyl-1H-pyrazol-4-yl)ethyl]amino]-5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]propanenitrile
0.000004 - 0.0000043
(3R)-3-([7-[(1-acetyl-2,3-dihydro-1H-indol-5-yl)amino]-5-methyl-1H-imidazo[4,5-b]pyridin-2-yl]amino)-3-(3-chlorophenyl)propanenitrile
0.0000012 - 0.0000078
1-[5-[(2-[[(1R)-1-(3-chlorophenyl)ethyl]amino]-5-methyl-1H-imidazo[4,5-b]pyridin-7-yl)amino]-2,3-dihydro-1H-indol-1-yl]ethan-1-one
0.000000065 - 0.024
2'-[(1S,2S)-2-[(3,4-dichlorobenzyl)carbamoyl]cyclohexyl]-6'-ethyl-4-hydroxy-6-oxo-1,6-dihydro-2,4'-bipyrimidine-5-carboxamide
0.000051
2-[(1S)-2-(4-chlorophenyl)cyclopentyl]-1H-benzimidazol-4-ol
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.00004 - 0.0095
2-[(2-[(1S,2S)-2-[(3,4-dichlorobenzyl)carbamoyl]cyclohexyl]-6-ethylpyrimidin-4-yl)sulfanyl]-1H-imidazole-5-carboxylic acid
0.000091
2-[1-(4-chlorophenyl)pyrrolidin-2-yl]-1H-benzimidazol-4-ol
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.00025
2-[2-(4-chlorophenyl)ethyl]-1H-benzimidazol-4-ol
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.00024
2-[[(1R)-1-(3-chlorophenyl)-3-hydroxypropyl]amino]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.0009
2-[[(1R)-1-(3-chlorophenyl)ethyl]amino]-5-ethyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.00025
2-[[(1R)-1-(3-chlorophenyl)ethyl]amino]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.00055
2-[[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]amino]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.00045
3-(3-chlorophenyl)-3-[(5-methyl-7-oxo-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)amino]propanamide
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.0002
3-(3-chlorophenyl)-3-[(5-methyl-7-oxo-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)amino]propanoic acid
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.000051
3-[(2S)-2-(4-hydroxy-1H-benzimidazol-2-yl)cyclopentyl]benzoic acid
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.00000013 - 0.2
3-[3-(2-[(1S,2S)-2-[(3,4-dichlorobenzyl)carbamoyl]cyclohexyl]-6-ethylpyrimidin-4-yl)-1,2,4-oxadiazol-5-yl]propanoic acid
0.0000032 - 0.0000082
3-[4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]-1-(methoxycarbonyl)piperidin-4-yl]propanoic acid
0.00032
5-(4-hydroxy-1H-benzimidazol-2-yl)-1-methyl-6-phenylpiperidin-2-one
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.038
CoA
Arabidopsis thaliana
-
-
0.027
L-ascorbate
Acinetobacter baumannii
pH not specified in the publication, temperature not specified in the publication
0.0000025 - 0.0000093
methyl (R)-4-(3-(2-cyano-1-((5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino)ethyl)benzyl)piperidine-1-carboxylate
0.0000051 - 0.000013
methyl 4-(2-cyanoethyl)-4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]piperidine-1-carboxylate
0.0000024 - 0.0000093
methyl 4-(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]benzene-1-sulfonyl)piperidine-1-carboxylate
0.0000088 - 0.00001
methyl 4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]-4-(3-hydroxypropyl)piperidine-1-carboxylate
0.0000049 - 0.0000081
methyl 4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]-4-[(Z)-(methoxyimino)methyl]piperidine-1-carboxylate
0.0000075 - 0.000024
methyl 4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]-4-[[(2-hydroxyethyl)amino]methyl]piperidine-1-carboxylate
0.0000027 - 0.0000082
methyl 4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)sulfanyl]piperidine-1-carboxylate
0.00019
N-[(1R)-1-(3-chlorophenyl)ethyl]-5-methyl-1H-imidazo[4,5-b]pyridin-2-amine
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
-
0.00041
N-[(1R)-1-(3-chlorophenyl)ethyl]-5-methyl[1,3]thiazolo[4,5-b]pyridin-2-amine
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.00041
N2-[(1R)-1-(3-chlorophenyl)ethyl]-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-2,7-diamine
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.03
PTX040334
Escherichia coli
-
IC50: 0.03 mM
0.000006
PTX042695
Escherichia coli
-
IC50: 0.000006 mM
0.000018
Sodium citrate
Acinetobacter baumannii
pH not specified in the publication, temperature not specified in the publication