2.7.7.3: pantetheine-phosphate adenylyltransferase
This is an abbreviated version!
For detailed information about pantetheine-phosphate adenylyltransferase, go to the full flat file.
Word Map on EC 2.7.7.3
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2.7.7.3
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ppats
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penultimate
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dpcoa
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pantothen
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pyrophosphate
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hexameric
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3\'-dephospho-coa
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nucleotidyltransferase
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dephosphocoenzyme
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phosphopantothenoylcysteine
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medicine
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drug development
- 2.7.7.3
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ppats
-
penultimate
-
dpcoa
-
pantothen
- pyrophosphate
-
hexameric
-
3\'-dephospho-coa
-
nucleotidyltransferase
-
dephosphocoenzyme
-
phosphopantothenoylcysteine
- medicine
- drug development
Reaction
Synonyms
3'-dephospho-CoA pyrophosphorylase, 4'-phosphopantetheine adenylyltransferase, 4-phosphopantetheine adenylyltransferase, CoaD, dephospho-CoA pyrophosphorylase, dephospho-coenzyme A pyrophosphorylase, Enterococcus faecalis PPAT, More, pantetheine phosphate adenylyltransferase, phosphopantetheine adenylyltransferase, PPAT
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General Information
General Information on EC 2.7.7.3 - pantetheine-phosphate adenylyltransferase
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malfunction
metabolism
additional information
enzyme inactivation effectively prevents bacterial viability
malfunction
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enzyme inhibition causes growth suppression of the bacteria
malfunction
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enzyme inhibition causes growth suppression of the bacteria
malfunction
enzyme inhibition causes growth suppression of the bacteria
malfunction
enzyme inhibition causes growth suppression of the bacteria, e.g. Escherichia coli strain ARC534, phenotype of enzyme knockout mutant Escherichia coli strain W3110, overview
malfunction
enzyme inhibition causes growth suppression of the bacteria, e.g. of Haemophilus influenzae strain ATCC 51907
malfunction
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enzyme inhibition causes growth suppression of the bacteria, e.g. of Staphylococcus aureus strain ARC516
malfunction
enzyme inhibition causes growth suppression of the bacteria, e.g. of Streptococcus pneumoniae strains D39 and ATCC 10813
malfunction
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enzyme inhibition causes growth suppression of the bacteria
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malfunction
-
enzyme inhibition causes growth suppression of the bacteria
-
malfunction
-
enzyme inhibition causes growth suppression of the bacteria, e.g. of Haemophilus influenzae strain ATCC 51907
-
malfunction
-
enzyme inhibition causes growth suppression of the bacteria
-
malfunction
-
enzyme inhibition causes growth suppression of the bacteria, e.g. of Staphylococcus aureus strain ARC516
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the enzyme catalyzes the fourth of five steps in the coenzyme A biosynthetic pathway
metabolism
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the enzyme catalyzes the penultimate step in the coenzyme A biosynthetic pathway
metabolism
the enzyme catalyzes the penultimate step in coenzyme A biosynthesis
the enzyme is allosteric in nature and regulated by coenzyme A through feedback inhibition. Structure-function analysis, and analysis of catalytic, allosteric and inhibitory mechanisms involved in regulation of PPAT. Changes in side chains R90 and D94 are responsible for transition between catalytic and allosteric inhibitory states. Diphosphate binds in close vicinity of ATP and produces a 10 A flip in the adenine ring of coenzyme A moiety. Transition of PPAT in Pseudomonas aeruginosa from substrate binding to inhibitory states is triggered by an arginine switch
additional information
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the enzyme is allosteric in nature and regulated by coenzyme A through feedback inhibition. Structure-function analysis, and analysis of catalytic, allosteric and inhibitory mechanisms involved in regulation of PPAT. Changes in side chains R90 and D94 are responsible for transition between catalytic and allosteric inhibitory states. Diphosphate binds in close vicinity of ATP and produces a 10 A flip in the adenine ring of coenzyme A moiety. Transition of PPAT in Pseudomonas aeruginosa from substrate binding to inhibitory states is triggered by an arginine switch