2.7.7.23: UDP-N-acetylglucosamine diphosphorylase

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For detailed information about UDP-N-acetylglucosamine diphosphorylase, go to the full flat file.

Reaction

Synonyms

acetylglucosamine 1-phosphate uridylyltransferase, AGX-1, AGX1, AGX2, amino-sugar-1-phosphate acetyltransferase, bifunctional N-acetyltransferase/uridylyltransferase, BmUAP, CL6EHI_021200, CL6EHI_039830, EcGlmU, EnhiA.01126.a, EnhiA.01126.b, GlcNAc-1-P uridyltransferase, GlcNAc-1-P UTase, GlcNAc-1-phosphate nucleotidylyltransferase, GLCNAC1PUT1, GLCNAC1PUT2, GlmU, GlmUMTB, hiGlmU, LmUAP1, LmUAP2, LOC_Os08g10600, Mmy, More, mummy, N-acetyl-D-glucosamine-1-phosphate uridylyltransferase, N-acetyl-glucosamine-1-phosphate uridyltransferase, N-acetylglucosamine 1-phosphate uridyltransferase, N-acetylglucosamine-1-phosphate uridyltransferase, N-acetylglucosamine-1-phosphate uridylyltransferase, N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase, Os08g10600, Rv1018c, spl29, spotted leaf 29, ST0452, ST0452 protein, STK_04520, Tb11.02.0120, UAP, UAP enzyme, UAP1, UAP2, UDP N-acetylglucosamine pyrophosphorylases 1, UDP N-acetylglucosamine pyrophosphorylases 2, UDP-GlcNAc pyrophosphorylase, UDP-GlcNAc pyrophosphorylase (UAP), UDP-HexNAc pyrophosphorylase, UDP-N-acetylgalactosamine pyrophosphorylase, UDP-N-acetylglucosamine diphosphorylase 1, UDP-N-acetylglucosamine diphosphorylase 2, UDP-N-acetylglucosamine pyrophosphorylase, UDP-N-acetylglucosamine pyrophosphorylase (UAP), UDP-N-acetylglucosamine pyrophosphorylase 1, UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase, UDP-N-acetylglucosamine-diphosphorylase, UDP-N-acetylhexosamine pyrophosphorylase, UDPacetylglucosamine pyrophosphorylase, UNAcP, uridine diphosphate N-acetylglucosamine pyrophosphorylase, uridine diphosphate-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine phosphorylase, uridine diphosphoacetylglucosamine pyrophosphorylase, uridine-diphospho-N-acetylglucosamine pyrophosphorylase, UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase, UTP:N-acetylglucosamine-1-P uridylyltransferase, Ydl103c protein

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.7 Nucleotidyltransferases

                2.7.7.23 UDP-N-acetylglucosamine diphosphorylase

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Results	in table
8	Activating Compound
29531	AA Sequence
17	Application
1	CAS Registry Number
49	Cloned(Commentary)
2	Cofactor
22	Crystallization (Commentary)
35	Disease/ Diagnostics
11	Expression
98	General Information
8	General Stability
55	IC50 Value
146	Inhibitors
30	kcat/KM [mM/s]
7	Ki Value [mM]
76	KM Value [mM]
7	Localization
77	Metals/Ions
36	Molecular Weight [Da]
139	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
477	Organism
9	Pathway
84	PDB ID
40	pH Optimum
5	pH Range
2	pH Stability
4	pI Value
1	Posttranslational Modification
247	Protein Variants
48	Purification (Commentary)
2	Reaction
1	Reaction Type
126	Reference
60	Source Tissue
73	Specific Activity [micromol/min/mg]
15	Storage Stability
258	Substrates and Products (Substrate)
38	Subunits
215	Synonyms
1	Systematic Name
30	Temperature Optimum [°C]
3	Temperature Range [°C]
5	Temperature Stability [°C]
42	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.7.7.23 - UDP-N-acetylglucosamine diphosphorylase

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SYSTEMATIC NAME

IUBMB Comments

UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase

Part of the pathway for acetamido sugar biosynthesis in bacteria and archaea. The enzyme from several bacteria (e.g., Escherichia coli, Bacillus subtilis and Haemophilus influenzae) has been shown to be bifunctional and also to possess the activity of EC 2.3.1.157, glucosamine-1-phosphate N-acetyltransferase [3,4,6]. The enzyme from plants and animals is also active toward N-acetyl-alpha-D-galactosamine 1-phosphate (cf. EC 2.7.7.83, UDP-N-acetylgalactosamine diphosphorylase) [5,7], while the bacterial enzyme shows low activity toward that substrate [4].