Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.7.7.23: UDP-N-acetylglucosamine diphosphorylase

This is an abbreviated version!
For detailed information about UDP-N-acetylglucosamine diphosphorylase, go to the full flat file.

Word Map on EC 2.7.7.23

Reaction

UTP
+
N-acetyl-alpha-D-glucosamine 1-phosphate
=
diphosphate
+
UDP-N-acetyl-alpha-D-glucosamine

Synonyms

acetylglucosamine 1-phosphate uridylyltransferase, AGX-1, AGX1, AGX2, amino-sugar-1-phosphate acetyltransferase, bifunctional N-acetyltransferase/uridylyltransferase, BmUAP, CL6EHI_021200, CL6EHI_039830, EcGlmU, EnhiA.01126.a, EnhiA.01126.b, GlcNAc-1-P uridyltransferase, GlcNAc-1-P UTase, GlcNAc-1-phosphate nucleotidylyltransferase, GLCNAC1PUT1, GLCNAC1PUT2, GlmU, GlmUMTB, hiGlmU, LmUAP1, LmUAP2, LOC_Os08g10600, Mmy, More, mummy, N-acetyl-D-glucosamine-1-phosphate uridylyltransferase, N-acetyl-glucosamine-1-phosphate uridyltransferase, N-acetylglucosamine 1-phosphate uridyltransferase, N-acetylglucosamine-1-phosphate uridyltransferase, N-acetylglucosamine-1-phosphate uridylyltransferase, N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase, Os08g10600, Rv1018c, spl29, spotted leaf 29, ST0452, ST0452 protein, STK_04520, Tb11.02.0120, UAP, UAP enzyme, UAP1, UAP2, UDP N-acetylglucosamine pyrophosphorylases 1, UDP N-acetylglucosamine pyrophosphorylases 2, UDP-GlcNAc pyrophosphorylase, UDP-GlcNAc pyrophosphorylase (UAP), UDP-HexNAc pyrophosphorylase, UDP-N-acetylgalactosamine pyrophosphorylase, UDP-N-acetylglucosamine diphosphorylase 1, UDP-N-acetylglucosamine diphosphorylase 2, UDP-N-acetylglucosamine pyrophosphorylase, UDP-N-acetylglucosamine pyrophosphorylase (UAP), UDP-N-acetylglucosamine pyrophosphorylase 1, UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase, UDP-N-acetylglucosamine-diphosphorylase, UDP-N-acetylhexosamine pyrophosphorylase, UDPacetylglucosamine pyrophosphorylase, UNAcP, uridine diphosphate N-acetylglucosamine pyrophosphorylase, uridine diphosphate-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine phosphorylase, uridine diphosphoacetylglucosamine pyrophosphorylase, uridine-diphospho-N-acetylglucosamine pyrophosphorylase, UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase, UTP:N-acetylglucosamine-1-P uridylyltransferase, Ydl103c protein

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.23 UDP-N-acetylglucosamine diphosphorylase

Reference

Reference on EC 2.7.7.23 - UDP-N-acetylglucosamine diphosphorylase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mengin-Lecreulx, D.; van Heijenoort, J.
Copurification of glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase activities of Escherichia coli: characterization of the glmU gene product as a bifunctional enzyme catalyzing two subsequent steps in the pathway for UDP-N-acetylglucosamine synthesis
J. Bacteriol.
176
5788-5795
1994
Escherichia coli
Manually annotated by BRENDA team
Pompeo, F.; Bourne, Y.; Van Heijenoort, J.; Fassy, F.; Mengin-Lecreulx, D.
Dissection of the bifunctional Escherichia coli N-acetylglucosamine-1-phosphate uridyltransferase enzyme into autonomously functional domains and evidence that trimerization is absolutely required for glucosamine-1-phosphate acetyltransferase activity and cell growth
J. Biol. Chem.
276
3833-3839
2001
Escherichia coli
Manually annotated by BRENDA team
Pattabiraman, T.N.; Bachhawat, B.K.
Purification of uridine diphosphoacetylglucosamine pyrophosphorylase from sheep brain
Biochim. Biophys. Acta
50
129-134
1961
Ovis aries
Manually annotated by BRENDA team
Strominger, J.L.; Smith, M.S.
Uridine diphosphoacetylglucosamine pyrophosphorylase
J. Biol. Chem.
234
1822-1827
1959
Bos taurus, Staphylococcus aureus
Manually annotated by BRENDA team
Yamamoto, K.; Kawai, H.; Moriguchi, M.; Tochikura, T.
Purification and charcterization of yeast UDP-N-acetylglucosamine pyrophosphorylase
Agric. Biol. Chem.
40
2275-2281
1976
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Yamamoto, K.; Kawai, H.; Moriguchi, M.; Tochikura, T.
The effect of magnesium ion on yeast UDP-N-acetylglucosamine pyrophosphorylase and its activation by dithiothreitol
J. Ferment. Technol.
56
57-58
1978
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Yamamoto, K.; Moriguchi, M.; Kawai, H.; Tochikura, T.
Purification and some properties of uridine diphosphate N-acetylglucosamine pyrophosphorylase from Neurospora crassa
Can. J. Microbiol.
25
1381-1386
1979
Neurospora crassa, Neurospora crassa IFO 6178
Manually annotated by BRENDA team
Yamamoto, K.; Moriguchi, M.; Kawai, H.; Tochikura, T.
Inhibition of UDP-N-acetylglucosamine pyrophosphorylase by uridine
Biochim. Biophys. Acta
614
367-372
1980
Saccharomyces cerevisiae, Neurospora crassa
Manually annotated by BRENDA team
Ullrich, J.; van Putten, J.P.
Identification of the gonococcal glmU gene encoding the enzyme N-acetylglucosamine 1-phosphate uridyltransferase involved in the synthesis of UDP-GlcNAc
J. Bacteriol.
177
6902-6909
1995
Neisseria gonorrhoeae (Q50986)
Manually annotated by BRENDA team
Szumilo, T.; Zeng, Y.; Pastuszak, I.; Drake, R.; Szumilo, H.; Elbein, A.D.
Purification to homogeneity and properties of UDP-GlcNAc (GalNAc) pyrophosphorylase
J. Biol. Chem.
271
13147-13154
1996
Sus scrofa
Manually annotated by BRENDA team
De Luca, C.; Lansing, M.; Crescenzi, F.; Martini, I.; Shen, G.J.; O'Regan, M.; Wong, C.H.
Overexpression, one-step purification and characterization of UDP-glucose dehydrogenase and UDP-N-acetylglucosamine pyrophosphorylase
Bioorg. Med. Chem.
4
131-141
1996
Escherichia coli
Manually annotated by BRENDA team
Bulik, D.A.; Lindmark, D.G.; Jarroll, E.L.
Purification and characterization of UDP-N-acetylglucosamine pyrophosphorylase from encysting Giardia
Mol. Biochem. Parasitol.
95
135-139
1998
Giardia intestinalis
Manually annotated by BRENDA team
Mio, T.; Yabe, T.; Arisawa, M.; Yamada-Okabe, H.
The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases. Gene cloning, protein expression, and catalytic mechanism
J. Biol. Chem.
273
14392-14397
1998
Homo sapiens, Candida albicans (O74933), Candida albicans, Saccharomyces cerevisiae (P43123), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Wang-Gillam, A.; Pastuszak, I.; Elbein, A.D.
A 17-amino acid insert changes UDP-N-acetylhexosamine pyrophosphorylase specificity from UDP-GalNAc to UDP-GlcNAc
J. Biol. Chem.
273
27055-27057
1998
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Wang-Gillam, A.; Pastuszak, I.; Stewart, M.; Drake, R.R.; Elbein, A.D.
Identification and modification of the uridine-binding site of the UDP-GalNAc (GlcNAc) pyrophosphorylase
J. Biol. Chem.
275
1433-1438
2000
Homo sapiens
Manually annotated by BRENDA team
Bulik, D.A.; van Ophem, P.; Manning, J.M.; Shen, Z.; Newburg, D.S.; Jarroll, E.L.
UDP-N-acetylglucosamine pyrophosphorylase, a key enzyme in encysting Giardia, is allosterically regulated
J. Biol. Chem.
275
14722-14728
2000
Giardia intestinalis
Manually annotated by BRENDA team
Sulzenbacher, G.; Gal, L.; Peneff, C.; Fassy, F.; Bourne, Y.
Crystal structure of Streptococcus pneumoniae N-acetylglucosamine-1-phosphate uridyltransferase bound to acetyl-coenzyme A reveals a novel active site architecture
J. Biol. Chem.
276
11844-11851
2001
Escherichia coli (P0ACC7), Streptococcus pneumoniae (Q97R46), Streptococcus pneumoniae
Manually annotated by BRENDA team
Shao, J.; Zhang, J.; Nahalka, J.; Wang, P.G.
Biocatalytic synthesis of uridine 5'-diphosphate N-acetylglucosamine by multiple enzymes co-immobilized on agarose beads
Chem. Commun. (Camb.)
2002
2586-2587
2002
Escherichia coli
-
Manually annotated by BRENDA team
Olsen, L.R.; Roderick, S.L.
Structure of the Escherichia coli GlmU pyrophosphorylase and acetyltransferase active sites
Biochemistry
40
1913-1921
2001
Escherichia coli (P0ACC7)
Manually annotated by BRENDA team
Kostrewa, D.; D'Arcy, A.; Takacs, B.; Kamber, M.
Crystal structures of Streptococcus pneumoniae N-acetylglucosamine-1-phosphate uridyltransferase, GlmU, in apo form at 2.33 A resolution and in complex with UDP-N-acetylglucosamine and Mg(2+) at 1.96 A resolution
J. Mol. Biol.
305
279-289
2001
Streptococcus pneumoniae (Q97R46)
Manually annotated by BRENDA team
Brown, K.; Pompeo, F.; Dixon, S.; Mengin-Lecreulx, D.; Cambillau, C.; Bourne, Y.
Crystal structure of the bifunctional N-acetylglucosamine 1-phosphate uridyltransferase from Escherichia coli: a paradigm for the related pyrophosphorylase superfamily
EMBO J.
18
4096-4107
1999
Escherichia coli
Manually annotated by BRENDA team
Mok, M.T.; Tay, E.; Sekyere, E.; Glenn, W.K.; Bagnara, A.S.; Edwards, M.R.
Giardia intestinalis: molecular characterization of UDP-N-acetylglucosamine pyrophosphorylase
Gene
357
73-82
2005
Giardia intestinalis (Q8MUP8), Giardia intestinalis
Manually annotated by BRENDA team
Mok, M.T.; Edwards, M.R.
Kinetic and physical characterization of the inducible UDP-N-acetylglucosamine pyrophosphorylase from Giardia intestinalis
J. Biol. Chem.
280
39363-39372
2005
Giardia intestinalis (Q8MUP8), Giardia intestinalis
Manually annotated by BRENDA team
Zhang, Z.; Tsujimura, M.; Akutsu, J.; Sasaki, M.; Tajima, H.; Kawarabayasi, Y.
Identification of an extremely thermostable enzyme with dual sugar-1-phosphate nucleotidylyltransferase activities from an acidothermophilic archaeon, Sulfolobus tokodaii strain 7
J. Biol. Chem.
280
9698-9705
2005
Sulfurisphaera tokodaii (Q975F9), Sulfurisphaera tokodaii 7 (Q975F9)
Manually annotated by BRENDA team
Maruyama, D.; Nishitani, Y.; Nonaka, T.; Kita, A.; Fukami, T.A.; Mio, T.; Yamada-Okabe, H.; Yamada-Okabe, T.; Miki, K.
Purification, crystallization and preliminary X-ray diffraction studies of UDP-N-acetylglucosamine pyrophosphorylase from Candida albicans
Acta Crystallogr. Sect. F
62
1206-1208
2006
Candida albicans
Manually annotated by BRENDA team
Maruyama, D.; Nishitani, Y.; Nonaka, T.; Kita, A.; Fukami, T.A.; Mio, T.; Yamada-Okabe, H.; Yamada-Okabe, T.; Miki, K.
Crystal structure of uridine-diphospho-N-acetylglucosamine pyrophosphorylase from Candida albicans and catalytic reaction mechanism
J. Biol. Chem.
282
17221-17230
2007
Candida albicans
Manually annotated by BRENDA team
Schimmelpfeng, K.; Strunk, M.; Stork, T.; Klaembt, C.
Mummy encodes an UDP-N-acetylglucosamine-dipohosphorylase and is required during Drosophila dorsal closure and nervous system development
Mech. Dev.
123
487-499
2006
Drosophila melanogaster
Manually annotated by BRENDA team
Yin, J.; Garen, C.R.; Cherney, M.M.; Cherney, L.T.; James, M.N.
Expression, purification and preliminary crystallographic analysis of N-acetylglucosamine-1-phosphate uridylyltransferase from Mycobacterium tuberculosis
Acta Crystallogr. Sect. F
F64
805-808
2008
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Manually annotated by BRENDA team
Guan, W.; Cai, L.; Fang, J.; Wu, B.; George Wang, P.
Enzymatic synthesis of UDP-GlcNAc/UDP-GalNAc analogs using N-acetylglucosamine 1-phosphate uridyltransferase (GlmU)
Chem. Commun. (Camb. )
2009
6976-6978
2009
Escherichia coli
Manually annotated by BRENDA team
Mochalkin, I.; Lightle, S.; Narasimhan, L.; Bornemeier, D.; Melnick, M.; Vanderroest, S.; McDowell, L.
Structure of a small-molecule inhibitor complexed with GlmU from Haemophilus influenzae reveals an allosteric binding site
Protein Sci.
17
577-582
2008
Haemophilus influenzae (P43889), Haemophilus influenzae
Manually annotated by BRENDA team
Zhou, Y.; Xin, Y.; Sha, S.; Ma, Y.
Kinetic properties of Mycobacterium tuberculosis bifunctional GlmU
Arch. Microbiol.
193
751-757
2011
Mycobacterium tuberculosis (P9WMN3), Mycobacterium tuberculosis H37Rv (P9WMN3)
Manually annotated by BRENDA team
Min, J.; Lin, D.; Zhang, Q.; Zhang, J.; Yu, Z.
Structure-based virtual screening of novel inhibitors of the uridyltransferase activity of Xanthomonas oryzae pv. oryzae GlmU
Eur. J. Med. Chem.
53
150-158
2012
Xanthomonas oryzae pv. oryzae (Q2P7P9), Xanthomonas oryzae pv. oryzae MAFF 311018 (Q2P7P9)
Manually annotated by BRENDA team
Jagtap, P.K.; Soni, V.; Vithani, N.; Jhingan, G.D.; Bais, V.S.; Nandicoori, V.K.; Prakash, B.
Substrate bound crystal structures reveal features unique to Mycobacterium tuberculosis N-acetyl-glucosamine-1-phosphate uridyltransferase and a catalytic mechanism for acetyltransfer
J. Biol. Chem.
287
39524-39537
2012
Mycobacterium tuberculosis (P9WMN3), Mycobacterium tuberculosis
Manually annotated by BRENDA team
Yang, T.; Echols, M.; Martin, A.; Bar-Peled, M.
Identification and characterization of a strict and a promiscuous N-acetylglucosamine-1-P uridylyltransferase in Arabidopsis
Biochem. J.
430
275-284
2010
Arabidopsis thaliana (O64765), Arabidopsis thaliana (Q940S3)
Manually annotated by BRENDA team
Santos Junior, M.; de Assis, S.; Goes-Neto, A.; Duarte, A.; Alves, R.; Comar, M.; Taranto, A.
Structure-based drug design studies of UDP-N-acetylglucosamine pyrophosphosrylase, a key enzyme for the control of witches broom disease
Chem. Cent. J.
7
48
2013
Moniliophthora perniciosa, Moniliophthora perniciosa (E2LRY8)
Manually annotated by BRENDA team
Arakane, Y.; Baguinon, M.C.; Jasrapuria, S.; Chaudhari, S.; Doyungan, A.; Kramer, K.J.; Muthukrishnan, S.; Beeman, R.W.
Both UDP N-acetylglucosamine pyrophosphorylases of Tribolium castaneum are critical for molting, survival and fecundity
Insect Biochem. Mol. Biol.
41
42-50
2011
Tribolium castaneum (D2KLJ1), Tribolium castaneum (D2KLJ2)
Manually annotated by BRENDA team
Santos Jr., M.; Goncalves, P.; Taranto, A.; Koblitz, M.; Goes-Neto, A.; Pirovani, C.; Cascardo, J.; Da Cruz, S.; Zingali, R.; Pereira, G.; Dias, C.; De Assis, S.
Purification, characterization and structural determination of UDP-N-acetylglucosamine pyrophosphorylase produced by Moniliophthora perniciosa
J. Braz. Chem. Soc.
22
1015-1023
2011
Moniliophthora perniciosa, Moniliophthora perniciosa CCMB 0257
-
Manually annotated by BRENDA team
Trempe, J.F.; Shenker, S.; Kozlov, G.; Gehring, K.
Self-association studies of the bifunctional N-acetylglucosamine-1-phosphate uridyltransferase from Escherichia coli
Protein Sci.
20
745-752
2011
Escherichia coli (P0ACC7)
Manually annotated by BRENDA team
Zhang, Z.; Akutsu, J.; Kawarabayasi, Y.
Identification of novel acetyltransferase activity on the thermostable protein ST0452 from Sulfolobus tokodaii strain 7
J. Bacteriol.
192
3287-3293
2010
Sulfurisphaera tokodaii (Q975F9), Sulfurisphaera tokodaii 7 (Q975F9)
Manually annotated by BRENDA team
Zhang, Z.; Akutsu, J.; Tsujimura, M.; Kawarabayasi, Y.
Increasing in archaeal GlcNAc-1-P uridyltransferase activity by targeted mutagenesis while retaining its extreme thermostability
J. Biochem.
141
553-562
2007
Sulfurisphaera tokodaii (Q975F9), Sulfurisphaera tokodaii 7 (Q975F9)
Manually annotated by BRENDA team
Zhang, Z.; Shimizu, Y.; Kawarabayasi, Y.
Characterization of the amino acid residues mediating the unique amino-sugar-1-phosphate acetyltransferase activity of the archaeal ST0452 protein
Extremophiles
19
417-427
2015
Sulfurisphaera tokodaii (Q975F9), Sulfurisphaera tokodaii, Sulfurisphaera tokodaii DSM 16993 / JCM 10545 / NBRC 100140 / 7 (Q975F9)
Manually annotated by BRENDA team
Vithani, N.; Bais, V.; Prakash, B.
GlmU (N-acetylglucosamine-1-phosphate uridyltransferase) bound to three magnesium ions and ATP at the active site
Acta Crystallogr. Sect. F
70
703-708
2014
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Sharma, R.; Rani, C.; Mehra, R.; Nargotra, A.; Chib, R.; Rajput, V.; Kumar, S.; Singh, S.; Sharma, P.; Khan, I.
Identification and characterization of novel small molecule inhibitors of the acetyltransferase activity of Escherichia coli N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU)
Appl. Microbiol. Biotechnol.
100
3071-3085
2015
Escherichia coli (P0ACC7), Escherichia coli ATCC 25922 (P0ACC7)
Manually annotated by BRENDA team
Patin, D.; Bayliss, M.; Mengin-Lecreulx, D.; Oyston, P.; Blanot, D.
Purification and biochemical characterisation of GlmU from Yersinia pestis
Arch. Microbiol.
197
371-378
2015
Yersinia pseudotuberculosis, Yersinia pseudotuberculosis YPIII
Manually annotated by BRENDA team
Sharma, R.; Lambu, M.R.; Jamwal, U.; Rani, C.; Chib, R.; Wazir, P.; Mukherjee, D.; Chaubey, A.; Khan, I.A.
Escherichia coli N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU) inhibitory activity of terreic acid isolated from Aspergillus terreus
J. Biomol. Screen.
21
342-353
2016
Escherichia coli (P0ACC7), Escherichia coli ATCC 25922 (P0ACC7)
Manually annotated by BRENDA team
Dziadek, B.; Brzostek, A.; Grzybowski, M.; Fol, M.; Krupa, A.; Kryczka, J.; Plocinski, P.; Kurdowska, A.; Dziadek, J.
Mycobacterium tuberculosis AtsG (Rv0296c), GlmU (Rv1018c) and SahH (Rv3248c) proteins function as the human IL-8-binding effectors and contribute to pathogen entry into human neutrophils
PLoS ONE
11
e0148030
2016
Mycobacterium tuberculosis (P9WMN3), Mycobacterium tuberculosis H37Rv (P9WMN3)
Manually annotated by BRENDA team
Soni, V.; Upadhayay, S.; Suryadevara, P.; Samla, G.; Singh, A.; Yogeeswari, P.; Sriram, D.; Nandicoori, V.K.
Depletion of M. tuberculosis GlmU from infected murine lungs effects the clearance of the pathogen
PLoS Pathog.
11
e1005235
2015
Mycobacterium tuberculosis (P9WMN3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WMN3)
Manually annotated by BRENDA team
Rani, C.; Mehra, R.; Sharma, R.; Chib, R.; Wazir, P.; Nargotra, A.; Khan, I.A.
High-throughput screen identifies small molecule inhibitors targeting acetyltransferase activity of Mycobacterium tuberculosis GlmU
Tuberculosis
95
664-677
2015
Mycobacterium tuberculosis (P9WMN3), Mycobacterium tuberculosis H37Rv (P9WMN3)
Manually annotated by BRENDA team
Urbaniak, M.D.; Collie, I.T.; Fang, W.; Aristotelous, T.; Eskilsson, S.; Raimi, O.G.; Harrison, J.; Navratilova, I.H.; Frearson, J.A.; van Aalten, D.M.; Ferguson, M.A.
A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei
ACS Chem. Biol.
8
1981-1987
2013
Homo sapiens (Q16222), Homo sapiens, Trypanosoma brucei, Trypanosoma brucei brucei (Q386Q8), Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927 (Q386Q8)
Manually annotated by BRENDA team
Edwards, T.; Gardberg, A.; Phan, I.; Zhang, Y.; Staker, B.; Myler, P.; Lorimer, D.
Structure of uridine diphosphate N-acetylglucosamine pyrophosphorylase from Entamoeba histolytica
Acta Crystallogr. Sect. F
71
560-565
2015
Entamoeba histolytica (C4M036), Entamoeba histolytica (C4MA87)
Manually annotated by BRENDA team
Humphreys, G.B.; Jud, M.C.; Monroe, K.M.; Kimball, S.S.; Higley, M.; Shipley, D.; Vrablik, M.C.; Bates, K.L.; Letsou, A.
Mummy, A UDP-N-acetylglucosamine pyrophosphorylase, modulates DPP signaling in the embryonic epidermis of Drosophila
Dev. Biol.
381
434-445
2013
Drosophila melanogaster, Drosophila melanogaster (Q9Y0Z0)
Manually annotated by BRENDA team
Shi, J.F.; Fu, J.; Mu, L.L.; Guo, W.C.; Li, G.Q.
Two Leptinotarsa uridine diphosphate N-acetylglucosamine pyrophosphorylases are specialized for chitin synthesis in larval epidermal cuticle and midgut peritrophic matrix
Insect Biochem. Mol. Biol.
68
1-12
2016
Leptinotarsa decemlineata (KT282116), Leptinotarsa decemlineata (KT282117)
Manually annotated by BRENDA team
Wang, Z.; Wang, Y.; Hong, X.; Hu, D.; Liu, C.; Yang, J.; Li, Y.; Huang, Y.; Feng, Y.; Gong, H.; Li, Y.; Fang, G.; Tang, H.; Li, Y.
Functional inactivation of UDP-N-acetylglucosamine pyrophosphorylase 1 (UAP1) induces early leaf senescence and defence responses in rice
J. Exp. Bot.
66
973-987
2015
Oryza sativa Japonica Group (Q6ZJ97), Oryza sativa Japonica Group ZH11 (Q6ZJ97)
Manually annotated by BRENDA team
Liu, X.; Li, F.; Li, D.; Ma, E.; Zhang, W.; Zhu, K.Y.; Zhang, J.
Molecular and functional analysis of UDP-N-acetylglucosamine pyrophosphorylases from the migratory locust, Locusta migratoria
PLoS ONE
8
e71970
2013
Locusta migratoria (T1RR64), Locusta migratoria (T1RRG3), Locusta migratoria
Manually annotated by BRENDA team
Wang, S.; Fu, X.; Liu, Y.; Liu, X.W.; Wang, L.; Fang, J.; Wang, P.G.
Probing the roles of conserved residues in uridyltransferase domain ofEscherichia coli K12 GlmU by site-directed mutagenesis
Carbohydr. Res.
413
70-74
2015
Escherichia coli (P0ACC7)
Manually annotated by BRENDA team
Jagtap, P.K.; Verma, S.K.; Vithani, N.; Bais, V.S.; Prakash, B.
Crystal structures identify an atypical two-metal-ion mechanism for uridyltransfer in GlmU: its significance to sugar nucleotidyl transferases
J. Mol. Biol.
425
1745-1759
2013
Mycobacterium tuberculosis (P9WMN3)
Manually annotated by BRENDA team
Tran, A.T.; Wen, D.; West, N.P.; Baker, E.N.; Britton, W.J.; Payne, R.J.
Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmU)
Org. Biomol. Chem.
11
8113-8126
2013
Mycobacterium tuberculosis (P9WMN3), Mycobacterium tuberculosis H37Rv (P9WMN3)
Manually annotated by BRENDA team
Qi, X.; Deng, W.; Gao, M.; Mao, B.; Xu, S.; Chen, C.; Zhang, Q.
Novel lead compound optimization and synthesized based on the target structure of Xanthomonas oryzae pv. oryzae GlmU
Pestic. Biochem. Physiol.
122
22-28
2015
Xanthomonas oryzae pv. oryzae
Manually annotated by BRENDA team
Honda, Y.; Zang, Q.; Shimizu, Y.; Dadashipour, M.; Zhang, Z.; Kawarabayasi, Y.
Increasing the thermostable sugar-1-phosphate nucleotidylyltransferase activities of the archaeal ST0452 protein through site saturation mutagenesis of the 97th amino acid position
Appl. Environ. Microbiol.
83
e02291
2017
Escherichia coli (P0ACC7), Sulfurisphaera tokodaii (Q975F9), Sulfurisphaera tokodaii, Sulfurisphaera tokodaii DSM 16993 (Q975F9), Escherichia coli K12 (P0ACC7)
Manually annotated by BRENDA team
Honda, Y.; Nakano, S.; Ito, S.; Dadashipour, M.; Zhang, Z.; Kawarabayasi, Y.
Improvement of ST0452 N-acetylglucosamine-1-phosphate uridyltransferase activity by the cooperative effect of two single mutations identified through structure-based protein engineering
Appl. Environ. Microbiol.
84
e002213-18
2018
Sulfurisphaera tokodaii (Q975F9), Sulfurisphaera tokodaii, Sulfurisphaera tokodaii DSM 16993 (Q975F9)
Manually annotated by BRENDA team
Dadashipour, M.; Iwamoto, M.; Hossain, M.M.; Akutsu, J.I.; Zhang, Z.; Kawarabayasi, Y.
Identification of a direct biosynthetic pathway for UDP-N-acetylgalactosamine from glucosamine-6-phosphate in thermophilic crenarchaeon Sulfolobus tokodaii
J. Bacteriol.
200
e00048-18
2018
Sulfurisphaera tokodaii (Q975F9), Sulfurisphaera tokodaii DSM 16993 (Q975F9)
Manually annotated by BRENDA team
Zhang, Z.; Akutsu, J.; Tsujimura, M.; Kawarabayasi, Y.
Increasing in archaeal GlcNAc-1-P uridyltransferase activity by targeted mutagenesis while retaining its extreme thermostability
J. Biochem.
141
553-562
2007
Sulfurisphaera tokodaii (Q975F9), Sulfurisphaera tokodaii DSM 16993 (Q975F9)
Manually annotated by BRENDA team
Zhang, Z.; Tsujimura, M.; Akutsu, J.; Sasaki, M.; Tajima, H.; Kawarabayasi, Y.
Identification of an extremely thermostable enzyme with dual sugar-1-phosphate nucleotidylyltransferase activities from an acidothermophilic archaeon, Sulfolobus tokodaii strain 7
J. Biol. Chem.
280
9698-9705
2005
Sulfurisphaera tokodaii (Q975F9), Sulfurisphaera tokodaii DSM 16993 (Q975F9)
Manually annotated by BRENDA team
Honda, Y.; Zang, Q.; Shimizu, Y.; Dadashipour, M.; Zhang, Z.; Kawarabayasi, Y.
Increasing the thermostable sugar-1-phosphate nucleotidylyltransferase activities of the archaeal ST0452 protein through site saturation mutagenesis of the 97th amino acid position
Appl. Environ. Microbiol.
83
e02291-16
2017
Escherichia coli (P0ACC7), Sulfurisphaera tokodaii (Q975F9), Sulfurisphaera tokodaii, Sulfurisphaera tokodaii DSM 16993 (Q975F9), Escherichia coli K12 (P0ACC7)
Manually annotated by BRENDA team
Sharma, R.; Rani, C.; Mehra, R.; Nargotra, A.; Chib, R.; Rajput, V.; Kumar, S.; Singh, S.; Sharma, P.; Khan, I.
Identification and characterization of novel small molecule inhibitors of the acetyltransferase activity of Escherichia coli N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU)
Appl. Microbiol. Biotechnol.
100
3071-3085
2016
Escherichia coli, Escherichia coli ATCC 25922
Manually annotated by BRENDA team
Craggs, P.D.; Mouilleron, S.; Rejzek, M.; de Chiara, C.; Young, R.J.; Field, R.A.; Argyrou, A.; de Carvalho, L.P.S.
The Mechanism of acetyl transfer catalyzed by Mycobacterium tuberculosis GlmU
Biochemistry
57
3387-3401
2018
Mycobacterium tuberculosis (A5U161), Mycobacterium tuberculosis ATCC 25177 (A5U161)
Manually annotated by BRENDA team
Han, X.; Chen, C.; Yan, Q.; Jia, L.; Taj, A.; Ma, Y.
Action of dicumarol on glucosamine-1-phosphate acetyltransferase of GlmU and Mycobacterium tuberculosis
Front. Microbiol.
10
1799
2019
Mycobacterium tuberculosis (A5U161)
Manually annotated by BRENDA team
Honda, Y.; Nakano, S.; Ito, S.; Dadashipour, M.; Zhang, Z.; Kawarabayasi, Y.
Improvement of ST0452 N-acetylglucosamine-1-phosphate uridyltransferase activity by the cooperative effect of two single mutations identified through structure-based protein engineering
Appl. Environ. Microbiol.
84
e02213-18
2018
Sulfurisphaera tokodaii (Q975F9), Sulfurisphaera tokodaii, Sulfurisphaera tokodaii 7 (Q975F9), Sulfurisphaera tokodaii DSM 16993 (Q975F9), Sulfurisphaera tokodaii JCM 10545 (Q975F9), Sulfurisphaera tokodaii NBRC 100140 (Q975F9)
Manually annotated by BRENDA team
Bais, V.S.; Aggarwal, P.; Bharadwaj, P.; Prakash, B.
Classification, characterization and structural analysis of sugar nucleotidylyltransferase family of enzymes
Biochem. Biophys. Res. Commun.
525
780-785
2020
Candida albicans (O74933), Mycobacterium tuberculosis (P9WMN3), Mycobacterium tuberculosis H37Rv (P9WMN3)
Manually annotated by BRENDA team
Palaka, B.K.; Velmurugan Ilavarasi, A.; Sapam, T.D.; Kotapati, K.V.; Nallala, V.S.; Khan, M.B.; Ampasala, D.R.
Molecular cloning, gene expression analysis, and in silico characterization of UDP-N-acetylglucosamine pyrophosphorylase from Bombyx mori
Biotechnol. Appl. Biochem.
66
880-899
2019
Bombyx mori (A0A089PRC4), Bombyx mori
Manually annotated by BRENDA team
Patel, H.M.; Palkar, M.; Karpoormath, R.
Exploring MDR-TB inhibitory potential of 4-aminoquinazolines as Mycobacterium tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmUMTB) inhibitors
Chem. Biodivers.
17
e2000237
2020
Mycobacterium tuberculosis (P9WMN3), Mycobacterium tuberculosis H37Rv (P9WMN3), Mycobacterium tuberculosis ATCC 25618 (P9WMN3)
Manually annotated by BRENDA team
Chen, X.; Raimi, O.G.; Ferenbach, A.T.; van Aalten, D.M.F.
A missense mutation in a patient with developmental delay affects the activity and structure of the hexosamine biosynthetic pathway enzyme AGX1
FEBS Lett.
595
110-122
2020
Homo sapiens (Q16222)
Manually annotated by BRENDA team
Braden, L.; Michaud, D.; Igboeli, O.O.; Dondrup, M.; Hamre, L.; Dalvin, S.; Purcell, S.L.; Kongshaug, H.; Eichner, C.; Nilsen, F.; Fast, M.D.
Identification of critical enzymes in the salmon louse chitin synthesis pathway as revealed by RNA interference-mediated abrogation of infectivity
Int. J. Parasitol.
50
873-889
2020
Lepeophtheirus salmonis
Manually annotated by BRENDA team
Sharma, R.; Lambu, M.R.; Jamwal, U.; Rani, C.; Chib, R.; Wazir, P.; Mukherjee, D.; Chaubey, A.; Khan, I.A.
Escherichia coli N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU) inhibitory activity of terreic acid isolated from Aspergillus terreus
J. Biomol. Screen.
21
342-353
2016
Escherichia coli (P0ACC7), Escherichia coli ATCC 25922 (P0ACC7)
Manually annotated by BRENDA team
Debets, M.F.; Tastan, O.Y.; Wisnovsky, S.P.; Malaker, S.A.; Angelis, N.; Moeckl, L.K.R.; Choi, J.; Flynn, H.; Wagner, L.J.S.; Bineva-Todd, G.; Antonopoulos, A.; Cioce, A.; Browne, W.M.; Li, Z.; Briggs, D.C.; Douglas, H.L.; Hess, G.T.; Agbay, A.J.; Roustan, C.; Kjaer, S.; Haslam, S.M.; Snijders, A.P.; Bassik, M.C.; , M.
Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation
Proc. Natl. Acad. Sci. USA
117
25293-25301
2020
Homo sapiens (Q16222)
Manually annotated by BRENDA team