2.7.7.2: FAD synthase
This is an abbreviated version!
For detailed information about FAD synthase, go to the full flat file.
Word Map on EC 2.7.7.2
-
2.7.7.2
-
desaturase
-
polyunsaturated
-
arachidonic
-
docosahexaenoic
-
linoleic
-
eicosapentaenoic
-
desaturation
-
elongase
-
elovl2
-
omega-6
-
delta-5
-
lcpufas
-
ammoniagenes
-
srebf1
-
gene-diet
-
flavokinase
-
synthesis
-
nutrition
- 2.7.7.2
-
desaturase
-
polyunsaturated
-
arachidonic
-
docosahexaenoic
-
linoleic
-
eicosapentaenoic
-
desaturation
- elongase
-
elovl2
-
omega-6
-
delta-5
-
lcpufas
- ammoniagenes
-
srebf1
-
gene-diet
- flavokinase
- synthesis
- nutrition
Reaction
Synonyms
adenosine triphosphate-riboflavin mononucleotide transadenylase, adenosine triphosphate-riboflavine mononucleotide transadenylase, ATP-FMN adenylyltransferase, ATP:FMN adenylyl transferase, ATP:FMN adenylyltransferase, AtRibF1, AtRibF2, FAD pyrophosphorylase, FAD synthase, FAD synthetase, FAD synthetase isoform 1, FAD synthetase isoform 2, Fad1, FADS, FADS-6, FADS1, FADS2, FLAD1, flavin adenine dinucleotide synthetase, FMN adenylyltransferase, FMN pyrophosphorylase, FMN:ATP adenylyltransferase, FMNAT, lysZ, MJ1179, More, ribF, RibL, riboflavin adenine dinucleotide pyrophosphorylase, riboflavin mononucleotide adenylyltransferase, riboflavine adenine dinucleotide adenylyltransferase, SPAP_1083
ECTree
2.7.7.2 FAD synthaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 2.7.7.2 - FAD synthase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
(1R,2S,4aS,4bS,7R,8aR,10aS)-7-hydroxy-2,4b-dimethyl-1-[(3-oxo-3H-indol-2-yl)methyl]tetradecahydrophenanthrene-2-carboxylic acid
inhibitor of the activity of the flavin adenylyl transferase module of the FADS
2-([1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl]carbamoyl)benzoic acid
inhibitor of the activity of the flavin adenylyl transferase module of the FADS
2-([[(9H-fluoren-9-yl)methoxy]carbonyl]amino)benzoic acid
inhibitor of the activity of the flavin adenylyl transferase module of the FADS, able to inhibit growth of Corynebacterium ammoniagenes and Mycobacterium tuberculosis
methyl 2-[(4-chlorophenyl)carbamoyl]-N-(3,5-dimethyl-1,2-oxazole-4-sulfonyl)hydrazine-1-carboximidothioate
56% resiudal activity at 0.25 mM, inhibitor of the activity of the flavin adenylyl transferase module of the FADS
N-(5-nitrothiophene-3-carbonyl)-2-[[4-(propan-2-yl)phenyl]carbamothioyl]hydrazine-1-carboxamide
inhibitor of the activity of the flavin adenylyl transferase module of the FADS, able to inhibit growth of Corynebacterium ammoniagenes and Mycobacterium tuberculosis
Urea
the enzymatic activity of isoform FADS2 decreases dramatically at increasing urea concentration, with a mid-point for activity loss at 2.1 m urea
additional information
-
no detectable inhibition with 2-[(hydroxyethyl)amino]-FMN, 2-morpholinyl-FMN, 2-(phenylamino)-FMN, 3-methyl-FMN, 3-(carboxymethyl)-FMN, 8-alpha-imidazolyl-FMN, 8-alpha-(N-methylimidazolyl)-FMN, 5'-phosphothionate, DL-glycerol 3-phosphate and propyl 3-phosphate
-
ATP
substrate inhibition; substrate inhibition; substrate inhibition
FAD
-
strong product inhibitor, 50% inhibition at 0.006 mM, competitive inhibition against ATP, mixed inhibition against FMN
FAD
-
strong product inhibitor, 50% inhibition at 0.006 mM, competitive inhibition against ATP, mixed inhibition against FMN
FAD
product inhibition, wild-type enzyme FMNAT is strongly inhibited by FAD, whereas D181A mutant enzyme has an attenuated product inhibition
FMN
substrate inhibition; substrate inhibition; substrate inhibition
