2.7.7.18: nicotinate-nucleotide adenylyltransferase

This is an abbreviated version!
For detailed information about nicotinate-nucleotide adenylyltransferase, go to the full flat file.

Word Map on EC 2.7.7.18

2.7.7.18

anthracis

falciparum

plasmodium

salvage

adenylylation

malaria

broad-spectrum

nadp

deamidated

medicine

drug development

analysis

synthesis

Reaction

Synonyms

adenylyltransferase, nicotinate mononucleotide, Arabidopsis thaliana nicotinate/nicotinamide mononucleotide adenyltransferase, AtNMNAT, deamido-NAD+ pyrophosphorylase, deamidonicotinamide adenine dinucleotide pyrophosphorylase, GlNMNAT, M6_Spy0291, nadD, NaMN AT, NaMN-ATase, NaMNAT, nicotinamide/nicotinate mononucleotide adenylyltransferase, nicotinamide/nicotinic acid mononucleotide adenylyltransferase, nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1, nicotinate mononucleotide adenylyltransferase, nicotinate/nicotinamide mononucleotide adenyltransferase, nicotinic acid mononucleotide adenylyltransferase, NMN/NaMN adenylyltransferase, NMN/NaMN adenylyltransferase 2, NMN/NaMN adenylyltransferase 3, NMNAT, NMNAT1, NMNAT2, NMNAT3, PF3D7_1327600, PfNMNAT, sp.NadD, TTHA1780

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.7 Nucleotidyltransferases

2.7.7.18 nicotinate-nucleotide adenylyltransferase

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Results	in table
40929	AA Sequence
8	Application
1	CAS Registry Number
12	Cloned(Commentary)
4	Cofactor
12	Crystallization (Commentary)
3	Disease/ Diagnostics
13	General Information
1	General Stability
22	IC50 Value
52	Inhibitors
32	kcat/KM [mM/s]
9	Ki Value [mM]
75	KM Value [mM]
8	Localization
10	Metals/Ions
15	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
55	Organism
12	Pathway
92	PDB ID
6	pH Optimum
1	pI Value
33	Protein Variants
9	Purification (Commentary)
1	Reaction
1	Reaction Type
49	Reference
10	Source Tissue
17	Specific Activity [micromol/min/mg]
3	Storage Stability
60	Substrates and Products (Substrate)
23	Subunits
58	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
5	Temperature Stability [°C]
22	Turnover Number [1/s]

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Application on EC 2.7.7.18 - nicotinate-nucleotide adenylyltransferase

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analysis

Thermus thermophilus

Q5SHF0

NMNAT can be applied to the colorimetric NMN or NaMN assays, which employ either adenylation of NMN to NAD by NMNAT or adenylation of NaMN to deamido-NAD (NaAD) by NMNAT followed by amidation of NaAD to NAD by NAD synthetase (NADS, EC 6.3.1.5) or an NAD cycling reaction using 12alpha-hydroxysteroid dehydrogenase (12a-HSD, EC 1.1.1.176) and diaphorase (DI, EC 1.6.99.3) to accumulate reduced 2-(2-methoxy-4-nitrophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium. The enzymatic cycling method enables detection of 0.5 mM (12.2 nM in the reaction mixture) NMN or NaMN in an automatic clinical analyzer

drug development

medicine

synthesis

overexpression of enzyme gene under anaerobic conditions in a strain lacking IdhA and pflB gene products leads to 3.21fold increase in NAD+ and 1.67fold increase in NADH in the recombinant strain. Enzyme expression restores cell growth and glucose utilization under anaerobic conditions. After 72 h, the recombinant strain can consume 14 g/l of lgucose and produce 6.23 g/l of succinic acid

722069